Diffuse mesangial sclerosis

[sbello]

HPO term
Diffuse mesangial sclerosis (HP:0001967)

Suggested revision and reasons
Diffuse mesangial sclerosis is defined as "Diffuse sclerosis of the mesangium, as manifestated by diffuse mesangial matrix expansion". By this definition I would have expected it to be a child of Mesangial matrix expansion (HP:0033493) but this currently isn't the case.

In addition Diffuse mesangial sclerosis has an exact synonym 'Mesangial sclerosis' but there is another HPO term Global mesangial sclerosis, so should the synonym type be broad instead of exact? The MP had 'mesangial sclerosis' as an exact synonym to 'expanded mesangial matrix' but based on the HPO I've changed that to a narrow synonym. If you decide that mesangial sclerosis terms do not belong under 'Mesangial matrix expansion' then I can change the synonym type to related.

Also, Global mesangial sclerosis is a sibling to Mesangial matrix expansion, if you decide to move the diffuse term then I would also suggest moving the global term.

Arising out of mgijax/mammalian-phenotype-ontology#4024

[pnrobinson]

@avizrosenberg @yongqunh
Hi Avi and Oliver,
We have the following two terms:

Global mesangial sclerosis HP:0033491
Diffuse mesangial sclerosis HP:0001967

Is it correct that the difference between the two is
diffuse (in all or almost all the glomeruli)
global (the entire glomerulus).

Do we also need:
segmental (only a part of the glomerulus)
focal (only in some glomeruli)?

thanks!; Peter