diff --git a/src/webgpu/listing_meta.json b/src/webgpu/listing_meta.json
index 3ef1fbca734f..9826a3e806ab 100644
--- a/src/webgpu/listing_meta.json
+++ b/src/webgpu/listing_meta.json
@@ -2168,5 +2168,8 @@
   "webgpu:shader,validation,expression,call,builtin,arrayLength:bool_type:*": { "subcaseMS": 0 },
   "webgpu:shader,validation,expression,call,builtin,arrayLength:type:*": { "subcaseMS": 0 },
   "webgpu:shader,validation,expression,call,builtin,arrayLength:access_mode:*": { "subcaseMS": 0 },
+  "webgpu:shader,validation,expression,unary,address_of_and_indirection:basic:*": { "subcaseMS": 0 },
+  "webgpu:shader,validation,expression,unary,address_of_and_indirection:composite:*": { "subcaseMS": 0 },
+  "webgpu:shader,validation,expression,unary,address_of_and_indirection:invalid:*": { "subcaseMS": 0 },
   "_end": ""
 }
diff --git a/src/webgpu/shader/validation/expression/unary/address_of_and_indirection.spec.ts b/src/webgpu/shader/validation/expression/unary/address_of_and_indirection.spec.ts
new file mode 100644
index 000000000000..a4558c13579a
--- /dev/null
+++ b/src/webgpu/shader/validation/expression/unary/address_of_and_indirection.spec.ts
@@ -0,0 +1,242 @@
+export const description = `
+Validation tests for unary address-of and indirection (dereference)
+`;
+
+import { makeTestGroup } from '../../../../../common/framework/test_group.js';
+import { keysOf } from '../../../../../common/util/data_tables.js';
+import { ShaderValidationTest } from '../../shader_validation_test.js';
+
+export const g = makeTestGroup(ShaderValidationTest);
+
+const kAddressSpaces = ['function', 'private', 'workgroup', 'uniform', 'storage'];
+const kAccessModes = ['read', 'read_write'];
+const kStorageTypes = ['bool', 'u32', 'i32', 'f32', 'f16'];
+const kCompositeTypes = ['array', 'struct', 'vec', 'mat'];
+const kDerefTypes = {
+  deref_address_of_identifier: {
+    wgsl: `(*(&a))`,
+    requires_pointer_composite_access: false,
+  },
+  deref_pointer: {
+    wgsl: `(*p)`,
+    requires_pointer_composite_access: false,
+  },
+  address_of_identifier: {
+    wgsl: `(&a)`,
+    requires_pointer_composite_access: true,
+  },
+  pointer: {
+    wgsl: `p`,
+    requires_pointer_composite_access: true,
+  },
+};
+
+g.test('basic')
+  .desc(
+    `Validates address-of (&) every supported variable type, ensuring the type is correct by
+    assigning to an explicitly typed pointer. Also validates dereferencing the reference,
+    ensuring the type is correct by assigning to an explicitly typed variable.`
+  )
+  .params(u =>
+    u
+      .combine('addressSpace', kAddressSpaces)
+      .combine('accessMode', kAccessModes)
+      .combine('storageType', kStorageTypes)
+      .combine('derefType', keysOf(kDerefTypes))
+      .filter(t => {
+        if (t.storageType === 'bool') {
+          return t.addressSpace === 'function' || t.addressSpace === 'private';
+        }
+        return true;
+      })
+      .filter(t => {
+        // This test does not test composite access
+        return !kDerefTypes[t.derefType].requires_pointer_composite_access;
+      })
+  )
+  .beforeAllSubcases(t => {
+    if (t.params.storageType === 'f16') {
+      t.selectDeviceOrSkipTestCase({ requiredFeatures: ['shader-f16'] });
+    }
+  })
+  .fn(t => {
+    const isLocal = t.params.addressSpace === 'function';
+    const deref = kDerefTypes[t.params.derefType];
+    // Only specify access mode for storage buffers
+    const commaAccessMode = t.params.addressSpace === 'storage' ? `, ${t.params.accessMode}` : '';
+
+    let varDecl = '';
+    if (t.params.addressSpace === 'uniform' || t.params.addressSpace === 'storage') {
+      varDecl += '@group(0) @binding(0) ';
+    }
+    varDecl += `var<${t.params.addressSpace}${commaAccessMode}> a : VarType;`;
+
+    const wgsl = `
+      ${t.params.storageType === 'f16' ? 'enable f16;' : ''}
+
+      alias VarType = ${t.params.storageType};
+      alias PtrType = ptr<${t.params.addressSpace}, VarType ${commaAccessMode}>;
+
+      ${isLocal ? '' : varDecl}
+
+      fn foo() {
+        ${isLocal ? varDecl : ''}
+        let p : PtrType = &a;
+        var deref : VarType = ${deref.wgsl};
+      }
+    `;
+
+    t.expectCompileResult(true, wgsl);
+  });
+
+g.test('composite')
+  .desc(
+    `Validates address-of (&) every supported variable type for composite types, ensuring the type
+    is correct by assigning to an explicitly typed pointer. Also validates dereferencing the
+    reference followed by member/index access, ensuring the type is correct by assigning to an
+    explicitly typed variable.`
+  )
+  .params(u =>
