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a/segmentmodel/assets/index-396a8699.js +++ /dev/null @@ -1,4 +0,0 @@ -import{b as Q}from"./index-462333f7.js";import{_ as Yn,L as Kn}from"./index-d89cadd6.js";import{L as nr}from"./__vite-browser-external-d053bc6e.js";import{R as ir}from"./remoteFile-1948951e.js";import"./_commonjsHelpers-de833af9.js";const lt=BigInt(32);function rr(e,n,t){const i=+!!t,r=+!t;return BigInt(e.getInt32(n,t)*r+e.getInt32(n+4,t)*i)<>lt),a=Number(t&BigInt(4294967295));i?(e.setInt32(n+4,r,i),e.setUint32(n,a,i)):(e.setInt32(n,r,i),e.setUint32(n+4,a,i))}function sr(e,n,t,i){const r=Number(t>>lt),a=Number(t&BigInt(4294967295));i?(e.setUint32(n+4,r,i),e.setUint32(n,a,i)):(e.setUint32(n,r,i),e.setUint32(n+4,a,i))}"getBigInt64"in DataView||(DataView.prototype.getBigInt64=function(e,n){return rr(this,e,n)});"getBigUint64"in DataView||(DataView.prototype.getBigUint64=function(e,n){return ar(this,e,n)});"setBigInt64"in DataView||(DataView.prototype.setBigInt64=function(e,n,t){or(this,e,n,t)});"setBigUint64"in 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t,i,r;do{if(i=e.window_size-e.lookahead-e.strstart,e.strstart>=n+(n-Y)&&(e.window.set(e.window.subarray(n,n+n-i),0),e.match_start-=n,e.strstart-=n,e.block_start-=n,e.insert>e.strstart&&(e.insert=e.strstart),sa(e),i+=n),e.strm.avail_in===0)break;if(t=Lt(e.strm,e.window,e.strstart+e.lookahead,i),e.lookahead+=t,e.lookahead+e.insert>=I)for(r=e.strstart-e.insert,e.ins_h=e.window[r],e.ins_h=ie(e,e.ins_h,e.window[r+1]);e.insert&&(e.ins_h=ie(e,e.ins_h,e.window[r+I-1]),e.prev[r&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=r,r++,e.insert--,!(e.lookahead+e.insert{let t=e.pending_buf_size-5>e.w_size?e.w_size:e.pending_buf_size-5,i,r,a,o=0,f=e.strm.avail_in;do{if(i=65535,a=e.bi_valid+42>>3,e.strm.avail_outr+e.strm.avail_in&&(i=r+e.strm.avail_in),i>a&&(i=a),i>8,e.pending_buf[e.pending-2]=~i,e.pending_buf[e.pending-1]=~i>>8,D(e.strm),r&&(r>i&&(r=i),e.strm.output.set(e.window.subarray(e.block_start,e.block_start+r),e.strm.next_out),e.strm.next_out+=r,e.strm.avail_out-=r,e.strm.total_out+=r,e.block_start+=r,i-=r),i&&(Lt(e.strm,e.strm.output,e.strm.next_out,i),e.strm.next_out+=i,e.strm.avail_out-=i,e.strm.total_out+=i)}while(o===0);return 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t,i;for(;;){if(e.lookahead=I&&(e.ins_h=ie(e,e.ins_h,e.window[e.strstart+I-1]),t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),t!==0&&e.strstart-t<=e.w_size-Y&&(e.match_length=ui(e,t)),e.match_length>=I)if(i=te(e,e.strstart-e.match_start,e.match_length-I),e.lookahead-=e.match_length,e.match_length<=e.max_lazy_match&&e.lookahead>=I){e.match_length--;do e.strstart++,e.ins_h=ie(e,e.ins_h,e.window[e.strstart+I-1]),t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart;while(--e.match_length!==0);e.strstart++}else e.strstart+=e.match_length,e.match_length=0,e.ins_h=e.window[e.strstart],e.ins_h=ie(e,e.ins_h,e.window[e.strstart+1]);else i=te(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++;if(i&&(V(e,!1),e.strm.avail_out===0))return B}return e.insert=e.strstart{let 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e.match_available&&(i=te(e,0,e.window[e.strstart-1]),e.match_available=0),e.insert=e.strstart{let t,i,r,a;const o=e.window;for(;;){if(e.lookahead<=ee){if(me(e),e.lookahead<=ee&&n===ne)return B;if(e.lookahead===0)break}if(e.match_length=0,e.lookahead>=I&&e.strstart>0&&(r=e.strstart-1,i=o[r],i===o[++r]&&i===o[++r]&&i===o[++r])){a=e.strstart+ee;do;while(i===o[++r]&&i===o[++r]&&i===o[++r]&&i===o[++r]&&i===o[++r]&&i===o[++r]&&i===o[++r]&&i===o[++r]&&re.lookahead&&(e.match_length=e.lookahead)}if(e.match_length>=I?(t=te(e,1,e.match_length-I),e.lookahead-=e.match_length,e.strstart+=e.match_length,e.match_length=0):(t=te(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++),t&&(V(e,!1),e.strm.avail_out===0))return B}return e.insert=0,n===L?(V(e,!0),e.strm.avail_out===0?ue:ke):e.sym_next&&(V(e,!1),e.strm.avail_out===0)?B:ve},ua=(e,n)=>{let t;for(;;){if(e.lookahead===0&&(me(e),e.lookahead===0)){if(n===ne)return B;break}if(e.match_length=0,t=te(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++,t&&(V(e,!1),e.strm.avail_out===0))return B}return e.insert=0,n===L?(V(e,!0),e.strm.avail_out===0?ue:ke):e.sym_next&&(V(e,!1),e.strm.avail_out===0)?B:ve};function H(e,n,t,i,r){this.good_length=e,this.max_lazy=n,this.nice_length=t,this.max_chain=i,this.func=r}const xe=[new H(0,0,0,0,hi),new H(4,4,8,4,wt),new H(4,5,16,8,wt),new H(4,6,32,32,wt),new H(4,4,16,16,de),new H(8,16,32,32,de),new H(8,16,128,128,de),new H(8,32,128,256,de),new H(32,128,258,1024,de),new H(32,258,258,4096,de)],ha=e=>{e.window_size=2*e.w_size,J(e.head),e.max_lazy_match=xe[e.level].max_lazy,e.good_match=xe[e.level].good_length,e.nice_match=xe[e.level].nice_length,e.max_chain_length=xe[e.level].max_chain,e.strstart=0,e.block_start=0,e.lookahead=0,e.insert=0,e.match_length=e.prev_length=I-1,e.match_available=0,e.ins_h=0};function ca(){this.strm=null,this.status=0,this.pending_buf=null,this.pending_buf_size=0,this.pending_out=0,this.pending=0,this.wrap=0,this.gzhead=null,this.gzindex=0,this.method=ut,this.last_flush=-1,this.w_size=0,this.w_bits=0,this.w_mask=0,this.window=null,this.window_size=0,this.prev=null,this.head=null,this.ins_h=0,this.hash_size=0,this.hash_bits=0,this.hash_mask=0,this.hash_shift=0,this.block_start=0,this.match_length=0,this.prev_match=0,this.match_available=0,this.strstart=0,this.match_start=0,this.lookahead=0,this.prev_length=0,this.max_chain_length=0,this.max_lazy_match=0,this.level=0,this.strategy=0,this.good_match=0,this.nice_match=0,this.dyn_ltree=new Uint16Array(ia*2),this.dyn_dtree=new Uint16Array((2*ta+1)*2),this.bl_tree=new Uint16Array((2*na+1)*2),J(this.dyn_ltree),J(this.dyn_dtree),J(this.bl_tree),this.l_desc=null,this.d_desc=null,this.bl_desc=null,this.bl_count=new Uint16Array(ra+1),this.heap=new Uint16Array(2*Rt+1),J(this.heap),this.heap_len=0,this.heap_max=0,this.depth=new 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e.state=f,f.strm=e,f.status=we,f.wrap=o,f.gzhead=null,f.w_bits=i,f.w_size=1<pi(e,n,ut,qr,Jr,Kr),_a=(e,n)=>{if(Me(e)||n>fn||n<0)return e?le(e,G):G;const t=e.state;if(!e.output||e.avail_in!==0&&!e.input||t.status===Se&&n!==L)return le(e,e.avail_out===0?gt:G);const i=t.last_flush;if(t.last_flush=n,t.pending!==0){if(D(e),e.avail_out===0)return t.last_flush=-1,R}else if(e.avail_in===0&&un(n)<=un(i)&&n!==L)return le(e,gt);if(t.status===Se&&e.avail_in!==0)return le(e,gt);if(t.status===we&&t.wrap===0&&(t.status=fe),t.status===we){let r=ut+(t.w_bits-8<<4)<<8,a=-1;if(t.strategy>=We||t.level<2?a=0:t.level<6?a=1:t.level===6?a=2:a=3,r|=a<<6,t.strstart!==0&&(r|=aa),r+=31-r%31,Ce(t,r),t.strstart!==0&&(Ce(t,e.adler>>>16),Ce(t,e.adler&65535)),e.adler=1,t.status=fe,D(e),t.pending!==0)return t.last_flush=-1,R}if(t.status===Gt){if(e.adler=0,T(t,31),T(t,139),T(t,8),t.gzhead)T(t,(t.gzhead.text?1:0)+(t.gzhead.hcrc?2:0)+(t.gzhead.extra?4:0)+(t.gzhead.name?8:0)+(t.gzhead.comment?16:0)),T(t,t.gzhead.time&255),T(t,t.gzhead.time>>8&255),T(t,t.gzhead.time>>16&255),T(t,t.gzhead.time>>24&255),T(t,t.level===9?2:t.strategy>=We||t.level<2?4:0),T(t,t.gzhead.os&255),t.gzhead.extra&&t.gzhead.extra.length&&(T(t,t.gzhead.extra.length&255),T(t,t.gzhead.extra.length>>8&255)),t.gzhead.hcrc&&(e.adler=z(e.adler,t.pending_buf,t.pending,0)),t.gzindex=0,t.status=Bt;else if(T(t,0),T(t,0),T(t,0),T(t,0),T(t,0),T(t,t.level===9?2:t.strategy>=We||t.level<2?4:0),T(t,oa),t.status=fe,D(e),t.pending!==0)return t.last_flush=-1,R}if(t.status===Bt){if(t.gzhead.extra){let r=t.pending,a=(t.gzhead.extra.length&65535)-t.gzindex;for(;t.pending+a>t.pending_buf_size;){let f=t.pending_buf_size-t.pending;if(t.pending_buf.set(t.gzhead.extra.subarray(t.gzindex,t.gzindex+f),t.pending),t.pending=t.pending_buf_size,t.gzhead.hcrc&&t.pending>r&&(e.adler=z(e.adler,t.pending_buf,t.pending-r,r)),t.gzindex+=f,D(e),t.pending!==0)return t.last_flush=-1,R;r=0,a-=f}let o=new Uint8Array(t.gzhead.extra);t.pending_buf.set(o.subarray(t.gzindex,t.gzindex+a),t.pending),t.pending+=a,t.gzhead.hcrc&&t.pending>r&&(e.adler=z(e.adler,t.pending_buf,t.pending-r,r)),t.gzindex=0}t.status=Ut}if(t.status===Ut){if(t.gzhead.name){let r=t.pending,a;do{if(t.pending===t.pending_buf_size){if(t.gzhead.hcrc&&t.pending>r&&(e.adler=z(e.adler,t.pending_buf,t.pending-r,r)),D(e),t.pending!