diff --git a/.github/workflows/pip.yml b/.github/workflows/pip.yml
index d1c745d..fa281f5 100644
--- a/.github/workflows/pip.yml
+++ b/.github/workflows/pip.yml
@@ -87,3 +87,8 @@ jobs:
           for file in "${test_files[@]}"; do
             python -m pytest "${file}" --doctest-modules
           done
+
+    - name: Demo interoperability with doctestplus
+      run: |
+        python -m pip install pytest-doctestplus
+        python -m pytest scipy_doctest/tests/ -v -k'alt_checker'
diff --git a/scipy_doctest/tests/test_pytest_configuration.py b/scipy_doctest/tests/test_pytest_configuration.py
index c5e44dd..b3ef952 100644
--- a/scipy_doctest/tests/test_pytest_configuration.py
+++ b/scipy_doctest/tests/test_pytest_configuration.py
@@ -91,3 +91,56 @@ def func():
     result = pytester.inline_run(f, '--doctest-modules')
     assert result.ret == pytest.ExitCode.TESTS_FAILED
 
+
+def test_alt_checker_doctestplus(pytester):
+    """Test an alternative Checker, from pytest-doctestplus."""
+    pytest.importorskip("pytest_doctestplus")
+
+    # create a temporary conftest.py file
+    pytester.makeconftest(
+        """
+        import doctest
+        from scipy_doctest.conftest import dt_config
+
+        # hack!
+        from pytest_doctestplus.output_checker import OutputChecker as _OutputCheckerImpl
+
+        # DTChecker expectes a `config` ctor argument, add it
+        class PDPChecker(_OutputCheckerImpl):
+            def __init__(self, config):
+                super().__init__()
+
+        # Register the checker
+        dt_config.CheckerKlass = PDPChecker
+        """
+    )
+
+    # create a temporary pytest test file
+    src = (
+        """
+        def func():
+            '''
+            The doctest below, when run from the command line,
+            - passes with `pytest --doctest-modules --doctest-plus`, and
+            - fails without `--doctest-plus`.
+
+            We however run this doctest using the PDPChecker, so it picks up
+            the FLOAT_CMP directive from doctestplus without a command-line switch.
+
+            >>> 2/3       # doctest: +FLOAT_CMP
+            0.666666
+            '''
+            pass
+        """
+    )
+
+    # run the doctest
+    f = pytester.makepyfile(src)
+    result = pytester.inline_run(f, '--doctest-modules')
+    assert result.ret == pytest.ExitCode.OK
+
+    # remove the directive and rerun
+    src_ = src.replace("# doctest: +FLOAT_CMP", "")
+    f_ = pytester.makepyfile(src_)
+    result = pytester.inline_run(f_, '--doctest-modules')
+    assert result.ret == pytest.ExitCode.TESTS_FAILED