NIH/NHGRI Clinical Data Ecosystem for Genomics (CDEG)_Due: March 2, 2026 #140
Description
Opportunity Summary – NIH/NHGRI Clinical Data Ecosystem for Genomics (CDEG)
Overview
The National Human Genome Research Institute (NHGRI) at NIH intends to release a Notice of Funding Opportunity (NOFO) in December 2025 to support the development of a Clinical Data Ecosystem for Genomics (CDEG). This initiative will fund cooperative agreements to build and pilot a network that demonstrates best practices for integrating, sharing, and using structured genomic data across healthcare systems.
- Opportunity Number: FOR-HG-26-005
- Mechanism: U01 Cooperative Agreement
- Estimated Post Date: December 1, 2025
- Application Due Date: March 2, 2026
- Estimated Award Date: October 30, 2026
- Estimated Project Start: October 30, 2026
- Expected Awards: TBD
- Total Program Funding: TBD
Research Scope
The CDEG initiative will fund projects that:
- Pilot a clinical genomic data ecosystem – demonstrate structured genomic data (GSD) sharing across diverse healthcare settings, including primary care.
- Develop standardized APIs – enable interoperability and access to genomic data across labs, providers, and patients.
- Build open-source clinical software and databases – leverage APIs to advance accessibility and reuse of genomic data.
- Test portability of genomic data – ensure patient data follows individuals across healthcare systems without barriers.
- Produce implementation resources – refine pilot ecosystem practices into scalable models for broad adoption.
Key focus areas:
- Computational genomics and biomedical data science.
- Electronic health record (EHR) integration and interoperability.
- Genomic data standards and cloud-based platforms.
- Open-source databases and software development.
- Clinical genomics implementation science.
- Health information exchange across care settings.
Eligibility
Eligible applicants include:
- Higher education institutions (public and private).
- Nonprofits with 501(c)(3) status.
- For-profit organizations (small and large businesses).
- Tribal governments and organizations.
- State, county, and local governments.
- Public housing and independent school districts.
No cost-sharing requirement.
Key Dates
- Forecasted Post Date: December 1, 2025
- Application Deadline: March 2, 2026
- Anticipated Award Date: October 30, 2026
- Start Date: October 30, 2026
Award Information
- Mechanism: U01 Cooperative Agreement
- Estimated Total Funding: TBD
- Expected Number of Awards: TBD
Strategic Fit for NumFOCUS
- Strong alignment with NumFOCUS-supported open-source data infrastructure projects that can enable genomic data interoperability and analysis.
- Relevant projects include:
- Zarr – scalable storage for large multidimensional genomic datasets.
- pandas, NumPy, SciPy – core data manipulation and statistical frameworks for genomic pipelines.
- ITK – image analysis tools adaptable to genomics and clinical biomarkers.
- MDAnalysis – molecular simulation analysis relevant for translational bioinformatics.
- Opportunity to position NumFOCUS projects as backbone infrastructure for APIs, cloud-enabled workflows, and EHR-integrated genomic applications.
- Opens pathways for partnerships between open-source developers, health systems, and clinical genomics researchers in scaling reproducible, accessible genomics software.