==0)return t.last_flush=-1,R;r=0}t.gzindexr&&(e.adler=z(e.adler,t.pending_buf,t.pending-r,r)),t.gzindex=0}t.status=Dt}if(t.status===Dt){if(t.gzhead.comment){let r=t.pending,a;do{if(t.pending===t.pending_buf_size){if(t.gzhead.hcrc&&t.pending>r&&(e.adler=z(e.adler,t.pending_buf,t.pending-r,r)),D(e),t.pending!==0)return t.last_flush=-1,R;r=0}t.gzindexr&&(e.adler=z(e.adler,t.pending_buf,t.pending-r,r))}t.status=Vt}if(t.status===Vt){if(t.gzhead.hcrc){if(t.pending+2>t.pending_buf_size&&(D(e),t.pending!==0))return t.last_flush=-1,R;T(t,e.adler&255),T(t,e.adler>>8&255),e.adler=0}if(t.status=fe,D(e),t.pending!==0)return t.last_flush=-1,R}if(e.avail_in!==0||t.lookahead!==0||n!==ne&&t.status!==Se){let r=t.level===0?hi(t,n):t.strategy===We?ua(t,n):t.strategy===Gr?la(t,n):xe[t.level].func(t,n);if((r===ue||r===ke)&&(t.status=Se),r===B||r===ue)return e.avail_out===0&&(t.last_flush=-1),R;if(r===ve&&(n===Pr?Fr(t):n!==fn&&(zt(t,0,0,!1),n===Zr&&(J(t.head),t.lookahead===0&&(t.strstart=0,t.block_start=0,t.insert=0))),D(e),e.avail_out===0))return t.last_flush=-1,R}return 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_getMainHeader(n,t=2e3){const{buffer:i}=await this.bbi.read(Q.Buffer.alloc(t),0,t,0,n),r=this._isBigEndian(i),a=Gn(r),o=a.headerParser.parse(i),{magic:f,asOffset:u,totalSummaryOffset:s}=o;if(o.fileType=f===Tt?"bigbed":"bigwig",u>t||s>t)return this._getMainHeader(n,t*2);if(u){const l=Number(o.asOffset);o.autoSql=Is(i.subarray(l,i.indexOf(0,l)))}if(o.totalSummaryOffset>t-8*5)return this._getMainHeader(n,t*2);if(o.totalSummaryOffset){const l=i.subarray(Number(o.totalSummaryOffset)),d=a.totalSummaryParser.parse(l);o.totalSummary={...d,basesCovered:Number(d.basesCovered)}}return{...o,isBigEndian:r}}_isBigEndian(n){let t=n.readInt32LE(0);if(t===jn||t===Tt)return!1;if(t=n.readInt32BE(0),t===jn||t===Tt)return!0;throw new Error("not a BigWig/BigBed file")}async _readChromTree(n,t){const i=n.isBigEndian,r=i?"big":"little",a=[],o={};let f=Number(n.unzoomedDataOffset);const u=Number(n.chromTreeOffset);for(;f%4!==0;)f+=1;const s=f-u,{buffer:l}=await this.bbi.read(Q.Buffer.alloc(s),0,s,Number(u),t),d=Gn(i),{keySize:c}=d.chromTreeParser.parse(l),h=new x().endianess(r).string("key",{stripNull:!0,length:c}).uint32("refId").uint32("refSize").saveOffset("offset"),_=new x().endianess(r).skip(c).uint64("childOffset").saveOffset("offset"),g=32,k=async y=>{let E=y;if(E>=l.length)throw new Error("reading beyond end of buffer");const C=d.isLeafNode.parse(l.subarray(E)),{isLeafNode:p,cnt:$}=C;if(E+=C.offset,p)for(let S=0;S<$;S+=1){const b=h.parse(l.subarray(E));E+=b.offset;const{key:w,refId:m,refSize:v}=b,N={name:w,id:m,length:v};o[this.renameRefSeqs(w)]=m,a[m]=N}else{const S=[];for(let b=0;b<$;b+=1){const w=_.parse(l.subarray(E)),{childOffset:m}=w;E+=w.offset,S.push(k(Number(m)-Number(u)))}await Promise.all(S)}};return await k(g),{refsByName:o,refsByNumber:a}}async getUnzoomedView(n){const{unzoomedIndexOffset:t,refsByName:i,uncompressBufSize:r,isBigEndian:a,fileType:o}=await this.getHeader(n);return new Ti(this.bbi,i,t,a,r>0,o)}async getFeatureStream(n,t,i,r){await this.getHeader(r);const a=this.renameRefSeqs(n);let o;const{basesPerSpan:f,scale:u}=r||{};return f?o=await this.getView(1/f,r):u?o=await this.getView(u,r):o=await this.getView(1,r),new P(s=>{o.readWigData(a,t,i,s,r)})}async getFeatures(n,t,i,r){const a=await this.getFeatureStream(n,t,i,r);return(await qi(a.pipe(Ns()))).flat()}}class Ls extends tr{async getView(n,t){const{zoomLevels:i,refsByName:r,fileSize:a,isBigEndian:o,uncompressBufSize:f}=await this.getHeader(t),u=1/n;let s=i.length;a||(s-=1);for(let l=s;l>=0;l-=1){const d=i[l];if(d&&d.reductionLevel<=2*u){const c=Number(d.indexOffset);return new Ti(this.bbi,r,c,o,f>0,"summary")}}return this.getUnzoomedView(t)}}function Ts(e){return e.filter(n=>!!n)}class Fs extends tr{constructor(){super(...arguments),this.readIndicesCache=new Yn({cache:new Kn({maxSize:1}),fill:(n,t)=>this._readIndices({...n,signal:t})})}readIndices(n={}){const{signal:t,...i}=n;return this.readIndicesCache.get(JSON.stringify(i),n,t)}async getView(n,t){return this.getUnzoomedView(t)}async _readIndices(n){const{extHeaderOffset:t,isBigEndian:i}=await this.getHeader(n),{buffer:r}=await this.bbi.read(Q.Buffer.alloc(64),0,64,Number(t)),a=i?"big":"little",o=new x().endianess(a).uint16("size").uint16("count").uint64("offset").parse(r),{count:f,offset:u}=o;if(f===0)return[];const s=20,l=s*f,{buffer:d}=await this.bbi.read(Q.Buffer.alloc(l),0,l,Number(u)),c=new x().endianess(a).int16("type").int16("fieldcount").uint64("offset").skip(4).int16("field"),h=[];for(let _=0;_{const{offset:f,field:u}=o,{buffer:s}=await this.bbi.read(Q.Buffer.alloc(32),0,32,Number(f),t),l=i?"big":"little",d=new x().endianess(l).int32("magic").int32("blockSize").int32("keySize").int32("valSize").uint64("itemCount"),{blockSize:c,keySize:h,valSize:_}=d.parse(s),g=new x().endianess(l).int8("nodeType").skip(1).int16("cnt").choice({tag:"nodeType",choices:{0:new x().array("leafkeys",{length:"cnt",type:new x().endianess(l).string("key",{length:h,stripNull:!0}).uint64("offset")}),1:new x().array("keys",{length:"cnt",type:new x().endianess(l).string("key",{length:h,stripNull:!0}).uint64("offset").uint32("length").uint32("reserved")})}}),k=async E=>{const C=Number(E),p=4+c*(h+_),{buffer:$}=await this.bbi.read(Q.Buffer.alloc(p),0,p,C,t),S=g.parse($);if(S.leafkeys){let b;for(let w=0;wnew P(u=>{r.readFeatures(u,[f],t)}).pipe(er((u,s)=>u.concat(s)),Ji(u=>{for(const s of u)s.field=f.field;return u})));return(await qi(Cs(...a))).filter(f=>{var u;return((u=f.rest)===null||u===void 0?void 0:u.split(" ")[(f.field||0)-3])===n})}}export{Fs as BigBed,Ls as BigWig}; diff --git a/segmentmodel/assets/index-4e587624.js b/segmentmodel/assets/index-4e587624.js deleted file mode 100644 index 2945652..0000000 --- a/segmentmodel/assets/index-4e587624.js +++ /dev/null @@ -1,3 +0,0 @@ -import{_ as J,L as K}from"./index-d89cadd6.js";import{b as Q}from"./index-462333f7.js";import{L as N}from"./__vite-browser-external-d053bc6e.js";import{u as z,L as G,a as W}from"./long-c1fdf4ae.js";import"./_commonjsHelpers-de833af9.js";function H(a){if(a.greaterThan(Number.MAX_SAFE_INTEGER)||a.lessThan(Number.MIN_SAFE_INTEGER))throw new Error("integer overflow");return a.toNumber()}class Z extends Error{}function L(a){if(a&&a.aborted){if(typeof DOMException<"u")throw new DOMException("aborted","AbortError");{const e=new Z("aborted");throw e.code="ERR_ABORTED",e}}}function ee(a,e){return e.minv.blockPosition-a.maxv.blockPosition<65e3&&e.maxv.blockPosition-a.minv.blockPosition<5e6}function j(a,e){const t=[];let n=null;return a.length===0?a:(a.sort(function(r,i){const o=r.minv.blockPosition-i.minv.blockPosition;return o!==0?o:r.minv.dataPosition-i.minv.dataPosition}),a.forEach(r=>{(!e||r.maxv.compareTo(e)>0)&&(n===null?(t.push(r),n=r):ee(n,r)?r.maxv.compareTo(n.maxv)>0&&(n.maxv=r.maxv):(t.push(r),n=r))}),t)}class ${constructor(e,t){this.blockPosition=e,this.dataPosition=t}toString(){return`${this.blockPosition}:${this.dataPosition}`}compareTo(e){return this.blockPosition-e.blockPosition||this.dataPosition-e.dataPosition}static min(...e){let t,n=0;for(;!t;n+=1)t=e[n];for(;n0&&(t=e[n]);return t}}function v(a,e=0,t=!1){if(t)throw new Error("big-endian virtual file offsets not implemented");return new $(a[e+7]*1099511627776+a[e+6]*4294967296+a[e+5]*16777216+a[e+4]*65536+a[e+3]*256+a[e+2],a[e+1]<<8|a[e])}class P{constructor(e,t,n,r=void 0){this.minv=e,this.maxv=t,this.bin=n,this._fetchedSize=r}toUniqueString(){return`${this.minv}..${this.maxv} (bin ${this.bin}, fetchedSize ${this.fetchedSize()})`}toString(){return this.toUniqueString()}compareTo(e){return this.minv.compareTo(e.minv)||this.maxv.compareTo(e.maxv)||this.bin-e.bin}fetchedSize(){return this._fetchedSize!==void 0?this._fetchedSize:this.maxv.blockPosition+65536-this.minv.blockPosition}}class X{constructor({filehandle:e,renameRefSeqs:t=n=>n}){this.filehandle=e,this.renameRefSeq=t}async getMetadata(e={}){const{indices:t,...n}=await this.parse(e);return n}_findFirstData(e,t){return e?e.compareTo(t)>0?t:e:t}async parse(e={}){return this.parseP||(this.parseP=this._parse(e).catch(t=>{throw this.parseP=void 0,t})),this.parseP}async hasRefSeq(e,t={}){return!!