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Releases: shz9/penprs

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v0.0.1

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@JackSong88 JackSong88 released this 25 Nov 01:42

PenPRS - v0.0.1

First official release of penprs, a Python package for penalized regression inference of polygenic risk scores (PRS) using linkage disequilibrium (LD) and GWAS summary statistics.

What's included:

  • Implementation of core models: LASSO, SSL (Spike-and-slab LASSO PRS), and SSLAlpha (alpha-heritability SSL model)
  • Integration with magenpy for data harmonization and LD computations
  • Command-line interface (penprs_fit) support
  • README contains a "Getting started" section. For additional details on the models and algorithms, refer to associated paper linked in the README.

Notes & Future work:

  • Future updates will add new models, enhancements to performance, and richer documentation.
  • Feedback, bug reports, and contributions are warmly welcomed!

Thanks for exploring penprs!