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review placement of loss of X cell terms #3954

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sbello opened this issue Mar 29, 2024 · 2 comments
Open

review placement of loss of X cell terms #3954

sbello opened this issue Mar 29, 2024 · 2 comments

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@sbello
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sbello commented Mar 29, 2024

We have the term 'loss of hippocampal neurons' this is currently not a child of 'decreased hippocampus cell number' seems like it should be.
We should also check the parents of other loss of X terms

@anna-anagnostop
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Should review annotations to:

  • hippocampus hypoplasia MP:0030004 (currently 3 annotations)
  • hippocampal neuron degeneration MP:0000811 (with 66 annotations)
  • decreased hippocampus cell density MP:0020635 (zero annotations but see Genotype MGI:5550547 annotated to 'hippocampal neuron degeneration')
  • decreased hippocampus cell number MP:0020629 (zero annotations)
  • loss of hippocampal neurons MP:0003240 (with 37 annotations)

@anna-anagnostop
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anna-anagnostop commented Dec 16, 2024

Other loss of X terms include:

  • loss of vibrissae MP:0001280 (inability to retain vibrissae, check EQ and placement under abnormal vibrissa number MP:0009003 , see also annotations to sparse vibirissae MP:0001283)
  • loss of eyelid cilia MP:0000425 (inability to retain vibrissae, check EQ and placement, see also annotations to decreased eyelid cilium number MP:0013897
  • loss of GABAergic neurons MP:0003246
  • loss of dopaminergic neurons MP:0003244 (also check annotations to decreased dopaminergic neuron number MP:0011448)
  • loss of glutamate neurons MP:0003248 (annotations do not match EQ)
  • loss of cortex neurons MP:0003241 (also check annotations to decreased cerebral cortex cell number MP:0020594)
  • loss of basal ganglia neurons MP:0003242 (annotations do not match EQ)

Loss of X neuron terms are generally defined as loss "commonly due to an apoptotic event" and use absent in their EQs.

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