((await this.parse(t)).indices[e]||{}).binIndex}}const te=21578324,O=14;function ne(a,e){return a+=1,e-=1,[[0,0],[1+(a>>26),1+(e>>26)],[9+(a>>23),9+(e>>23)],[73+(a>>20),73+(e>>20)],[585+(a>>17),585+(e>>17)],[4681+(a>>14),4681+(e>>14)]]}class A extends X{async lineCount(e,t={}){const n=await this.parse(t);if(!n)return-1;const r=n.refNameToId[e];if(!n.indices[r])return-1;const{stats:o}=n.indices[r];return o?o.lineCount:-1}async _parse(e={}){const t=await this.filehandle.readFile(e),n=await z(t);if(L(e.signal),n.readUInt32LE(0)!==te)throw new Error("Not a TBI file");const r=n.readInt32LE(4),i=n.readInt32LE(8),o=i&65536?"zero-based-half-open":"1-based-closed",u={0:"generic",1:"SAM",2:"VCF"}[i&15];if(!u)throw new Error(`invalid Tabix preset format flags ${i}`);const c={ref:n.readInt32LE(12),start:n.readInt32LE(16),end:n.readInt32LE(20)},h=n.readInt32LE(24),f=5,l=((1<<(f+1)*3)-1)/7,b=2**(14+f*3),x=h?String.fromCharCode(h):null,w=n.readInt32LE(28),I=n.readInt32LE(32),{refNameToId:m,refIdToName:p}=this._parseNameBytes(n.slice(36,36+I));let d=36+I,g;return{indices:new Array(r).fill(0).map(()=>{const E=n.readInt32LE(d);d+=4;const k={};let R;for(let C=0;Cl+1)throw new Error("tabix index contains too many bins, please use a CSI index");if(y===l+1){const S=n.readInt32LE(d);d+=4,S===2&&(R=this.parsePseudoBin(n,d)),d+=16*S}else{const S=n.readInt32LE(d);d+=4;const M=new Array(S);for(let B=0;B>O>=s.linearIndex.length?s.linearIndex.length-1:t>>O]:new $(0,0))||console.warn("querying outside of possible tabix range");const c=ne(t,n),h=[];for(const[w,I]of c)for(let m=w;m<=I;m++)if(s.binIndex[m]){const p=s.binIndex[m];for(let d=0;d>14,f-1),x=Math.min(n>>14,f-1);for(let w=b;w<=x;++w){const I=s.linearIndex[w];I&&(!l||I.compareTo(l)<0)&&(l=I)}return j(h,l)}}const ie=21582659,re=38359875;function oe(a,e){return a*2**e}function q(a,e){return Math.floor(a/2**e)}class U extends X{constructor(e){super(e),this.maxBinNumber=0,this.depth=0,this.minShift=0}async lineCount(e,t={}){const n=await this.parse(t);if(!n)return-1;const r=n.refNameToId[e];if(!n.indices[r])return-1;const{stats:o}=n.indices[r];return o?o.lineCount:-1}async indexCov(){throw new Error("CSI indexes do not support indexcov")}parseAuxData(e,t){const n=e.readInt32LE(t),r=n&65536?"zero-based-half-open":"1-based-closed",i={0:"generic",1:"SAM",2:"VCF"}[n&15];if(!i)throw new Error(`invalid Tabix preset format flags ${n}`);const o={ref:e.readInt32LE(t+4),start:e.readInt32LE(t+8),end:e.readInt32LE(t+12)},s=e.readInt32LE(t+16),u=s?String.fromCharCode(s):null,c=e.readInt32LE(t+20),h=e.readInt32LE(t+24),{refIdToName:f,refNameToId:l}=this._parseNameBytes(e.slice(t+28,t+28+h));return{refIdToName:f,refNameToId:l,skipLines:c,metaChar:u,columnNumbers:o,format:i,coordinateType:r}}_parseNameBytes(e){let t=0,n=0;const r=[],i={};for(let o=0;o=30?this.parseAuxData(t,16):{refIdToName:[],refNameToId:{},metaChar:null,columnNumbers:{ref:0,start:1,end:2},coordinateType:"zero-based-half-open",format:"generic"},s=t.readInt32LE(16+i);let u,c=16+i+4;const h=new Array(s).fill(0).map(()=>{const f=t.readInt32LE(c);c+=4;const l={};let b;for(let x=0;xthis.maxBinNumber)b=this.parsePseudoBin(t,c+4),c+=4+8+4+16+16;else{const I=v(t,c+4);u=this._findFirstData(u,I);const m=t.readInt32LE(c+12);c+=16;const p=new Array(m);for(let d=0;d2**50&&(t=2**34),t-=1;let n=0,r=0,i=this.minShift+this.depth*3;const o=[];for(;n<=this.depth;i-=3,r+=oe(1,n*3),n+=1){const s=r+q(e,i),u=r+q(t,i);if(u-s+o.length>this.maxBinNumber)throw new Error(`query ${e}-${t} is too large for current binning scheme (shift ${this.minShift}, depth ${this.depth}), try a smaller query or a coarser index binning scheme`);o.push([s,u])}return o}}const D=typeof TextDecoder<"u"?new TextDecoder("utf-8"):void 0;function se(a){return new Promise(e=>setTimeout(e,a))}class he{constructor({path:e,filehandle:t,tbiPath:n,tbiFilehandle:r,csiPath:i,csiFilehandle:o,yieldTime:s=500,chunkSizeLimit:u=5e7,renameRefSeqs:c=f=>f,chunkCacheSize:h=5*2**20}){if(t)this.filehandle=t;else if(e)this.filehandle=new N(e);else throw new TypeError("must provide either filehandle or path");if(r)this.index=new A({filehandle:r,renameRefSeqs:c});else if(o)this.index=new U({filehandle:o,renameRefSeqs:c});else if(n)this.index=new A({filehandle:new N(n),renameRefSeqs:c});else if(i)this.index=new U({filehandle:new N(i),renameRefSeqs:c});else if(e)this.index=new A({filehandle:new N(`${e}.tbi`),renameRefSeqs:c});else throw new TypeError("must provide one of tbiFilehandle, tbiPath, csiFilehandle, or csiPath");this.chunkSizeLimit=u,this.renameRefSeq=c,this.yieldTime=s,this.chunkCache=new J({cache:new K({maxSize:Math.floor(h/65536)}),fill:(f,l)=>this.readChunk(f,{signal:l})})}async getLines(e,t,n,r){let i,o={},s;if(typeof r>"u")throw new TypeError("line callback must be provided");if(typeof r=="function"?s=r:(o=r,s=r.lineCallback),e===void 0)throw new TypeError("must provide a reference sequence name");if(!s)throw new TypeError("line callback must be provided");const u=await this.index.getMetadata(o);if(L(i),t||(t=0),n||(n=u.maxRefLength),!(t<=n))throw new TypeError("invalid start and end coordinates. start must be less than or equal to end");if(t===n)return;const c=await this.index.blocksForRange(e,t,n,o);L(i);for(let f=0;fthis.chunkSizeLimit)throw new Error(`Too much data. Chunk size ${l.toLocaleString()} bytes exceeds chunkSizeLimit of ${this.chunkSizeLimit.toLocaleString()}.`)}let h=Date.now();for(let f=0;f=I[p++];);p--}const{startCoordinate:E,overlaps:k}=this.checkLine(u,e,t,n,T);if(l!==void 0&&E!==void 0&&l>E)throw new Error(`Lines not sorted by start coordinate (${l} > ${E}), this file is not usable with Tabix.`);if(l=E,k)s(T.trim(),w[p]*256+(m-I[p])+b.minv.dataPosition+1);else if(E!==void 0&&E>=n)return;this.yieldTime&&h-Date.now()>this.yieldTime&&(h=Date.now(),L(i),await se(1)),m=d+1}}}async getMetadata(e={}){return this.index.getMetadata(e)}async getHeaderBuffer(e={}){const{firstDataLine:t,metaChar:n,maxBlockSize:r}=await this.getMetadata(e);L(e.signal);const i=((t==null?void 0:t.blockPosition)||0)+r;let o=await this._readRegion(0,i,e);L(e.signal);try{o=await z(o)}catch(s){throw console.error(s),new Error(`error decompressing block ${s.code} at 0 (length ${i}) ${s}`)}if(n){let s=-1;const u=` -`.charCodeAt(0),c=n.charCodeAt(0);for(let h=0;h=r)return{startCoordinate:m,overlaps:!1};if((l===0||l===f)&&m+1<=n)return{startCoordinate:m,overlaps:!1}}else if(c==="VCF"&&x===4)I=i.slice(w,p);else if(x===l){let d;if(c==="VCF"?d=this._getVcfEnd(m,I,i.slice(w,p)):d=parseInt(i.slice(w,p),10),d<=n)return{overlaps:!1}}if(w=p+1,x+=1,x>b)break}return{startCoordinate:m,overlaps:!0}}_getVcfEnd(e,t,n){let r=e+t.length;const i=n.indexOf("SVTYPE=TRA")!==-1;if(n[0]!=="."&&!i){let o=";";for(let s=0;s>lt),r=Number(t&BigInt(4294967295));i?(e.setInt32(n+4,a,i),e.setUint32(n,r,i)):(e.setInt32(n,a,i),e.setUint32(n+4,r,i))}function sr(e,n,t,i){const a=Number(t>>lt),r=Number(t&BigInt(4294967295));i?(e.setUint32(n+4,a,i),e.setUint32(n,r,i)):(e.setUint32(n,a,i),e.setUint32(n+4,r,i))}"getBigInt64"in DataView||(DataView.prototype.getBigInt64=function(e,n){return rr(this,e,n)});"getBigUint64"in DataView||(DataView.prototype.getBigUint64=function(e,n){return ar(this,e,n)});"setBigInt64"in 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+`}pushPath(n){n&&this.scopes[this.scopes.length-1].push(n)}popPath(n){n&&this.scopes[this.scopes.length-1].pop()}pushScope(n){this.scopes.push([n])}popScope(){this.scopes.pop()}addImport(n){if(!this.importPath)return`(${n})`;let t=this.reverseImports.get(n);return t||(t=this.imports.push(n)-1,this.reverseImports.set(n,t)),`${this.importPath}[${t}]`}addReference(n){this.references.has(n)||this.references.set(n,{resolved:!1,requested:!1})}markResolved(n){const t=this.references.get(n);t&&(t.resolved=!0)}markRequested(n){n.forEach(t=>{const i=this.references.get(t);i&&(i.requested=!0)})}getUnresolvedReferences(){return Array.from(this.references).filter(([n,t])=>!t.resolved&&!t.requested).map(([n,t])=>n)}}const Z=new Map,ae="___parser_",M={uint8:1,uint16le:2,uint16be:2,uint32le:4,uint32be:4,int8:1,int16le:2,int16be:2,int32le:4,int32be:4,int64be:8,int64le:8,uint64be:8,uint64le:8,floatle:4,floatbe:4,doublele:8,doublebe:8},Ye={uint8:"Uint8",uint16le:"Uint16",uint16be:"Uint16",uint32le:"Uint32",uint32be:"Uint32",int8:"Int8",int16le:"Int16",int16be:"Int16",int32le:"Int32",int32be:"Int32",int64be:"BigInt64",int64le:"BigInt64",uint64be:"BigUint64",uint64le:"BigUint64",floatle:"Float32",floatbe:"Float32",doublele:"Float64",doublebe:"Float64"},Ke={uint8:!1,uint16le:!0,uint16be:!1,uint32le:!0,uint32be:!1,int8:!1,int16le:!0,int16be:!1,int32le:!0,int32be:!1,int64be:!1,int64le:!0,uint64be:!1,uint64le:!0,floatle:!0,floatbe:!1,doublele:!0,doublebe:!1};class