diff --git a/hwy/cache_control.h b/hwy/cache_control.h
index b03341ba94..90743cd3f2 100644
--- a/hwy/cache_control.h
+++ b/hwy/cache_control.h
@@ -98,9 +98,10 @@ template <typename T>
 HWY_INLINE HWY_ATTR_CACHE void Prefetch(const T* p) {
   (void)p;
 #ifndef HWY_DISABLE_CACHE_CONTROL
-#if HWY_ARCH_X86
+// Use _mm_prefetch on x86/x64, except when clang-cl is compiled with -mno-mmx.
+#if HWY_ARCH_X86 && !(HWY_COMPILER_CLANGCL && !defined(__MMX__))
   _mm_prefetch(reinterpret_cast<const char*>(p), _MM_HINT_T0);
-#elif HWY_COMPILER_GCC  // includes clang
+#elif HWY_COMPILER_GCC || HWY_COMPILER_CLANGCL  // includes clang
   // Hint=0 (NTA) behavior differs, but skipping outer caches is probably not
   // desirable, so use the default 3 (keep in caches).
   __builtin_prefetch(p, /*write=*/0, /*hint=*/3);