Acceptor_variant.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "import pandas as pd\n",
    "import numpy as np\n",
    "from src import preprocess"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "accp = pd.read_csv('./PreprocessData/variant-acceptor.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [],
   "source": [
    "ref_seq_matrix = []\n",
    "alt_seq_matrix = []\n",
    "for i in range(len(accp)):\n",
    "    ref_seq_matrix.append(preprocess.transform_seq_to_Vmatrix(accp['ref.sequence'][i]))\n",
    "    alt_seq_matrix.append(preprocess.transform_seq_to_Vmatrix(accp['alt.sequence'][i]))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [],
   "source": [
    "ref_seq_matrix = np.asarray(ref_seq_matrix)\n",
    "alt_seq_matrix = np.asarray(alt_seq_matrix)\n",
    "\n",
    "ref_seq_matrix = ref_seq_matrix.reshape(ref_seq_matrix.shape[0], ref_seq_matrix.shape[1], ref_seq_matrix.shape[2], 1)\n",
    "alt_seq_matrix = alt_seq_matrix.reshape(alt_seq_matrix.shape[0], alt_seq_matrix.shape[1], alt_seq_matrix.shape[2], 1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [],
   "source": [
    "ref_class = [1 for i in range(len(ref_seq_matrix))]\n",
    "alt_class = [0 for i in range(len(alt_seq_matrix))]"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Loading Models"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Using TensorFlow backend.\n"
     ]
    }
   ],
   "source": [
    "from keras.models import load_model\n",
    "from src import calculate\n",
    "\n",
    "acceptor_Vmodel_1 = load_model('./Models/accp_Vmodel_1-1.hf5')\n",
    "acceptor_Vmodel_2 = load_model('./Models/accp_Vmodel_2-1.hf5')\n",
    "acceptor_Vmodel_3 = load_model('./Models/accp_Vmodel_3-1.hf5')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [],
   "source": [
    "y1_var_ref_predict = acceptor_Vmodel_1.predict_proba(ref_seq_matrix)\n",
    "y1_var_ref_predict_classes = acceptor_Vmodel_1.predict_classes(ref_seq_matrix)\n",
    "\n",
    "y1_var_alt_predict = acceptor_Vmodel_1.predict_proba(alt_seq_matrix)\n",
    "y1_var_alt_predict_classes = acceptor_Vmodel_1.predict_classes(alt_seq_matrix)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Sequence[113] is 1 and Pathogenic Score: log10(0.9726365208625793/0.4789036214351654) = 0.3077024519443512\n",
      "Sequence[171] is 1 and Pathogenic Score: log10(0.8837357759475708/0.8041802644729614) = 0.040969040244817734\n",
      "Sequence[187] is 1 and Pathogenic Score: log10(0.8640497326850891/0.8012401461601257) = 0.03277604654431343\n",
      "Sequence[217] is 1 and Pathogenic Score: log10(0.7979162931442261/0.2358863651752472) = 0.5292544960975647\n",
      "Sequence[247] is 1 and Pathogenic Score: log10(0.9927720427513123/0.9119475483894348) = 0.03687966614961624\n",
      "Sequence[252] is 1 and Pathogenic Score: log10(0.9364356398582458/0.08065523952245712) = 1.064845323562622\n",
      "Sequence[254] is 1 and Pathogenic Score: log10(0.9364356398582458/0.1757759153842926) = 0.7265185713768005\n",
      "Sequence[501] is 1 and Pathogenic Score: log10(0.9773878455162048/0.964396059513092) = 0.005811482667922974\n",
      "Sequence[525] is 1 and Pathogenic Score: log10(0.9298864603042603/0.6863031387329102) = 0.1319139301776886\n",
      "Sequence[539] is 1 and Pathogenic Score: log10(0.9524368047714233/0.07384178042411804) = 1.1105340719223022\n",
      "Sequence[557] is 1 and Pathogenic Score: log10(0.9954794645309448/0.7346361875534058) = 0.1319599747657776\n",
      "Sequence[627] is 1 and Pathogenic Score: log10(0.9900264739990234/0.9058542251586914) = 0.038588494062423706\n",
      "Sequence[638] is 1 and Pathogenic Score: log10(0.9232343435287476/0.2508150637149811) = 0.5659583210945129\n",
      "Sequence[649] is 1 and Pathogenic Score: log10(0.9601731896400452/0.34158504009246826) = 0.44885072112083435\n",
      "Sequence[653] is 1 and Pathogenic Score: log10(0.8527231216430664/0.8763043880462646) = -0.011846940033137798\n",
      "Sequence[655] is 1 and Pathogenic Score: log10(0.9526259899139404/0.10724963992834091) = 0.9485265612602234\n",
      "Sequence[656] is 1 and Pathogenic Score: log10(0.9117868542671204/0.14706683158874512) = 0.7923786044120789\n",
      "Sequence[664] is 1 and Pathogenic Score: log10(0.7763067483901978/0.10192608088254929) = 0.8817480206489563\n",
      "Sequence[711] is 1 and Pathogenic Score: log10(0.9742242693901062/0.9766581654548645) = -0.0010836431756615639\n",
      "Sequence[713] is 1 and Pathogenic Score: log10(0.9919008016586304/0.991838276386261) = 2.73864916380262e-05\n",
      "Sequence[739] is 1 and Pathogenic Score: log10(0.9924293160438538/0.7179797291755676) = 0.14058740437030792\n",
      "Sequence[742] is 1 and Pathogenic Score: log10(0.8964120745658875/0.040467336773872375) = 1.3454030752182007\n",
      "Sequence[743] is 1 and Pathogenic Score: log10(0.9946824908256531/0.8085387349128723) = 0.08998364955186844\n",
      "Sequence[761] is 1 and Pathogenic Score: log10(0.8577584028244019/0.015136811882257462) = 1.7533305883407593\n",
      "Sequence[762] is 1 and Pathogenic Score: log10(0.9778681993484497/0.9695765972137451) = 0.003698172979056835\n",
      "Sequence[763] is 1 and Pathogenic Score: log10(0.6163835525512695/0.006680075079202652) = 1.9650696516036987\n",
      "Sequence[764] is 1 and Pathogenic Score: log10(0.9205740094184875/0.12104427814483643) = 0.8811144232749939\n",
      "Sequence[765] is 1 and Pathogenic Score: log10(0.9621497988700867/0.9693199396133423) = -0.003224440850317478\n",
      "Sequence[766] is 1 and Pathogenic Score: log10(0.9621497988700867/0.4840514063835144) = 0.2983511984348297\n",
      "Sequence[767] is 1 and Pathogenic Score: log10(0.9621497988700867/0.7559418678283691) = 0.10475429892539978\n",
      "Sequence[842] is 1 and Pathogenic Score: log10(0.963018536567688/0.9323749542236328) = 0.01404403243213892\n",
      "Sequence[843] is 1 and Pathogenic Score: log10(0.9338812828063965/0.0784839540719986) = 1.0755107402801514\n",
      "Sequence[861] is 1 and Pathogenic Score: log10(0.9301950931549072/0.1281178593635559) = 0.8609643578529358\n",
      "Sequence[876] is 1 and Pathogenic Score: log10(0.9765215516090393/0.14322039484977722) = 0.8336769938468933\n",
      "Sequence[917] is 1 and Pathogenic Score: log10(0.9267140030860901/0.0618891641497612) = 1.1753311157226562\n",
      "Sequence[918] is 1 and Pathogenic Score: log10(0.9267140030860901/0.8650500774383545) = 0.029904495924711227\n",
      "Sequence[938] is 1 and Pathogenic Score: log10(0.9793779253959656/0.5572149157524109) = 0.2449275702238083\n",
      "Sequence[939] is 1 and Pathogenic Score: log10(0.9793779253959656/0.9231379628181458) = 0.025683710351586342\n",
      "Sequence[976] is 1 and Pathogenic Score: log10(0.9485774636268616/0.019205890595912933) = 1.6936383247375488\n",
      "Sequence[1098] is 1 and Pathogenic Score: log10(0.7999942302703857/0.21817179024219513) = 0.5642882585525513\n",
      "Sequence[1144] is 1 and Pathogenic Score: log10(0.9758053421974182/0.5707414150238037) = 0.23292382061481476\n",
      "Sequence[1145] is 1 and Pathogenic Score: log10(0.9543015360832214/0.7926293611526489) = 0.08061547577381134\n",
      "Sequence[1152] is 1 and Pathogenic Score: log10(0.9538949131965637/0.05125432834029198) = 1.2697700262069702\n",
      "Sequence[1273] is 1 and Pathogenic Score: log10(0.9795534610748291/0.8132185339927673) = 0.08082088828086853\n",
      "Sequence[1338] is 1 and Pathogenic Score: log10(0.8767723441123962/0.5177842378616333) = 0.22873800992965698\n",
      "Sequence[1339] is 1 and Pathogenic Score: log10(0.8767723441123962/0.11594308167695999) = 0.8786420226097107\n",
      "Sequence[1340] is 1 and Pathogenic Score: log10(0.9812782406806946/0.15607279539108276) = 0.7984649538993835\n",
      "Sequence[1343] is 1 and Pathogenic Score: log10(0.9900252819061279/0.3445880711078644) = 0.45834606885910034\n",
      "Sequence[1359] is 1 and Pathogenic Score: log10(0.9582040905952454/0.9078050255775452) = 0.023465460166335106\n",
      "Sequence[1366] is 1 and Pathogenic Score: log10(0.817772388458252/0.008949299342930317) = 1.9608434438705444\n",
      "Sequence[1379] is 1 and Pathogenic Score: log10(0.9490271806716919/0.9505302309989929) = -0.0006872723461128771\n",
      "Sequence[1394] is 1 and Pathogenic Score: log10(0.9899348616600037/0.9612672328948975) = 0.0127624636515975\n",
      "Sequence[1395] is 1 and Pathogenic Score: log10(0.9899348616600037/0.9556529521942139) = 0.015306436456739902\n",
      "Sequence[1396] is 1 and Pathogenic Score: log10(0.9899348616600037/0.9779099225997925) = 0.005307760089635849\n",
      "Sequence[1405] is 1 and Pathogenic Score: log10(0.9143943190574646/0.31476810574531555) = 0.4631427824497223\n",
      "Sequence[1446] is 1 and Pathogenic Score: log10(0.8809950947761536/0.07229258865118027) = 1.0858796834945679\n",
      "Sequence[1458] is 1 and Pathogenic Score: log10(0.9474570155143738/0.07390027493238449) = 1.1079134941101074\n",
      "Sequence[1459] is 1 and Pathogenic Score: log10(0.9474570155143738/0.12010449171066284) = 0.897000253200531\n",
      "Sequence[1470] is 1 and Pathogenic Score: log10(0.951604425907135/0.24323265254497528) = 0.5924345850944519\n",
      "Sequence[1471] is 1 and Pathogenic Score: log10(0.951604425907135/0.5312763452529907) = 0.2531359791755676\n",
      "Sequence[1498] is 1 and Pathogenic Score: log10(0.9824538826942444/0.9620944261550903) = 0.00909445621073246\n",
      "Sequence[1565] is 1 and Pathogenic Score: log10(0.9182507395744324/0.8603876829147339) = 0.028267091140151024\n",
      "Sequence[1569] is 1 and Pathogenic Score: log10(0.9419549703598022/0.2749808728694916) = 0.5347276329994202\n",
      "Sequence[1623] is 1 and Pathogenic Score: log10(0.9163306951522827/0.5824002027511597) = 0.19683073461055756\n",
      "Sequence[1677] is 1 and Pathogenic Score: log10(0.9621058702468872/0.6978470087051392) = 0.1394626498222351\n",
      "Sequence[1710] is 1 and Pathogenic Score: log10(0.714292585849762/0.06131787970662117) = 1.066288948059082\n",
      "Sequence[1725] is 1 and Pathogenic Score: log10(0.9756786823272705/0.9735907912254333) = 0.000930379843339324\n",
      "Sequence[1743] is 1 and Pathogenic Score: log10(0.29258158802986145/0.02406792901456356) = 1.0848082304000854\n",
      "Sequence[1793] is 1 and Pathogenic Score: log10(0.9858210682868958/0.6914879083633423) = 0.1540134996175766\n",
      "Sequence[1906] is 1 and Pathogenic Score: log10(0.9887527227401733/0.182070791721344) = 0.7348474264144897\n",
      "Sequence[1994] is 1 and Pathogenic Score: log10(0.9839764833450317/0.9638465642929077) = 0.00897681899368763\n",
      "Sequence[1998] is 1 and Pathogenic Score: log10(0.9427168965339661/0.1657445728778839) = 0.754941999912262\n",
      "Sequence[1999] is 1 and Pathogenic Score: log10(0.8959530591964722/0.4625234007835388) = 0.2871515452861786\n",
      "Sequence[2001] is 1 and Pathogenic Score: log10(0.9979873895645142/0.9979609251022339) = 1.1493218153191265e-05\n",
      "Sequence[2002] is 1 and Pathogenic Score: log10(0.9751620292663574/0.0648113489151001) = 1.177425742149353\n",
      "Sequence[2046] is 1 and Pathogenic Score: log10(0.9932734966278076/0.7761222720146179) = 0.10713868588209152\n",
      "Sequence[2061] is 1 and Pathogenic Score: log10(0.9949554800987244/0.9925211071968079) = 0.0010639034444466233\n",
      "Sequence[2091] is 1 and Pathogenic Score: log10(0.9533146023750305/0.9111627340316772) = 0.01964031532406807\n",
      "Sequence[2118] is 1 and Pathogenic Score: log10(0.9489074945449829/0.3908149302005768) = 0.3852527141571045\n",
      "Sequence[2119] is 1 and Pathogenic Score: log10(0.9839090704917908/0.7568894028663635) = 0.11392254382371902\n",
      "Sequence[2120] is 1 and Pathogenic Score: log10(0.8650559186935425/0.7421877384185791) = 0.06653042137622833\n",
      "Sequence[2147] is 1 and Pathogenic Score: log10(0.11639628559350967/0.010694120079278946) = 1.0367940664291382\n",
      "Sequence[2151] is 1 and Pathogenic Score: log10(0.7160824537277222/0.005450238939374685) = 2.1185474395751953\n",
      "Sequence[2154] is 1 and Pathogenic Score: log10(0.4075758457183838/0.2095862329006195) = 0.2888456881046295\n",
      "Sequence[2155] is 1 and Pathogenic Score: log10(0.4075758457183838/0.04759872704744339) = 0.9326131343841553\n",
      "Sequence[2156] is 1 and Pathogenic Score: log10(0.4075758457183838/0.07205183058977127) = 0.7525634169578552\n",
      "Sequence[2174] is 1 and Pathogenic Score: log10(0.939298152923584/0.20526131987571716) = 0.6604963541030884\n",
      "Sequence[2287] is 1 and Pathogenic Score: log10(0.9596856832504272/0.9593984484672546) = 0.00012997987505514175\n",
      "Sequence[2328] is 1 and Pathogenic Score: log10(0.8580288290977478/0.22650378942489624) = 0.5784264206886292\n",
      "Sequence[2414] is 1 and Pathogenic Score: log10(0.9787012338638306/0.35675910115242004) = 0.4382750689983368\n",
      "Sequence[2471] is 1 and Pathogenic Score: log10(0.9537537097930908/0.32077184319496155) = 0.4732400178909302\n",
      "Sequence[2538] is 1 and Pathogenic Score: log10(0.9169524908065796/0.7852969765663147) = 0.06731289625167847\n",
      "Sequence[2543] is 1 and Pathogenic Score: log10(0.9648776650428772/0.4313850998878479) = 0.34960711002349854\n",
      "Sequence[2611] is 1 and Pathogenic Score: log10(0.9443648457527161/0.38245078921318054) = 0.3925642669200897\n",
      "Sequence[2656] is 1 and Pathogenic Score: log10(0.8681101202964783/0.029534995555877686) = 1.4682378768920898\n",
      "Sequence[2755] is 1 and Pathogenic Score: log10(0.8593276739120483/0.13189910352230072) = 0.8139169812202454\n",
      "Sequence[2770] is 1 and Pathogenic Score: log10(0.943354070186615/0.4458891451358795) = 0.32544782757759094\n",
      "Sequence[2938] is 1 and Pathogenic Score: log10(0.9663277268409729/0.3898920714855194) = 0.3941800594329834\n",
      "Sequence[2942] is 1 and Pathogenic Score: log10(0.976691484451294/0.10363716632127762) = 0.9742418527603149\n",
      "Sequence[2976] is 1 and Pathogenic Score: log10(0.9506383538246155/0.34542739391326904) = 0.4396585524082184\n",
      "Sequence[2988] is 1 and Pathogenic Score: log10(0.3780446946620941/0.3494269549846649) = 0.03418673947453499\n",
      "Sequence[3003] is 1 and Pathogenic Score: log10(0.8749306201934814/0.01211268175393343) = 1.8587332963943481\n",
      "Sequence[3005] is 1 and Pathogenic Score: log10(0.9010531306266785/0.4061223268508911) = 0.3460935354232788\n",
      "Sequence[3046] is 1 and Pathogenic Score: log10(0.754769504070282/0.025120025500655174) = 1.4777942895889282\n",
      "Sequence[3161] is 1 and Pathogenic Score: log10(0.9918117523193359/0.49868834018707275) = 0.2986000180244446\n",
      "Sequence[3314] is 1 and Pathogenic Score: log10(0.9177437424659729/0.050292037427425385) = 1.261222243309021\n",
      "Sequence[3331] is 1 and Pathogenic Score: log10(0.9626815915107727/0.3150446116924286) = 0.4851106107234955\n",
      "Sequence[3340] is 1 and Pathogenic Score: log10(0.9446459412574768/0.2815673351287842) = 0.5256868004798889\n",
      "Sequence[3386] is 1 and Pathogenic Score: log10(0.8482518792152405/0.12020107358694077) = 0.8486164808273315\n",
      "Sequence[3396] is 1 and Pathogenic Score: log10(0.9168888926506042/0.5590775609016418) = 0.21484465897083282\n",
      "Sequence[3398] is 1 and Pathogenic Score: log10(0.9597223997116089/0.9773074388504028) = -0.007885563187301159\n",
      "Sequence[3516] is 1 and Pathogenic Score: log10(0.9902639389038086/0.7764678597450256) = 0.10562746971845627\n",
      "Sequence[3543] is 1 and Pathogenic Score: log10(0.8857884407043457/0.3928201496601105) = 0.35313624143600464\n",
      "Sequence[3545] is 1 and Pathogenic Score: log10(0.8857884407043457/0.04664742946624756) = 1.2785022258758545\n",
      "Sequence[3588] is 1 and Pathogenic Score: log10(0.9908390641212463/0.9530602693557739) = 0.01688276045024395\n",
      "Sequence[3593] is 1 and Pathogenic Score: log10(0.8412306308746338/0.038690291345119476) = 1.3373130559921265\n",
      "Sequence[3608] is 1 and Pathogenic Score: log10(0.9490890502929688/0.12440826743841171) = 0.8824577331542969\n",
      "Sequence[3609] is 1 and Pathogenic Score: log10(0.9580546021461487/0.43732526898384094) = 0.34058570861816406\n",
      "Sequence[3618] is 1 and Pathogenic Score: log10(0.7780803442001343/0.033388830721378326) = 1.3674232959747314\n",
      "Sequence[3787] is 1 and Pathogenic Score: log10(0.6249179840087891/0.48351815342903137) = 0.11141025274991989\n",
      "Sequence[3803] is 1 and Pathogenic Score: log10(0.8976403474807739/0.08324556052684784) = 1.0327413082122803\n",
      "Sequence[3805] is 1 and Pathogenic Score: log10(0.9740734100341797/0.6837092638015747) = 0.15372022986412048\n",
      "Sequence[3807] is 1 and Pathogenic Score: log10(0.9095534682273865/0.03759736567735672) = 1.3836708068847656\n",