S{constructor(){this.varName="",this.type="",this.options={},this.endian="be",this.useContextVariables=!1}static start(){return new S}primitiveGenerateN(n,t){const i=Ye[n],a=Ke[n];t.pushCode(`${t.generateVariable(this.varName)} = dataView.get${i}(offset, 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this.primitiveN("int32be",n,t)}bigIntVersionCheck(){if(!DataView.prototype.getBigInt64)throw new Error("BigInt64 is unsupported on this runtime")}int64(n,t={}){return this.bigIntVersionCheck(),this.primitiveN(this.useThisEndian("int64"),n,t)}int64be(n,t={}){return this.bigIntVersionCheck(),this.primitiveN("int64be",n,t)}int64le(n,t={}){return this.bigIntVersionCheck(),this.primitiveN("int64le",n,t)}uint64(n,t={}){return this.bigIntVersionCheck(),this.primitiveN(this.useThisEndian("uint64"),n,t)}uint64be(n,t={}){return this.bigIntVersionCheck(),this.primitiveN("uint64be",n,t)}uint64le(n,t={}){return this.bigIntVersionCheck(),this.primitiveN("uint64le",n,t)}floatle(n,t={}){return this.primitiveN("floatle",n,t)}floatbe(n,t={}){return this.primitiveN("floatbe",n,t)}doublele(n,t={}){return this.primitiveN("doublele",n,t)}doublebe(n,t={}){return this.primitiveN("doublebe",n,t)}bitN(n,t,i){return i.length=n,this.setNextParser("bit",t,i)}bit1(n,t={}){return this.bitN(1,n,t)}bit2(n,t={}){return this.bitN(2,n,t)}bit3(n,t={}){return this.bitN(3,n,t)}bit4(n,t={}){return this.bitN(4,n,t)}bit5(n,t={}){return this.bitN(5,n,t)}bit6(n,t={}){return this.bitN(6,n,t)}bit7(n,t={}){return this.bitN(7,n,t)}bit8(n,t={}){return this.bitN(8,n,t)}bit9(n,t={}){return this.bitN(9,n,t)}bit10(n,t={}){return this.bitN(10,n,t)}bit11(n,t={}){return this.bitN(11,n,t)}bit12(n,t={}){return this.bitN(12,n,t)}bit13(n,t={}){return this.bitN(13,n,t)}bit14(n,t={}){return this.bitN(14,n,t)}bit15(n,t={}){return this.bitN(15,n,t)}bit16(n,t={}){return this.bitN(16,n,t)}bit17(n,t={}){return this.bitN(17,n,t)}bit18(n,t={}){return this.bitN(18,n,t)}bit19(n,t={}){return this.bitN(19,n,t)}bit20(n,t={}){return this.bitN(20,n,t)}bit21(n,t={}){return this.bitN(21,n,t)}bit22(n,t={}){return this.bitN(22,n,t)}bit23(n,t={}){return this.bitN(23,n,t)}bit24(n,t={}){return this.bitN(24,n,t)}bit25(n,t={}){return this.bitN(25,n,t)}bit26(n,t={}){return this.bitN(26,n,t)}bit27(n,t={}){return this.bitN(27,n,t)}bit28(n,t={}){return this.bitN(28,n,t)}bit29(n,t={}){return this.bitN(29,n,t)}bit30(n,t={}){return this.bitN(30,n,t)}bit31(n,t={}){return this.bitN(31,n,t)}bit32(n,t={}){return this.bitN(32,n,t)}namely(n){return Z.set(n,this),this.alias=n,this}skip(n,t={}){return this.seek(n,t)}seek(n,t={}){if(t.assert)throw new Error("assert option on seek is not allowed.");return this.setNextParser("seek","",{length:n})}string(n,t){if(!t.zeroTerminated&&!t.length&&!t.greedy)throw new Error("One of length, zeroTerminated, or greedy must be defined for string.");if((t.zeroTerminated||t.length)&&t.greedy)throw new Error("greedy is mutually exclusive with length and zeroTerminated for string.");if(t.stripNull&&!(t.length||t.greedy))throw new Error("length or greedy must be defined if stripNull is enabled.");return t.encoding=t.encoding||"utf8",this.setNextParser("string",n,t)}buffer(n,t){if(!t.length&&!t.readUntil)throw new Error("length or readUntil must be defined for buffer.");return this.setNextParser("buffer",n,t)}wrapped(n,t){if(typeof t!="object"&&typeof n=="object"&&(t=n,n=""),!t||!t.wrapper||!t.type)throw new Error("Both wrapper and type must be defined for wrapped.");if(!t.length&&!t.readUntil)throw new Error("length or readUntil must be defined for wrapped.");return this.setNextParser("wrapper",n,t)}array(n,t){if(!t.readUntil&&!t.length&&!t.lengthInBytes)throw new Error("One of readUntil, length and lengthInBytes must be defined for array.");if(!t.type)throw new Error("type is required for array.");if(typeof t.type=="string"&&!Z.has(t.type)&&!(t.type in M))throw new Error(`Array element type "${t.type}" is unkown.`);return this.setNextParser("array",n,t)}choice(n,t){if(typeof t!="object"&&typeof n=="object"&&(t=n,n=""),!t)throw new Error("tag and choices are are required for choice.");if(!t.tag)throw new Error("tag is requird for choice.");if(!t.choices)throw new Error("choices is required for choice.");for(const i in t.choices){const a=parseInt(i,10),r=t.choices[a];if(isNaN(a))throw new Error(`Choice key "${i}" is not a number.`);if(typeof r=="string"&&!Z.has(r)&&!(r in M))throw new Error(`Choice type "${r}" is unkown.`)}return this.setNextParser("choice",n,t)}nest(n,t){if(typeof t!="object"&&typeof n=="object"&&(t=n,n=""),!t||!t.type)throw new Error("type is required for nest.");if(!(t.type instanceof S)&&!Z.has(t.type))throw new Error("type must be a known parser name or a Parser object.");if(!(t.type instanceof S)&&!n)throw new Error("type must be a Parser object if the variable name is omitted.");return this.setNextParser("nest",n,t)}pointer(n,t){if(!t.offset)throw new Error("offset is required for pointer.");if(!t.type)throw new Error("type is required for pointer.");if(typeof t.type=="string"&&!(t.type in M)&&!Z.has(t.type))throw new Error(`Pointer type "${t.type}" is unkown.`);return this.setNextParser("pointer",n,t)}saveOffset(n,t={}){return this.setNextParser("saveOffset",n,t)}endianness(n){switch(n.toLowerCase()){case"little":this.endian="le";break;case"big":this.endian="be";break;default:throw new Error('endianness must be one of "little" or "big"')}return this}endianess(n){return this.endianness(n)}useContextVars(n=!0){return this.useContextVariables=n,this}create(n){if(!(n instanceof Function))throw new Error("Constructor must be a Function object.");return this.constructorFn=n,this}getContext(n){const t=new fr(n,this.useContextVariables);return t.pushCode("var dataView = new DataView(buffer.buffer, buffer.byteOffset, buffer.length);"),this.alias?(this.addAliasedCode(t),t.pushCode(`return ${ae+this.alias}(0).result;`)):this.addRawCode(t),t}getCode(){const n="imports";return this.getContext(n).code}addRawCode(n){n.pushCode("var offset = 0;"),n.pushCode(`var vars = ${this.constructorFn?"new constructorFn()":"{}"};`),n.pushCode("vars.$parent = null;"),n.pushCode("vars.$root = 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n=NaN;if(Object.keys(M).indexOf(this.type)>=0)n=M[this.type];else if(this.type==="string"&&typeof this.options.length=="number")n=this.options.length;else if(this.type==="buffer"&&typeof this.options.length=="number")n=this.options.length;else if(this.type==="array"&&typeof this.options.length=="number"){let t=NaN;typeof this.options.type=="string"?t=M[this.options.type]:this.options.type instanceof S&&(t=this.options.type.sizeOf()),n=this.options.length*t}else this.type==="seek"?n=this.options.length:this.type==="nest"?n=this.options.type.sizeOf():this.type||(n=0);return this.next&&(n+=this.next.sizeOf()),n}parse(n){return this.compiled||this.compile(),this.compiled(n,this.constructorFn)}setNextParser(n,t,i){const a=new S;return a.type=n,a.varName=t,a.options=i,a.endian=this.endian,this.head?this.head.next=a:this.next=a,this.head=a,this}generate(n){if(this.type){switch(this.type){case"uint8":case"uint16le":case"uint16be":case"uint32le":case"uint32be":case"int8":case"int16le":case"int16be":case"int32le":case"int32be":case"int64be":case"int64le":case"uint64be":case"uint64le":case"floatle":case"floatbe":case"doublele":case"doublebe":this.primitiveGenerateN(this.type,n);break;case"bit":this.generateBit(n);break;case"string":this.generateString(n);break;case"buffer":this.generateBuffer(n);break;case"seek":this.generateSeek(n);break;case"nest":this.generateNest(n);break;case"array":this.generateArray(n);break;case"choice":this.generateChoice(n);break;case"pointer":this.generatePointer(n);break;case"saveOffset":this.generateSaveOffset(n);break;case"wrapper":this.generateWrapper(n);break}this.type!=="bit"&&this.generateAssert(n)}const t=n.generateVariable(this.varName);return this.options.formatter&&this.type!