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+---
+title: snpEff cache location change in pipelines using snpEff
+subtitle: All pipelines using snpEff are affected by the change of the default cache location in snpEff happening in August 2025.
+category:
+  - pipelines
+  - configuration
+type: incompatibility
+severity: high
+publishedDate: "2025-10-22"
+reporter:
+  - maxulysse
+  -
+reviewer:
+  - maxulysse
+  -
+pipelines:
+  - name: sarek
+    versions:
+      - 2.12.0
+  - name: rnavar
+    versions:
+      - 4.2.0
+modules:
+  - name: snpeff_download
+  - name: snpeff_snpeff
+subworkflows:
+  - name: vcf_annotation_snpeff
+nextflowVersions:
+  - ">=25.04.0 <25.04.3"
+references:
+  - title: snpeff issue regarding change of hosting location of cache and binaries
+    description: Issues reporting the issue with snpeff download after the change of hosting location
+    url: https://github.com/pcingola/SnpEff/issues/602
+---
+
+# Issue
+
+https://github.com/pcingola/SnpEff/issues/602
+
+snpeff download is broken with older versions of sarek/rnavar due to changes in location for the storage of snpeff cache.
+snpeff download works with newer versions of sarek/rnavar with an updated of snpeff, but cache 105 is now not valid anymore (hopefully until a fix comes).
+
+-> https://github.com/pcingola/SnpEff/issues/609