      "Sequence[3808] is 1 and Pathogenic Score: log10(0.9474619030952454/0.9101735353469849) = 0.01743755303323269\n",
      "Sequence[3865] is 1 and Pathogenic Score: log10(0.368051141500473/0.018303213641047478) = 1.3033808469772339\n",
      "Sequence[3902] is 1 and Pathogenic Score: log10(0.5943811535835266/0.43691179156303406) = 0.13367125391960144\n",
      "Sequence[3925] is 1 and Pathogenic Score: log10(0.6715866923332214/0.6947569251060486) = -0.014730794355273247\n",
      "Sequence[3965] is 1 and Pathogenic Score: log10(0.9667956233024597/0.7849754691123962) = 0.09047860652208328\n",
      "Sequence[3966] is 1 and Pathogenic Score: log10(0.9667956233024597/0.13847653567790985) = 0.8439584970474243\n",
      "Sequence[4027] is 1 and Pathogenic Score: log10(0.8861780762672424/0.13569042086601257) = 0.8149718046188354\n",
      "Sequence[4190] is 1 and Pathogenic Score: log10(0.9688027501106262/0.8712915778160095) = 0.046071864664554596\n",
      "Sequence[4208] is 1 and Pathogenic Score: log10(0.9856755137443542/0.8454001545906067) = 0.06667164713144302\n",
      "Sequence[4347] is 1 and Pathogenic Score: log10(0.9773744940757751/0.9310774803161621) = 0.021075168624520302\n",
      "Sequence[4349] is 1 and Pathogenic Score: log10(0.9564921259880066/0.9403186440467834) = 0.007406348362565041\n",
      "Sequence[4352] is 1 and Pathogenic Score: log10(0.9099838733673096/0.28487250208854675) = 0.5043832063674927\n",
      "Sequence[4366] is 1 and Pathogenic Score: log10(0.22304396331310272/0.061619557440280914) = 0.5586718916893005\n",
      "Sequence[4373] is 1 and Pathogenic Score: log10(0.6793785095214844/0.17927461862564087) = 0.5785930156707764\n",
      "Sequence[4415] is 1 and Pathogenic Score: log10(0.9670288562774658/0.7868932485580444) = 0.08952360600233078\n",
      "Sequence[4428] is 1 and Pathogenic Score: log10(0.6890966296195984/0.05691322684288025) = 1.0830669403076172\n",
      "Sequence[4436] is 1 and Pathogenic Score: log10(0.8908559679985046/0.341936320066452) = 0.4158622622489929\n",
      "Sequence[4448] is 1 and Pathogenic Score: log10(0.9529584050178528/0.22209812700748444) = 0.632529079914093\n",
      "Sequence[4477] is 1 and Pathogenic Score: log10(0.9622770547866821/0.8113024830818176) = 0.07411733269691467\n",
      "Sequence[4480] is 1 and Pathogenic Score: log10(0.9662624001502991/0.11965776234865189) = 0.9071542024612427\n",
      "Sequence[4527] is 1 and Pathogenic Score: log10(0.8769850134849548/0.14152373373508453) = 0.7921628952026367\n",
      "Sequence[4581] is 1 and Pathogenic Score: log10(0.9670708179473877/0.29336825013160706) = 0.51804518699646\n",
      "Sequence[4614] is 1 and Pathogenic Score: log10(0.99580979347229/0.9921457171440125) = 0.0016009402461349964\n",
      "Sequence[4616] is 1 and Pathogenic Score: log10(0.99580979347229/0.952976405620575) = 0.019094225019216537\n",
      "Sequence[4631] is 1 and Pathogenic Score: log10(0.9805373549461365/0.0612187422811985) = 1.2045797109603882\n",
      "Sequence[4645] is 1 and Pathogenic Score: log10(0.8809031248092651/0.29895153641700745) = 0.4693273603916168\n",
      "Sequence[4725] is 1 and Pathogenic Score: log10(0.9921063184738159/0.3409135341644287) = 0.4639139473438263\n",
      "Sequence[4886] is 1 and Pathogenic Score: log10(0.9615482091903687/0.02074579894542694) = 1.6660408973693848\n",
      "Sequence[4930] is 1 and Pathogenic Score: log10(0.9643703103065491/0.17347519099712372) = 0.7450065016746521\n",
      "Sequence[4935] is 1 and Pathogenic Score: log10(0.9530255198478699/0.33594265580177307) = 0.4528394043445587\n",
      "Sequence[4942] is 1 and Pathogenic Score: log10(0.9878125786781311/0.9222503900527954) = 0.029825715348124504\n",
      "Sequence[4943] is 1 and Pathogenic Score: log10(0.9878125786781311/0.9716666340827942) = 0.007157240528613329\n",
      "Sequence[4962] is 1 and Pathogenic Score: log10(0.9751272201538086/0.26981568336486816) = 0.5579940676689148\n",
      "Sequence[5047] is 1 and Pathogenic Score: log10(0.9402183890342712/0.883910059928894) = 0.026820652186870575\n",
      "Sequence[5308] is 1 and Pathogenic Score: log10(0.8715407848358154/0.1190750002861023) = 0.8644671440124512\n",
      "Sequence[5461] is 1 and Pathogenic Score: log10(0.974232017993927/0.07475608587265015) = 1.1150158643722534\n",
      "Sequence[5463] is 1 and Pathogenic Score: log10(0.9827662706375122/0.8135442733764648) = 0.08206905424594879\n",
      "Sequence[5548] is 1 and Pathogenic Score: log10(0.8391685485839844/0.01884118653833866) = 1.6487410068511963\n",
      "Sequence[5555] is 1 and Pathogenic Score: log10(0.9935230016708374/0.3821386992931366) = 0.4149569272994995\n",
      "Sequence[5556] is 1 and Pathogenic Score: log10(0.9296627044677734/0.05307364463806152) = 1.2434464693069458\n",
      "Sequence[5558] is 1 and Pathogenic Score: log10(0.9647114872932434/0.6214973330497742) = 0.190958172082901\n",
      "Sequence[5563] is 1 and Pathogenic Score: log10(0.8998722434043884/0.6469733119010925) = 0.14329449832439423\n",
      "Sequence[5575] is 1 and Pathogenic Score: log10(0.9902288913726807/0.9865185618400574) = 0.0016303405864164233\n",
      "Sequence[5577] is 1 and Pathogenic Score: log10(0.9622879028320312/0.06633225083351135) = 1.1615803241729736\n",
      "Sequence[5586] is 1 and Pathogenic Score: log10(0.9955440163612366/0.3846895396709442) = 0.4129500687122345\n",
      "Sequence[5591] is 1 and Pathogenic Score: log10(0.9364692568778992/0.42687591910362244) = 0.3411918878555298\n",
      "Sequence[5594] is 1 and Pathogenic Score: log10(0.9702615737915039/0.8486486077308655) = 0.05816094949841499\n",
      "Sequence[5608] is 1 and Pathogenic Score: log10(0.9876664876937866/0.9170583486557007) = 0.03221335634589195\n",
      "Sequence[5641] is 1 and Pathogenic Score: log10(0.8357124924659729/0.6385695934295654) = 0.11684867739677429\n",
      "Sequence[5644] is 1 and Pathogenic Score: log10(0.9769397974014282/0.9026477336883545) = 0.03434950113296509\n",
      "Sequence[5650] is 1 and Pathogenic Score: log10(0.847105085849762/0.12978819012641907) = 0.8147021532058716\n",
      "Sequence[5653] is 1 and Pathogenic Score: log10(0.8501358032226562/0.03319908678531647) = 1.4083621501922607\n",
      "Sequence[5675] is 1 and Pathogenic Score: log10(0.890920877456665/0.18594716489315033) = 0.6804496049880981\n",
      "Sequence[5690] is 1 and Pathogenic Score: log10(0.7743528485298157/0.12803715467453003) = 0.7816028594970703\n",
      "Sequence[5692] is 1 and Pathogenic Score: log10(0.9924319982528687/0.9047276973724365) = 0.04018288850784302\n",
      "Sequence[5694] is 1 and Pathogenic Score: log10(0.9036182165145874/0.8400753736495972) = 0.03166673704981804\n",
      "Sequence[5695] is 1 and Pathogenic Score: log10(0.9036182165145874/0.10030588507652283) = 0.954658567905426\n",
      "Sequence[5697] is 1 and Pathogenic Score: log10(0.9529157876968384/0.8393172025680542) = 0.055128391832113266\n",
      "Sequence[5699] is 1 and Pathogenic Score: log10(0.8348597288131714/0.20058293640613556) = 0.619319498538971\n",
      "Sequence[5700] is 1 and Pathogenic Score: log10(0.9876612424850464/0.9761502742767334) = 0.005091319791972637\n",
      "Sequence[5701] is 1 and Pathogenic Score: log10(0.9876612424850464/0.9623500108718872) = 0.011274964548647404\n",
      "Sequence[5722] is 1 and Pathogenic Score: log10(0.9409469366073608/0.32286739349365234) = 0.46454092860221863\n",
      "Sequence[5762] is 1 and Pathogenic Score: log10(0.9000604748725891/0.7345036864280701) = 0.08827769756317139\n",
      "Sequence[5764] is 1 and Pathogenic Score: log10(0.9835109710693359/0.8046523928642273) = 0.08717088401317596\n",
      "Sequence[5778] is 1 and Pathogenic Score: log10(0.9859445095062256/0.18741562962532043) = 0.7210466861724854\n",
      "Sequence[5780] is 1 and Pathogenic Score: log10(0.9819524884223938/0.3755819499492645) = 0.4173857569694519\n",
      "Sequence[5815] is 1 and Pathogenic Score: log10(0.9843540191650391/0.1697002351284027) = 0.763468861579895\n",
      "Sequence[5820] is 1 and Pathogenic Score: log10(0.9889000654220581/0.9948403239250183) = -0.002600977662950754\n",
      "Sequence[5823] is 1 and Pathogenic Score: log10(0.9551617503166199/0.8962964415550232) = 0.027625272050499916\n",
      "Sequence[5915] is 1 and Pathogenic Score: log10(0.9613771438598633/0.8611931800842285) = 0.04779320955276489\n",
      "Sequence[5925] is 1 and Pathogenic Score: log10(0.980230987071991/0.8108264803886414) = 0.08240051567554474\n",
      "Sequence[5927] is 1 and Pathogenic Score: log10(0.9881922602653503/0.9817953705787659) = 0.002820468507707119\n",
      "Sequence[5935] is 1 and Pathogenic Score: log10(0.9403895735740662/0.5423290133476257) = 0.23904496431350708\n",
      "Sequence[5988] is 1 and Pathogenic Score: log10(0.9616022109985352/0.9652659296989441) = -0.0016515287570655346\n",
      "Sequence[5989] is 1 and Pathogenic Score: log10(0.6004857420921326/0.015817657113075256) = 1.5793604850769043\n",
      "Sequence[6003] is 1 and Pathogenic Score: log10(0.7920278906822205/0.11116389185190201) = 0.8527767062187195\n",
      "Sequence[6020] is 1 and Pathogenic Score: log10(0.9904384016990662/0.9479796886444092) = 0.019028425216674805\n",
      "Sequence[6064] is 1 and Pathogenic Score: log10(0.9511013031005859/0.9650741815567017) = -0.006333925295621157\n",
      "Sequence[6065] is 1 and Pathogenic Score: log10(0.9440742135047913/0.9439979195594788) = 3.509995440253988e-05\n",
      "Sequence[6081] is 1 and Pathogenic Score: log10(0.9840967655181885/0.9910823106765747) = -0.003071932354941964\n",
      "Sequence[6094] is 1 and Pathogenic Score: log10(0.7630375027656555/0.19698800146579742) = 0.588106095790863\n",
      "Sequence[6096] is 1 and Pathogenic Score: log10(0.9785677790641785/0.07355354726314545) = 1.1239873170852661\n",
      "Sequence[6107] is 1 and Pathogenic Score: log10(0.8125993609428406/0.2297063171863556) = 0.5487035512924194\n",
      "Sequence[6114] is 1 and Pathogenic Score: log10(0.7968440055847168/0.025441201403737068) = 1.4958356618881226\n",
      "Sequence[6160] is 1 and Pathogenic Score: log10(0.9840683341026306/0.9843577146530151) = -0.0001276883704122156\n",
      "Sequence[6190] is 1 and Pathogenic Score: log10(0.9791148900985718/0.7881488800048828) = 0.09422536939382553\n",
      "Sequence[6446] is 1 and Pathogenic Score: log10(0.6602073907852173/0.1305401772260666) = 0.7039361596107483\n",
      "Sequence[6466] is 1 and Pathogenic Score: log10(0.49395641684532166/0.3581741154193878) = 0.1395944356918335\n",
      "Sequence[6644] is 1 and Pathogenic Score: log10(0.9237257242202759/0.013119456358253956) = 1.8476271629333496\n",
      "Sequence[6687] is 1 and Pathogenic Score: log10(0.7967419028282166/0.08236109465360641) = 0.9855955243110657\n",
      "Sequence[6688] is 1 and Pathogenic Score: log10(0.9757149815559387/0.04029914736747742) = 1.384027123451233\n",
      "Sequence[6751] is 1 and Pathogenic Score: log10(0.968513011932373/0.9349231123924255) = 0.015329576097428799\n",
      "Sequence[6752] is 1 and Pathogenic Score: log10(0.968513011932373/0.5910228490829468) = 0.21450118720531464\n",
      "Sequence[6753] is 1 and Pathogenic Score: log10(0.968513011932373/0.9245444536209106) = 0.02017766237258911\n",
      "Sequence[6764] is 1 and Pathogenic Score: log10(0.9920142292976379/0.9762651324272156) = 0.006950126960873604\n",
      "Sequence[6770] is 1 and Pathogenic Score: log10(0.8132534027099609/0.04005284979939461) = 1.307592511177063\n",
      "Sequence[6853] is 1 and Pathogenic Score: log10(0.49385908246040344/0.004294768441468477) = 2.0606632232666016\n",
      "Sequence[6911] is 1 and Pathogenic Score: log10(0.8845311999320984/0.8984197378158569) = -0.006766141392290592\n",
      "Sequence[6919] is 1 and Pathogenic Score: log10(0.9596763849258423/0.9531108736991882) = 0.0029813845176249743\n",
      "Sequence[6925] is 1 and Pathogenic Score: log10(0.988490104675293/0.9334414005279541) = 0.024885259568691254\n",
      "Sequence[7015] is 1 and Pathogenic Score: log10(0.9805871248245239/0.17341479659080505) = 0.7524000406265259\n",
      "Sequence[7080] is 1 and Pathogenic Score: log10(0.8205070495605469/0.10013972967863083) = 0.9134759306907654\n",
      "Sequence[7148] is 1 and Pathogenic Score: log10(0.8742663264274597/0.1348709911108017) = 0.8117251992225647\n",
      "Sequence[7240] is 1 and Pathogenic Score: log10(0.9641642570495605/0.88297438621521) = 0.0382029190659523\n",
      "Sequence[7248] is 1 and Pathogenic Score: log10(0.9508187770843506/0.08586440235376358) = 1.0442845821380615\n",
      "Sequence[7303] is 1 and Pathogenic Score: log10(0.9522948265075684/0.9176530838012695) = 0.016092894598841667\n",
      "Sequence[7325] is 1 and Pathogenic Score: log10(0.8982909917831421/0.0707034319639206) = 1.1039766073226929\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Sequence[7365] is 1 and Pathogenic Score: log10(0.7014657258987427/0.08011595904827118) = 0.9422874450683594\n",
      "Sequence[7452] is 1 and Pathogenic Score: log10(0.8723604679107666/0.21308143436908722) = 0.6121503710746765\n",
      "Sequence[7456] is 1 and Pathogenic Score: log10(0.9703676700592041/0.9314913749694824) = 0.0177574772387743\n",
      "Sequence[7462] is 1 and Pathogenic Score: log10(0.927844226360321/0.6659914255142212) = 0.1440064162015915\n",
      "Sequence[7518] is 1 and Pathogenic Score: log10(0.9700524210929871/0.06870178878307343) = 1.1498271226882935\n",
      "Sequence[7601] is 1 and Pathogenic Score: log10(0.7862632274627686/0.13645805418491364) = 0.7605687975883484\n",
      "Sequence[7905] is 1 and Pathogenic Score: log10(0.9770305156707764/0.9375842213630676) = 0.017897849902510643\n",
      "Sequence[7908] is 1 and Pathogenic Score: log10(0.9093672037124634/0.3174482583999634) = 0.4570663273334503\n",
      "Sequence[7928] is 1 and Pathogenic Score: log10(0.9180649518966675/0.21163031458854675) = 0.6372955441474915\n",
      "Sequence[7929] is 1 and Pathogenic Score: log10(0.7395191192626953/0.03135204687714577) = 1.3726835250854492\n",
      "Sequence[8072] is 1 and Pathogenic Score: log10(0.9738881587982178/0.5857769846916199) = 0.22077679634094238\n",
      "Sequence[8240] is 1 and Pathogenic Score: log10(0.9857231974601746/0.4362925589084625) = 0.35397714376449585\n",
      "Sequence[8260] is 1 and Pathogenic Score: log10(0.960057258605957/0.9570024609565735) = 0.0013840892352163792\n",
      "Sequence[8325] is 1 and Pathogenic Score: log10(0.9737319350242615/0.7477118968963623) = 0.11470510810613632\n",
      "Sequence[8333] is 1 and Pathogenic Score: log10(0.9517244696617126/0.10294890403747559) = 0.9658895134925842\n",
      "Sequence[8453] is 1 and Pathogenic Score: log10(0.8182658553123474/0.7137182950973511) = 0.059367597103118896\n",
      "Sequence[8455] is 1 and Pathogenic Score: log10(0.9587228298187256/0.8558241724967957) = 0.049308523535728455\n",
      "Sequence[8489] is 1 and Pathogenic Score: log10(0.8091240525245667/0.18662449717521667) = 0.6370464563369751\n",
      "Sequence[8555] is 1 and Pathogenic Score: log10(0.9874904751777649/0.9371034502983093) = 0.022745365276932716\n",
      "Sequence[8556] is 1 and Pathogenic Score: log10(0.9874904751777649/0.9704331755638123) = 0.007567304652184248\n",
      "Sequence[8557] is 1 and Pathogenic Score: log10(0.9874904751777649/0.8523576855659485) = 0.06391103565692902\n",
      "Sequence[8558] is 1 and Pathogenic Score: log10(0.953307032585144/0.29929444193840027) = 0.5031341314315796\n",
      "Sequence[8565] is 1 and Pathogenic Score: log10(0.22754588723182678/0.08190138638019562) = 0.44377774000167847\n",
      "Sequence[8589] is 1 and Pathogenic Score: log10(0.6812710762023926/0.05923895537853241) = 1.0607125759124756\n",
      "Sequence[8592] is 1 and Pathogenic Score: log10(0.8890227675437927/0.08069325983524323) = 1.0420756340026855\n",
      "Sequence[8618] is 1 and Pathogenic Score: log10(0.8240812420845032/0.14800551533699036) = 0.7456921339035034\n",
      "Sequence[8623] is 1 and Pathogenic Score: log10(0.9440562129020691/0.16836893558502197) = 0.7487359046936035\n",
      "Sequence[8624] is 1 and Pathogenic Score: log10(0.9440562129020691/0.07328209280967712) = 1.1100000143051147\n",
      "Sequence[8626] is 1 and Pathogenic Score: log10(0.9861802458763123/0.8284169435501099) = 0.0757073163986206\n",
      "Sequence[8627] is 1 and Pathogenic Score: log10(0.9861802458763123/0.8971912264823914) = 0.04107125848531723\n",
      "Sequence[8651] is 1 and Pathogenic Score: log10(0.7128322720527649/0.004806265700608492) = 2.1711795330047607\n",
      "Sequence[8652] is 1 and Pathogenic Score: log10(0.7128322720527649/0.10324677079916) = 0.8391108512878418\n",
      "Sequence[8653] is 1 and Pathogenic Score: log10(0.9766567945480347/0.038910161703825) = 1.3996789455413818\n",
