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Machine learning AMP prediction models vs. homology (BLAST) to find AMPs in proteomes

The files required to run the code in these Rmd files can be obtained by clicking here or by using the command:

wget 'https://cloudstor.aarnet.edu.au/plus/s/yXYa5zVk5rrvRpz/download' -O data.tgz
tar -zxvf data.tgz 

sessionInfo()

R version 4.1.2 (2021-11-01)
Platform: x86_64-apple-darwin17.0 (64-bit)
Running under: macOS Monterey 12.3.1

Matrix products: default
LAPACK: /Library/Frameworks/R.framework/Versions/4.1/Resources/lib/libRlapack.dylib

locale:
[1] en_AU.UTF-8/en_AU.UTF-8/en_AU.UTF-8/C/en_AU.UTF-8/en_AU.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] ggtree_3.0.4        randomcoloR_1.1.0.1 broom_0.7.11        ggtext_0.1.1        pals_1.7           
 [6] treeio_1.16.2       ape_5.6-1           precrec_0.12.7      patchwork_1.1.1     ampir_1.1.0        
[11] forcats_0.5.1       stringr_1.4.0       dplyr_1.0.7         purrr_0.3.4         readr_2.1.1        
[16] tidyr_1.1.4         tibble_3.1.6        ggplot2_3.3.5       tidyverse_1.3.1    

loaded via a namespace (and not attached):
 [1] Rtsne_0.15           colorspace_2.0-2     ellipsis_0.3.2       class_7.3-19         Peptides_2.4.4      
 [6] fs_1.5.2             aplot_0.1.2          gridtext_0.1.4       dichromat_2.0-0      rstudioapi_0.13     
[11] listenv_0.8.0        prodlim_2019.11.13   fansi_1.0.2          lubridate_1.8.0      xml2_1.3.3          
[16] codetools_0.2-18     splines_4.1.2        knitr_1.37           jsonlite_1.7.2       pROC_1.18.0         
[21] caret_6.0-90         cluster_2.1.2        dbplyr_2.1.1         mapproj_1.2.8        compiler_4.1.2      
[26] httr_1.4.2           backports_1.4.1      assertthat_0.2.1     Matrix_1.3-4         fastmap_1.1.0       
[31] lazyeval_0.2.2       cli_3.1.0            htmltools_0.5.2      tools_4.1.2          gtable_0.3.0        
[36] glue_1.6.0           reshape2_1.4.4       maps_3.4.0           V8_4.0.0             Rcpp_1.0.8          
[41] cellranger_1.1.0     vctrs_0.3.8          nlme_3.1-153         iterators_1.0.13     timeDate_3043.102   
[46] gower_0.2.2          xfun_0.30            globals_0.14.0       rvest_1.0.2          lifecycle_1.0.1     
[51] future_1.23.0        MASS_7.3-54          scales_1.1.1         ipred_0.9-12         hms_1.1.1           
[56] parallel_4.1.2       yaml_2.2.1           curl_4.3.2           ggfun_0.0.4          yulab.utils_0.0.4   
[61] rpart_4.1-15         stringi_1.7.6        foreach_1.5.1        tidytree_0.3.7       lava_1.6.10         
[66] rlang_0.4.12         pkgconfig_2.0.3      evaluate_0.14        lattice_0.20-45      recipes_0.1.17      
[71] tidyselect_1.1.1     parallelly_1.30.0    plyr_1.8.6           magrittr_2.0.1       R6_2.5.1            
[76] generics_0.1.1       DBI_1.1.2            pillar_1.6.4         haven_2.4.3          withr_2.4.3         
[81] survival_3.2-13      nnet_7.3-16          future.apply_1.8.1   modelr_0.1.8         crayon_1.4.2        
[86] utf8_1.2.2           tzdb_0.2.0           rmarkdown_2.13       grid_4.1.2           readxl_1.3.1        
[91] data.table_1.14.2    ModelMetrics_1.2.2.2 reprex_2.0.1         digest_0.6.29        gridGraphics_0.5-1  
[96] stats4_4.1.2         munsell_0.5.0        ggplotify_0.1.0  

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Effectiveness of AMP prediction using machine learning versus sequence similarity

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