+    u
+      .combine('addressSpace', kAddressSpaces)
+      .combine('accessMode', kAccessModes)
+      .combine('storageType', kStorageTypes)
+      .combine('compositeType', kCompositeTypes)
+      .combine('derefType', keysOf(kDerefTypes))
+      .filter(t => {
+        if (t.storageType === 'bool') {
+          return t.addressSpace === 'function' || t.addressSpace === 'private';
+        }
+        return true;
+      })
+      .filter(t => {
+        if (t.compositeType === 'mat') {
+          return t.storageType === 'f32' || t.storageType === 'f16';
+        }
+        return true;
+      })
+  )
+  .beforeAllSubcases(t => {
+    if (t.params.storageType === 'f16') {
+      t.selectDeviceOrSkipTestCase({ requiredFeatures: ['shader-f16'] });
+    }
+  })
+  .fn(t => {
+    const isLocal = t.params.addressSpace === 'function';
+    const deref = kDerefTypes[t.params.derefType];
+    // Only specify access mode for storage buffers
+    const commaAccessMode = t.params.addressSpace === 'storage' ? `, ${t.params.accessMode}` : '';
+
+    let varDecl = '';
+    if (t.params.addressSpace === 'uniform' || t.params.addressSpace === 'storage') {
+      varDecl += '@group(0) @binding(0) ';
+    }
+    varDecl += `var<${t.params.addressSpace}${commaAccessMode}> a : VarType;`;
+
+    let wgsl = `
+          ${t.params.storageType === 'f16' ? 'enable f16;' : ''}`;
+
+    switch (t.params.compositeType) {
+      case 'array':
+        wgsl += `
+          struct S { @align(16) member : ${t.params.storageType} }
+          alias VarType = array<S, 10>;
+          alias PtrType = ptr<${t.params.addressSpace}, VarType ${commaAccessMode}>;
+          ${isLocal ? '' : varDecl}
+
+          fn foo() {
+            ${isLocal ? varDecl : ''}
+            let p : PtrType = &a;
+            var deref : ${t.params.storageType} = ${deref.wgsl}[0].member;
+          }`;
+        break;
+      case 'struct':
+        wgsl += `
+          struct S { member : ${t.params.storageType} }
+          alias VarType = S;
+          alias PtrType = ptr<${t.params.addressSpace}, VarType ${commaAccessMode}>;
+          ${isLocal ? '' : varDecl}
+
+          fn foo() {
+            ${isLocal ? varDecl : ''}
+            let p : PtrType = &a;
+            var deref : ${t.params.storageType} = ${deref.wgsl}.member;
+          }`;
+        break;
+      case 'vec':
+        wgsl += `
+          alias VarType = vec3<${t.params.storageType}>;
+          alias PtrType = ptr<${t.params.addressSpace}, VarType ${commaAccessMode}>;
+          ${isLocal ? '' : varDecl}
+
+          fn foo() {
+            ${isLocal ? varDecl : ''}
+            let p : PtrType = &a;
+            var deref_member : ${t.params.storageType} = ${deref.wgsl}.x;
+            var deref_index : ${t.params.storageType} = ${deref.wgsl}[0];
+          }`;
+        break;
+      case 'mat':
+        wgsl += `
+          alias VarType = mat2x3<${t.params.storageType}>;
+          alias PtrType = ptr<${t.params.addressSpace}, VarType ${commaAccessMode}>;
+          ${isLocal ? '' : varDecl}
+
+          fn foo() {
+            ${isLocal ? varDecl : ''}
+            let p : PtrType = &a;
+            var deref_vec : vec3<${t.params.storageType}> = ${deref.wgsl}[0];
+            var deref_elem : ${t.params.storageType} = ${deref.wgsl}[0][0];
+          }`;
+        break;
+    }
+
+    let shouldPass = true;
+    if (
+      kDerefTypes[t.params.derefType].requires_pointer_composite_access &&
+      !t.hasLanguageFeature('pointer_composite_access')
+    ) {
+      shouldPass = false;
+    }
+
+    t.expectCompileResult(shouldPass, wgsl);
+  });
+
+const kInvalidCases = {
+  address_of_let: `
+    let a = 1;
+    let p = &a;`,
+  address_of_texture: `
+    let p = &t;`,
+  address_of_sampler: `
+    let p = &s;`,
+  address_of_function: `
+    let p = &func;`,
+  address_of_vector_elem_via_member: `
+    var a : vec3<f32>();
+    let p = &a.x;`,
+  address_of_vector_elem_via_index: `
+    var a : vec3<f32>();
+    let p = &a[0];`,
+  address_of_matrix_elem: `
+    var a : mat2x3<f32>();
+    let p = &a[0][0];`,
+  deref_non_pointer: `
+    var a = 1;
+    let p = *a;
+  `,
+};
+g.test('invalid')
+  .desc('Test invalid cases of unary address-of and dereference')
+  .params(u => u.combine('case', keysOf(kInvalidCases)))
+  .fn(t => {
+    const wgsl = `
+      @group(0) @binding(0) var s : sampler;
+      @group(0) @binding(1) var t : texture_2d<f32>;
+      fn func() {}
+      fn main() {
+        ${kInvalidCases[t.params.case]}
+      }
+    `;
+    t.expectCompileResult(false, wgsl);
+  });