v1.15

allow GC filtering on discovery

v1.14

Bug fix for bedannotator where an empty output column would be added if no bed files were specified. Also changed BED file input to be zero-based

bug fix release

This release errors out if the user tries to use a reference with more than a million contigs, as we currently don't support that for positional information output

1.12.a: pre-release release for per-off-target scores

pre-release to test out writing per-off-target scores (only for Doench 2016 CFDs right now)

1.12: Output counts for 'dangerous' scoring metric

small update to allow for untagged (numbers only) output for the dangerous scoring metric

add patterned, random guide generation and free-energy calculations

1.11

add thanks

bug fix release

Fix a major bug with Cpf1 (or any 5' PAM motif) where some indexed blocks weren't being processed correctly. As a temporary fix we no longer make index blocks for these enzymes and only use linear blocks. This will be fixed in future releases. The does require regenerating any Cpf1 databases.

small column name change

I can't seem to get CFD scores right in my head. Changing the Doench 2016 score title to 'DoenchCFD_maxOT' which better reflects what we've always returned

Release 1.9.9

consolidate changes from the 1.9.9 release candidates, and revert the CFD score name

release candidate with new column names

release candidate with new column names for Doensch CFD scores