Decouple biological capabilities from organisms into reusable modules,
reconstruct living systems with software engineering paradigms.

About • Quick Start • Docs • Concepts • Roadmap • Contribute

🧬 What is Wetware Engineering?

Wetware Engineering is an interdisciplinary framework that applies software engineering paradigms to biological system construction. 💡 This is not "running biology as software", but rebuilding life systems using programming paradigms. Key Innovations: 🧩 Bio-Component Organs, tissues, actuators as composable modules 🔌 Bio-Interface Standardized connections for plug-and-play 📝 Bio-DSL Domain-specific language for system composition ⚙️ Bio-Runtime Resource scheduling and monitoring system

┌────────────────────────────┐ │ Traditional Biology │ │ ──────────────────── │ │ 🔬 Monolithic organisms │ │ 📝 Ad-hoc protocols │ │ 🔄 Manual integration │ │ 📊 Implicit dependencies │ └────────────────────────────┘ ⬇️ ┌────────────────────────────┐ │ Wetware Engineering │ │ ──────────────────── │ │ 🧩 Modular components │ │ 📋 Standard interfaces │ │ ⚡ Plug-and-play │ │ 📦 Managed dependencies │ └────────────────────────────┘

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🚀 Quick Start

# Clone the repository
git clone https://github.com/tukuaiai/wetware-engineering.git
cd wetware-engineering

# Explore documentation
ls i18n/en/    # English docs
ls i18n/zh/    # 中文文档

💻 Try Bio-DSL Example

// Define components
COMPONENT muscle FROM "muscle-actuator-human-skeletal@^2.3"
COMPONENT sensor FROM "piezo-force-sensor@~1.1"
COMPONENT controller FROM "neural-organoid-spinal@>=0.8"

// Connect components
CONNECT sensor.output TO controller.input
CONNECT controller.output TO muscle.stimulation

// Runtime configuration
RUNTIME {
  perfusion: { temperature: 37°C, flow_rate: 0.5 mL/min },
  control: { mode: "closed_loop" }
}

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📚 Documentation

📖 Wetware Engineering Core

Document	EN	中文	Description
Quick Start	📄	📄	5-minute introduction
Plain Language	📄	📄	Zero-barrier explanation
Core Concepts	📄	📄	Complete introduction
Manifesto	📄	📄	Vision & principles
Technical Spec	📄	📄	Bio-Component Spec & DSL

🧠 Immortality Project

📁 Core Documents — Architecture, 27 Elements, Technical Blueprint

Document	EN	中文
Overview	📄	📄
Human 3.0 Architecture	📄	📄
Architecture (Academic)	📄	📄
27 Elements	📄	📄
27 Elements (Academic)	📄	📄
Technical Blueprint	📄	📄
Blueprint (Academic)	📄	📄

🎭 Philosophy — Emotion Modeling, Experience Machine

Document	EN	中文
Emotion Modeling	📄	📄
Emotion Modeling (Academic)	📄	📄
Experience Machine	📄	📄
Experience Machine (Academic)	📄	📄

📢 Guides — Social Media, Outreach

Document	EN	中文
Human 3.0 Social Media	📄	📄
Social Media (Academic)	📄	📄

📄 Academic Paper

Resource	Link
📥 Preprint PDF (13 pages)	Download
📝 LaTeX Source	View
📖 Markdown Draft	Read

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🎯 Core Concepts

Component-Interface-Runtime ┌─────────────────────────────────┐ │ WETWARE ENGINEERING │ ├──────────┬──────────┬───────────┤ │COMPONENT │INTERFACE │ RUNTIME │ │(Module) │ (API) │(Orchestr.)│ ├──────────┼──────────┼───────────┤ │◆ Actuator│◆ Power │◆ Schedule │ │◆ Sensor │◆ Signal │◆ Resource │ │◆ Process │◆ Isolate │◆ Monitor │ │◆ Metabol │◆ Mechani │◆ Fault │ └──────────┴──────────┴───────────┘

Software ↔ Wetware Mapping Software Wetware Example Package Manager Bio-Registry Discovery Semver Bio-Versioning [email protected] API Contract Bio-Interface I/O spec Unit Test Viability Test Verification Container Perfusion Life support

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📁 Project Structure

wetware-engineering/
├── 📄 README.md              # You are here
├── 📄 AGENTS.md              # AI Agent guide
├── 📄 CONTRIBUTING.md        # Contribution guide
├── 📄 LICENSE                # CC BY-SA 4.0
│
├── 🌐 i18n/
│   ├── en/                   # English documentation
│   └── zh/                   # 中文文档
│
├── 📝 paper/arxiv/           # Academic paper (13 pages)
│
└── ⚙️ .github/workflows/     # CI/CD

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🗺️ Roadmap

Status	Milestone
✅	Core concept definition
✅	Bio-Component Spec v0.1
✅	Bio-DSL syntax draft
✅	Bilingual documentation (EN/中文)
✅	Academic paper preprint
🚧	arXiv submission
📋	Reference implementation (Python/TypeScript)
📋	Bio-DSL parser
📋	Component registry prototype

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🤝 Contributing

We welcome contributions! See CONTRIBUTING.md for details.

git clone https://github.com/YOUR_USERNAME/wetware-engineering.git
git checkout -b feature/your-feature
git commit -m "feat: add something awesome"
git push origin feature/your-feature

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❓ FAQ

What's the difference between Wetware Engineering and Synthetic Biology?

Synthetic biology operates at the gene/molecular level (e.g., BioBricks), while Wetware Engineering operates at the organ/system level. They are complementary: synthetic biology defines component internals, Wetware Engineering defines how components combine.

Can Bio-DSL actually run?

Currently Bio-DSL is a conceptual specification with no runtime implementation. Its value lies in providing a standardized system description language, laying the foundation for future toolchains.

What are the practical applications?

Short-term: Conceptual framework & standard specifications
Mid-term: Toolchain development
Long-term: Reusable, composable biological systems engineering

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🔗 Links & Resources

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📄 License

This project is licensed under CC BY-SA 4.0 — Free to share and adapt with attribution.

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