add Flynn23 - 10.1021/acsinfecdis.3c00125, Fix #933 (#950)

KaimingTao · hivdb-bot · web-flow · commit 18ba07616cfb · 2023-08-16T17:18:29.000-07:00
* add Flynn23 - 10.1021/acsinfecdis.3c00125, Fix #933 * Autogenerated data updated by HIVDB Bot --------- Co-authored-by: HIVDB Bot <hivdbteam@stanford.edu>
diff --git a/tables/articles.csv b/tables/articles.csv
@@ -786,6 +786,7 @@ Wu23,10.1016/j.ccell.2023.04.005,NULL,"Wu, M",2023,2023-06-27,NULL
 Kiso23,10.1038/s41467-023-39704-x,NULL,"Kiso, M",2023,2023-08-15,NULL
 Jiang23,10.1021/acs.biochem.3c00075,NULL,"Jiang, H",2023,2023-08-16,NULL
 Iketani23,10.1101/2022.06.23.497404,NULL,"Iketani, S",2023,2023-08-16,NULL
-Kiso23b,10.1038/s41467-023-40018-1,NULL,"Kiso, M",2023,2023-08-15,NULL
-Lin23,10.1038/s42003-023-05071-y,NULL,"Lin, M",2023,2023-08-15,NULL
-Takashita23,10.1016/j.antiviral.2023.105671,NULL,"Takashita, E",2023,2023-08-15,NULL
+Kiso23b,10.1038/s41467-023-40018-1,NULL,"Kiso, M",2023,2023-08-16,NULL
+Lin23,10.1038/s42003-023-05071-y,NULL,"Lin, M",2023,2023-08-16,NULL
+Takashita23,10.1016/j.antiviral.2023.105671,NULL,"Takashita, E",2023,2023-08-16,NULL
+Flynn23,10.1021/acsinfecdis.3c00125,NULL,"Flynn, JM",2023,2023-08-16,NULL
diff --git a/tables/isolate_mutations.csv b/tables/isolate_mutations.csv
@@ -24844,5 +24844,6 @@ Omicron/XBB.1.5 full genome,N,203,K,NULL,NULL
 Omicron/XBB.1.5 full genome,N,204,R,NULL,NULL
 Omicron/XBB.1.5 full genome,N,413,R,NULL,NULL
 3CLpro:T25I,_3CLpro,25,I,NULL,NULL
+3CLpro:T25E,_3CLpro,25,E,NULL,NULL
 3CLpro:S46P,_3CLpro,46,P,NULL,NULL
 3CLpro:D48N,_3CLpro,48,N,NULL,NULL
diff --git a/tables/isolates.csv b/tables/isolates.csv
@@ -1625,5 +1625,6 @@ BA.2.75 Spike:F490S,Omicron/BA.2.75/F490S,FALSE,NULL,NULL,NULL,TRUE
 DS.1 Spike,DS.1,FALSE,NULL,NULL,NULL,TRUE
 Omicron/XBB.1.5 full genome,Omicron/XBB.1.5,FALSE,NULL,NULL,NULL,TRUE
 3CLpro:T25I,NULL,FALSE,NULL,NULL,NULL,TRUE
+3CLpro:T25E,NULL,FALSE,NULL,NULL,NULL,TRUE
 3CLpro:S46P,NULL,FALSE,NULL,NULL,NULL,TRUE
 3CLpro:D48N,NULL,FALSE,NULL,NULL,NULL,TRUE
diff --git a/tables/ref_isolate_pairs/flynn23-pair.csv b/tables/ref_isolate_pairs/flynn23-pair.csv
@@ -0,0 +1,3 @@
+﻿ref_name,control_iso_name,iso_name
+Flynn23,Wuhan-Hu-1 3CLpro,3CLpro:M49L
+Flynn23,Wuhan-Hu-1 3CLpro,3CLpro:T25E
diff --git a/tables/rx_compounds/flynn23-drug.csv b/tables/rx_compounds/flynn23-drug.csv
@@ -0,0 +1,3 @@
+ref_name,rx_name,drug_name
+Flynn23,Ensitrelvir,Ensitrelvir
+Flynn23,Nirmatrelvir,Nirmatrelvir
diff --git a/tables/rx_potency/flynn23-pot.csv b/tables/rx_potency/flynn23-pot.csv
@@ -0,0 +1,7 @@
+﻿ref_name,rx_name,iso_name,section,assay_name,potency_type,potency,cumulative_count,potency_upper_limit,potency_lower_limit,potency_unit,date_added
+Flynn23,Ensitrelvir,Wuhan-Hu-1 3CLpro,Figure 5,FRET,Ki,1.04,1,NULL,NULL,nM,2023-08-16
+Flynn23,Ensitrelvir,3CLpro:M49L,Figure 5,FRET,Ki,40.2,1,NULL,NULL,nM,2023-08-16
+Flynn23,Ensitrelvir,3CLpro:T25E,Figure 5,FRET,Ki,394.4,1,NULL,NULL,nM,2023-08-16
+Flynn23,Nirmatrelvir,Wuhan-Hu-1 3CLpro,Figure 5,FRET,Ki,0.97,1,NULL,NULL,nM,2023-08-16
+Flynn23,Nirmatrelvir,3CLpro:M49L,Figure 5,FRET,Ki,0.72,1,NULL,NULL,nM,2023-08-16
+Flynn23,Nirmatrelvir,3CLpro:T25E,Figure 5,FRET,Ki,1.2,1,NULL,NULL,nM,2023-08-16
diff --git a/tables/treatments.csv b/tables/treatments.csv
@@ -38059,6 +38059,8 @@ Dioverti22,Remdesivir
 Drouin21,Remdesivir
 Fahnøe22,Remdesivir
 FDA21d,Nirmatrelvir
+Flynn23,Ensitrelvir
+Flynn23,Nirmatrelvir
 Gandhi22,Remdesivir
 Garcia-Vidal22,Remdesivir
 Gliga22,Remdesivir

Original file line number	Diff line number	Diff line change
`@@ -0,0 +1,3 @@`
	`1`	`+ref_name,control_iso_name,iso_name`
	`2`	`+Flynn23,Wuhan-Hu-1 3CLpro,3CLpro:M49L`
	`3`	`+Flynn23,Wuhan-Hu-1 3CLpro,3CLpro:T25E`
Original file line number	Diff line number	Diff line change
`@@ -0,0 +1,3 @@`
	`1`	`+ref_name,rx_name,drug_name`
	`2`	`+Flynn23,Ensitrelvir,Ensitrelvir`
	`3`	`+Flynn23,Nirmatrelvir,Nirmatrelvir`