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imputeTBculture

This repository contains R code for the analysis conducted in the manuscript title "Methods for Handling Missing Data in Serially Sampled Sputum Specimens for Mycobacterial Culture Conversion Calculation".

Citation
Malatesta, S., Weir, I.R., Weber, S.E. et al. Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation. BMC Med Res Methodol 22, 297 (2022). https://doi.org/10.1186/s12874-022-01782-8

Code Files

desc_stats_plots.R

This program contains code to generate descriptive summary tables included as results.

methods.R

This program contains code to implement available case analysis, last observation carried forward, and multiple imputation.

smear_example.R

This program contains code for the illustrative example conducted in the paper estimating the association between smear status and time to culture conversion.

About

R code for applying different methods for handling missing data when using repeated measures to assess a time to event outcome. Project was motivated by the need to analyze time to culture conversion as a primary outcome in tuberculosis clinical trials.

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