=="bit"&&this.generateFormatter(n,t,this.options.formatter),this.generateNext(n)}generateAssert(n){if(!this.options.assert)return;const t=n.generateVariable(this.varName);switch(typeof this.options.assert){case"function":{const i=n.addImport(this.options.assert);n.pushCode(`if (!${i}.call(vars, ${t})) {`)}break;case"number":n.pushCode(`if (${this.options.assert} !== ${t}) {`);break;case"string":n.pushCode(`if (${JSON.stringify(this.options.assert)} !== ${t}) {`);break;default:throw new Error("assert option must be a string, number or a function.")}n.generateError(`"Assertion error: ${t} is " + ${JSON.stringify(this.options.assert.toString())}`),n.pushCode("}")}generateNext(n){return this.next&&(n=this.next.generate(n)),n}generateBit(n){const t=JSON.parse(JSON.stringify(this));if(t.options=this.options,t.generateAssert=this.generateAssert.bind(this),t.generateFormatter=this.generateFormatter.bind(this),t.varName=n.generateVariable(t.varName),n.bitFields.push(t),!this.next||this.next&&["bit","nest"].indexOf(this.next.type)<0){const i=n.generateTmpVariable();n.pushCode(`var ${i} = 0;`);const a=(l=0)=>{let p=0;for(let c=l;c32)break;p+=h}return p},r=l=>(l<=8?(n.pushCode(`${i} = dataView.getUint8(offset);`),l=8):l<=16?(n.pushCode(`${i} = dataView.getUint16(offset);`),l=16):l<=24?(n.pushCode(`${i} = (dataView.getUint16(offset) << 8) | dataView.getUint8(offset + 2);`),l=24):(n.pushCode(`${i} = dataView.getUint32(offset);`),l=32),n.pushCode(`offset += ${l/8};`),l);let o=0;const f=this.endian==="be";let u=0,s=0;n.bitFields.forEach((l,p)=>{let c=l.options.length;if(c>s){if(s){const g=-1>>>32-s;n.pushCode(`${l.varName} = (${i} & 0x${g.toString(16)}) << ${c-s};`),c-=s}o=0,s=u=r(a(p)-s)}const h=f?u-o-c:o,_=-1>>>32-c;n.pushCode(`${l.varName} ${c> ${h} & 0x${_.toString(16)};`),l.options.length===32&&n.pushCode(`${l.varName} >>>= 0`),l.options.assert&&l.generateAssert(n),l.options.formatter&&l.generateFormatter(n,l.varName,l.options.formatter),o+=c,s-=c}),n.bitFields=[]}}generateSeek(n){const t=n.generateOption(this.options.length);n.pushCode(`offset += ${t};`)}generateString(n){const t=n.generateVariable(this.varName),i=n.generateTmpVariable(),a=this.options.encoding,r=a.toLowerCase()==="hex",o='b => b.toString(16).padStart(2, "0")';if(this.options.length&&this.options.zeroTerminated){const f=this.options.length;n.pushCode(`var ${i} = offset;`),n.pushCode(`while(dataView.getUint8(offset++) !== 0 && offset - ${i} < ${f});`);const u=`offset - ${i} < ${f} ? offset - 1 : offset`;n.pushCode(r?`${t} = Array.from(buffer.subarray(${i}, ${u}), ${o}).join('');`:`${t} = new TextDecoder('${a}').decode(buffer.subarray(${i}, ${u}));`)}else if(this.options.length){const 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i=this.options.readUntil,a=n.generateTmpVariable(),r=n.generateTmpVariable();n.pushCode(`var ${a} = offset;`),n.pushCode(`var ${r} = 0;`),n.pushCode("while (offset < buffer.length) {"),n.pushCode(`${r} = dataView.getUint8(offset);`);const o=n.addImport(i);n.pushCode(`if (${o}.call(${n.generateVariable()}, ${r}, buffer.subarray(offset))) break;`),n.pushCode("offset += 1;"),n.pushCode("}"),n.pushCode(`${t} = buffer.subarray(${a}, offset);`)}else if(this.options.readUntil==="eof")n.pushCode(`${t} = buffer.subarray(offset);`);else{const i=n.generateOption(this.options.length);n.pushCode(`${t} = buffer.subarray(offset, offset + ${i});`),n.pushCode(`offset += ${i};`)}this.options.clone&&n.pushCode(`${t} = buffer.constructor.from(${t});`)}generateArray(n){const t=n.generateOption(this.options.length),i=n.generateOption(this.options.lengthInBytes),a=this.options.type,r=n.generateTmpVariable(),o=n.generateVariable(this.varName),f=n.generateTmpVariable(),u=this.options.key,s=typeof u=="string";if(s?n.pushCode(`${o} = {};`):n.pushCode(`${o} = [];`),typeof this.options.readUntil=="function"?n.pushCode("do {"):this.options.readUntil==="eof"?n.pushCode(`for (var ${r} = 0; offset < buffer.length; ${r}++) {`):i!==void 0?n.pushCode(`for (var ${r} = offset + ${i}; offset < ${r}; ) {`):n.pushCode(`for (var ${r} = ${t}; ${r} > 0; ${r}--) {`),typeof a=="string")if(Z.get(a)){const l=n.generateTmpVariable();if(n.pushCode(`var ${l} = ${ae+a}(offset, {`),n.useContextVariables){const p=n.generateVariable();n.pushCode(`$parent: ${p},`),n.pushCode(`$root: ${p}.$root,`),!this.options.readUntil&&i===void 0&&n.pushCode(`$index: ${t} - ${r},`)}n.pushCode("});"),n.pushCode(`var ${f} = ${l}.result; offset = ${l}.offset;`),a!==this.alias&&n.addReference(a)}else{const l=Ye[a],p=Ke[a];n.pushCode(`var ${f} = dataView.get${l}(offset, ${p});`),n.pushCode(`offset += ${M[a]};`)}else if(a instanceof S){n.pushCode(`var ${f} = {};`);const l=n.generateVariable();n.pushScope(f),n.useContextVariables&&(n.pushCode(`${f}.$parent = ${l};`),n.pushCode(`${f}.$root = ${l}.$root;`),!this.options.readUntil&&i===void 0&&n.pushCode(`${f}.$index = ${t} - ${r};`)),a.generate(n),n.useContextVariables&&(n.pushCode(`delete ${f}.$parent;`),n.pushCode(`delete ${f}.$root;`),n.pushCode(`delete ${f}.$index;`)),n.popScope()}if(s?n.pushCode(`${o}[${f}.${u}] = ${f};`):n.pushCode(`${o}.push(${f});`),n.pushCode("}"),typeof this.options.readUntil=="function"){const l=this.options.readUntil,p=n.addImport(l);n.pushCode(`while (!${p}.call(${n.generateVariable()}, ${f}, buffer.subarray(offset)));`)}}generateChoiceCase(n,t,i){if(typeof i=="string"){const a=n.generateVariable(this.varName);if(Z.has(i)){const r=n.generateTmpVariable();n.pushCode(`var ${r} = ${ae+i}(offset, {`),n.useContextVariables&&(n.pushCode(`$parent: ${a}.$parent,`),n.pushCode(`$root: ${a}.$root,`)),n.pushCode("});"),n.pushCode(`${a} = ${r}.result; offset = ${r}.offset;`),i!==this.alias&&n.addReference(i)}else{const r=Ye[i],o=Ke[i];n.pushCode(`${a} = dataView.get${r}(offset, ${o});`),n.pushCode(`offset += ${M[i]}`)}}else i instanceof S&&(n.pushPath(t),i.generate(n),n.popPath(t))}generateChoice(n){const t=n.generateOption(this.options.tag),i=n.generateVariable(this.varName);if(this.varName&&(n.pushCode(`${i} = {};`),n.useContextVariables)){const a=n.generateVariable();n.pushCode(`${i}.$parent = ${a};`),n.pushCode(`${i}.$root = ${a}.$root;`)}n.pushCode(`switch(${t}) {`);for(const a in this.options.choices){const r=parseInt(a,10),o=this.options.choices[r];n.pushCode(`case ${r}:`),this.generateChoiceCase(n,this.varName,o),n.pushCode("break;")}n.pushCode("default:"),this.options.defaultChoice?this.generateChoiceCase(n,this.varName,this.options.defaultChoice):n.generateError(`"Met undefined tag value " + ${t} + " at choice"`),n.pushCode("}"),this.varName&&n.useContextVariables&&(n.pushCode(`delete ${i}.$parent;`),n.pushCode(`delete 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t,i;for(;;){if(e.lookahead=I&&(e.ins_h=ne(e,e.ins_h,e.window[e.strstart+I-1]),t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),t!==0&&e.strstart-t<=e.w_size-Y&&(e.match_length=ui(e,t)),e.match_length>=I)if(i=ee(e,e.strstart-e.match_start,e.match_length-I),e.lookahead-=e.match_length,e.match_length<=e.max_lazy_match&&e.lookahead>=I){e.match_length--;do e.strstart++,e.ins_h=ne(e,e.ins_h,e.window[e.strstart+I-1]),t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart;while(--e.match_length!==0);e.strstart++}else e.strstart+=e.match_length,e.match_length=0,e.ins_h=e.window[e.strstart],e.ins_h=ne(e,e.ins_h,e.window[e.strstart+1]);else i=ee(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++;if(i&&(V(e,!1),e.strm.avail_out===0))return B}return e.insert=e.strstart{let t,i,a;for(;;){if(e.lookahead=I&&(e.ins_h=ne(e,e.ins_h,e.window[e.strstart+I-1]),t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart),e.prev_length=e.match_length,e.prev_match=e.match_start,e.match_length=I-1,t!==0&&e.prev_length4096)&&(e.match_length=I-1)),e.prev_length>=I&&e.match_length<=e.prev_length){a=e.strstart+e.lookahead-I,i=ee(e,e.strstart-1-e.prev_match,e.prev_length-I),e.lookahead-=e.prev_length-1,e.prev_length-=2;do++e.strstart<=a&&(e.ins_h=ne(e,e.ins_h,e.window[e.strstart+I-1]),t=e.prev[e.strstart&e.w_mask]=e.head[e.ins_h],e.head[e.ins_h]=e.strstart);while(--e.prev_length!