diff --git a/src/webgpu/compat/api/validation/encoding/cmds/copyTextureToTexture.spec.ts b/src/webgpu/compat/api/validation/encoding/cmds/copyTextureToTexture.spec.ts
index ed15d2fad985..cd551f9b63a4 100644
--- a/src/webgpu/compat/api/validation/encoding/cmds/copyTextureToTexture.spec.ts
+++ b/src/webgpu/compat/api/validation/encoding/cmds/copyTextureToTexture.spec.ts
@@ -3,15 +3,17 @@ Tests limitations of copyTextureToTextures in compat mode.
 `;
 
 import { makeTestGroup } from '../../../../../../common/framework/test_group.js';
-import { kCompressedTextureFormats, kTextureFormatInfo } from '../../../../../format_info.js';
+import {
+  kAllTextureFormats,
+  kCompressedTextureFormats,
+  kTextureFormatInfo,
+} from '../../../../../format_info.js';
 import { CompatibilityTest } from '../../../../compatibility_test.js';
 
 export const g = makeTestGroup(CompatibilityTest);
 
 g.test('compressed')
-  .desc(
-    `Tests that you can not call copyTextureToTextures with compressed textures in compat mode.`
-  )
+  .desc(`Tests that you can not call copyTextureToTexture with compressed textures in compat mode.`)
   .params(u => u.combine('format', kCompressedTextureFormats))
   .beforeAllSubcases(t => {
     const { format } = t.params;
@@ -46,3 +48,47 @@ g.test('compressed')
       encoder.finish();
     });
   });
+
+g.test('multisample')
+  .desc(`Test that you can not call copyTextureToTexture with multisample textures in compat mode.`)
+  .params(u =>
+    u
+      .beginSubcases()
+      .combine('format', kAllTextureFormats)
+      .filter(({ format }) => {
+        const info = kTextureFormatInfo[format];
+        return info.multisample && !info.feature;
+      })
+  )
+  .fn(t => {
+    const { format } = t.params;
+    const { blockWidth, blockHeight } = kTextureFormatInfo[format];
+
+    t.skipIfTextureFormatNotSupported(format as GPUTextureFormat);
+
+    const srcTexture = t.device.createTexture({
+      size: [blockWidth, blockHeight, 1],
+      format,
+      sampleCount: 4,
+      usage: GPUTextureUsage.COPY_SRC | GPUTextureUsage.RENDER_ATTACHMENT,
+    });
+    t.trackForCleanup(srcTexture);
+
+    const dstTexture = t.device.createTexture({
+      size: [blockWidth, blockHeight, 1],
+      format,
+      sampleCount: 4,
+      usage: GPUTextureUsage.COPY_DST | GPUTextureUsage.RENDER_ATTACHMENT,
+    });
+    t.trackForCleanup(dstTexture);
+
+    const encoder = t.device.createCommandEncoder();
+    encoder.copyTextureToTexture({ texture: srcTexture }, { texture: dstTexture }, [
+      blockWidth,
+      blockHeight,
+      1,
+    ]);
+    t.expectGPUError('validation', () => {
+      encoder.finish();
+    });
+  });
diff --git a/src/webgpu/listing_meta.json b/src/webgpu/listing_meta.json
index 7890d0c7fe37..4357795529c6 100644
--- a/src/webgpu/listing_meta.json
+++ b/src/webgpu/listing_meta.json
@@ -845,6 +845,7 @@
   "webgpu:compat,api,validation,createBindGroupLayout:unsupportedStorageTextureFormats:*": { "subcaseMS": 0.601 },
   "webgpu:compat,api,validation,encoding,cmds,copyTextureToBuffer:compressed:*": { "subcaseMS": 202.929 },
   "webgpu:compat,api,validation,encoding,cmds,copyTextureToTexture:compressed:*": { "subcaseMS": 0.600 },
+  "webgpu:compat,api,validation,encoding,cmds,copyTextureToTexture:multisample:*": { "subcaseMS": 0.600 },
   "webgpu:compat,api,validation,encoding,programmable,pipeline_bind_group_compat:twoDifferentTextureViews,compute_pass,unused:*": { "subcaseMS": 1.501 },
   "webgpu:compat,api,validation,encoding,programmable,pipeline_bind_group_compat:twoDifferentTextureViews,compute_pass,used:*": { "subcaseMS": 49.405 },
   "webgpu:compat,api,validation,encoding,programmable,pipeline_bind_group_compat:twoDifferentTextureViews,render_pass,unused:*": { "subcaseMS": 16.002 },