New MP terms: increased/decreased susceptibility to hyperoxia induced injury

[MonikaTomczuk]

Request for new terms, J:344867 (PMID: 37553579)

Term: increased susceptibility to hyperoxia-induced injury
Synonym: decreased resistance to hyperoxia-induced injury
Definition: greater than the normal reaction to hyperoxia

Term: decreased susceptibility to hyperoxia-induced injury
Synonym: increased resistance to hyperoxia-induced injury
Definition: less than the normal reaction to hyperoxia

Suggested parent term for both terms: abnormal response to injury MP:0005164; do we want an abnormal response to hyperoxia induced injury term so that the increased/decreased terms can be children?

Sue, I struggle to come up with good definitions because I get confused between describing how much injury there is (greater injury with increased susceptibility) versus how much the body reacts (decreased response of body to injury and thus there is more injury). In this case, wild-type females are protected from hyperoxia-induced injury compared to males, showing better alveolarization, distal lung vascular development and blood vessel formation in hyperoxia conditions. Mutant females are no longer protected, so show less alveolarization, distal lung vascular development and blood vessel formation so there is more damage.

MGI:mtomczuk
ORCID:0009-0005-7755-8314