==0);if(e.match_available=0,e.match_length=I-1,e.strstart++,i&&(V(e,!1),e.strm.avail_out===0))return B}else if(e.match_available){if(i=ee(e,0,e.window[e.strstart-1]),i&&V(e,!1),e.strstart++,e.lookahead--,e.strm.avail_out===0)return B}else e.match_available=1,e.strstart++,e.lookahead--}return e.match_available&&(i=ee(e,0,e.window[e.strstart-1]),e.match_available=0),e.insert=e.strstart{let t,i,a,r;const o=e.window;for(;;){if(e.lookahead<=Q){if(me(e),e.lookahead<=Q&&n===te)return B;if(e.lookahead===0)break}if(e.match_length=0,e.lookahead>=I&&e.strstart>0&&(a=e.strstart-1,i=o[a],i===o[++a]&&i===o[++a]&&i===o[++a])){r=e.strstart+Q;do;while(i===o[++a]&&i===o[++a]&&i===o[++a]&&i===o[++a]&&i===o[++a]&&i===o[++a]&&i===o[++a]&&i===o[++a]&&ae.lookahead&&(e.match_length=e.lookahead)}if(e.match_length>=I?(t=ee(e,1,e.match_length-I),e.lookahead-=e.match_length,e.strstart+=e.match_length,e.match_length=0):(t=ee(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++),t&&(V(e,!1),e.strm.avail_out===0))return B}return e.insert=0,n===L?(V(e,!0),e.strm.avail_out===0?le:ke):e.sym_next&&(V(e,!1),e.strm.avail_out===0)?B:ve},ua=(e,n)=>{let t;for(;;){if(e.lookahead===0&&(me(e),e.lookahead===0)){if(n===te)return B;break}if(e.match_length=0,t=ee(e,0,e.window[e.strstart]),e.lookahead--,e.strstart++,t&&(V(e,!1),e.strm.avail_out===0))return B}return e.insert=0,n===L?(V(e,!0),e.strm.avail_out===0?le:ke):e.sym_next&&(V(e,!1),e.strm.avail_out===0)?B:ve};function H(e,n,t,i,a){this.good_length=e,this.max_lazy=n,this.nice_length=t,this.max_chain=i,this.func=a}const Ne=[new H(0,0,0,0,hi),new H(4,4,8,4,wt),new H(4,5,16,8,wt),new H(4,6,32,32,wt),new H(4,4,16,16,ce),new H(8,16,32,32,ce),new H(8,16,128,128,ce),new H(8,32,128,256,ce),new H(32,128,258,1024,ce),new H(32,258,258,4096,ce)],ha=e=>{e.window_size=2*e.w_size,q(e.head),e.max_lazy_match=Ne[e.level].max_lazy,e.good_match=Ne[e.level].good_length,e.nice_match=Ne[e.level].nice_length,e.max_chain_length=Ne[e.level].max_chain,e.strstart=0,e.block_start=0,e.lookahead=0,e.insert=0,e.match_length=e.prev_length=I-1,e.match_available=0,e.ins_h=0};function ca(){this.strm=null,this.status=0,this.pending_buf=null,this.pending_buf_size=0,this.pending_out=0,this.pending=0,this.wrap=0,this.gzhead=null,this.gzindex=0,this.method=ut,this.last_flush=-1,this.w_size=0,this.w_bits=0,this.w_mask=0,this.window=null,this.window_size=0,this.prev=null,this.head=null,this.ins_h=0,this.hash_size=0,this.hash_bits=0,this.hash_mask=0,this.hash_shift=0,this.block_start=0,this.match_length=0,this.prev_match=0,this.match_available=0,this.strstart=0,this.match_start=0,this.lookahead=0,this.prev_length=0,this.max_chain_length=0,this.max_lazy_match=0,this.level=0,this.strategy=0,this.good_match=0,this.nice_match=0,this.dyn_ltree=new Uint16Array(ia*2),this.dyn_dtree=new Uint16Array((2*ta+1)*2),this.bl_tree=new Uint16Array((2*na+1)*2),q(this.dyn_ltree),q(this.dyn_dtree),q(this.bl_tree),this.l_desc=null,this.d_desc=null,this.bl_desc=null,this.bl_count=new Uint16Array(ra+1),this.heap=new Uint16Array(2*Rt+1),q(this.heap),this.heap_len=0,this.heap_max=0,this.depth=new 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t.last_flush=-1,R}if(t.status===Gt){if(e.adler=0,T(t,31),T(t,139),T(t,8),t.gzhead)T(t,(t.gzhead.text?1:0)+(t.gzhead.hcrc?2:0)+(t.gzhead.extra?4:0)+(t.gzhead.name?8:0)+(t.gzhead.comment?16:0)),T(t,t.gzhead.time&255),T(t,t.gzhead.time>>8&255),T(t,t.gzhead.time>>16&255),T(t,t.gzhead.time>>24&255),T(t,t.level===9?2:t.strategy>=We||t.level<2?4:0),T(t,t.gzhead.os&255),t.gzhead.extra&&t.gzhead.extra.length&&(T(t,t.gzhead.extra.length&255),T(t,t.gzhead.extra.length>>8&255)),t.gzhead.hcrc&&(e.adler=z(e.adler,t.pending_buf,t.pending,0)),t.gzindex=0,t.status=Bt;else if(T(t,0),T(t,0),T(t,0),T(t,0),T(t,0),T(t,t.level===9?2:t.strategy>=We||t.level<2?4:0),T(t,oa),t.status=se,D(e),t.pending!==0)return t.last_flush=-1,R}if(t.status===Bt){if(t.gzhead.extra){let a=t.pending,r=(t.gzhead.extra.length&65535)-t.gzindex;for(;t.pending+r>t.pending_buf_size;){let f=t.pending_buf_size-t.pending;if(t.pending_buf.set(t.gzhead.extra.subarray(t.gzindex,t.gzindex+f),t.pending),t.pending=t.pending_buf_size,t.gzhead.hcrc&&t.pending>a&&(e.adler=z(e.adler,t.pending_buf,t.pending-a,a)),t.gzindex+=f,D(e),t.pending!==0)return t.last_flush=-1,R;a=0,r-=f}let o=new Uint8Array(t.gzhead.extra);t.pending_buf.set(o.subarray(t.gzindex,t.gzindex+r),t.pending),t.pending+=r,t.gzhead.hcrc&&t.pending>a&&(e.adler=z(e.adler,t.pending_buf,t.pending-a,a)),t.gzindex=0}t.status=Ut}if(t.status===Ut){if(t.gzhead.name){let a=t.pending,r;do{if(t.pending===t.pending_buf_size){if(t.gzhead.hcrc&&t.pending>a&&(e.adler=z(e.adler,t.pending_buf,t.pending-a,a)),D(e),t.pending!==0)return t.last_flush=-1,R;a=0}t.gzindexa&&(e.adler=z(e.adler,t.pending_buf,t.pending-a,a)),t.gzindex=0}t.status=Dt}if(t.status===Dt){if(t.gzhead.comment){let 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Ra(){this.input=null,this.next_in=0,this.avail_in=0,this.total_in=0,this.output=null,this.next_out=0,this.avail_out=0,this.total_out=0,this.msg="",this.state=null,this.data_type=2,this.adler=0}var bi=Ra;const gi=Object.prototype.toString,{Z_NO_FLUSH:Ba,Z_SYNC_FLUSH:Ua,Z_FULL_FLUSH:Da,Z_FINISH:Va,Z_OK:rt,Z_STREAM_END:La,Z_DEFAULT_COMPRESSION:Fa,Z_DEFAULT_STRATEGY:Pa,Z_DEFLATED:Za}=Ze;function Yt(e){this.options=ht.assign({level:Fa,method:Za,chunkSize:16384,windowBits:15,memLevel:8,strategy:Pa},e||{});let n=this.options;n.raw&&n.windowBits>0?n.windowBits=-n.windowBits:n.gzip&&n.windowBits>0&&n.windowBits<16&&(n.windowBits+=16),this.err=0,this.msg="",this.ended=!1,this.chunks=[],this.strm=new bi,this.strm.avail_out=0;let t=Ie.deflateInit2(this.strm,n.level,n.method,n.windowBits,n.memLevel,n.strategy);if(t!==rt)throw new Error(ge[t]);if(n.header&&Ie.deflateSetHeader(this.strm,n.header),n.dictionary){let i;if(typeof 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t.next_out>0&&this.onData(t.output.subarray(0,t.next_out)),a=Ie.deflateEnd(this.strm),this.onEnd(a),this.ended=!0,a===rt;if(t.avail_out===0){this.onData(t.output);continue}if(r>0&&t.next_out>0){this.onData(t.output.subarray(0,t.next_out)),t.avail_out=0;continue}if(t.avail_in===0)break}return!0};Yt.prototype.onData=function(e){this.chunks.push(e)};Yt.prototype.onEnd=function(e){e===rt&&(this.result=ht.flattenChunks(this.chunks)),this.chunks=[],this.err=e,this.msg=this.strm.msg};const Xe=16209,Ma=16191;var Ha=function(n,t){let i,a,r,o,f,u,s,l,p,c,h,_,g,k,m,E,C,d,$,N,b,y,w,v;const x=n.state;i=n.next_in,w=n.input,a=i+(n.avail_in-5),r=n.next_out,v=n.output,o=r-(t-n.avail_out),f=r+(n.avail_out-257),u=x.dmax,s=x.wsize,l=x.whave,p=x.wnext,c=x.window,h=x.hold,_=x.bits,g=x.lencode,k=x.distcode,m=(1<>>24,h>>>=d,_-=d,d=C>>>16&255,d===0)v[r++]=C&65535;else 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Xa=0,wi=1,mi=2,{Z_FINISH:_n,Z_BLOCK:qa,Z_TREES:qe,Z_OK:ue,Z_STREAM_END:Ja,Z_NEED_DICT:Qa,Z_STREAM_ERROR:F,Z_DATA_ERROR:yi,Z_MEM_ERROR:vi,Z_BUF_ERROR:eo,Z_DEFLATED:bn}=Ze,ct=16180,gn=16181,wn=16182,mn=16183,yn=16184,vn=16185,kn=16186,$n=16187,En=16188,Cn=16189,at=16190,K=16191,yt=16192,Sn=16193,vt=16194,Nn=16195,xn=16196,In=16197,Tn=16198,Je=16199,Qe=16200,An=16201,On=16202,zn=16203,Rn=16204,Bn=16205,kt=16206,Un=16207,Dn=16208,A=16209,ki=16210,$i=16211,to=852,no=592,io=15,ro=io,Vn=e=>(e>>>24&255)+(e>>>8&65280)+((e&65280)<<8)+((e&255)<<24);function ao(){this.strm=null,this.mode=0,this.last=!1,this.wrap=0,this.havedict=!1,this.flags=0,this.dmax=0,this.check=0,this.total=0,this.head=null,this.wbits=0,this.wsize=0,this.whave=0,this.wnext=0,this.window=null,this.hold=0,this.bits=0,this.length=0,this.offset=0,this.extra=0,this.lencode=null,this.distcode=null,this.lenbits=0,this.distbits=0,this.ncode=0,this.nlen=0,this.ndist=0,this.have=0,this.next=null,this.lens=new 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F;t=e.state,t.mode===K&&(t.mode=yt),o=e.next_out,a=e.output,u=e.avail_out,r=e.next_in,i=e.input,f=e.avail_in,s=t.hold,l=t.bits,p=f,c=u,y=ue;e:for(;;)switch(t.mode){case ct:if(t.wrap===0){t.mode=yt;break}for(;l<16;){if(f===0)break e;f--,s+=i[r++]<>>8&255,t.check=z(t.check,w,2,0),s=0,l=0,t.mode=gn;break}if(t.head&&(t.head.done=!1),!(t.wrap&1)||(((s&255)<<8)+(s>>8))%31){e.msg="incorrect header check",t.mode=A;break}if((s&15)!