      "Sequence[8674] is 1 and Pathogenic Score: log10(0.9694945812225342/0.9757413864135742) = -0.002789350226521492\n",
      "Sequence[8675] is 1 and Pathogenic Score: log10(0.9694945812225342/0.5920814871788025) = 0.2141638994216919\n",
      "Sequence[8678] is 1 and Pathogenic Score: log10(0.1629638969898224/0.005278176162391901) = 1.489607572555542\n",
      "Sequence[8680] is 1 and Pathogenic Score: log10(0.1629638969898224/0.02738432213664055) = 0.7745894193649292\n",
      "Sequence[8697] is 1 and Pathogenic Score: log10(0.886246383190155/0.40799134969711304) = 0.33690351247787476\n",
      "Sequence[8699] is 1 and Pathogenic Score: log10(0.9058296084403992/0.11513657867908478) = 0.8958331942558289\n",
      "Sequence[8724] is 1 and Pathogenic Score: log10(0.93654465675354/0.284091591835022) = 0.5180701017379761\n",
      "Sequence[8962] is 1 and Pathogenic Score: log10(0.5140584707260132/0.02932707779109478) = 1.2437437772750854\n",
      "Sequence[8968] is 1 and Pathogenic Score: log10(0.8975501656532288/0.12922918796539307) = 0.8416981101036072\n",
      "Sequence[9034] is 1 and Pathogenic Score: log10(0.2008647471666336/0.07527197152376175) = 0.42627042531967163\n",
      "Sequence[9048] is 1 and Pathogenic Score: log10(0.8824915289878845/0.07921430468559265) = 1.0469069480895996\n",
      "Sequence[9049] is 1 and Pathogenic Score: log10(0.6282258629798889/0.45543918013572693) = 0.13968542218208313\n",
      "Sequence[9050] is 1 and Pathogenic Score: log10(0.6282258629798889/0.09717923402786255) = 0.8105423450469971\n",
      "Sequence[9051] is 1 and Pathogenic Score: log10(0.9846220016479492/0.0960649847984314) = 1.0107043981552124\n",
      "Sequence[9052] is 1 and Pathogenic Score: log10(0.9846220016479492/0.9862704873085022) = -0.0007265016320161521\n",
      "Sequence[9054] is 1 and Pathogenic Score: log10(0.9859123826026917/0.9093260169029236) = 0.03511872515082359\n",
      "Sequence[9235] is 1 and Pathogenic Score: log10(0.984902560710907/0.9515278935432434) = 0.014971747994422913\n",
      "Sequence[9354] is 1 and Pathogenic Score: log10(0.9796754121780396/0.9120927453041077) = 0.03104322962462902\n",
      "Sequence[9382] is 1 and Pathogenic Score: log10(0.9813093543052673/0.5015188455581665) = 0.2915186882019043\n",
      "Sequence[9519] is 1 and Pathogenic Score: log10(0.9663076996803284/0.014987143687903881) = 1.8093966245651245\n",
      "Sequence[9559] is 1 and Pathogenic Score: log10(0.7339796423912048/0.15679681301116943) = 0.6703467965126038\n",
      "Sequence[9561] is 1 and Pathogenic Score: log10(0.9420192837715149/0.18238528072834015) = 0.7130699753761292\n",
      "Sequence[9598] is 1 and Pathogenic Score: log10(0.9891290664672852/0.9362455010414124) = 0.023863211274147034\n",
      "Sequence[9615] is 1 and Pathogenic Score: log10(0.964090883731842/0.4028063416481018) = 0.37902167439460754\n",
      "Sequence[9632] is 1 and Pathogenic Score: log10(0.9632379412651062/0.8107314705848694) = 0.07485656440258026\n",
      "Sequence[9683] is 1 and Pathogenic Score: log10(0.9857925772666931/0.5699142813682556) = 0.23797601461410522\n",
      "Sequence[9722] is 1 and Pathogenic Score: log10(0.9603240489959717/0.9368057250976562) = 0.010768250562250614\n",
      "Sequence[9784] is 1 and Pathogenic Score: log10(0.979385495185852/0.9494896531105042) = 0.013463452458381653\n",
      "Sequence[9785] is 1 and Pathogenic Score: log10(0.979385495185852/0.8061695694923401) = 0.08452728390693665\n",
      "Sequence[9786] is 1 and Pathogenic Score: log10(0.979385495185852/0.8036104440689087) = 0.08590808510780334\n",
      "Sequence[9787] is 1 and Pathogenic Score: log10(0.7701080441474915/0.3008798658847809) = 0.408158540725708\n",
      "Sequence[9789] is 1 and Pathogenic Score: log10(0.984814465045929/0.981014609336853) = 0.0016789243090897799\n",
      "Sequence[9790] is 1 and Pathogenic Score: log10(0.946001410484314/0.9224667549133301) = 0.010941040702164173\n",
      "Sequence[9791] is 1 and Pathogenic Score: log10(0.9773197174072266/0.9484180808067322) = 0.013036815449595451\n",
      "Sequence[9804] is 1 and Pathogenic Score: log10(0.9715327024459839/0.39984503388404846) = 0.38556572794914246\n",
      "Sequence[9843] is 1 and Pathogenic Score: log10(0.985880434513092/0.9878750443458557) = -0.0008777736220508814\n",
      "Sequence[9886] is 1 and Pathogenic Score: log10(0.6710642576217651/0.1898673176765442) = 0.5483138561248779\n",
      "Sequence[9888] is 1 and Pathogenic Score: log10(0.8459014296531677/0.8162125945091248) = 0.015516447834670544\n",
      "Sequence[9893] is 1 and Pathogenic Score: log10(0.972162127494812/0.17665566504001617) = 0.7406111359596252\n",
      "Sequence[9902] is 1 and Pathogenic Score: log10(0.9884020686149597/0.9847614765167236) = 0.0016025907825678587\n",
      "Sequence[9910] is 1 and Pathogenic Score: log10(0.8274279832839966/0.12234756350517273) = 0.8301348686218262\n",
      "Sequence[9962] is 1 and Pathogenic Score: log10(0.934377133846283/0.7333828806877136) = 0.1051914319396019\n",
      "Sequence[9973] is 1 and Pathogenic Score: log10(0.9867417216300964/0.9264533519744873) = 0.027379915118217468\n",
      "Sequence[10090] is 1 and Pathogenic Score: log10(0.5558244585990906/0.07884601503610611) = 0.8481578826904297\n",
      "Sequence[10126] is 1 and Pathogenic Score: log10(0.9193830490112305/0.053941503167152405) = 1.231573462486267\n",
      "Sequence[10130] is 1 and Pathogenic Score: log10(0.9715778231620789/0.5962622165679932) = 0.21204030513763428\n",
      "Sequence[10142] is 1 and Pathogenic Score: log10(0.950395405292511/0.1163281500339508) = 0.9122195243835449\n",
      "Sequence[10144] is 1 and Pathogenic Score: log10(0.950395405292511/0.15343371033668518) = 0.7919835448265076\n",
      "Sequence[10151] is 1 and Pathogenic Score: log10(0.9917953610420227/0.9387537837028503) = 0.02387036569416523\n",
      "Sequence[10181] is 1 and Pathogenic Score: log10(0.2665655016899109/0.7699952721595764) = -0.4606841206550598\n",
      "Sequence[10182] is 1 and Pathogenic Score: log10(0.7002402544021606/0.11995206028223038) = 0.7662393450737\n",
      "Sequence[10183] is 1 and Pathogenic Score: log10(0.2665655016899109/0.014430324546992779) = 1.266527771949768\n",
      "Sequence[10186] is 1 and Pathogenic Score: log10(0.9815919399261475/0.09411884099245071) = 1.0182543992996216\n",
      "Sequence[10197] is 1 and Pathogenic Score: log10(0.984769344329834/0.08498229086399078) = 1.0640060901641846\n",
      "Sequence[10198] is 1 and Pathogenic Score: log10(0.984769344329834/0.8396077752113342) = 0.06925805658102036\n",
      "Sequence[10199] is 1 and Pathogenic Score: log10(0.984769344329834/0.5963202118873596) = 0.21785500645637512\n",
      "Sequence[10200] is 1 and Pathogenic Score: log10(0.984769344329834/0.8927615284919739) = 0.04259904474020004\n",
      "Sequence[10201] is 1 and Pathogenic Score: log10(0.984769344329834/0.959035336971283) = 0.011499891988933086\n",
      "Sequence[10212] is 1 and Pathogenic Score: log10(0.9940080642700195/0.9929754734039307) = 0.0004513719759415835\n",
      "Sequence[10214] is 1 and Pathogenic Score: log10(0.9933261871337891/0.7423416972160339) = 0.12648801505565643\n",
      "Sequence[10221] is 1 and Pathogenic Score: log10(0.9376264214515686/0.32789626717567444) = 0.45629334449768066\n",
      "Sequence[10235] is 1 and Pathogenic Score: log10(0.9678500294685364/0.5628255009651184) = 0.23543429374694824\n",
      "Sequence[10238] is 1 and Pathogenic Score: log10(0.9708592891693115/0.23877233266830444) = 0.6091722846031189\n",
      "Sequence[10245] is 1 and Pathogenic Score: log10(0.9753681421279907/0.7822989225387573) = 0.09579581767320633\n",
      "Sequence[10356] is 1 and Pathogenic Score: log10(0.8908414244651794/0.06947007030248642) = 1.1080026626586914\n",
      "Sequence[10431] is 1 and Pathogenic Score: log10(0.9287967681884766/0.22898823022842407) = 0.6081075072288513\n",
      "Sequence[10632] is 1 and Pathogenic Score: log10(0.88099205493927/0.03502342477440834) = 1.4006134271621704\n",
      "Sequence[10687] is 1 and Pathogenic Score: log10(0.9778333306312561/0.937764585018158) = 0.01817101426422596\n",
      "Sequence[10820] is 1 and Pathogenic Score: log10(0.9610036015510559/0.9275457859039307) = 0.015389643609523773\n",
      "Sequence[10826] is 1 and Pathogenic Score: log10(0.5805983543395996/0.090450718998909) = 0.8074637651443481\n",
      "Sequence[10836] is 1 and Pathogenic Score: log10(0.958349883556366/0.7047423720359802) = 0.13349372148513794\n",
      "Sequence[10850] is 1 and Pathogenic Score: log10(0.8742783665657043/0.16921348869800568) = 0.7132147550582886\n",
      "Sequence[10851] is 1 and Pathogenic Score: log10(0.9799133539199829/0.9762312769889832) = 0.0016349826473742723\n",
      "Sequence[10888] is 1 and Pathogenic Score: log10(0.17819161713123322/0.07260122150182724) = 0.38994333148002625\n",
      "Sequence[10908] is 1 and Pathogenic Score: log10(0.6887783408164978/0.22940729558467865) = 0.4774722754955292\n",
      "Sequence[10912] is 1 and Pathogenic Score: log10(0.9631014466285706/0.9401865601539612) = 0.010457994416356087\n",
      "Sequence[10913] is 1 and Pathogenic Score: log10(0.9631014466285706/0.8853887915611267) = 0.0365380235016346\n",
      "Sequence[11050] is 1 and Pathogenic Score: log10(0.9874649047851562/0.5482520461082458) = 0.2555413842201233\n",
      "Sequence[11070] is 1 and Pathogenic Score: log10(0.9620047211647034/0.74302077293396) = 0.11217623203992844\n",
      "Sequence[11098] is 1 and Pathogenic Score: log10(0.8150417804718018/0.5168653130531311) = 0.19780248403549194\n",
      "Sequence[11102] is 1 and Pathogenic Score: log10(0.854100227355957/0.12745007872581482) = 0.8261687159538269\n",
      "Sequence[11110] is 1 and Pathogenic Score: log10(0.8266832828521729/0.014381565153598785) = 1.7595330476760864\n",
      "Sequence[11115] is 1 and Pathogenic Score: log10(0.9746987223625183/0.9227851629257202) = 0.0237697996199131\n",
      "Sequence[11124] is 1 and Pathogenic Score: log10(0.9889326095581055/0.9027397632598877) = 0.03960410878062248\n",
      "Sequence[11148] is 1 and Pathogenic Score: log10(0.9802346229553223/0.1882064938545227) = 0.7166954278945923\n",
      "Sequence[11154] is 1 and Pathogenic Score: log10(0.8977168202400208/0.5506086945533752) = 0.21229630708694458\n",
      "Sequence[11186] is 1 and Pathogenic Score: log10(0.9901021718978882/0.9732999205589294) = 0.007433322723954916\n",
      "Sequence[11212] is 1 and Pathogenic Score: log10(0.9702363014221191/0.19000288844108582) = 0.7081173062324524\n",
      "Sequence[11236] is 1 and Pathogenic Score: log10(0.9576965570449829/0.9771494269371033) = -0.008733054623007774\n",
      "Sequence[11237] is 1 and Pathogenic Score: log10(0.5505524277687073/0.7975932359695435) = -0.16098280251026154\n",
      "Sequence[11245] is 1 and Pathogenic Score: log10(0.9580975770950317/0.7559320330619812) = 0.10292698442935944\n",
      "Sequence[11257] is 1 and Pathogenic Score: log10(0.9848182797431946/0.4973371922969818) = 0.2967051863670349\n",
      "Sequence[11260] is 1 and Pathogenic Score: log10(0.9317498207092285/0.3542991876602173) = 0.4199291467666626\n"
     ]
    }
   ],
   "source": [
    "alt_less = 0\n",
    "alt_less_than_0_5 = 0\n",
    "for i in range(len(y1_var_ref_predict)):\n",
    "    if accp['class'][i] == 1:\n",
    "        if y1_var_alt_predict[i][1] < 0.5 and y1_var_ref_predict[i][1] >= 0.5: alt_less+=1\n",
    "        if y1_var_alt_predict[i][1] < 0.5: alt_less_than_0_5+=1\n",
    "        print(\"Sequence[{0}] is {1} and Pathogenic Score: log10({2}/{3}) = {4}\".format(i, accp['class'][i], y1_var_ref_predict[i][1], y1_var_alt_predict[i][1], calculate.calculate_mutation_score(y1_var_ref_predict[i][1], y1_var_alt_predict[i][1])))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [],
   "source": [
    "y2_var_ref_predict = acceptor_Vmodel_2.predict_proba(ref_seq_matrix)\n",
    "y2_var_ref_predict_classes = acceptor_Vmodel_2.predict_classes(ref_seq_matrix)\n",
    "\n",
    "y2_var_alt_predict = acceptor_Vmodel_2.predict_proba(alt_seq_matrix)\n",
    "y2_var_alt_predict_classes = acceptor_Vmodel_2.predict_classes(alt_seq_matrix)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Sequence[113] is 1 and Pathogenic Score: log10(0.9196118116378784/0.6413964033126831) = 0.15647803246974945\n",
      "Sequence[171] is 1 and Pathogenic Score: log10(0.8265446424484253/0.8351724147796631) = -0.004509839229285717\n",
      "Sequence[187] is 1 and Pathogenic Score: log10(0.6547959446907043/0.5577994585037231) = 0.06962788850069046\n",
      "Sequence[217] is 1 and Pathogenic Score: log10(0.7840296626091003/0.35628417134284973) = 0.34253597259521484\n",
      "Sequence[247] is 1 and Pathogenic Score: log10(0.9726210832595825/0.858012318611145) = 0.054450154304504395\n",
      "Sequence[252] is 1 and Pathogenic Score: log10(0.8959714770317078/0.34010785818099976) = 0.4206775426864624\n",
      "Sequence[254] is 1 and Pathogenic Score: log10(0.8959714770317078/0.2292425036430359) = 0.5919990539550781\n",
      "Sequence[501] is 1 and Pathogenic Score: log10(0.9525958895683289/0.943087100982666) = 0.004356890916824341\n",
      "Sequence[525] is 1 and Pathogenic Score: log10(0.8986486196517944/0.7222657799720764) = 0.09489285945892334\n",
      "Sequence[539] is 1 and Pathogenic Score: log10(0.8052064180374146/0.07726673036813736) = 1.0179146528244019\n",
      "Sequence[557] is 1 and Pathogenic Score: log10(0.9886753559112549/0.8460121154785156) = 0.06767711788415909\n",
      "Sequence[627] is 1 and Pathogenic Score: log10(0.9644378423690796/0.9211080074310303) = 0.019963663071393967\n",
      "Sequence[638] is 1 and Pathogenic Score: log10(0.7887402176856995/0.2488933950662613) = 0.5009206533432007\n",
      "Sequence[649] is 1 and Pathogenic Score: log10(0.8244808912277222/0.4943224787712097) = 0.22217024862766266\n",
      "Sequence[653] is 1 and Pathogenic Score: log10(0.7909305095672607/0.8319224119186401) = -0.021944506093859673\n",
      "Sequence[655] is 1 and Pathogenic Score: log10(0.863097608089447/0.3012518584728241) = 0.45713019371032715\n",
      "Sequence[656] is 1 and Pathogenic Score: log10(0.6508383750915527/0.156504824757576) = 0.6189454197883606\n",
      "Sequence[664] is 1 and Pathogenic Score: log10(0.6334480047225952/0.21879759430885315) = 0.4616684019565582\n",
      "Sequence[711] is 1 and Pathogenic Score: log10(0.8951153755187988/0.9276316165924072) = -0.015496519394218922\n",
      "Sequence[713] is 1 and Pathogenic Score: log10(0.9737398624420166/0.9744353294372559) = -0.0003100692410953343\n",
      "Sequence[739] is 1 and Pathogenic Score: log10(0.9805516004562378/0.5382486581802368) = 0.26048749685287476\n",
      "Sequence[742] is 1 and Pathogenic Score: log10(0.6051825881004333/0.045307330787181854) = 1.1257179975509644\n",
      "Sequence[743] is 1 and Pathogenic Score: log10(0.9906627535820007/0.8639636039733887) = 0.05943040922284126\n",
      "Sequence[761] is 1 and Pathogenic Score: log10(0.8270096778869629/0.02702944725751877) = 1.485673427581787\n",
      "Sequence[762] is 1 and Pathogenic Score: log10(0.9702448844909668/0.9567182660102844) = 0.006097304169088602\n",
      "Sequence[763] is 1 and Pathogenic Score: log10(0.2667189836502075/0.004330543801188469) = 1.7895114421844482\n",
      "Sequence[764] is 1 and Pathogenic Score: log10(0.6081882119178772/0.07340213656425476) = 0.9183292984962463\n",
      "Sequence[765] is 1 and Pathogenic Score: log10(0.9056066274642944/0.9306412935256958) = -0.011842736974358559\n",
      "Sequence[766] is 1 and Pathogenic Score: log10(0.9056066274642944/0.7591767907142639) = 0.0765966847538948\n",
      "Sequence[767] is 1 and Pathogenic Score: log10(0.9056066274642944/0.50638747215271) = 0.2524566352367401\n",
      "Sequence[842] is 1 and Pathogenic Score: log10(0.939689040184021/0.8597464561462402) = 0.03861378878355026\n",
      "Sequence[843] is 1 and Pathogenic Score: log10(0.8329101800918579/0.19364087283611298) = 0.6336011290550232\n",
      "Sequence[861] is 1 and Pathogenic Score: log10(0.8668296933174133/0.2542644143104553) = 0.5326482057571411\n",
      "Sequence[876] is 1 and Pathogenic Score: log10(0.8857547044754028/0.31831035017967224) = 0.44446271657943726\n",
      "Sequence[917] is 1 and Pathogenic Score: log10(0.8459382653236389/0.021707450971007347) = 1.590729832649231\n",
      "Sequence[918] is 1 and Pathogenic Score: log10(0.8459382653236389/0.711931049823761) = 0.07490074634552002\n",
      "Sequence[938] is 1 and Pathogenic Score: log10(0.9588010311126709/0.6858119964599609) = 0.14552342891693115\n",
      "Sequence[939] is 1 and Pathogenic Score: log10(0.9588010311126709/0.8664423227310181) = 0.04398881271481514\n",
      "Sequence[976] is 1 and Pathogenic Score: log10(0.9051775336265564/0.027210846543312073) = 1.5219917297363281\n",
