diff --git a/README.md b/README.md
index 99120f2..078d196 100644
--- a/README.md
+++ b/README.md
@@ -150,8 +150,11 @@ This would NOT modify the following labels:
   - docs
 ```
 
-Running ``labels sync`` without the ``dryrun`` option also updates the labels
-file, so that section names match the ``name`` parameter.
+You can also synchronize your repository with labels defined in multiple files:
+
+```text
+labels sync -o hackebrot -r pytest-emoji -f issue-labels.toml -f release-labels.toml
+```
 
 If **labels** encounters any errors while sending requests to the GitHub API,
 it will print information about the failure and continue with the next label
diff --git a/src/labels/cli.py b/src/labels/cli.py
index e5f0d69..a4e8ec4 100644
--- a/src/labels/cli.py
+++ b/src/labels/cli.py
@@ -151,25 +151,28 @@ def fetch_cmd(context: LabelsContext, owner: str, repo: str, filename: str) -> N
 @click.option(
     "-f",
     "--filename",
-    help="Filename for labels",
-    default="labels.toml",
+    help="Filenames for labels",
+    default=["labels.toml"],
     type=click.Path(exists=True),
     required=True,
+    multiple=True,
 )
 def sync_cmd(
-    context: LabelsContext, owner: str, repo: str, filename: str, dryrun: bool
+    context: LabelsContext,
+    owner: str,
+    repo: str,
+    filename: typing.List[str],
+    dryrun: bool,
 ) -> None:
-    """Sync labels with a GitHub repository.
-
-    On success this will also update the local labels file, so that section
-    names match the `name` parameter.
-    """
+    """Sync labels with a GitHub repository."""
     labels_to_delete = {}
     labels_to_update = {}
     labels_to_create = {}
     labels_to_ignore = {}
 
-    local_labels = read_labels(filename)
+    local_labels = {}
+    for file in filename:
+        local_labels.update(read_labels(file))
 
     repository = Repository(owner, repo)
 
@@ -244,15 +247,6 @@ def sync_cmd(
     if failures:
         sys.exit(1)
 
-    # Make sure to write the local labels file to update TOML sections
-    write_labels(
-        filename,
-        sorted(
-            local_labels.values(),
-            key=operator.attrgetter("name", "description", "color"),
-        ),
-    )
-
 
 def dryrun_echo(
     labels_to_delete: Labels_Dict,
diff --git a/tests/conftest.py b/tests/conftest.py
index 6f150c6..615c1fe 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -290,7 +290,7 @@ def fixture_mock_delete_label(
 def fixture_mock_sync(
     base_url: str, repo_owner: str, repo_name: str, response_list_labels: ResponseLabels
 ) -> Generator:
-    with responses.RequestsMock() as rsps:
+    with responses.RequestsMock(assert_all_requests_are_fired=False) as rsps:
         # Response mock for when sync requests the existing remote labels
         rsps.add(
             responses.GET,
@@ -317,6 +317,23 @@ def fixture_mock_sync(
             content_type="application/json",
         )
 
+        # Response mock for when sync creates the "other" label
+        rsps.add(
+            responses.POST,
+            f"{base_url}/repos/{repo_owner}/{repo_name}/labels",
+            json={
+                "id": 8080,
+                "node_id": "4848",
+                "url": f"{base_url}/repos/{repo_owner}/{repo_name}/labels/other",
+                "name": "other",
+                "description": "Some other label",
+                "color": "000000",
+                "default": False,
+            },
+            status=201,
+            content_type="application/json",
+        )
+
         # Response mock for when sync edits the "bug" label
         rsps.add(
             responses.PATCH,
@@ -455,3 +472,9 @@ def fixture_labels_file_load() -> str:
 def fixture_labels_file_sync(tmpdir: Any) -> str:
     """Return a filepath to an existing labels file for the sync test."""
     return "tests/sync.toml"
+
+
+@pytest.fixture(name="other_labels_file_sync")
+def fixture_other_labels_file_sync() -> str:
+    """Return a filepath to another existing labels file for the sync test."""
+    return "tests/other-sync.toml"
diff --git a/tests/other-sync.toml b/tests/other-sync.toml
new file mode 100644
index 0000000..e82b6e7
--- /dev/null
+++ b/tests/other-sync.toml
@@ -0,0 +1,4 @@
+[other]
+color = "000000"
+name = "other"
+description = "Some other label"
diff --git a/tests/test_cli.py b/tests/test_cli.py
index cae7e59..52db0e9 100644
--- a/tests/test_cli.py
+++ b/tests/test_cli.py
@@ -204,3 +204,31 @@ def test_sync_dryrun(
         "  - docs\n"
     )
     assert output in result.output
+
+
+@pytest.mark.usefixtures("mock_sync", "mock_repo_info")
+@pytest.mark.parametrize(
+    "repo_owner, repo_name, remote_url",
+    [("pytest-dev", "pytest", "git@github.com:hackebrot/pytest-emoji.git")],
+    ids=["sync_multiple"],
+)
+def test_sync_multiple_files(
+    run_cli: typing.Callable,
+    repo_owner: str,
+    repo_name: str,
+    labels_file_sync: str,
+    other_labels_file_sync: str,
+) -> None:
+    """Test that sync with multiple files works as designed."""
+    result = run_cli(
+        f"-v sync -o {repo_owner} -r {repo_name}"
+        + f" -f {labels_file_sync} -f {other_labels_file_sync}"
+    )
+    assert result.exit_code == 0
+    assert f"Requesting labels for {repo_owner}/{repo_name}" in result.output
+    assert f"Deleting label 'infra' for {repo_owner}/{repo_name}" in result.output
+    assert f"Editing label 'bug' for {repo_owner}/{repo_name}" in result.output
+    assert (
+        f"Creating label 'dependencies' for {repo_owner}/{repo_name}" in result.output
+    )
+    assert f"Creating label 'other' for {repo_owner}/{repo_name}" in result.output