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43 changes: 43 additions & 0 deletions sites/main-site/src/content/advisories/snpeff_change_location.md
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---
title: snpEff cache location change in pipelines using snpEff
subtitle: All pipelines using snpEff are affected by the change of the default cache location in snpEff happening in August 2025.
category:
- pipelines
- configuration
type: incompatibility
severity: high
publishedDate: "2025-10-22"
reporter:
- maxulysse
-
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- maxulysse
-
- maxulysse

reviewer:
- maxulysse
-
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- maxulysse
-
- mashehu

pipelines:
- name: sarek
versions:
- 2.12.0
- name: rnavar
versions:
- 4.2.0
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are these versions correct?

modules:
- name: snpeff_download
- name: snpeff_snpeff
subworkflows:
- name: vcf_annotation_snpeff
nextflowVersions:
- ">=25.04.0 <25.04.3"
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i don't think this is dependent on Nextflow

references:
- title: snpeff issue regarding change of hosting location of cache and binaries
description: Issues reporting the issue with snpeff download after the change of hosting location
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description: Issues reporting the issue with snpeff download after the change of hosting location
description: GitHub issue about the problem with snpeff download after the change of hosting location

url: https://github.com/pcingola/SnpEff/issues/602
---

# Issue

https://github.com/pcingola/SnpEff/issues/602
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not needed. will be added at the end

Suggested change
https://github.com/pcingola/SnpEff/issues/602


snpeff download is broken with older versions of sarek/rnavar due to changes in location for the storage of snpeff cache.
snpeff download works with newer versions of sarek/rnavar with an updated of snpeff, but cache 105 is now not valid anymore (hopefully until a fix comes).

-> https://github.com/pcingola/SnpEff/issues/609
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-> https://github.com/pcingola/SnpEff/issues/609

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