      "Sequence[1098] is 1 and Pathogenic Score: log10(0.6653172969818115/0.22683371603488922) = 0.4673212170600891\n",
      "Sequence[1144] is 1 and Pathogenic Score: log10(0.9140907526016235/0.4207035005092621) = 0.3370131850242615\n",
      "Sequence[1145] is 1 and Pathogenic Score: log10(0.8627927899360657/0.5997785329818726) = 0.1579156070947647\n",
      "Sequence[1152] is 1 and Pathogenic Score: log10(0.8765097856521606/0.12025927752256393) = 0.8626381754875183\n",
      "Sequence[1273] is 1 and Pathogenic Score: log10(0.9438598155975342/0.8027607798576355) = 0.07032133638858795\n",
      "Sequence[1338] is 1 and Pathogenic Score: log10(0.5921698212623596/0.27138403058052063) = 0.33886200189590454\n",
      "Sequence[1339] is 1 and Pathogenic Score: log10(0.5921698212623596/0.043393202126026154) = 1.1350245475769043\n",
      "Sequence[1340] is 1 and Pathogenic Score: log10(0.943219006061554/0.10064379870891571) = 0.9718254804611206\n",
      "Sequence[1343] is 1 and Pathogenic Score: log10(0.9880732893943787/0.5331794619560242) = 0.2679157555103302\n",
      "Sequence[1359] is 1 and Pathogenic Score: log10(0.9172280430793762/0.832356870174408) = 0.04216773435473442\n",
      "Sequence[1366] is 1 and Pathogenic Score: log10(0.6745309829711914/0.01741856336593628) = 1.5879895687103271\n",
      "Sequence[1379] is 1 and Pathogenic Score: log10(0.6660478115081787/0.6574329733848572) = 0.0056539117358624935\n",
      "Sequence[1394] is 1 and Pathogenic Score: log10(0.9734870791435242/0.9167952537536621) = 0.026057837530970573\n",
      "Sequence[1395] is 1 and Pathogenic Score: log10(0.9734870791435242/0.8826618194580078) = 0.04253586754202843\n",
      "Sequence[1396] is 1 and Pathogenic Score: log10(0.9734870791435242/0.9272333979606628) = 0.02114110440015793\n",
      "Sequence[1405] is 1 and Pathogenic Score: log10(0.5741008520126343/0.17003047466278076) = 0.5284614562988281\n",
      "Sequence[1446] is 1 and Pathogenic Score: log10(0.7482219338417053/0.13966089487075806) = 0.7289556264877319\n",
      "Sequence[1458] is 1 and Pathogenic Score: log10(0.915355384349823/0.12390540540218353) = 0.8684995174407959\n",
      "Sequence[1459] is 1 and Pathogenic Score: log10(0.915355384349823/0.08326957374811172) = 1.0411033630371094\n",
      "Sequence[1470] is 1 and Pathogenic Score: log10(0.9194395542144775/0.24164102971553802) = 0.5803525447845459\n",
      "Sequence[1471] is 1 and Pathogenic Score: log10(0.9194395542144775/0.37504082918167114) = 0.38944464921951294\n",
      "Sequence[1498] is 1 and Pathogenic Score: log10(0.9580053091049194/0.9274215698242188) = 0.014090745709836483\n",
      "Sequence[1565] is 1 and Pathogenic Score: log10(0.8723073601722717/0.8108654022216797) = 0.031720783561468124\n",
      "Sequence[1569] is 1 and Pathogenic Score: log10(0.7918468713760376/0.35680294036865234) = 0.34621280431747437\n",
      "Sequence[1623] is 1 and Pathogenic Score: log10(0.6804357767105103/0.3373953104019165) = 0.3046480715274811\n",
      "Sequence[1677] is 1 and Pathogenic Score: log10(0.9381872415542603/0.8066464066505432) = 0.06560633331537247\n",
      "Sequence[1710] is 1 and Pathogenic Score: log10(0.4739900529384613/0.06588565558195114) = 0.8569783568382263\n",
      "Sequence[1725] is 1 and Pathogenic Score: log10(0.920922577381134/0.9362242817878723) = -0.007156785577535629\n",
      "Sequence[1743] is 1 and Pathogenic Score: log10(0.2421184629201889/0.05760405957698822) = 0.6235747933387756\n",
      "Sequence[1793] is 1 and Pathogenic Score: log10(0.9765779376029968/0.6066707968711853) = 0.20675380527973175\n",
      "Sequence[1906] is 1 and Pathogenic Score: log10(0.9786847233772278/0.4100480377674103) = 0.3778080642223358\n",
      "Sequence[1994] is 1 and Pathogenic Score: log10(0.9681783318519592/0.9430265426635742) = 0.011431417427957058\n",
      "Sequence[1998] is 1 and Pathogenic Score: log10(0.9520334005355835/0.4431557357311249) = 0.33209583163261414\n",
      "Sequence[1999] is 1 and Pathogenic Score: log10(0.8096690773963928/0.3431338965892792) = 0.3728439211845398\n",
      "Sequence[2001] is 1 and Pathogenic Score: log10(0.9892567992210388/0.9871074557304382) = 0.0009445864707231522\n",
      "Sequence[2002] is 1 and Pathogenic Score: log10(0.9488648772239685/0.16929128766059875) = 0.7485697865486145\n",
      "Sequence[2046] is 1 and Pathogenic Score: log10(0.9913942217826843/0.9038845300674438) = 0.04013342410326004\n",
      "Sequence[2061] is 1 and Pathogenic Score: log10(0.9719834327697754/0.9575884342193604) = 0.0064799608662724495\n",
      "Sequence[2091] is 1 and Pathogenic Score: log10(0.960342288017273/0.8132131099700928) = 0.07222166657447815\n",
      "Sequence[2118] is 1 and Pathogenic Score: log10(0.8783358335494995/0.41129061579704285) = 0.3295117914676666\n",
      "Sequence[2119] is 1 and Pathogenic Score: log10(0.9304682016372681/0.7958021759986877) = 0.06789640337228775\n",
      "Sequence[2120] is 1 and Pathogenic Score: log10(0.8700878024101257/0.7367901802062988) = 0.07221925258636475\n",
      "Sequence[2147] is 1 and Pathogenic Score: log10(0.05039042606949806/0.009012039750814438) = 0.7475249171257019\n",
      "Sequence[2151] is 1 and Pathogenic Score: log10(0.685382068157196/0.011888694018125534) = 1.7607985734939575\n",
      "Sequence[2154] is 1 and Pathogenic Score: log10(0.12024246901273727/0.059327997267246246) = 0.30679821968078613\n",
      "Sequence[2155] is 1 and Pathogenic Score: log10(0.12024246901273727/0.024641873314976692) = 0.6883841753005981\n",
      "Sequence[2156] is 1 and Pathogenic Score: log10(0.12024246901273727/0.06879983097314835) = 0.24247051775455475\n",
      "Sequence[2174] is 1 and Pathogenic Score: log10(0.869353711605072/0.36889931559562683) = 0.37228864431381226\n",
      "Sequence[2287] is 1 and Pathogenic Score: log10(0.9260876774787903/0.9355379939079285) = -0.004409332759678364\n",
      "Sequence[2328] is 1 and Pathogenic Score: log10(0.5806871652603149/0.13378272950649261) = 0.637542188167572\n",
      "Sequence[2414] is 1 and Pathogenic Score: log10(0.9515488147735596/0.3749167323112488) = 0.4044962525367737\n",
      "Sequence[2471] is 1 and Pathogenic Score: log10(0.9796247482299805/0.6907888054847717) = 0.15171444416046143\n",
      "Sequence[2538] is 1 and Pathogenic Score: log10(0.7099752426147461/0.5407254099845886) = 0.11826641112565994\n",
      "Sequence[2543] is 1 and Pathogenic Score: log10(0.8493989706039429/0.23361332714557648) = 0.5606141090393066\n",
      "Sequence[2611] is 1 and Pathogenic Score: log10(0.8453648686408997/0.5753424763679504) = 0.16711774468421936\n",
      "Sequence[2656] is 1 and Pathogenic Score: log10(0.22939345240592957/0.04656905680894852) = 0.6924835443496704\n",
      "Sequence[2755] is 1 and Pathogenic Score: log10(0.6319364905357361/0.15941309928894043) = 0.5981494188308716\n",
      "Sequence[2770] is 1 and Pathogenic Score: log10(0.8467379808425903/0.43881699442863464) = 0.2854655981063843\n",
      "Sequence[2938] is 1 and Pathogenic Score: log10(0.952560544013977/0.44606778025627136) = 0.3294917047023773\n",
      "Sequence[2942] is 1 and Pathogenic Score: log10(0.9392670392990112/0.11606408655643463) = 0.9080912470817566\n",
      "Sequence[2976] is 1 and Pathogenic Score: log10(0.9373859763145447/0.5530781149864197) = 0.22913199663162231\n",
      "Sequence[2988] is 1 and Pathogenic Score: log10(0.37094828486442566/0.4224485754966736) = -0.056460484862327576\n",
      "Sequence[3003] is 1 and Pathogenic Score: log10(0.6389538645744324/0.011315824463963509) = 1.7517832517623901\n",
      "Sequence[3005] is 1 and Pathogenic Score: log10(0.9015283584594727/0.6534385085105896) = 0.13977466523647308\n",
      "Sequence[3046] is 1 and Pathogenic Score: log10(0.6375682353973389/0.062459833920001984) = 1.0089259147644043\n",
      "Sequence[3161] is 1 and Pathogenic Score: log10(0.9889605641365051/0.6139251589775085) = 0.20706354081630707\n",
      "Sequence[3314] is 1 and Pathogenic Score: log10(0.9345667958259583/0.14269912242889404) = 0.8161890506744385\n",
      "Sequence[3331] is 1 and Pathogenic Score: log10(0.9625758528709412/0.5397536754608154) = 0.2512393295764923\n",
      "Sequence[3340] is 1 and Pathogenic Score: log10(0.9432004690170288/0.5177741646766663) = 0.2604636251926422\n",
      "Sequence[3386] is 1 and Pathogenic Score: log10(0.7727396488189697/0.3607909679412842) = 0.3307775557041168\n",
      "Sequence[3396] is 1 and Pathogenic Score: log10(0.8786631226539612/0.6635180115699768) = 0.12196969985961914\n",
      "Sequence[3398] is 1 and Pathogenic Score: log10(0.8605998754501343/0.9263553619384766) = -0.03197633475065231\n",
      "Sequence[3516] is 1 and Pathogenic Score: log10(0.9632881283760071/0.7379794716835022) = 0.11571191996335983\n",
      "Sequence[3543] is 1 and Pathogenic Score: log10(0.7790004014968872/0.31853052973747253) = 0.388386607170105\n",
      "Sequence[3545] is 1 and Pathogenic Score: log10(0.7790004014968872/0.0682528167963028) = 1.0574171543121338\n",
      "Sequence[3588] is 1 and Pathogenic Score: log10(0.9766485095024109/0.9415249824523926) = 0.01590641960501671\n",
      "Sequence[3593] is 1 and Pathogenic Score: log10(0.8137348890304565/0.2642691731452942) = 0.48843643069267273\n",
      "Sequence[3608] is 1 and Pathogenic Score: log10(0.9176209568977356/0.32482343912124634) = 0.45101597905158997\n",
      "Sequence[3609] is 1 and Pathogenic Score: log10(0.9335198998451233/0.5991337895393372) = 0.19259977340698242\n",
      "Sequence[3618] is 1 and Pathogenic Score: log10(0.5387431383132935/0.05802907422184944) = 0.9677361249923706\n",
      "Sequence[3787] is 1 and Pathogenic Score: log10(0.5797728300094604/0.3675251603126526) = 0.19797077775001526\n",
      "Sequence[3803] is 1 and Pathogenic Score: log10(0.6165634393692017/0.19548752903938293) = 0.4988587200641632\n",
      "Sequence[3805] is 1 and Pathogenic Score: log10(0.8603534698486328/0.4858824610710144) = 0.2481456845998764\n",
      "Sequence[3807] is 1 and Pathogenic Score: log10(0.6906497478485107/0.02316659688949585) = 1.4743956327438354\n",
      "Sequence[3808] is 1 and Pathogenic Score: log10(0.8570935726165771/0.7975136041641235) = 0.03129014000296593\n",
      "Sequence[3865] is 1 and Pathogenic Score: log10(0.13278073072433472/0.03722884878516197) = 0.5522554516792297\n",
      "Sequence[3902] is 1 and Pathogenic Score: log10(0.5183913111686707/0.3636966347694397) = 0.15391841530799866\n",
      "Sequence[3925] is 1 and Pathogenic Score: log10(0.3430786430835724/0.3518342971801758) = -0.010944481007754803\n",
      "Sequence[3965] is 1 and Pathogenic Score: log10(0.9564149975776672/0.8724761605262756) = 0.03989281505346298\n",
      "Sequence[3966] is 1 and Pathogenic Score: log10(0.9564149975776672/0.6044591665267944) = 0.19927942752838135\n",
      "Sequence[4027] is 1 and Pathogenic Score: log10(0.5882993936538696/0.0636090561747551) = 0.9660794734954834\n",
      "Sequence[4190] is 1 and Pathogenic Score: log10(0.9104236364364624/0.6785074472427368) = 0.12768889963626862\n",
      "Sequence[4208] is 1 and Pathogenic Score: log10(0.9509402513504028/0.7107692360877991) = 0.12642459571361542\n",
      "Sequence[4347] is 1 and Pathogenic Score: log10(0.9586232304573059/0.936757504940033) = 0.010020754300057888\n",
      "Sequence[4349] is 1 and Pathogenic Score: log10(0.945151686668396/0.9325595498085022) = 0.005824917461723089\n",
      "Sequence[4352] is 1 and Pathogenic Score: log10(0.6611929535865784/0.12259190529584885) = 0.7318664193153381\n",
      "Sequence[4366] is 1 and Pathogenic Score: log10(0.14003275334835052/0.06148533150553703) = 0.35745808482170105\n",
      "Sequence[4373] is 1 and Pathogenic Score: log10(0.5740016102790833/0.29043564200401306) = 0.29586318135261536\n",
      "Sequence[4415] is 1 and Pathogenic Score: log10(0.8962223529815674/0.6179295182228088) = 0.16147683560848236\n",
      "Sequence[4428] is 1 and Pathogenic Score: log10(0.513128399848938/0.06696107238531113) = 0.884403645992279\n",
      "Sequence[4436] is 1 and Pathogenic Score: log10(0.7887306809425354/0.3878251612186432) = 0.3082927465438843\n",
      "Sequence[4448] is 1 and Pathogenic Score: log10(0.9439175724983215/0.38262683153152466) = 0.3921586573123932\n",
      "Sequence[4477] is 1 and Pathogenic Score: log10(0.8559584617614746/0.5845758318901062) = 0.16561183333396912\n",
      "Sequence[4480] is 1 and Pathogenic Score: log10(0.8858940005302429/0.08354099094867706) = 1.025482177734375\n",
      "Sequence[4527] is 1 and Pathogenic Score: log10(0.8685384392738342/0.27656251192092896) = 0.496995747089386\n",
      "Sequence[4581] is 1 and Pathogenic Score: log10(0.9688568711280823/0.7168704867362976) = 0.1308189332485199\n",
      "Sequence[4614] is 1 and Pathogenic Score: log10(0.9934679865837097/0.9846267104148865) = 0.0038822651840746403\n",
      "Sequence[4616] is 1 and Pathogenic Score: log10(0.9934679865837097/0.9463167786598206) = 0.021117335185408592\n",
      "Sequence[4631] is 1 and Pathogenic Score: log10(0.9843467473983765/0.3602546155452728) = 0.43653854727745056\n",
      "Sequence[4645] is 1 and Pathogenic Score: log10(0.8020941615104675/0.3571412265300751) = 0.3513853847980499\n",
      "Sequence[4725] is 1 and Pathogenic Score: log10(0.9751929640769958/0.4281453490257263) = 0.3574993312358856\n",
      "Sequence[4886] is 1 and Pathogenic Score: log10(0.8618058562278748/0.12958696484565735) = 0.8228481411933899\n",
      "Sequence[4930] is 1 and Pathogenic Score: log10(0.9289917945861816/0.16106708347797394) = 0.7610051035881042\n",
      "Sequence[4935] is 1 and Pathogenic Score: log10(0.8626344203948975/0.5615291595458984) = 0.18645447492599487\n",
      "Sequence[4942] is 1 and Pathogenic Score: log10(0.9926542043685913/0.9545082449913025) = 0.017018290236592293\n",
      "Sequence[4943] is 1 and Pathogenic Score: log10(0.9926542043685913/0.9845269918441772) = 0.003570335218682885\n",
      "Sequence[4962] is 1 and Pathogenic Score: log10(0.9535791277885437/0.40495792031288147) = 0.37194687128067017\n",
      "Sequence[5047] is 1 and Pathogenic Score: log10(0.9404642581939697/0.8706666827201843) = 0.03349035233259201\n",
      "Sequence[5308] is 1 and Pathogenic Score: log10(0.7449350953102112/0.27801504731178284) = 0.42805016040802\n",
      "Sequence[5461] is 1 and Pathogenic Score: log10(0.9523119330406189/0.06715413928031921) = 1.1517064571380615\n",
      "Sequence[5463] is 1 and Pathogenic Score: log10(0.9460089802742004/0.8451385498046875) = 0.04896736517548561\n",
      "Sequence[5548] is 1 and Pathogenic Score: log10(0.7655187249183655/0.034948769956827164) = 1.3405239582061768\n",
      "Sequence[5555] is 1 and Pathogenic Score: log10(0.9803850650787354/0.22564199566841125) = 0.6379767656326294\n",
      "Sequence[5556] is 1 and Pathogenic Score: log10(0.7183012962341309/0.048986129462718964) = 1.1662335395812988\n",
      "Sequence[5558] is 1 and Pathogenic Score: log10(0.802314281463623/0.39221665263175964) = 0.31081846356391907\n",
      "Sequence[5563] is 1 and Pathogenic Score: log10(0.7387360334396362/0.4426804184913635) = 0.22239898145198822\n",
      "Sequence[5575] is 1 and Pathogenic Score: log10(0.9847516417503357/0.9643005728721619) = 0.00911427941173315\n",
      "Sequence[5577] is 1 and Pathogenic Score: log10(0.8334794640541077/0.022029200568795204) = 1.577896237373352\n",
      "Sequence[5586] is 1 and Pathogenic Score: log10(0.9899858832359314/0.6585783958435059) = 0.17702153325080872\n",
      "Sequence[5591] is 1 and Pathogenic Score: log10(0.8901326060295105/0.4788006544113159) = 0.2692999541759491\n",
      "Sequence[5594] is 1 and Pathogenic Score: log10(0.9754162430763245/0.9079388976097107) = 0.03113335557281971\n",
      "Sequence[5608] is 1 and Pathogenic Score: log10(0.9779159426689148/0.9222407937049866) = 0.025457175448536873\n",
      "Sequence[5641] is 1 and Pathogenic Score: log10(0.8055496215820312/0.6178436279296875) = 0.11521371454000473\n",
      "Sequence[5644] is 1 and Pathogenic Score: log10(0.9500871300697327/0.8094030022621155) = 0.06959864497184753\n",
      "Sequence[5650] is 1 and Pathogenic Score: log10(0.8089325428009033/0.4829292297363281) = 0.2240287959575653\n",
      "Sequence[5653] is 1 and Pathogenic Score: log10(0.7567012906074524/0.13241127133369446) = 0.7569994926452637\n",
      "Sequence[5675] is 1 and Pathogenic Score: log10(0.7671812176704407/0.4774062931537628) = 0.20600982010364532\n",
      "Sequence[5690] is 1 and Pathogenic Score: log10(0.6075740456581116/0.104503333568573) = 0.7644690275192261\n",
      "Sequence[5692] is 1 and Pathogenic Score: log10(0.9904911518096924/0.9100216031074524) = 0.036798905581235886\n",
      "Sequence[5694] is 1 and Pathogenic Score: log10(0.8082380890846252/0.6370683908462524) = 0.10335326939821243\n",
