The ACTI Model (Agent-based Ctl-Tumor Interaction Model)
The ACTI Model is an agent-based model that simulates interaction between Cytotoxic T-Lymphocytes and tumor cells. It is callibrated on melanoma cells and conventionnal target cells in collaboration with Pr. Salvatore Valitutti (CRCT - INSERM) and the results of the study it has been used is published in Nature Scientific Reports. If you use this model, please cite the paper :)
The ACTI Model is based on the open-source simulation platform MecaCell developed in our research group. It is available on github. Please follow the installation instruction of the master branch before proceed.
You will need cmake 2.8+ and a recent C++ compiler (C++11 support is required). QT5.2+ is necessary if you want a graphical interface.
- Clone this repository (git clone [email protected]:scussatb/ACTI-Model.git)
- In the ACTI-Model directory, create a directory "build"
- In this new directory, run
- cmake ..
- make
To run the model, in the build directory:
- ./src/mecaBase ctlTumorRatio killDur inhRad inhProb simDur tumTyp
- ctlTumorRatio is the ratio ctl/tumor in the experiment
- killDur is the duration of 1 kill for a CTL
- inhRad is the inhibition radius when a tumor cell is killed
- inhProb is the probability for a CTL to be inhibited if a tumor dies in the inhibition radius
- simDur is the duration of the simulation in hours
- tumType is the tumor cell line (D10 or JY)