==bn){e.msg="unknown compression method",t.mode=A;break}if(s>>>=4,l-=4,b=(s&15)+8,t.wbits===0&&(t.wbits=b),b>15||b>t.wbits){e.msg="invalid window size",t.mode=A;break}t.dmax=1<>8&1),t.flags&512&&t.wrap&4&&(w[0]=s&255,w[1]=s>>>8&255,t.check=z(t.check,w,2,0)),s=0,l=0,t.mode=wn;case wn:for(;l<32;){if(f===0)break e;f--,s+=i[r++]<>>8&255,w[2]=s>>>16&255,w[3]=s>>>24&255,t.check=z(t.check,w,4,0)),s=0,l=0,t.mode=mn;case mn:for(;l<16;){if(f===0)break e;f--,s+=i[r++]<>8),t.flags&512&&t.wrap&4&&(w[0]=s&255,w[1]=s>>>8&255,t.check=z(t.check,w,2,0)),s=0,l=0,t.mode=yn;case 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n.closed=!0,n}(),e}();Xt.EMPTY;function zi(e){return e instanceof Xt||e&&"closed"in e&&O(e.remove)&&O(e.add)&&O(e.unsubscribe)}function Zn(e){O(e)?e():e.unsubscribe()}var Ri={onUnhandledError:null,onStoppedNotification:null,Promise:void 0,useDeprecatedSynchronousErrorHandling:!1,useDeprecatedNextContext:!1},Pt={setTimeout:function(e,n){for(var t=[],i=2;i=2,!1,!0))}var Ns=function(e,n){return e.push(n),e};function xs(){return $e(function(e,n){er(Ns,[])(e).subscribe(n)})}const jn=-2003829722,Tt=-2021002517;function Is(e){return new TextDecoder().decode(e)}function Gn(e){const n=e?"big":"little",t=new S().endianess(n).int32("magic").uint16("version").uint16("numZoomLevels").uint64("chromTreeOffset").uint64("unzoomedDataOffset").uint64("unzoomedIndexOffset").uint16("fieldCount").uint16("definedFieldCount").uint64("asOffset").uint64("totalSummaryOffset").uint32("uncompressBufSize").uint64("extHeaderOffset").array("zoomLevels",{length:"numZoomLevels",type:new S().endianess(n).uint32("reductionLevel").uint32("reserved").uint64("dataOffset").uint64("indexOffset")}),i=new S().endianess(n).uint64("basesCovered").doublele("scoreMin").doublele("scoreMax").doublele("scoreSum").doublele("scoreSumSquares"),a=new S().endianess(n).uint32("magic").uint32("blockSize").uint32("keySize").uint32("valSize").uint64("itemCount"),r=new S().endianess(n).uint8("isLeafNode").skip(1).uint16("cnt").saveOffset("offset");return{chromTreeParser:a,totalSummaryParser:i,headerParser:t,isLeafNode:r}}class tr{getHeader(n){return this.headerP||(this.headerP=this._getHeader(n).catch(t=>{throw this.headerP=void 0,t})),this.headerP}constructor(n){const{filehandle:t,renameRefSeqs:i=o=>o,path:a,url:r}=n;if(this.renameRefSeqs=i,t)this.bbi=t;else if(r)this.bbi=new ir(r);else if(a)this.bbi=new nr(a);else throw new Error("no file given")}async _getHeader(n){const t=await this._getMainHeader(n),i=await this._readChromTree(t,n);return{...t,...i}}async _getMainHeader(n,t=2e3){const{buffer:i}=await this.bbi.read(J.Buffer.alloc(t),0,t,0,n),a=this._isBigEndian(i),r=Gn(a),o=r.headerParser.parse(i),{magic:f,asOffset:u,totalSummaryOffset:s}=o;if(o.fileType=f===Tt?"bigbed":"bigwig",u>t||s>t)return this._getMainHeader(n,t*2);if(u){const l=Number(o.asOffset);o.autoSql=Is(i.subarray(l,i.indexOf(0,l)))}if(o.totalSummaryOffset>t-8*5)return this._getMainHeader(n,t*2);if(o.totalSummaryOffset){const l=i.subarray(Number(o.totalSummaryOffset)),p=r.totalSummaryParser.parse(l);o.totalSummary={...p,basesCovered:Number(p.basesCovered)}}return{...o,isBigEndian:a}}_isBigEndian(n){let t=n.readInt32LE(0);if(t===jn||t===Tt)return!1;if(t=n.readInt32BE(0),t===jn||t===Tt)return!0;throw new Error("not a BigWig/BigBed file")}async _readChromTree(n,t){const i=n.isBigEndian,a=i?"big":"little",r=[],o={};let f=Number(n.unzoomedDataOffset);const u=Number(n.chromTreeOffset);for(;f%4!==0;)f+=1;const s=f-u,{buffer:l}=await this.bbi.read(J.Buffer.alloc(s),0,s,Number(u),t),p=Gn(i),{keySize:c}=p.chromTreeParser.parse(l),h=new S().endianess(a).string("key",{stripNull:!0,length:c}).uint32("refId").uint32("refSize").saveOffset("offset"),_=new S().endianess(a).skip(c).uint64("childOffset").saveOffset("offset"),g=32,k=async m=>{let E=m;if(E>=l.length)throw new Error("reading beyond end of buffer");const C=p.isLeafNode.parse(l.subarray(E)),{isLeafNode:d,cnt:$}=C;if(E+=C.offset,d)for(let N=0;N<$;N+=1){const b=h.parse(l.subarray(E));E+=b.offset;const{key:y,refId:w,refSize:v}=b,x={name:y,id:w,length:v};o[this.renameRefSeqs(y)]=w,r[w]=x}else{const N=[];for(let b=0;b<$;b+=1){const y=_.parse(l.subarray(E)),{childOffset:w}=y;E+=y.offset,N.push(k(Number(w)-Number(u)))}await Promise.all(N)}};return await k(g),{refsByName:o,refsByNumber:r}}async getUnzoomedView(n){const{unzoomedIndexOffset:t,refsByName:i,uncompressBufSize:a,isBigEndian:r,fileType:o}=await this.getHeader(n);return new Ti(this.bbi,i,t,r,a>0,o)}async getFeatureStream(n,t,i,a){await this.getHeader(a);const r=this.renameRefSeqs(n);let o;const{basesPerSpan:f,scale:u}=a||{};return f?o=await this.getView(1/f,a):u?o=await this.getView(u,a):o=await this.getView(1,a),new P(s=>{o.readWigData(r,t,i,s,a).catch(l=>s.error(l))})}async getFeatures(n,t,i,a){const r=await this.getFeatureStream(n,t,i,a);return(await qi(r.pipe(xs()))).flat()}}class Ls extends tr{async getView(n,t){const{zoomLevels:i,refsByName:a,fileSize:r,isBigEndian:o,uncompressBufSize:f}=await this.getHeader(t),u=1/n;let s=i.length;r||(s-=1);for(let l=s;l>=0;l-=1){const p=i[l];if(p&&p.reductionLevel<=2*u){const c=Number(p.indexOffset);return new Ti(this.bbi,a,c,o,f>0,"summary")}}return this.getUnzoomedView(t)}}function Ts(e){return e.filter(n=>!!n)}class Fs extends tr{constructor(){super(...arguments),this.readIndicesCache=new Yn({cache:new Kn({maxSize:1}),fill:(n,t)=>this._readIndices({...n,signal:t})})}readIndices(n={}){const{signal:t,...i}=n;return 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+};`)(this)}else this.pushAll=()=>{for(let e=0;eUh){const e=this.dataUpdaters.map((r,i)=>`const u${i} = that.dataUpdaters[${i}];`).join(` +`),n=this.dataUpdaters.map((r,i)=>` u${i}(datum);`).join(` +`);this.updateFromDatum=new Function("that","datum",`${e} +return function unrolledUpdateFromDatum(datum) { +${n} +};`)(this)}else this.updateFromDatum=e=>{for(let n=0;n{const w=(y-u)/l,v=Math.floor(w);return Gr(x&&v==w?v-1:v,0,t-1)};function p(y,x,w){if(a)return;if(x>s)s=x;else{a=!0,console.debug("Items are not ordered properly. Disabling binned index.");return}const v=n(y);if(vx&&(i[C]=x),c[C]s)s=x;else{a=!0,console.debug("Items (vertices) are not ordered properly. Disabling binned index.");return}const v=n(y),C=r(y);if(vx&&(i[M]=x),c[M]{const v=h(y,!1),C=h(x,!0),S=i[v],E=Math.max(c[C],S);return w[0]=S,w[1]=E,w},g=()=>{if(a)return;for(let x=1;x0;x--)y&&i[x]==zh?(i[x]=c[x],y=!1):i[x-1]>i[x]&&(i[x-1]=i[x]);return m};return p.getIndex=g,d.getIndex=g,n==r?p:d}function FS(){let t=0,e,n=0;const r=new Map,i=s=>(s===e||(n=r.get(s),n===void 0&&(n=t++,r.set(s,n)),e=s),n);return i.addAll=s=>{for(const o of s)i(o)},i.invert=s=>{for(const o of r.entries())if(o[1]==s)return o[0]},i.domain=()=>[...r.keys()],i}class Xs{constructor({encoders:e,numVertices:n=void 0,attributes:r=[]}){this.encoders=e,this.variableEncoders=Object.fromEntries(Object.entries(e).filter(([s,o])=>r.includes(s)&&o&&!o.constant));const i=[..._m(e).entries()].filter(([s,o])=>s[1]&&o.length>1).map(([s,o])=>o);this.allocatedVertices=n,this.variableBuilder=new ES(n);for(const[s,o]of Object.entries(this.variableEncoders)){const a=o.dataAccessor;if(!a)continue;const c=i.find(w=>w.find(v=>v==s));if(c&&s!=c[0])continue;const u=a.asNumberAccessor(),f=o.scale,{largeHp:l,arrayConstructor:h,discrete:p,numComponents:d}=Ys(f,s),m=[0,0];let g;f&&p&&"domain"in f&&(g=FS(),g.addAll(f.domain()));const y=g?w=>g(a(w)):l?w=>Dm(u(w),m):u,x=c?Kl(c):s;this.variableBuilder.addConverter(x,{f:y,numComponents:d,arrayReference:l?m:void 0,targetArrayType:h})}this.lastOffset=0,this.rangeMap=new Mt([],JSON.stringify)}registerBatch(e){var s;const n=this.lastOffset,r=this.variableBuilder.vertexCount,i=r-n;i&&this.rangeMap.set(e,{offset:n,count:i,xIndex:(s=this.xIndexer)==null?void 0:s.getIndex()}),this.lastOffset=r}addBatches(e){for(const[n,r]of e)this.addBatch(n,r)}addBatch(e,n,r=0,i=n.length){this.prepareXIndexer(n,r,i);for(let s=r;s{this.addToXIndex=f=>{},this.xIndexer=void 0},s=(u=this.encoders.x)==null?void 0:u.channelDef;if(!("buildIndex"in s)||!s.buildIndex||!e.length||r-n<0){i();return}const o=f=>{var l;return f&&ue((l=f.scale)==null?void 0:l.type)&&f},a=o(this.variableEncoders.x),c=o(this.variableEncoders.x2);if(a&&!a.constant&&(!c||!c.constant)){const f=a.dataAccessor.asNumberAccessor(),l=c?c.dataAccessor.asNumberAccessor():f,h=[f(e[n]),l(e[r-1])];if(h[1]>h[0]){this.xIndexer=SS(50,h,f,l);let p=this.variableBuilder.vertexCount;this.addToXIndex=d=>{let m=this.variableBuilder.vertexCount;this.xIndexer(d,p,m),p=m}}else i()}else i()}addToXIndex(e){}toArrays(){return{arrays:this.variableBuilder.arrays,vertexCount:this.variableBuilder.vertexCount,allocatedVertices:this.allocatedVertices,rangeMap:this.rangeMap}}}class TS extends Xs{constructor({encoders:e,attributes:n,numItems:r}){super({encoders:e,attributes:n,numVertices:r*6}),this.variableBuilder.configure();const i=this.variableBuilder.pushAll;this.pushAllSixTimes=r>500?new Function("pushAll",`return function unrolledPushAllSixTimes() { + pushAll(); pushAll(); pushAll(); pushAll(); pushAll(); pushAll(); +};`)(i):function(){i(),i(),i(),i(),i(),i()}}addBatch(e,n,r=0,i=n.length){if(!