      "Sequence[5695] is 1 and Pathogenic Score: log10(0.8082380890846252/0.020796284079551697) = 1.5895535945892334\n",
      "Sequence[5697] is 1 and Pathogenic Score: log10(0.9160457849502563/0.5618940591812134) = 0.21226274967193604\n",
      "Sequence[5699] is 1 and Pathogenic Score: log10(0.6182532906532288/0.1641596257686615) = 0.5759000778198242\n",
      "Sequence[5700] is 1 and Pathogenic Score: log10(0.9813931584358215/0.9533526301383972) = 0.012589440681040287\n",
      "Sequence[5701] is 1 and Pathogenic Score: log10(0.9813931584358215/0.9635463953018188) = 0.007970374077558517\n",
      "Sequence[5722] is 1 and Pathogenic Score: log10(0.9060428142547607/0.6009597778320312) = 0.1783033162355423\n",
      "Sequence[5762] is 1 and Pathogenic Score: log10(0.7238252758979797/0.6615270972251892) = 0.03908611834049225\n",
      "Sequence[5764] is 1 and Pathogenic Score: log10(0.9520003199577332/0.7463966012001038) = 0.10566745698451996\n",
      "Sequence[5778] is 1 and Pathogenic Score: log10(0.9569210410118103/0.22821980714797974) = 0.62252277135849\n",
      "Sequence[5780] is 1 and Pathogenic Score: log10(0.8525196313858032/0.4915633797645569) = 0.2391248494386673\n",
      "Sequence[5815] is 1 and Pathogenic Score: log10(0.9657192230224609/0.5975381731987) = 0.20848523080348969\n",
      "Sequence[5820] is 1 and Pathogenic Score: log10(0.9869022369384766/0.9879184365272522) = -0.00044694406096823514\n",
      "Sequence[5823] is 1 and Pathogenic Score: log10(0.8665593266487122/0.63186115026474) = 0.13717663288116455\n",
      "Sequence[5915] is 1 and Pathogenic Score: log10(0.8879701495170593/0.655603289604187) = 0.1317572444677353\n",
      "Sequence[5925] is 1 and Pathogenic Score: log10(0.9455118775367737/0.648686945438385) = 0.16363182663917542\n",
      "Sequence[5927] is 1 and Pathogenic Score: log10(0.9622884392738342/0.9474712014198303) = 0.006739244796335697\n",
      "Sequence[5935] is 1 and Pathogenic Score: log10(0.8061895370483398/0.34951087832450867) = 0.3629764914512634\n",
      "Sequence[5988] is 1 and Pathogenic Score: log10(0.9228711724281311/0.9254189133644104) = -0.0011972958454862237\n",
      "Sequence[5989] is 1 and Pathogenic Score: log10(0.4317395091056824/0.03460724279284477) = 1.0960547924041748\n",
      "Sequence[6003] is 1 and Pathogenic Score: log10(0.5907353758811951/0.1926301121711731) = 0.48666879534721375\n",
      "Sequence[6020] is 1 and Pathogenic Score: log10(0.9914423823356628/0.9712664484977722) = 0.008929095230996609\n",
      "Sequence[6064] is 1 and Pathogenic Score: log10(0.8320610523223877/0.8670664429664612) = -0.01789717562496662\n",
      "Sequence[6065] is 1 and Pathogenic Score: log10(0.9314455389976501/0.9440569877624512) = -0.0058407410979270935\n",
      "Sequence[6081] is 1 and Pathogenic Score: log10(0.9826221466064453/0.9906820058822632) = -0.0035477306228131056\n",
      "Sequence[6094] is 1 and Pathogenic Score: log10(0.5790367126464844/0.2922312319278717) = 0.29697948694229126\n",
      "Sequence[6096] is 1 and Pathogenic Score: log10(0.9387092590332031/0.013283352367579937) = 1.8492233753204346\n",
      "Sequence[6107] is 1 and Pathogenic Score: log10(0.7400375604629517/0.4386531114578247) = 0.22713255882263184\n",
      "Sequence[6114] is 1 and Pathogenic Score: log10(0.4300398528575897/0.014661361463367939) = 1.4673343896865845\n",
      "Sequence[6160] is 1 and Pathogenic Score: log10(0.9411410093307495/0.9440026879310608) = -0.0013185340212658048\n",
      "Sequence[6190] is 1 and Pathogenic Score: log10(0.9605236053466797/0.7969141006469727) = 0.08109652251005173\n",
      "Sequence[6446] is 1 and Pathogenic Score: log10(0.5740599632263184/0.02427486702799797) = 1.3738003969192505\n",
      "Sequence[6466] is 1 and Pathogenic Score: log10(0.19854627549648285/0.14793114364147186) = 0.12780213356018066\n",
      "Sequence[6644] is 1 and Pathogenic Score: log10(0.5719206929206848/0.010082127526402473) = 1.7537835836410522\n",
      "Sequence[6687] is 1 and Pathogenic Score: log10(0.5930370092391968/0.18924759328365326) = 0.4960514307022095\n",
      "Sequence[6688] is 1 and Pathogenic Score: log10(0.9385993480682373/0.14050112664699554) = 0.824800431728363\n",
      "Sequence[6751] is 1 and Pathogenic Score: log10(0.924537181854248/0.8504056334495544) = 0.036298271268606186\n",
      "Sequence[6752] is 1 and Pathogenic Score: log10(0.924537181854248/0.2625179588794708) = 0.5467653870582581\n",
      "Sequence[6753] is 1 and Pathogenic Score: log10(0.924537181854248/0.835640549659729) = 0.0439048707485199\n",
      "Sequence[6764] is 1 and Pathogenic Score: log10(0.9645938873291016/0.9354200959205627) = 0.013337804935872555\n",
      "Sequence[6770] is 1 and Pathogenic Score: log10(0.5798078775405884/0.066293865442276) = 0.9418107867240906\n",
      "Sequence[6853] is 1 and Pathogenic Score: log10(0.26125192642211914/0.005102465394884348) = 1.7092794179916382\n",
      "Sequence[6911] is 1 and Pathogenic Score: log10(0.6970964074134827/0.7484164834022522) = -0.03085050918161869\n",
      "Sequence[6919] is 1 and Pathogenic Score: log10(0.9561411738395691/0.9338915348052979) = 0.010225599631667137\n",
      "Sequence[6925] is 1 and Pathogenic Score: log10(0.9434438347816467/0.6935275197029114) = 0.13365234434604645\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Sequence[7015] is 1 and Pathogenic Score: log10(0.9320966601371765/0.22741395235061646) = 0.612643837928772\n",
      "Sequence[7080] is 1 and Pathogenic Score: log10(0.8394901752471924/0.27726927399635315) = 0.48111385107040405\n",
      "Sequence[7148] is 1 and Pathogenic Score: log10(0.7889232039451599/0.33447837829589844) = 0.37266668677330017\n",
      "Sequence[7240] is 1 and Pathogenic Score: log10(0.9075250625610352/0.7616549134254456) = 0.07610037177801132\n",
      "Sequence[7248] is 1 and Pathogenic Score: log10(0.8830877542495728/0.29720407724380493) = 0.4729490876197815\n",
      "Sequence[7303] is 1 and Pathogenic Score: log10(0.8891603350639343/0.8558668494224548) = 0.01657385379076004\n",
      "Sequence[7325] is 1 and Pathogenic Score: log10(0.6721853613853455/0.28998374938964844) = 0.3651154041290283\n",
      "Sequence[7365] is 1 and Pathogenic Score: log10(0.49675801396369934/0.2340400069952011) = 0.32685476541519165\n",
      "Sequence[7452] is 1 and Pathogenic Score: log10(0.6381638050079346/0.1079292818903923) = 0.7717928886413574\n",
      "Sequence[7456] is 1 and Pathogenic Score: log10(0.966282308101654/0.8845447301864624) = 0.03838423267006874\n",
      "Sequence[7462] is 1 and Pathogenic Score: log10(0.8340785503387451/0.4446685016155243) = 0.2731705904006958\n",
      "Sequence[7518] is 1 and Pathogenic Score: log10(0.9739930033683777/0.11100178211927414) = 0.9432258605957031\n",
      "Sequence[7601] is 1 and Pathogenic Score: log10(0.7470144033432007/0.4497271180152893) = 0.22037988901138306\n",
      "Sequence[7905] is 1 and Pathogenic Score: log10(0.9371694922447205/0.9049416184425354) = 0.015197568573057652\n",
      "Sequence[7908] is 1 and Pathogenic Score: log10(0.7695281505584717/0.30182087421417236) = 0.4064752459526062\n",
      "Sequence[7928] is 1 and Pathogenic Score: log10(0.8954974412918091/0.5275903940200806) = 0.22976747155189514\n",
      "Sequence[7929] is 1 and Pathogenic Score: log10(0.7123798727989197/0.035167429596185684) = 1.3065710067749023\n",
      "Sequence[8072] is 1 and Pathogenic Score: log10(0.9413713216781616/0.847918689250946) = 0.04540674388408661\n",
      "Sequence[8240] is 1 and Pathogenic Score: log10(0.9607234001159668/0.6737692952156067) = 0.1540871411561966\n",
      "Sequence[8260] is 1 and Pathogenic Score: log10(0.8409894108772278/0.865684449672699) = -0.012569088488817215\n",
      "Sequence[8325] is 1 and Pathogenic Score: log10(0.9265077114105225/0.7505966424942017) = 0.09144242107868195\n",
      "Sequence[8333] is 1 and Pathogenic Score: log10(0.9060695171356201/0.08025896549224854) = 1.0526679754257202\n",
      "Sequence[8453] is 1 and Pathogenic Score: log10(0.787959635257721/0.6259538531303406) = 0.09996163845062256\n",
      "Sequence[8455] is 1 and Pathogenic Score: log10(0.9281069040298462/0.6843516826629639) = 0.1323186606168747\n",
      "Sequence[8489] is 1 and Pathogenic Score: log10(0.7264035940170288/0.3302808701992035) = 0.3422945737838745\n",
      "Sequence[8555] is 1 and Pathogenic Score: log10(0.9866944551467896/0.91755211353302) = 0.03155192732810974\n",
      "Sequence[8556] is 1 and Pathogenic Score: log10(0.9866944551467896/0.9680266380310059) = 0.008295363746583462\n",
      "Sequence[8557] is 1 and Pathogenic Score: log10(0.9866944551467896/0.8928598761558533) = 0.0433993898332119\n",
      "Sequence[8558] is 1 and Pathogenic Score: log10(0.9158753156661987/0.48250246047973633) = 0.2783368229866028\n",
      "Sequence[8565] is 1 and Pathogenic Score: log10(0.0729980394244194/0.036039087921381) = 0.3065374195575714\n",
      "Sequence[8589] is 1 and Pathogenic Score: log10(0.2037111520767212/0.037319086492061615) = 0.7370837926864624\n",
      "Sequence[8592] is 1 and Pathogenic Score: log10(0.7611802220344543/0.255558043718338) = 0.47399795055389404\n",
      "Sequence[8618] is 1 and Pathogenic Score: log10(0.43212488293647766/0.11313173174858093) = 0.5820248126983643\n",
      "Sequence[8623] is 1 and Pathogenic Score: log10(0.6892420053482056/0.12921273708343506) = 0.7270663976669312\n",
      "Sequence[8624] is 1 and Pathogenic Score: log10(0.6892420053482056/0.1363798975944519) = 0.7036213874816895\n",
      "Sequence[8626] is 1 and Pathogenic Score: log10(0.9681985974311829/0.7961076498031616) = 0.0849926546216011\n",
      "Sequence[8627] is 1 and Pathogenic Score: log10(0.9681985974311829/0.9174277782440186) = 0.0233925674110651\n",
      "Sequence[8651] is 1 and Pathogenic Score: log10(0.6470500826835632/0.014779671095311642) = 1.6412731409072876\n",
      "Sequence[8652] is 1 and Pathogenic Score: log10(0.6470500826835632/0.09732590615749359) = 0.8227094411849976\n",
      "Sequence[8653] is 1 and Pathogenic Score: log10(0.9379859566688538/0.1664537489414215) = 0.7509027719497681\n",
      "Sequence[8674] is 1 and Pathogenic Score: log10(0.6449228525161743/0.7771163582801819) = -0.08097827434539795\n",
      "Sequence[8675] is 1 and Pathogenic Score: log10(0.6449228525161743/0.0684770867228508) = 0.9739624857902527\n",
      "Sequence[8678] is 1 and Pathogenic Score: log10(0.13956506550312042/0.04502082243561745) = 0.4913632869720459\n",
      "Sequence[8680] is 1 and Pathogenic Score: log10(0.13956506550312042/0.03876083716750145) = 0.5563835501670837\n",
      "Sequence[8697] is 1 and Pathogenic Score: log10(0.9190582036972046/0.6921241879463196) = 0.12315899133682251\n",
      "Sequence[8699] is 1 and Pathogenic Score: log10(0.7093402147293091/0.16446611285209656) = 0.6347781419754028\n",
      "Sequence[8724] is 1 and Pathogenic Score: log10(0.8435916900634766/0.28315597772598267) = 0.4741065502166748\n",
      "Sequence[8962] is 1 and Pathogenic Score: log10(0.3258804976940155/0.029084954410791397) = 1.0493899583816528\n",
      "Sequence[8968] is 1 and Pathogenic Score: log10(0.6266431212425232/0.1476728618144989) = 0.6277195811271667\n",
      "Sequence[9034] is 1 and Pathogenic Score: log10(0.12443722784519196/0.05986100807785988) = 0.31780633330345154\n",
      "Sequence[9048] is 1 and Pathogenic Score: log10(0.783839225769043/0.014691667631268501) = 1.7271559238433838\n",
      "Sequence[9049] is 1 and Pathogenic Score: log10(0.6066468358039856/0.45056888461112976) = 0.12917472422122955\n",
      "Sequence[9050] is 1 and Pathogenic Score: log10(0.6066468358039856/0.15190228819847107) = 0.6013716459274292\n",
      "Sequence[9051] is 1 and Pathogenic Score: log10(0.9407865405082703/0.13220861554145813) = 0.8522313237190247\n",
      "Sequence[9052] is 1 and Pathogenic Score: log10(0.9407865405082703/0.9452621340751648) = -0.0020611612126231194\n",
      "Sequence[9054] is 1 and Pathogenic Score: log10(0.9851439595222473/0.9493246078491211) = 0.016084961593151093\n",
      "Sequence[9235] is 1 and Pathogenic Score: log10(0.9396804571151733/0.8337065577507019) = 0.05196699500083923\n",
      "Sequence[9354] is 1 and Pathogenic Score: log10(0.9730013012886047/0.8181681632995605) = 0.07527084648609161\n",
      "Sequence[9382] is 1 and Pathogenic Score: log10(0.9596884846687317/0.565001368522644) = 0.2300807684659958\n",
      "Sequence[9519] is 1 and Pathogenic Score: log10(0.9524037837982178/0.16366451978683472) = 0.7648665904998779\n",
      "Sequence[9559] is 1 and Pathogenic Score: log10(0.39733612537384033/0.12066581845283508) = 0.5175737738609314\n",
      "Sequence[9561] is 1 and Pathogenic Score: log10(0.8534808158874512/0.28919902443885803) = 0.46999692916870117\n",
      "Sequence[9598] is 1 and Pathogenic Score: log10(0.9833362102508545/0.8912511467933655) = 0.04270191490650177\n",
      "Sequence[9615] is 1 and Pathogenic Score: log10(0.8010069727897644/0.13016559183597565) = 0.7891401052474976\n",
      "Sequence[9632] is 1 and Pathogenic Score: log10(0.8781589269638062/0.43357613682746887) = 0.30650776624679565\n",
      "Sequence[9683] is 1 and Pathogenic Score: log10(0.9669617414474487/0.85587078332901) = 0.053001098334789276\n",
      "Sequence[9722] is 1 and Pathogenic Score: log10(0.8883705139160156/0.7994657158851624) = 0.045794274657964706\n",
      "Sequence[9784] is 1 and Pathogenic Score: log10(0.9009876847267151/0.8784974813461304) = 0.010978346690535545\n",
      "Sequence[9785] is 1 and Pathogenic Score: log10(0.9009876847267151/0.7418718338012695) = 0.08438995480537415\n",
      "Sequence[9786] is 1 and Pathogenic Score: log10(0.9009876847267151/0.3357164263725281) = 0.4287462532520294\n",
      "Sequence[9787] is 1 and Pathogenic Score: log10(0.5531328916549683/0.16715925931930542) = 0.5196990370750427\n",
      "Sequence[9789] is 1 and Pathogenic Score: log10(0.9490059614181519/0.8944950699806213) = 0.02569098025560379\n",
      "Sequence[9790] is 1 and Pathogenic Score: log10(0.8982730507850647/0.8523388504981995) = 0.022796064615249634\n",
      "Sequence[9791] is 1 and Pathogenic Score: log10(0.9454278945922852/0.886254608631134) = 0.02806990221142769\n",
      "Sequence[9804] is 1 and Pathogenic Score: log10(0.9742743372917175/0.5458787679672241) = 0.25158506631851196\n",
      "Sequence[9843] is 1 and Pathogenic Score: log10(0.9524796009063721/0.9719144105911255) = -0.008772331289947033\n",
      "Sequence[9886] is 1 and Pathogenic Score: log10(0.5827485918998718/0.30317410826683044) = 0.28378909826278687\n",
      "Sequence[9888] is 1 and Pathogenic Score: log10(0.7599930763244629/0.638922393321991) = 0.07536152005195618\n",
      "Sequence[9893] is 1 and Pathogenic Score: log10(0.8777631521224976/0.2619569003582001) = 0.5251474976539612\n",
      "Sequence[9902] is 1 and Pathogenic Score: log10(0.9771819710731506/0.9766189455986023) = 0.0002502969582565129\n",
      "Sequence[9910] is 1 and Pathogenic Score: log10(0.6540119051933289/0.19359974563121796) = 0.5286808609962463\n",
      "Sequence[9962] is 1 and Pathogenic Score: log10(0.880806028842926/0.7343610525131226) = 0.07897063344717026\n",
      "Sequence[9973] is 1 and Pathogenic Score: log10(0.9679379463195801/0.8866510987281799) = 0.03809475898742676\n",
      "Sequence[10090] is 1 and Pathogenic Score: log10(0.40825891494750977/0.18270105123519897) = 0.34919461607933044\n",
      "Sequence[10126] is 1 and Pathogenic Score: log10(0.8224013447761536/0.09571386873722076) = 0.9341089129447937\n",
      "Sequence[10130] is 1 and Pathogenic Score: log10(0.9463632106781006/0.609369158744812) = 0.1911773830652237\n",
      "Sequence[10142] is 1 and Pathogenic Score: log10(0.9338114261627197/0.2711055278778076) = 0.5371208190917969\n",
      "Sequence[10144] is 1 and Pathogenic Score: log10(0.9338114261627197/0.24896986782550812) = 0.5741123557090759\n",
      "Sequence[10151] is 1 and Pathogenic Score: log10(0.9182312488555908/0.5532279014587402) = 0.22004801034927368\n",
      "Sequence[10181] is 1 and Pathogenic Score: log10(0.49815380573272705/0.7620882987976074) = -0.18464183807373047\n",
      "Sequence[10182] is 1 and Pathogenic Score: log10(0.6036986708641052/0.2134407013654709) = 0.4515429735183716\n",
      "Sequence[10183] is 1 and Pathogenic Score: log10(0.49815380573272705/0.08199182897806168) = 0.7835928797721863\n",
      "Sequence[10186] is 1 and Pathogenic Score: log10(0.9546107053756714/0.01899506337940693) = 1.7011855840682983\n",
      "Sequence[10197] is 1 and Pathogenic Score: log10(0.9368521571159363/0.1570764183998108) = 0.7755600810050964\n",
      "Sequence[10198] is 1 and Pathogenic Score: log10(0.9368521571159363/0.6174061298370361) = 0.18110011518001556\n",
      "Sequence[10199] is 1 and Pathogenic Score: log10(0.9368521571159363/0.4418121874332428) = 0.32643336057662964\n",
