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Adds a new cell type representing skeletal cells at the murine rib periosteal surface that exhibit hybrid osteochondral properties during injury repair, co-expressing both cartilage (Sox9, Col2a1) and bone (Runx2, Col1a1) markers.
Changes
Term ID: CL_9900000 (temporary ID range)
Parent: skeletogenic cell (CL_0007001)
Location: periosteum (UBERON_0002515) via part_of relationship
Taxon: Mus musculus (NCBITaxon_10090)
Reference: PMID:30983567
Contributor: ORCID 0009-0000-8480-9277
Implementation
Added declaration at line 3294 and full term definition at lines 35476-35485 in src/ontology/cl-edit.owl, following standard CL formatting with all required metadata annotations.
Original prompt
This section details on the original issue you should resolve
<issue_title>[NTR] hybrid osteochondral skeletal cell</issue_title>
<issue_description>Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl
Preferred term label
hybrid osteochondral skeletal cell
Synonyms (add reference(s), please)
Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A skeletal cell at the periosteal surface of the murine rib that displays hybrid osteochondral properties, emerging within the large callus that bridges segmental rib defects. It derives from a Sox9-expressing periosteal skeletal stem/progenitor subpopulation that constitutes only a small fraction of uninjured rib periosteum. After injury, these cells populate the callus and co-express cartilage and bone regulators Sox9 and Runx2, as well as matrix genes Col2a1 and Col1a1, while exhibiting dual chondrocyte/osteoblast properties.
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hybrid osteochondral skeletal cellIAO_0000115 "A skeletal cell at the periosteal surface of the murine rib that displays hybrid osteochondral properties, emerging within the large callus that bridges segmental rib defects. It derives from a Sox9-expressing periosteal skeletal stem/progenitor subpopulation that constitutes only a small fraction of uninjured rib periosteum. After injury, these cells populate the callus and co-express cartilage and bone regulators Sox9 and Runx2, as well as matrix genes Col2a1 and Col1a1, while exhibiting dual chondrocyte/osteoblast properties."
hybrid osteochondral skeletal celldefinition "A skeletal cell at the periosteal surface of the murine rib that displays hybrid osteochondral properties, emerging within the large callus that bridges segmental rib defects. It derives from a Sox9-expressing periosteal skeletal stem/progenitor subpopulation that constitutes only a small fraction of uninjured rib periosteum. After injury, these cells populate the callus and co-express cartilage and bone regulators Sox9 and Runx2, as well as matrix genes Col2a1 and Col1a1, while exhibiting dual chondrocyte/osteoblast properties."
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Caroline-99
requested review from
RiveraAndrea83
and removed request for
Caroline-99
Adds a new cell type representing skeletal cells at the murine rib periosteal surface that exhibit hybrid osteochondral properties during injury repair, co-expressing both cartilage (Sox9, Col2a1) and bone (Runx2, Col1a1) markers.
Changes
part_ofrelationshipImplementation
Added declaration at line 3294 and full term definition at lines 35476-35485 in
src/ontology/cl-edit.owl, following standard CL formatting with all required metadata annotations.Original prompt
💡 You can make Copilot smarter by setting up custom instructions, customizing its development environment and configuring Model Context Protocol (MCP) servers. Learn more Copilot coding agent tips in the docs.