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SMARCA4
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @richterRecurrentMutationID32012, @dengSMARCA4HaploinsufficientCell2024, @lohrDiscoveryPrioritizationSomatic2012, @krysiakRecurrentSomaticMutations2017, @nadeuGenomicEpigenomicInsights2020, @lunningMutationChromatinModifiers2015,
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SMARCA4 is a member of the SWI/SNF family of proteins. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which can allow expression of genes repressed by chromatin. Overall, components of SWI/SNF have been identified as an emerging theme in germinal centre-derived B-cell lymphomas. [@lunningMutationChromatinModifiers2015]
Driver mutations affecting this gene in DLBCL/FL/BL have been experimentally demonstrated to cause a reduction or loss of function (LOF).[@fernandoFunctionalCharacterizationSMARCA42020]
include:tables/table1_SMARCA4.md
include:tables/DLBCL_SMARCA4.md
include:tables/dnds_SMARCA4.md
include:tables/browser_SMARCA4.md
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