      "Sequence[10200] is 1 and Pathogenic Score: log10(0.9368521571159363/0.7921091914176941) = 0.07288599014282227\n",
      "Sequence[10201] is 1 and Pathogenic Score: log10(0.9368521571159363/0.8609797358512878) = 0.036678116768598557\n",
      "Sequence[10212] is 1 and Pathogenic Score: log10(0.978329062461853/0.9661749005317688) = 0.0054292078129947186\n",
      "Sequence[10214] is 1 and Pathogenic Score: log10(0.9753088355064392/0.7259078621864319) = 0.12826064229011536\n",
      "Sequence[10221] is 1 and Pathogenic Score: log10(0.8425604701042175/0.20303940773010254) = 0.61802077293396\n",
      "Sequence[10235] is 1 and Pathogenic Score: log10(0.9341168999671936/0.750442624092102) = 0.09508372098207474\n",
      "Sequence[10238] is 1 and Pathogenic Score: log10(0.9532257914543152/0.5672250986099243) = 0.22544033825397491\n",
      "Sequence[10245] is 1 and Pathogenic Score: log10(0.9517298936843872/0.7197925448417664) = 0.12130637466907501\n",
      "Sequence[10356] is 1 and Pathogenic Score: log10(0.47907862067222595/0.10793840140104294) = 0.6472308039665222\n",
      "Sequence[10431] is 1 and Pathogenic Score: log10(0.8293657302856445/0.14392082393169403) = 0.7606224417686462\n",
      "Sequence[10632] is 1 and Pathogenic Score: log10(0.7346634864807129/0.06748376786708832) = 1.0368890762329102\n",
      "Sequence[10687] is 1 and Pathogenic Score: log10(0.9701601266860962/0.8950983881950378) = 0.03497263044118881\n",
      "Sequence[10820] is 1 and Pathogenic Score: log10(0.9314610958099365/0.8841999173164368) = 0.022614266723394394\n",
      "Sequence[10826] is 1 and Pathogenic Score: log10(0.7383650541305542/0.3246976137161255) = 0.35679203271865845\n",
      "Sequence[10836] is 1 and Pathogenic Score: log10(0.7948939204216003/0.46363863348960876) = 0.23412956297397614\n",
      "Sequence[10850] is 1 and Pathogenic Score: log10(0.7234870195388794/0.1321544200181961) = 0.7383490800857544\n",
      "Sequence[10851] is 1 and Pathogenic Score: log10(0.9662477970123291/0.9639309644699097) = 0.001042573363520205\n",
      "Sequence[10888] is 1 and Pathogenic Score: log10(0.3428681194782257/0.1363449990749359) = 0.40048789978027344\n",
      "Sequence[10908] is 1 and Pathogenic Score: log10(0.38360360264778137/0.132721945643425) = 0.4609399437904358\n",
      "Sequence[10912] is 1 and Pathogenic Score: log10(0.8842604756355286/0.7975836396217346) = 0.04480397701263428\n",
      "Sequence[10913] is 1 and Pathogenic Score: log10(0.8842604756355286/0.5719435214996338) = 0.18922707438468933\n",
      "Sequence[11050] is 1 and Pathogenic Score: log10(0.9669874906539917/0.794022262096405) = 0.08558817952871323\n",
      "Sequence[11070] is 1 and Pathogenic Score: log10(0.8022697567939758/0.33583226799964905) = 0.37819796800613403\n",
      "Sequence[11098] is 1 and Pathogenic Score: log10(0.6931627988815308/0.6212000846862793) = 0.04760371893644333\n",
      "Sequence[11102] is 1 and Pathogenic Score: log10(0.7288898825645447/0.20013567805290222) = 0.561337411403656\n",
      "Sequence[11110] is 1 and Pathogenic Score: log10(0.5201586484909058/0.024710429832339287) = 1.3232555389404297\n",
      "Sequence[11115] is 1 and Pathogenic Score: log10(0.9053829908370972/0.8714485168457031) = 0.016590597108006477\n",
      "Sequence[11124] is 1 and Pathogenic Score: log10(0.9439404606819153/0.6344053149223328) = 0.17257778346538544\n",
      "Sequence[11148] is 1 and Pathogenic Score: log10(0.9530614018440247/0.3459177017211914) = 0.44014808535575867\n",
      "Sequence[11154] is 1 and Pathogenic Score: log10(0.661940336227417/0.27740877866744995) = 0.3776986300945282\n",
      "Sequence[11186] is 1 and Pathogenic Score: log10(0.9713410139083862/0.9533178806304932) = 0.008133966475725174\n",
      "Sequence[11212] is 1 and Pathogenic Score: log10(0.9812307953834534/0.5869231224060059) = 0.22318996489048004\n",
      "Sequence[11236] is 1 and Pathogenic Score: log10(0.9293931722640991/0.9614471197128296) = -0.014725920744240284\n",
      "Sequence[11237] is 1 and Pathogenic Score: log10(0.3560642898082733/0.5455813407897949) = -0.1853310763835907\n",
      "Sequence[11245] is 1 and Pathogenic Score: log10(0.8048696517944336/0.5592482686042786) = 0.15812091529369354\n",
      "Sequence[11257] is 1 and Pathogenic Score: log10(0.9514734745025635/0.3612971305847168) = 0.4205321669578552\n",
      "Sequence[11260] is 1 and Pathogenic Score: log10(0.7284079790115356/0.4345189034938812) = 0.22436602413654327\n"
     ]
    }
   ],
   "source": [
    "alt_less_2 = 0\n",
    "alt_2_less_than_0_5 = 0\n",
    "for i in range(len(y2_var_ref_predict)):\n",
    "    if accp['class'][i] == 1:\n",
    "        if y2_var_alt_predict[i][1] < 0.5 and y2_var_ref_predict[i][1] >= 0.5: alt_less_2+=1\n",
    "        if y2_var_alt_predict[i][1] < 0.5: alt_2_less_than_0_5+=1\n",
    "        print(\"Sequence[{0}] is {1} and Pathogenic Score: log10({2}/{3}) = {4}\".format(i, accp['class'][i], y2_var_ref_predict[i][1], y2_var_alt_predict[i][1], calculate.calculate_mutation_score(y2_var_ref_predict[i][1], y2_var_alt_predict[i][1])))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [],
   "source": [
    "y3_var_ref_predict = acceptor_Vmodel_3.predict_proba(ref_seq_matrix)\n",
    "y3_var_ref_predict_classes = acceptor_Vmodel_3.predict_classes(ref_seq_matrix)\n",
    "\n",
    "y3_var_alt_predict = acceptor_Vmodel_3.predict_proba(alt_seq_matrix)\n",
    "y3_var_alt_predict_classes = acceptor_Vmodel_3.predict_classes(alt_seq_matrix)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Sequence[113] is 1 and Pathogenic Score: log10(0.9187245965003967/0.9018204212188721) = 0.008065263740718365\n",
      "Sequence[171] is 1 and Pathogenic Score: log10(0.8799456357955933/0.964343249797821) = -0.0397757962346077\n",
      "Sequence[187] is 1 and Pathogenic Score: log10(0.6093025803565979/0.6376147866249084) = -0.019725365564227104\n",
      "Sequence[217] is 1 and Pathogenic Score: log10(0.4773847162723541/0.5292174816131592) = -0.04476567730307579\n",
      "Sequence[247] is 1 and Pathogenic Score: log10(0.9873933792114258/0.9875260591506958) = -5.8350891777081415e-05\n",
      "Sequence[252] is 1 and Pathogenic Score: log10(0.9371836185455322/0.8536840081214905) = 0.040527526289224625\n",
      "Sequence[254] is 1 and Pathogenic Score: log10(0.9371836185455322/0.14430208504199982) = 0.8125520944595337\n",
      "Sequence[501] is 1 and Pathogenic Score: log10(0.914861261844635/0.88211989402771) = 0.0158276055008173\n",
      "Sequence[525] is 1 and Pathogenic Score: log10(0.8981754183769226/0.9082892537117004) = -0.004863012582063675\n",
      "Sequence[539] is 1 and Pathogenic Score: log10(0.7605618834495544/0.04902862012386322) = 1.1906849145889282\n",
      "Sequence[557] is 1 and Pathogenic Score: log10(0.9933130145072937/0.9813575744628906) = 0.0052588642574846745\n",
      "Sequence[627] is 1 and Pathogenic Score: log10(0.9795036315917969/0.9832806587219238) = -0.001671433448791504\n",
      "Sequence[638] is 1 and Pathogenic Score: log10(0.8412022590637207/0.6034411191940308) = 0.1442655324935913\n",
      "Sequence[649] is 1 and Pathogenic Score: log10(0.9474343061447144/0.9436184167861938) = 0.001752717886120081\n",
      "Sequence[653] is 1 and Pathogenic Score: log10(0.9046483635902405/0.9193372130393982) = -0.006995050702244043\n",
      "Sequence[655] is 1 and Pathogenic Score: log10(0.818471372127533/0.549940824508667) = 0.17268754541873932\n",
      "Sequence[656] is 1 and Pathogenic Score: log10(0.7993623614311218/0.6751622557640076) = 0.07333552837371826\n",
      "Sequence[664] is 1 and Pathogenic Score: log10(0.7007760405540466/0.6862778067588806) = 0.009079297073185444\n",
      "Sequence[711] is 1 and Pathogenic Score: log10(0.9609146118164062/0.9638332724571228) = -0.0013171059545129538\n",
      "Sequence[713] is 1 and Pathogenic Score: log10(0.9860848188400269/0.9859393835067749) = 6.403716542990878e-05\n",
      "Sequence[739] is 1 and Pathogenic Score: log10(0.9821155071258545/0.9823024868965149) = -8.268765668617561e-05\n",
      "Sequence[742] is 1 and Pathogenic Score: log10(0.8938459157943726/0.12023575603961945) = 0.8712289929389954\n",
      "Sequence[743] is 1 and Pathogenic Score: log10(0.994113028049469/0.9813142418861389) = 0.005627644248306751\n",
      "Sequence[761] is 1 and Pathogenic Score: log10(0.7985379695892334/0.06044571474194527) = 1.1209300756454468\n",
      "Sequence[762] is 1 and Pathogenic Score: log10(0.9740153551101685/0.9647331237792969) = 0.004158590920269489\n",
      "Sequence[763] is 1 and Pathogenic Score: log10(0.19348041713237762/0.0027042466681450605) = 1.8545907735824585\n",
      "Sequence[764] is 1 and Pathogenic Score: log10(0.7478589415550232/0.03243808448314667) = 1.3627644777297974\n",
      "Sequence[765] is 1 and Pathogenic Score: log10(0.8096364736557007/0.9009532332420349) = -0.04641219228506088\n",
      "Sequence[766] is 1 and Pathogenic Score: log10(0.8096364736557007/0.7939225435256958) = 0.008511939086019993\n",
      "Sequence[767] is 1 and Pathogenic Score: log10(0.8096364736557007/0.8219805955886841) = -0.006571489851921797\n",
      "Sequence[842] is 1 and Pathogenic Score: log10(0.9655724763870239/0.8575212359428406) = 0.05153997242450714\n",
      "Sequence[843] is 1 and Pathogenic Score: log10(0.9399279356002808/0.1502791792154312) = 0.7961957454681396\n",
      "Sequence[861] is 1 and Pathogenic Score: log10(0.8920922875404358/0.8990224599838257) = -0.003360750386491418\n",
      "Sequence[876] is 1 and Pathogenic Score: log10(0.9361628293991089/0.19226059317588806) = 0.6874611377716064\n",
      "Sequence[917] is 1 and Pathogenic Score: log10(0.7710387706756592/0.036668289452791214) = 1.3227856159210205\n",
      "Sequence[918] is 1 and Pathogenic Score: log10(0.7710387706756592/0.7010611295700073) = 0.041320350021123886\n",
      "Sequence[938] is 1 and Pathogenic Score: log10(0.9631384015083313/0.9033436179161072) = 0.027835723012685776\n",
      "Sequence[939] is 1 and Pathogenic Score: log10(0.9631384015083313/0.8486453294754028) = 0.05496246740221977\n",
      "Sequence[976] is 1 and Pathogenic Score: log10(0.9387456774711609/0.14764897525310516) = 0.8033174872398376\n",
      "Sequence[1098] is 1 and Pathogenic Score: log10(0.5108564496040344/0.49232974648475647) = 0.0160428024828434\n",
      "Sequence[1144] is 1 and Pathogenic Score: log10(0.8595289587974548/0.43257343769073486) = 0.29820066690444946\n",
      "Sequence[1145] is 1 and Pathogenic Score: log10(0.9150915145874023/0.5731480717658997) = 0.20319770276546478\n",
      "Sequence[1152] is 1 and Pathogenic Score: log10(0.9129364490509033/0.8305903077125549) = 0.041053690016269684\n",
      "Sequence[1273] is 1 and Pathogenic Score: log10(0.9676446318626404/0.9155431389808655) = 0.024037091061472893\n",
      "Sequence[1338] is 1 and Pathogenic Score: log10(0.5653582811355591/0.4905704855918884) = 0.06162234768271446\n",
      "Sequence[1339] is 1 and Pathogenic Score: log10(0.5653582811355591/0.02067568711936474) = 1.4368637800216675\n",
      "Sequence[1340] is 1 and Pathogenic Score: log10(0.876543402671814/0.8851642608642578) = -0.004250447265803814\n",
      "Sequence[1343] is 1 and Pathogenic Score: log10(0.9750359654426575/0.3062659502029419) = 0.5029218792915344\n",
      "Sequence[1359] is 1 and Pathogenic Score: log10(0.9184349179267883/0.753186047077179) = 0.08614612370729446\n",
      "Sequence[1366] is 1 and Pathogenic Score: log10(0.6368340253829956/0.37810462713241577) = 0.2264142632484436\n",
      "Sequence[1379] is 1 and Pathogenic Score: log10(0.6523063778877258/0.6291700005531311) = 0.015683613717556\n",
      "Sequence[1394] is 1 and Pathogenic Score: log10(0.925327479839325/0.7806843519210815) = 0.07381998002529144\n",
      "Sequence[1395] is 1 and Pathogenic Score: log10(0.925327479839325/0.7822255492210388) = 0.07296346127986908\n",
      "Sequence[1396] is 1 and Pathogenic Score: log10(0.925327479839325/0.880042314529419) = 0.021791880950331688\n",
      "Sequence[1405] is 1 and Pathogenic Score: log10(0.22462594509124756/0.10710545629262924) = 0.32164832949638367\n",
      "Sequence[1446] is 1 and Pathogenic Score: log10(0.7389642000198364/0.7228049039840698) = 0.009602316655218601\n",
      "Sequence[1458] is 1 and Pathogenic Score: log10(0.8422433137893677/0.8528574109077454) = -0.005438853055238724\n",
      "Sequence[1459] is 1 and Pathogenic Score: log10(0.8422433137893677/0.6728367805480957) = 0.09752785414457321\n",
      "Sequence[1470] is 1 and Pathogenic Score: log10(0.9472296237945557/0.9442427158355713) = 0.001371651771478355\n",
      "Sequence[1471] is 1 and Pathogenic Score: log10(0.9472296237945557/0.9300157427787781) = 0.007964985445141792\n",
      "Sequence[1498] is 1 and Pathogenic Score: log10(0.9723379015922546/0.944574773311615) = 0.012580891139805317\n",
      "Sequence[1565] is 1 and Pathogenic Score: log10(0.9556254148483276/0.9282151460647583) = 0.012639027088880539\n",
      "Sequence[1569] is 1 and Pathogenic Score: log10(0.8567662835121155/0.8293688297271729) = 0.014114651829004288\n",
      "Sequence[1623] is 1 and Pathogenic Score: log10(0.8969695568084717/0.4412890076637268) = 0.3080545961856842\n",
      "Sequence[1677] is 1 and Pathogenic Score: log10(0.8989062905311584/0.838200569152832) = 0.030366450548171997\n",
      "Sequence[1710] is 1 and Pathogenic Score: log10(0.2136928141117096/0.07241402566432953) = 0.469967246055603\n",
      "Sequence[1725] is 1 and Pathogenic Score: log10(0.9144005179405212/0.9123779535293579) = 0.0009616853785701096\n",
      "Sequence[1743] is 1 and Pathogenic Score: log10(0.15385204553604126/0.1828470081090927) = -0.0749845877289772\n",
      "Sequence[1793] is 1 and Pathogenic Score: log10(0.9753084182739258/0.3086619973182678) = 0.49965882301330566\n",
      "Sequence[1906] is 1 and Pathogenic Score: log10(0.9718673825263977/0.28082284331321716) = 0.5391745567321777\n",
      "Sequence[1994] is 1 and Pathogenic Score: log10(0.9935805797576904/0.9908077120780945) = 0.0012137005105614662\n",
      "Sequence[1998] is 1 and Pathogenic Score: log10(0.9603818655014038/0.9571342468261719) = 0.0014710902469232678\n",
      "Sequence[1999] is 1 and Pathogenic Score: log10(0.8338401913642883/0.7154229879379272) = 0.06651993840932846\n",
      "Sequence[2001] is 1 and Pathogenic Score: log10(0.9790626764297485/0.9767645001411438) = 0.0010206225560978055\n",
      "Sequence[2002] is 1 and Pathogenic Score: log10(0.9934595823287964/0.7114312648773193) = 0.14501725137233734\n",
      "Sequence[2046] is 1 and Pathogenic Score: log10(0.9941564798355103/0.6578857898712158) = 0.17930425703525543\n",
      "Sequence[2061] is 1 and Pathogenic Score: log10(0.9703350067138672/0.9597921371459961) = 0.004744514357298613\n",
      "Sequence[2091] is 1 and Pathogenic Score: log10(0.9373602867126465/0.728050708770752) = 0.10974491387605667\n",
      "Sequence[2118] is 1 and Pathogenic Score: log10(0.9501903057098389/0.8898612260818481) = 0.028488334268331528\n",
      "Sequence[2119] is 1 and Pathogenic Score: log10(0.8934016227722168/0.9002570509910583) = -0.003319795709103346\n",
      "Sequence[2120] is 1 and Pathogenic Score: log10(0.5707124471664429/0.5999851822853088) = -0.021723173558712006\n",
      "Sequence[2147] is 1 and Pathogenic Score: log10(0.07276865094900131/0.07851163297891617) = -0.03298969939351082\n",
      "Sequence[2151] is 1 and Pathogenic Score: log10(0.8914319276809692/0.1175965741276741) = 0.8796935081481934\n",
      "Sequence[2154] is 1 and Pathogenic Score: log10(0.07975365966558456/0.05216459184885025) = 0.1843748241662979\n",
      "Sequence[2155] is 1 and Pathogenic Score: log10(0.07975365966558456/0.07938017696142197) = 0.002038542879745364\n",
      "Sequence[2156] is 1 and Pathogenic Score: log10(0.07975365966558456/0.07448069751262665) = 0.029706889763474464\n",
      "Sequence[2174] is 1 and Pathogenic Score: log10(0.8033877015113831/0.787293553352356) = 0.00878848135471344\n",
      "Sequence[2287] is 1 and Pathogenic Score: log10(0.8781227469444275/0.8695425987243652) = 0.004264365416020155\n",
      "Sequence[2328] is 1 and Pathogenic Score: log10(0.20873874425888062/0.21051214635372162) = -0.003674090839922428\n",
      "Sequence[2414] is 1 and Pathogenic Score: log10(0.9454532861709595/0.8318749666213989) = 0.055582012981176376\n",
      "Sequence[2471] is 1 and Pathogenic Score: log10(0.9207132458686829/0.7682478427886963) = 0.07862306386232376\n",
      "Sequence[2538] is 1 and Pathogenic Score: log10(0.8792119026184082/0.7400285005569458) = 0.0748450979590416\n",
      "Sequence[2543] is 1 and Pathogenic Score: log10(0.8884921669960022/0.7724967002868652) = 0.06075698137283325\n",
      "Sequence[2611] is 1 and Pathogenic Score: log10(0.8718850016593933/0.8604236841201782) = 0.005746856797486544\n",
      "Sequence[2656] is 1 and Pathogenic Score: log10(0.15224285423755646/0.16545303165912628) = -0.03613780438899994\n",
