Issues

• New CRAN release to aid with Eigen 5.0.1 transition

  openpharma/mmrm#575 · Filter by author eddelbuettel opened on Sep 30, 2026
  2

  

• Support for emp_start to apply to other non-spatial covariance structures

  enhancement
  openpharma/mmrm#562 · Filter by author jmiahjones-lilly opened on Apr 17, 2026
  2

• Support for constrained longitudinal data analysis (cLDA) parametrization

  enhancement
  openpharma/mmrm#551 · Filter by author DavidJesse21 opened on Nov 24, 2025
  2

• Comparison to SAS’ PROC MIXED

  openpharma/mmrm#538 · Filter by author W-APrince opened on Sep 29, 2025
  6

• Diagonal covariance structure, un-unique intra subject levels

  enhancement
  openpharma/mmrm#505 · Filter by author PharmCat opened on May 7, 2025
  5

• Calculate (approximate) covariance matrix for covariance estimates themselves

  enhancementSP13
  openpharma/mmrm#493 · Filter by author danielinteractive opened on Dec 11, 2024

• Add a spatial covariance structure implementing patient level random effects induced covariance

  enhancementSP8
  openpharma/mmrm#480 · Filter by author danielinteractive opened on Nov 9, 2024

• Add an application vignette

  documentationgood first issue
  openpharma/mmrm#448 · Filter by author danielinteractive opened on Jun 27, 2024
  7

• potentially improve warning/error messages

  devopsSP3
  openpharma/mmrm#393 · Filter by author clarkliming opened on Dec 19, 2023
  2

• Once default optimizer fails, try all optimizers but with increased number of iterations

  enhancementSP3
  openpharma/mmrm#385 · Filter by author danielinteractive opened on Dec 13, 2023
  2

• Bootstrapping functionality or interface with bootstrap packages

  openpharma/mmrm#372 · Filter by author danielinteractive opened on Nov 15, 2023

• Add acf (and maybe vignette with some plot examples)

  enhancementSP5
  openpharma/mmrm#371 · Filter by author Generalized opened on Nov 13, 2023
  3

• Cook's distance or DFFIT, DFBETA, leverage

  enhancementSP5
  openpharma/mmrm#368 · Filter by author Generalized opened on Nov 4, 2023
  10

• explore the possibility of using sandwich method to obtain the prediction sd

  enhancement
  openpharma/mmrm#345 · Filter by author clarkliming opened on Aug 31, 2023
  1

• Format simulation results in simulations/missing-data-benchmarks

  openpharma/mmrm#326 · Filter by author PhilBoileau opened on Aug 2, 2023
  

• SAS Proc Mixed: random element

  enhancement
  openpharma/mmrm#300 · Filter by author WouterMpublic opened on Jun 22, 2023
  11

• Blank out non-observed pairs in estimated covariance matrix display

  enhancement
  openpharma/mmrm#279 · Filter by author danielinteractive opened on Jun 2, 2023

• Add Matérn covariance function

  enhancement
  openpharma/mmrm#256 · Filter by author kkmann opened on Mar 26, 2023
  2

• Raise errors as warnings to avoid capture and re-emission of errors during fit

  discussionenhancement
  openpharma/mmrm#229 · Filter by author dgkf opened on Jan 24, 2023
  1

• use roxytypes and roxylint packages

  devopsdocumentationSP5
  openpharma/mmrm#228 · Filter by author dgkf opened on Jan 24, 2023
  6

• Consider nested covariance structures?

  discussion
  openpharma/mmrm#174 · Filter by author danielinteractive opened on Nov 8, 2022
  13

• Include obsweight functionality

  discussion
  openpharma/mmrm#106 · Filter by author danielinteractive opened on Sep 6, 2022