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Releases: shz9/penprs
Releases · shz9/penprs
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v0.0.1
PenPRS - v0.0.1
First official release of penprs, a Python package for penalized regression inference of polygenic risk scores (PRS) using linkage disequilibrium (LD) and GWAS summary statistics.
What's included:
- Implementation of core models:
LASSO,SSL(Spike-and-slab LASSO PRS), andSSLAlpha(alpha-heritability SSL model) - Integration with
magenpyfor data harmonization and LD computations - Command-line interface (
penprs_fit) support - README contains a "Getting started" section. For additional details on the models and algorithms, refer to associated paper linked in the README.
Notes & Future work:
- Future updates will add new models, enhancements to performance, and richer documentation.
- Feedback, bug reports, and contributions are warmly welcomed!
Thanks for exploring penprs!