      "Sequence[2755] is 1 and Pathogenic Score: log10(0.6442775726318359/0.020061375573277473) = 1.5067123174667358\n",
      "Sequence[2770] is 1 and Pathogenic Score: log10(0.6986875534057617/0.4242521822452545) = 0.21665892004966736\n",
      "Sequence[2938] is 1 and Pathogenic Score: log10(0.8893060684204102/0.0832490399479866) = 1.0286719799041748\n",
      "Sequence[2942] is 1 and Pathogenic Score: log10(0.9481176137924194/0.17119614779949188) = 0.7433682084083557\n",
      "Sequence[2976] is 1 and Pathogenic Score: log10(0.9310683012008667/0.8483182787895203) = 0.040422722697257996\n",
      "Sequence[2988] is 1 and Pathogenic Score: log10(0.7185330390930176/0.7321226000785828) = -0.008137060329318047\n",
      "Sequence[3003] is 1 and Pathogenic Score: log10(0.594355046749115/0.016291698440909386) = 1.5620795488357544\n",
      "Sequence[3005] is 1 and Pathogenic Score: log10(0.8712289333343506/0.7076050639152527) = 0.09034133702516556\n",
      "Sequence[3046] is 1 and Pathogenic Score: log10(0.7354176044464111/0.46363914012908936) = 0.2003539353609085\n",
      "Sequence[3161] is 1 and Pathogenic Score: log10(0.9912448525428772/0.6475937366485596) = 0.18487830460071564\n",
      "Sequence[3314] is 1 and Pathogenic Score: log10(0.7163088321685791/0.44767439365386963) = 0.20413804054260254\n",
      "Sequence[3331] is 1 and Pathogenic Score: log10(0.9619066715240479/0.29070502519607544) = 0.519680380821228\n",
      "Sequence[3340] is 1 and Pathogenic Score: log10(0.9587653279304504/0.2081184834241867) = 0.6634016633033752\n",
      "Sequence[3386] is 1 and Pathogenic Score: log10(0.6663207411766052/0.6439788341522217) = 0.014811762608587742\n",
      "Sequence[3396] is 1 and Pathogenic Score: log10(0.9204118847846985/0.9160416126251221) = 0.002067037858068943\n",
      "Sequence[3398] is 1 and Pathogenic Score: log10(0.8316562175750732/0.9226676225662231) = -0.04510144516825676\n",
      "Sequence[3516] is 1 and Pathogenic Score: log10(0.9769133925437927/0.9464355111122131) = 0.013765049166977406\n",
      "Sequence[3543] is 1 and Pathogenic Score: log10(0.8705775737762451/0.7711566686630249) = 0.052664849907159805\n",
      "Sequence[3545] is 1 and Pathogenic Score: log10(0.8705775737762451/0.07065991312265396) = 1.0906343460083008\n",
      "Sequence[3588] is 1 and Pathogenic Score: log10(0.9144916534423828/0.9231235980987549) = -0.00408009672537446\n",
      "Sequence[3593] is 1 and Pathogenic Score: log10(0.8197851181030273/0.6401513814926147) = 0.10741735994815826\n",
      "Sequence[3608] is 1 and Pathogenic Score: log10(0.9373272061347961/0.9419845342636108) = -0.002152540720999241\n",
      "Sequence[3609] is 1 and Pathogenic Score: log10(0.9810428619384766/0.980947732925415) = 4.2088544432772323e-05\n",
      "Sequence[3618] is 1 and Pathogenic Score: log10(0.34355759620666504/0.32160714268684387) = 0.028673846274614334\n",
      "Sequence[3787] is 1 and Pathogenic Score: log10(0.18225479125976562/0.2131139189004898) = -0.0679328590631485\n",
      "Sequence[3803] is 1 and Pathogenic Score: log10(0.6817532777786255/0.7028186917304993) = -0.013216057792305946\n",
      "Sequence[3805] is 1 and Pathogenic Score: log10(0.9641406536102295/0.9605593681335449) = 0.001616207999177277\n",
      "Sequence[3807] is 1 and Pathogenic Score: log10(0.6617907285690308/0.021638892590999603) = 1.4854856729507446\n",
      "Sequence[3808] is 1 and Pathogenic Score: log10(0.8575248122215271/0.8171701431274414) = 0.02093419060111046\n",
      "Sequence[3865] is 1 and Pathogenic Score: log10(0.24098582565784454/0.07922852039337158) = 0.4831099510192871\n",
      "Sequence[3902] is 1 and Pathogenic Score: log10(0.6378479599952698/0.5139778256416321) = 0.09377279877662659\n",
      "Sequence[3925] is 1 and Pathogenic Score: log10(0.5636274814605713/0.5778889060020447) = -0.010852187871932983\n",
      "Sequence[3965] is 1 and Pathogenic Score: log10(0.8047858476638794/0.7923058867454529) = 0.006787464022636414\n",
      "Sequence[3966] is 1 and Pathogenic Score: log10(0.8047858476638794/0.6347866654396057) = 0.1030525341629982\n",
      "Sequence[4027] is 1 and Pathogenic Score: log10(0.7047107219696045/0.5026761293411255) = 0.14672262966632843\n",
      "Sequence[4190] is 1 and Pathogenic Score: log10(0.9201527833938599/0.8681954145431519) = 0.025242440402507782\n",
      "Sequence[4208] is 1 and Pathogenic Score: log10(0.8249067068099976/0.8127192258834839) = 0.006464302074164152\n",
      "Sequence[4347] is 1 and Pathogenic Score: log10(0.9679120182991028/0.9545588493347168) = 0.006033180747181177\n",
      "Sequence[4349] is 1 and Pathogenic Score: log10(0.8103083968162537/0.7571278214454651) = 0.02948113903403282\n",
      "Sequence[4352] is 1 and Pathogenic Score: log10(0.5987600684165955/0.01658765599131584) = 1.5574678182601929\n",
      "Sequence[4366] is 1 and Pathogenic Score: log10(0.1548583209514618/0.1652882695198059) = -0.02830749750137329\n",
      "Sequence[4373] is 1 and Pathogenic Score: log10(0.34796640276908875/0.3612888753414154) = -0.01631726697087288\n",
      "Sequence[4415] is 1 and Pathogenic Score: log10(0.9396410584449768/0.8859037160873413) = 0.025575460866093636\n",
      "Sequence[4428] is 1 and Pathogenic Score: log10(0.7294721007347107/0.7284644842147827) = 0.0006002947338856757\n",
      "Sequence[4436] is 1 and Pathogenic Score: log10(0.5827183723449707/0.6025537252426147) = -0.014537064358592033\n",
      "Sequence[4448] is 1 and Pathogenic Score: log10(0.8622512817382812/0.09222830086946487) = 0.9707696437835693\n",
      "Sequence[4477] is 1 and Pathogenic Score: log10(0.8868579864501953/0.853006899356842) = 0.01690153405070305\n",
      "Sequence[4480] is 1 and Pathogenic Score: log10(0.7136250734329224/0.027395032346248627) = 1.415798306465149\n",
      "Sequence[4527] is 1 and Pathogenic Score: log10(0.7239044904708862/0.028783174231648445) = 1.4005426168441772\n",
      "Sequence[4581] is 1 and Pathogenic Score: log10(0.864541232585907/0.09386669099330902) = 0.9642742276191711\n",
      "Sequence[4614] is 1 and Pathogenic Score: log10(0.993759274482727/0.983875572681427) = 0.004341001622378826\n",
      "Sequence[4616] is 1 and Pathogenic Score: log10(0.993759274482727/0.9520131945610046) = 0.01863822154700756\n",
      "Sequence[4631] is 1 and Pathogenic Score: log10(0.9670903086662292/0.24933794140815735) = 0.5886786580085754\n",
      "Sequence[4645] is 1 and Pathogenic Score: log10(0.9595802426338196/0.9312688112258911) = 0.013006217777729034\n",
      "Sequence[4725] is 1 and Pathogenic Score: log10(0.9888820052146912/0.5013335943222046) = 0.29501765966415405\n",
      "Sequence[4886] is 1 and Pathogenic Score: log10(0.22383621335029602/0.003249106230214238) = 1.8381664752960205\n",
      "Sequence[4930] is 1 and Pathogenic Score: log10(0.961829423904419/0.2216806411743164) = 0.6373702883720398\n",
      "Sequence[4935] is 1 and Pathogenic Score: log10(0.6661969423294067/0.6638123989105225) = 0.0015573001001030207\n",
      "Sequence[4942] is 1 and Pathogenic Score: log10(0.9943496584892273/0.9563794732093811) = 0.016908902674913406\n",
      "Sequence[4943] is 1 and Pathogenic Score: log10(0.9943496584892273/0.9919062852859497) = 0.0010684997541829944\n",
      "Sequence[4962] is 1 and Pathogenic Score: log10(0.9894431829452515/0.9755744934082031) = 0.006130434572696686\n",
      "Sequence[5047] is 1 and Pathogenic Score: log10(0.9507951736450195/0.8794393539428711) = 0.033881090581417084\n",
      "Sequence[5308] is 1 and Pathogenic Score: log10(0.5910376310348511/0.5744510293006897) = 0.012362108565866947\n",
      "Sequence[5461] is 1 and Pathogenic Score: log10(0.9294551610946655/0.12962020933628082) = 0.8555557131767273\n",
      "Sequence[5463] is 1 and Pathogenic Score: log10(0.978158175945282/0.9780489206314087) = 4.850759432883933e-05\n",
      "Sequence[5548] is 1 and Pathogenic Score: log10(0.8928442001342773/0.08607389032840729) = 1.0159043073654175\n",
      "Sequence[5555] is 1 and Pathogenic Score: log10(0.9664695858955383/0.24573789536952972) = 0.5947160720825195\n",
      "Sequence[5556] is 1 and Pathogenic Score: log10(0.5819891691207886/0.3021581470966339) = 0.28468057513237\n",
      "Sequence[5558] is 1 and Pathogenic Score: log10(0.934109091758728/0.8425623178482056) = 0.04479556903243065\n",
      "Sequence[5563] is 1 and Pathogenic Score: log10(0.912760317325592/0.5658826231956482) = 0.20763039588928223\n",
      "Sequence[5575] is 1 and Pathogenic Score: log10(0.9975674152374268/0.9924607872962952) = 0.002228902652859688\n",
      "Sequence[5577] is 1 and Pathogenic Score: log10(0.8219428062438965/0.04958992078900337) = 1.219448208808899\n",
      "Sequence[5586] is 1 and Pathogenic Score: log10(0.9940218329429626/0.6527087092399597) = 0.1826765090227127\n",
      "Sequence[5591] is 1 and Pathogenic Score: log10(0.931512713432312/0.13325153291225433) = 0.8445165753364563\n",
      "Sequence[5594] is 1 and Pathogenic Score: log10(0.9872397780418396/0.9847552180290222) = 0.0010943730594590306\n",
      "Sequence[5608] is 1 and Pathogenic Score: log10(0.9793086647987366/0.9804558753967285) = -0.0005084649892523885\n",
      "Sequence[5641] is 1 and Pathogenic Score: log10(0.7525447010993958/0.4518093466758728) = 0.22157709300518036\n",
      "Sequence[5644] is 1 and Pathogenic Score: log10(0.9182149767875671/0.7649450302124023) = 0.07931412756443024\n",
      "Sequence[5650] is 1 and Pathogenic Score: log10(0.8004354238510132/0.7909733653068542) = 0.005164433270692825\n",
      "Sequence[5653] is 1 and Pathogenic Score: log10(0.9120154976844788/0.7632371187210083) = 0.07734275609254837\n",
      "Sequence[5675] is 1 and Pathogenic Score: log10(0.5999929308891296/0.583513617515564) = 0.0120951347053051\n",
      "Sequence[5690] is 1 and Pathogenic Score: log10(0.7842934131622314/0.24804526567459106) = 0.49994760751724243\n",
      "Sequence[5692] is 1 and Pathogenic Score: log10(0.9958333969116211/0.9961608648300171) = -0.00014278458547778428\n",
      "Sequence[5694] is 1 and Pathogenic Score: log10(0.8971120119094849/0.7133902907371521) = 0.09951945394277573\n",
      "Sequence[5695] is 1 and Pathogenic Score: log10(0.8971120119094849/0.12397637218236923) = 0.8595077395439148\n",
      "Sequence[5697] is 1 and Pathogenic Score: log10(0.9400755167007446/0.6615328192710876) = 0.15261134505271912\n",
      "Sequence[5699] is 1 and Pathogenic Score: log10(0.5557124018669128/0.5583535432815552) = -0.002059184480458498\n",
      "Sequence[5700] is 1 and Pathogenic Score: log10(0.9929788708686829/0.981975257396698) = 0.004839446395635605\n",
      "Sequence[5701] is 1 and Pathogenic Score: log10(0.9929788708686829/0.9745732545852661) = 0.008125531487166882\n",
      "Sequence[5722] is 1 and Pathogenic Score: log10(0.6857160329818726/0.6834046840667725) = 0.0014663434121757746\n",
      "Sequence[5762] is 1 and Pathogenic Score: log10(0.2695397436618805/0.2939421832561493) = -0.037639107555150986\n",
      "Sequence[5764] is 1 and Pathogenic Score: log10(0.9228708148002625/0.9296236634254456) = -0.003166262758895755\n",
      "Sequence[5778] is 1 and Pathogenic Score: log10(0.9459310173988342/0.165099635720253) = 0.7581133246421814\n",
      "Sequence[5780] is 1 and Pathogenic Score: log10(0.6644094586372375/0.6420083045959473) = 0.014895164407789707\n",
      "Sequence[5815] is 1 and Pathogenic Score: log10(0.9809157252311707/0.45481857657432556) = 0.3337935209274292\n",
      "Sequence[5820] is 1 and Pathogenic Score: log10(0.9906967878341675/0.9935029149055481) = -0.0012283939868211746\n",
      "Sequence[5823] is 1 and Pathogenic Score: log10(0.8023297786712646/0.6703343987464905) = 0.07806141674518585\n",
      "Sequence[5915] is 1 and Pathogenic Score: log10(0.7661513090133667/0.4724026918411255) = 0.21000219881534576\n",
      "Sequence[5925] is 1 and Pathogenic Score: log10(0.9770609736442566/0.841438353061676) = 0.06489937752485275\n",
      "Sequence[5927] is 1 and Pathogenic Score: log10(0.9800546169281006/0.9787606596946716) = 0.0005737715982832015\n",
      "Sequence[5935] is 1 and Pathogenic Score: log10(0.8820905685424805/0.7838823199272156) = 0.05126231163740158\n",
      "Sequence[5988] is 1 and Pathogenic Score: log10(0.9703139066696167/0.9758829474449158) = -0.0024854729417711496\n",
      "Sequence[5989] is 1 and Pathogenic Score: log10(0.7188812494277954/0.028092630207538605) = 1.4080647230148315\n",
      "Sequence[6003] is 1 and Pathogenic Score: log10(0.4483626186847687/0.23748522996902466) = 0.2759927809238434\n",
      "Sequence[6020] is 1 and Pathogenic Score: log10(0.9975284934043884/0.997225821018219) = 0.00013179135567042977\n",
      "Sequence[6064] is 1 and Pathogenic Score: log10(0.9997103810310364/0.9996912479400635) = 8.335201528097969e-06\n",
      "Sequence[6065] is 1 and Pathogenic Score: log10(0.999804675579071/0.9998373985290527) = -1.4211628695193212e-05\n",
      "Sequence[6081] is 1 and Pathogenic Score: log10(0.9950077533721924/0.9965181350708008) = -0.0006587536190636456\n",
      "Sequence[6094] is 1 and Pathogenic Score: log10(0.14052921533584595/0.12900139391422272) = 0.03717223182320595\n",
      "Sequence[6096] is 1 and Pathogenic Score: log10(0.9701098799705505/0.26839274168014526) = 0.5580501556396484\n",
      "Sequence[6107] is 1 and Pathogenic Score: log10(0.8053026795387268/0.7865010499954224) = 0.010259832255542278\n",
      "Sequence[6114] is 1 and Pathogenic Score: log10(0.10123651474714279/0.09258470684289932) = 0.03879791498184204\n",
      "Sequence[6160] is 1 and Pathogenic Score: log10(0.9721839427947998/0.9674614071846008) = 0.0021147998049855232\n",
      "Sequence[6190] is 1 and Pathogenic Score: log10(0.9884859323501587/0.9613670110702515) = 0.012081287801265717\n",
      "Sequence[6446] is 1 and Pathogenic Score: log10(0.7333601713180542/0.030150674283504486) = 1.386020302772522\n",
      "Sequence[6466] is 1 and Pathogenic Score: log10(0.2623284161090851/0.11805523931980133) = 0.3467600643634796\n",
      "Sequence[6644] is 1 and Pathogenic Score: log10(0.41134193539619446/0.007836534641683102) = 1.720078945159912\n",
      "Sequence[6687] is 1 and Pathogenic Score: log10(0.5898644328117371/0.31585389375686646) = 0.27126598358154297\n",
      "Sequence[6688] is 1 and Pathogenic Score: log10(0.9690330624580383/0.2612862288951874) = 0.5692220330238342\n",
      "Sequence[6751] is 1 and Pathogenic Score: log10(0.9049375057220459/0.8689266443252563) = 0.01763545162975788\n",
      "Sequence[6752] is 1 and Pathogenic Score: log10(0.9049375057220459/0.7339933514595032) = 0.09092647582292557\n",
      "Sequence[6753] is 1 and Pathogenic Score: log10(0.9049375057220459/0.7882585525512695) = 0.05994991585612297\n",
      "Sequence[6764] is 1 and Pathogenic Score: log10(0.9912962913513184/0.9922406673431396) = -0.0004135439812671393\n",
      "Sequence[6770] is 1 and Pathogenic Score: log10(0.7903121113777161/0.7763694524765015) = 0.007730184122920036\n",
      "Sequence[6853] is 1 and Pathogenic Score: log10(0.29500314593315125/0.12913954257965088) = 0.35876739025115967\n",
      "Sequence[6911] is 1 and Pathogenic Score: log10(0.918407142162323/0.9391130805015564) = -0.00968264415860176\n",
      "Sequence[6919] is 1 and Pathogenic Score: log10(0.9803590774536133/0.9766225814819336) = 0.0016583980759605765\n",
      "Sequence[6925] is 1 and Pathogenic Score: log10(0.9859366416931152/0.9561456441879272) = 0.013324951753020287\n",
      "Sequence[7015] is 1 and Pathogenic Score: log10(0.9783374667167664/0.3379593789577484) = 0.4616241753101349\n",
      "Sequence[7080] is 1 and Pathogenic Score: log10(0.9725463390350342/0.7626911401748657) = 0.10556162148714066\n",
      "Sequence[7148] is 1 and Pathogenic Score: log10(0.9048494100570679/0.9116928577423096) = -0.003272246103733778\n",
      "Sequence[7240] is 1 and Pathogenic Score: log10(0.7174818515777588/0.48873427510261536) = 0.1667381376028061\n",
      "Sequence[7248] is 1 and Pathogenic Score: log10(0.7848169803619385/0.539334774017334) = 0.16290996968746185\n",
      "Sequence[7303] is 1 and Pathogenic Score: log10(0.7795856595039368/0.7926299571990967) = -0.007206631358712912\n",
      "Sequence[7325] is 1 and Pathogenic Score: log10(0.26028841733932495/0.27977970242500305) = -0.03136137127876282\n",
      "Sequence[7365] is 1 and Pathogenic Score: log10(0.16189901530742645/0.15105627477169037) = 0.03010544180870056\n",
      "Sequence[7452] is 1 and Pathogenic Score: log10(0.5681477785110474/0.014652649872004986) = 1.5885452032089233\n",
      "Sequence[7456] is 1 and Pathogenic Score: log10(0.6296021938323975/0.4048134386539459) = 0.19181130826473236\n",
      "Sequence[7462] is 1 and Pathogenic Score: log10(0.6573973894119263/0.19293895363807678) = 0.5324080586433411\n",
      "Sequence[7518] is 1 and Pathogenic Score: log10(0.9361577033996582/0.8466147184371948) = 0.043663207441568375\n",
      "Sequence[7601] is 1 and Pathogenic Score: log10(0.5196813941001892/0.5710883140563965) = -0.040966104716062546\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Sequence[7905] is 1 and Pathogenic Score: log10(0.9114989042282104/0.9090141654014587) = 0.0011855110060423613\n",
      "Sequence[7908] is 1 and Pathogenic Score: log10(0.8059986233711243/0.04485384747385979) = 1.2545346021652222\n",
      "Sequence[7928] is 1 and Pathogenic Score: log10(0.7333165407180786/0.37110060453414917) = 0.2957998216152191\n",
      "Sequence[7929] is 1 and Pathogenic Score: log10(0.8143590688705444/0.0664680153131485) = 1.0882031917572021\n",
      "Sequence[8072] is 1 and Pathogenic Score: log10(0.9734550714492798/0.7688956260681152) = 0.10244852304458618\n",
      "Sequence[8240] is 1 and Pathogenic Score: log10(0.9860572814941406/0.4442532956600189) = 0.34627148509025574\n",
      "Sequence[8260] is 1 and Pathogenic Score: log10(0.8802881240844727/0.9262105226516724) = -0.022084858268499374\n",
      "Sequence[8325] is 1 and Pathogenic Score: log10(0.9535447955131531/0.8877264857292175) = 0.0310619305819273\n",
      "Sequence[8333] is 1 and Pathogenic Score: log10(0.9093281626701355/0.753997802734375) = 0.08135055750608444\n",
      "Sequence[8453] is 1 and Pathogenic Score: log10(0.8657782673835754/0.6515325903892517) = 0.12347051501274109\n",
      "Sequence[8455] is 1 and Pathogenic Score: log10(0.9219083189964294/0.8313506245613098) = 0.04490352421998978\n",
      "Sequence[8489] is 1 and Pathogenic Score: log10(0.7471227645874023/0.03231588378548622) = 1.3639758825302124\n",
      "Sequence[8555] is 1 and Pathogenic Score: log10(0.9919241070747375/0.9386599659919739) = 0.02397017367184162\n",
      "Sequence[8556] is 1 and Pathogenic Score: log10(0.9919241070747375/0.9808746576309204) = 0.004864942282438278\n",
      "Sequence[8557] is 1 and Pathogenic Score: log10(0.9919241070747375/0.9839385151863098) = 0.003510459093376994\n",
      "Sequence[8558] is 1 and Pathogenic Score: log10(0.9230455160140991/0.1629585176706314) = 0.7531460523605347\n",
      "Sequence[8565] is 1 and Pathogenic Score: log10(0.007593020796775818/0.006735878065228462) = 0.052020363509655\n",
      "Sequence[8589] is 1 and Pathogenic Score: log10(0.13844527304172516/0.15067099034786224) = -0.03675151988863945\n",
      "Sequence[8592] is 1 and Pathogenic Score: log10(0.8559778928756714/0.8677481412887573) = -0.0059311348013579845\n",
      "Sequence[8618] is 1 and Pathogenic Score: log10(0.3996029198169708/0.4021736681461334) = -0.0027849734760820866\n",
      "Sequence[8623] is 1 and Pathogenic Score: log10(0.9077766537666321/0.10012052208185196) = 0.9574559330940247\n",
      "Sequence[8624] is 1 and Pathogenic Score: log10(0.9077766537666321/0.7771967649459839) = 0.06744801998138428\n",
      "Sequence[8626] is 1 and Pathogenic Score: log10(0.9903163313865662/0.9564186334609985) = 0.015125924721360207\n",
      "Sequence[8627] is 1 and Pathogenic Score: log10(0.9903163313865662/0.98338782787323) = 0.0030490963254123926\n",
      "Sequence[8651] is 1 and Pathogenic Score: log10(0.8142175078392029/0.0471995547413826) = 1.236802577972412\n",
      "Sequence[8652] is 1 and Pathogenic Score: log10(0.8142175078392029/0.3531796932220459) = 0.36274468898773193\n",
      "Sequence[8653] is 1 and Pathogenic Score: log10(0.7852943539619446/0.03970050439238548) = 1.2962363958358765\n",
      "Sequence[8674] is 1 and Pathogenic Score: log10(0.9810950756072998/0.9824861288070679) = -0.0006153309950605035\n",
      "Sequence[8675] is 1 and Pathogenic Score: log10(0.9810950756072998/0.980895459651947) = 8.836570486892015e-05\n",
      "Sequence[8678] is 1 and Pathogenic Score: log10(0.28628772497177124/0.3069182336330414) = -0.03021995723247528\n",
      "Sequence[8680] is 1 and Pathogenic Score: log10(0.28628772497177124/0.14465487003326416) = 0.29646965861320496\n",
      "Sequence[8697] is 1 and Pathogenic Score: log10(0.7104842066764832/0.5796747803688049) = 0.08837004005908966\n",
      "Sequence[8699] is 1 and Pathogenic Score: log10(0.8858868479728699/0.08067041635513306) = 1.0406639575958252\n",
      "Sequence[8724] is 1 and Pathogenic Score: log10(0.9366484880447388/0.9422705769538879) = -0.0025989983696490526\n",
      "Sequence[8962] is 1 and Pathogenic Score: log10(0.32526057958602905/0.2814609706401825) = 0.06281325221061707\n",
      "Sequence[8968] is 1 and Pathogenic Score: log10(0.7392975687980652/0.2046293318271637) = 0.5578513741493225\n",
      "Sequence[9034] is 1 and Pathogenic Score: log10(0.07087332755327225/0.022781502455472946) = 0.49290046095848083\n",
      "Sequence[9048] is 1 and Pathogenic Score: log10(0.7877798080444336/0.7737169861793518) = 0.007822737097740173\n",
      "Sequence[9049] is 1 and Pathogenic Score: log10(0.658089816570282/0.5727214217185974) = 0.060341764241456985\n",
      "Sequence[9050] is 1 and Pathogenic Score: log10(0.658089816570282/0.642578125) = 0.010359227657318115\n",
      "Sequence[9051] is 1 and Pathogenic Score: log10(0.9444683194160461/0.16124381124973297) = 0.7677043676376343\n",
      "Sequence[9052] is 1 and Pathogenic Score: log10(0.9444683194160461/0.9486240744590759) = -0.001906746532768011\n",
      "Sequence[9054] is 1 and Pathogenic Score: log10(0.9891461133956909/0.9721611142158508) = 0.007522224448621273\n",
      "Sequence[9235] is 1 and Pathogenic Score: log10(0.9696884751319885/0.9233224391937256) = 0.021278860047459602\n",
      "Sequence[9354] is 1 and Pathogenic Score: log10(0.9847543239593506/0.8894713521003723) = 0.04419592767953873\n",
      "Sequence[9382] is 1 and Pathogenic Score: log10(0.9271243214607239/0.1257205605506897) = 0.8677316904067993\n",
      "Sequence[9519] is 1 and Pathogenic Score: log10(0.8879194259643555/0.6822367906570435) = 0.11443842947483063\n",
      "Sequence[9559] is 1 and Pathogenic Score: log10(0.3176785111427307/0.25633201003074646) = 0.09318497776985168\n",
      "Sequence[9561] is 1 and Pathogenic Score: log10(0.840363621711731/0.8290290832519531) = 0.005897499155253172\n",
      "Sequence[9598] is 1 and Pathogenic Score: log10(0.9905334711074829/0.9287561178207397) = 0.027967488393187523\n",
      "Sequence[9615] is 1 and Pathogenic Score: log10(0.8473832607269287/0.8375495076179504) = 0.005069368053227663\n",
      "Sequence[9632] is 1 and Pathogenic Score: log10(0.6147444844245911/0.38967958092689514) = 0.19798699021339417\n",
      "Sequence[9683] is 1 and Pathogenic Score: log10(0.987509548664093/0.9873768091201782) = 5.839481673319824e-05\n",
      "Sequence[9722] is 1 and Pathogenic Score: log10(0.830505907535553/0.7188026309013367) = 0.06273304671049118\n",
      "Sequence[9784] is 1 and Pathogenic Score: log10(0.8527626395225525/0.8866625428199768) = -0.016930202022194862\n",
      "Sequence[9785] is 1 and Pathogenic Score: log10(0.8527626395225525/0.8599230647087097) = -0.003631435800343752\n",
      "Sequence[9786] is 1 and Pathogenic Score: log10(0.8527626395225525/0.7116613984107971) = 0.07855475693941116\n",
      "Sequence[9787] is 1 and Pathogenic Score: log10(0.8584608435630798/0.43041014671325684) = 0.29983800649642944\n",
      "Sequence[9789] is 1 and Pathogenic Score: log10(0.9348106980323792/0.7547364830970764) = 0.09292832016944885\n",
      "Sequence[9790] is 1 and Pathogenic Score: log10(0.9223606586456299/0.9264283776283264) = -0.0019110884750261903\n",
      "Sequence[9791] is 1 and Pathogenic Score: log10(0.9269056916236877/0.8982812166213989) = 0.013623232953250408\n",
      "Sequence[9804] is 1 and Pathogenic Score: log10(0.9908146262168884/0.9914652705192566) = -0.0002850980672519654\n",
      "Sequence[9843] is 1 and Pathogenic Score: log10(0.9304924607276917/0.9582940340042114) = -0.01278593484312296\n",
      "Sequence[9886] is 1 and Pathogenic Score: log10(0.45500054955482483/0.3819814920425415) = 0.07596960663795471\n",
      "Sequence[9888] is 1 and Pathogenic Score: log10(0.3468005061149597/0.23724247515201569) = 0.16488727927207947\n",
      "Sequence[9893] is 1 and Pathogenic Score: log10(0.9701631665229797/0.26875436305999756) = 0.557489275932312\n",
      "Sequence[9902] is 1 and Pathogenic Score: log10(0.9897274374961853/0.9905104041099548) = -0.00034343547304160893\n",
      "Sequence[9910] is 1 and Pathogenic Score: log10(0.8482881784439087/0.8476307392120361) = 0.00033669767435640097\n",
      "Sequence[9962] is 1 and Pathogenic Score: log10(0.841793954372406/0.834837794303894) = 0.0036037100944668055\n",
      "Sequence[9973] is 1 and Pathogenic Score: log10(0.9954867959022522/0.9648884534835815) = 0.013558404520154\n",
      "Sequence[10090] is 1 and Pathogenic Score: log10(0.09299317747354507/0.092094287276268) = 0.004218377638608217\n",
      "Sequence[10126] is 1 and Pathogenic Score: log10(0.722074568271637/0.040462858974933624) = 1.2515255212783813\n",
      "Sequence[10130] is 1 and Pathogenic Score: log10(0.9273109436035156/0.9120215177536011) = 0.007220281753689051\n",
      "Sequence[10142] is 1 and Pathogenic Score: log10(0.9164746403694153/0.11033859848976135) = 0.919393002986908\n",
      "Sequence[10144] is 1 and Pathogenic Score: log10(0.9164746403694153/0.8050731420516968) = 0.05628509446978569\n",
      "Sequence[10151] is 1 and Pathogenic Score: log10(0.6927648186683655/0.395254909992218) = 0.2437085509300232\n",
      "Sequence[10181] is 1 and Pathogenic Score: log10(0.8587803840637207/0.8618528842926025) = -0.0015510320663452148\n",
      "Sequence[10182] is 1 and Pathogenic Score: log10(0.6723625659942627/0.42331066727638245) = 0.20094430446624756\n",
      "Sequence[10183] is 1 and Pathogenic Score: log10(0.8587803840637207/0.6516969799995422) = 0.11983639746904373\n",
      "Sequence[10186] is 1 and Pathogenic Score: log10(0.978010356426239/0.334539532661438) = 0.46589601039886475\n",
      "Sequence[10197] is 1 and Pathogenic Score: log10(0.8406181335449219/0.056261561810970306) = 1.174386978149414\n",
      "Sequence[10198] is 1 and Pathogenic Score: log10(0.8406181335449219/0.6045551896095276) = 0.1431627869606018\n",
      "Sequence[10199] is 1 and Pathogenic Score: log10(0.8406181335449219/0.6171392202377319) = 0.1342156082391739\n",
      "Sequence[10200] is 1 and Pathogenic Score: log10(0.8406181335449219/0.8665000796318054) = -0.013169839978218079\n",
      "Sequence[10201] is 1 and Pathogenic Score: log10(0.8406181335449219/0.850741982460022) = -0.005199104081839323\n",
      "Sequence[10212] is 1 and Pathogenic Score: log10(0.9591543674468994/0.9559378623962402) = 0.0014588616322726011\n",
      "Sequence[10214] is 1 and Pathogenic Score: log10(0.9929591417312622/0.6145057678222656) = 0.20840542018413544\n",
      "Sequence[10221] is 1 and Pathogenic Score: log10(0.8732385635375977/0.0722406730055809) = 1.0823510885238647\n",
      "Sequence[10235] is 1 and Pathogenic Score: log10(0.9680522084236145/0.9196062684059143) = 0.02229687012732029\n",
      "Sequence[10238] is 1 and Pathogenic Score: log10(0.9851927757263184/0.9531270265579224) = 0.014370420947670937\n",
      "Sequence[10245] is 1 and Pathogenic Score: log10(0.9817788600921631/0.9776703119277954) = 0.0018212401773780584\n",
      "Sequence[10356] is 1 and Pathogenic Score: log10(0.4939214289188385/0.5186414122581482) = -0.02120932936668396\n",
      "Sequence[10431] is 1 and Pathogenic Score: log10(0.6917616128921509/0.024739498272538185) = 1.4465655088424683\n",
      "Sequence[10632] is 1 and Pathogenic Score: log10(0.806634783744812/0.045028701424598694) = 1.2531875371932983\n",
      "Sequence[10687] is 1 and Pathogenic Score: log10(0.9747563600540161/0.9358024597167969) = 0.017711902037262917\n",
      "Sequence[10820] is 1 and Pathogenic Score: log10(0.9776766300201416/0.9682536721229553) = 0.004206072073429823\n",
      "Sequence[10826] is 1 and Pathogenic Score: log10(0.4730554223060608/0.29386159777641296) = 0.2067691832780838\n",
      "Sequence[10836] is 1 and Pathogenic Score: log10(0.6004272699356079/0.3034110367298126) = 0.2964290380477905\n",
      "Sequence[10850] is 1 and Pathogenic Score: log10(0.6868961453437805/0.4674683213233948) = 0.16713888943195343\n",
      "Sequence[10851] is 1 and Pathogenic Score: log10(0.77312833070755/0.7114241123199463) = 0.036122992634773254\n",
      "Sequence[10888] is 1 and Pathogenic Score: log10(0.5564572215080261/0.5319265723228455) = 0.019580090418457985\n",
      "Sequence[10908] is 1 and Pathogenic Score: log10(0.23841170966625214/0.24914243817329407) = -0.01912013627588749\n",
      "Sequence[10912] is 1 and Pathogenic Score: log10(0.8734602928161621/0.7529683709144592) = 0.06446640938520432\n",
      "Sequence[10913] is 1 and Pathogenic Score: log10(0.8734602928161621/0.46236228942871094) = 0.27626073360443115\n",
      "Sequence[11050] is 1 and Pathogenic Score: log10(0.9394663572311401/0.8268438577651978) = 0.05545772984623909\n",
      "Sequence[11070] is 1 and Pathogenic Score: log10(0.7355912327766418/0.2573927640914917) = 0.4560402035713196\n",
      "Sequence[11098] is 1 and Pathogenic Score: log10(0.21081893146038055/0.1568538248538971) = 0.12841448187828064\n",
      "Sequence[11102] is 1 and Pathogenic Score: log10(0.7300171256065369/0.029656702652573586) = 1.3912101984024048\n",
      "Sequence[11110] is 1 and Pathogenic Score: log10(0.6265276670455933/0.603108286857605) = 0.016544949263334274\n",
      "Sequence[11115] is 1 and Pathogenic Score: log10(0.9690154790878296/0.9712623953819275) = -0.0010058501502498984\n",
      "Sequence[11124] is 1 and Pathogenic Score: log10(0.9677569270133972/0.7890046834945679) = 0.08868672698736191\n",
      "Sequence[11148] is 1 and Pathogenic Score: log10(0.9802873730659485/0.35983356833457947) = 0.43525171279907227\n",
      "Sequence[11154] is 1 and Pathogenic Score: log10(0.4520750939846039/0.23021498322486877) = 0.2930769920349121\n",
      "Sequence[11186] is 1 and Pathogenic Score: log10(0.9899835586547852/0.990724503993988) = -0.00032491274760104716\n",
      "Sequence[11212] is 1 and Pathogenic Score: log10(0.9132843613624573/0.9195751547813416) = -0.00298121920786798\n",
      "Sequence[11236] is 1 and Pathogenic Score: log10(0.9629614949226379/0.9889739751815796) = -0.011575952172279358\n",
      "Sequence[11237] is 1 and Pathogenic Score: log10(0.5992336869239807/0.6910697221755981) = -0.061925649642944336\n",
      "Sequence[11245] is 1 and Pathogenic Score: log10(0.7012647986412048/0.7133159041404724) = -0.007399856578558683\n",
      "Sequence[11257] is 1 and Pathogenic Score: log10(0.9602797031402588/0.21461831033229828) = 0.6507309675216675\n",
      "Sequence[11260] is 1 and Pathogenic Score: log10(0.8790481686592102/0.7328777313232422) = 0.07898116111755371\n"
     ]
    }
   ],
   "source": [
    "alt_less_3 = 0\n",
    "alt_3_less_than_0_5 = 0\n",
    "for i in range(len(y3_var_ref_predict)):\n",
    "    if accp['class'][i] == 1:\n",
    "        if y3_var_alt_predict[i][1] < 0.5 and y3_var_ref_predict[i][1] >= 0.5: alt_less_3+=1\n",
    "        if y3_var_alt_predict[i][1] < 0.5: alt_3_less_than_0_5+=1\n",
    "        print(\"Sequence[{0}] is {1} and Pathogenic Score: log10({2}/{3}) = {4}\".format(i, accp['class'][i], y3_var_ref_predict[i][1], y3_var_alt_predict[i][1], calculate.calculate_mutation_score(y3_var_ref_predict[i][1], y3_var_alt_predict[i][1])))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
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       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
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       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>ref.sequence</th>\n",
       "      <th>alt.sequence</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>class</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>10944</td>\n",
       "      <td>10944</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>356</td>\n",
       "      <td>356</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "       ref.sequence  alt.sequence\n",
       "class                            \n",
       "0             10944         10944\n",
       "1               356           356"
      ]
     },
     "execution_count": 13,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "accp.groupby('class').count()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.5449438202247191"
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "alt_less_than_0_5/356"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.5308988764044944"
      ]
     },
     "execution_count": 15,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "alt_2_less_than_0_5/356"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.3707865168539326"
      ]
     },
     "execution_count": 16,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "alt_3_less_than_0_5/356"
   ]
  }
 ],
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