(i<=r)){this.prepareXIndexer(n,r,i);for(let s=r;sc,this.updateVertexCoord=this.variableBuilder.createUpdater("vertexCoord",2),this.updateTextureCoord=this.variableBuilder.createUpdater("textureCoord",2),this.updateWidth=this.variableBuilder.createUpdater("width",1),this.variableBuilder.configure()}addBatch(e,n,r=0,i=n.length){const s=this.properties.align||"left",o=this.properties.logoLetters??!1,a=this.metadata.common.base,c=this.metadata.common.scaleH;let u=-lr;switch(this.properties.baseline){case"top":u+=this.metrics.capHeight;break;case"middle":u+=this.metrics.capHeight/2;break;case"bottom":u-=this.metrics.descent;break}const f=this.encoders.text,l=[0,0];this.updateVertexCoord(l);const h=[0,0];this.updateTextureCoord(h),this.prepareXIndexer(n,r,i);for(let p=r;p0.0){float sd=abs(d)-halfStrokeWidth;return mix(stroke,d<=0.0 ? fill : vec4(0.0),distanceToRatio(sd));}else{return fill*distanceToRatio(-d);}}`,MS="uniform highp float uZero;vec3 getDiscreteColor(sampler2D s,int index){return texelFetch(s,ivec2(index % textureSize(s,0).x,0),0).rgb;}vec3 getInterpolatedColor(sampler2D s,float unitValue){return texture(s,vec2(unitValue,0.0)).rgb;}float clampToRange(float value,vec2 range){return clamp(value,min(range[0],range[1]),max(range[0],range[1]));}float scaleIdentity(float value){return value;}float scaleIdentity(uint value){return float(value);}float scaleLinear(float value,vec2 domain,vec2 range){float domainSpan=domain[1]-domain[0];float rangeSpan=range[1]-range[0];return(value-domain[0])/domainSpan*rangeSpan+range[0];}float scaleLog(float value,vec2 domain,vec2 range,float base){return scaleLinear(log(value)/log(base),log(domain)/log(base),range);}float symlog(float value,float constant){return sign(value)*log(abs(value/constant)+1.0);}float scaleSymlog(float value,vec2 domain,vec2 range,float constant){return scaleLinear(symlog(value,constant),vec2(symlog(domain[0],constant),symlog(domain[1],constant)),range);}float scalePow(float value,vec2 domain,vec2 range,float exponent){return scaleLinear(pow(abs(value),exponent)*sign(value),pow(abs(domain),vec2(exponent))*sign(domain),range);}float scaleBand(uint value,vec2 domainExtent,vec2 range,float paddingInner,float paddingOuter,float align,float band){float start=range[0];float stop=range[1];float rangeSpan=stop-start;float n=domainExtent[1]-domainExtent[0];paddingInner=int(n)>1 ? paddingInner : 0.0;float step=rangeSpan/max(1.0,n-paddingInner+paddingOuter*2.0);start+=(rangeSpan-step*(n-paddingInner))*align;float bandwidth=step*(1.0-paddingInner);return start+(float(value)-domainExtent[0])*step+bandwidth*band;}const int lowBits=12;const float lowDivisor=pow(2.0,float(lowBits));const uint lowMask=uint(lowDivisor-1.0);vec2 splitUint(uint value){uint valueLo=value&lowMask;uint valueHi=value-valueLo;return vec2(float(valueHi),float(valueLo));}/***High precision variant of scaleBand for index/locus scales*/float scaleBandHp(uint value,vec3 domainExtent,vec2 range,float paddingInner,float paddingOuter,float align,float band){float start=range[0];float stop=range[1];float rangeSpan=stop-start;vec2 domainStart=domainExtent.xy;float n=domainExtent[2];float step=rangeSpan/max(1.0,n-paddingInner+paddingOuter*2.0);start+=(rangeSpan-step*(n-paddingInner))*align;float bandwidth=step*(1.0-paddingInner);vec2 splitValue=splitUint(value);float inf=1.0/uZero;float hi=max(splitValue[0]-domainStart[0],-inf);float lo=max(splitValue[1]-domainStart[1],-inf);return dot(vec4(start,hi,lo,bandwidth),vec4(1.0,step,step,band));}/***High precision variant of scaleBand for index/locus scales for large*domains where 32bit uints are not sufficient to represent the domain.*/float scaleBandHp(uvec2 value,vec3 domainExtent,vec2 range,float paddingInner,float paddingOuter,float align,float band){float start=range[0];float stop=range[1];float rangeSpan=stop-start;vec2 domainStart=domainExtent.xy;float n=domainExtent[2];float step=rangeSpan/max(1.0,n-paddingInner+paddingOuter*2.0);start+=(rangeSpan-step*(n-paddingInner))*align;float bandwidth=step*(1.0-paddingInner);vec2 splitValue=vec2(float(value[0])*lowDivisor,float(value[1]));float inf=1.0/uZero;float hi=max(splitValue[0]-domainStart[0],-inf);float lo=max(splitValue[1]-domainStart[1],-inf);return dot(vec4(start,hi,lo,bandwidth),vec4(1.0,step,step,band));}",kS=`/***Describes where a sample facet should be shown. Interpolating between the*current and target positions/heights allows for transitioning between facet*configurations.*/struct SampleFacetPosition{float pos;float height;float targetPos;float targetHeight;};/***Trasition fraction[0,1]between the current and target configurations.*/uniform float uTransitionOffset; +#if !defined(SAMPLE_FACET_UNIFORM) && !defined(SAMPLE_FACET_TEXTURE) +SampleFacetPosition getSampleFacetPos(){return SampleFacetPosition(0.0,1.0,0.0,1.0);} +#elif defined(SAMPLE_FACET_UNIFORM) +/***Location and height of the band on the Y axis on a normalized[0,1]scale.*Elements: curr pos,curr height,target pos,target height*/uniform vec4 uSampleFacet;SampleFacetPosition getSampleFacetPos(){return SampleFacetPosition(1.0-uSampleFacet.x-uSampleFacet.y,uSampleFacet.y,1.0-uSampleFacet.z-uSampleFacet.w,uSampleFacet.w);} +#elif defined(SAMPLE_FACET_TEXTURE) +uniform sampler2D uSampleFacetTexture;SampleFacetPosition getSampleFacetPos(){vec4 texel=texelFetch(uSampleFacetTexture,ivec2(int(attr_facetIndex),0),0);return SampleFacetPosition(1.0-texel.r-texel.g,texel.g,1.0-texel.r-texel.g,texel.g);} +#endif +bool isFacetedSamples(SampleFacetPosition facetPos){return facetPos!=SampleFacetPosition(0.0,1.0,0.0,1.0);}bool isFacetedSamples(){return isFacetedSamples(getSampleFacetPos());}bool isInTransit(){return uTransitionOffset>0.0;}float getTransitionFraction(float xPos){return smoothstep(0.0,0.7+uTransitionOffset,(xPos-uTransitionOffset)*2.0);}vec2 applySampleFacet(vec2 pos){SampleFacetPosition facetPos=getSampleFacetPos();if(!isFacetedSamples(facetPos)){return pos;}else if(isInTransit()){vec2 interpolated=mix(vec2(facetPos.pos,facetPos.height),vec2(facetPos.targetPos,facetPos.targetHeight),getTransitionFraction(pos.x));return vec2(pos.x,interpolated[0]+pos.y*interpolated[1]);}else{return vec2(pos.x,facetPos.pos+pos.y*facetPos.height);}}float getSampleFacetHeight(vec2 pos){SampleFacetPosition facetPos=getSampleFacetPos();if(!isFacetedSamples(facetPos)){return 1.0;}else if(isInTransit()){return mix(facetPos.height,facetPos.targetHeight,getTransitionFraction(pos.x));}else{return facetPos.height;}}`,BS=`/**Based on concepts presented at:*https:*https:*/out highp vec4 vPickingColor;/***Passes the unique id to the fragment shader as a color if picking is enabled.*Returns true if picking is enabled.*/bool setupPicking(){if(uPickingEnabled){ +#ifdef uniqueId_DEFINED +uint id=attr_uniqueId;vPickingColor=vec4(ivec4(id>>0,id>>8,id>>16,id>>24)&0xFF)/float(0xFF); +#else +vPickingColor=vec4(1.0); +#endif +return true;}return false;}`,PS="in highp vec4 vPickingColor;",Eo=Symbol("cacheMap");function tc(t,e,n){let r=Wi(t).get(e);return r===void 0&&(r=n(e),Wi(t).set(e,r)),r}function OS(t,e){Wi(t).delete(e)}function Co(t,e){const n=Wi(t);for(const r of n.keys())r.startsWith(e)&&n.delete(r);Wi(t).delete(e)}function km(t){t[Eo]=new Map}function Wi(t){return t[Eo]||km(t),t[Eo]}function LS(t,e,n,r){const i=H(t)?t:t.name,s=!H(t)&&t.extent||[0,1];if(n===void 0&&!H(t)&&(n=t.count),i){const o=Hl(i);if(je(o)){const a=Bm(o,{extent:s,count:n});return nc(e,{minMag:e.LINEAR,format:e.RGB,height:1,wrap:e.CLAMP_TO_EDGE},a,r)}else{if(he(o))return bu(o,e);throw new Error("Unknown scheme: "+i)}}}function NS(t,e="rgb",n,r){const i=ja(t,H(e)?e:e.type,H(e)?void 0:e.gamma),s=Bm(i);return nc(n,{minMag:n.LINEAR,format:n.RGB,height:1,wrap:n.CLAMP_TO_EDGE},s,r)}function $S(t,e,n,r){const i=Math.max(t.length,n||0),s=new Float32Array(i);for(let o=0;oa/(r-1)).map(a=>i+a/s).map(t);return n&&o.reverse(),Pm(o)}function Pm(t,e){const n=Math.max(t.length,e||0),r=new Uint8Array(n*3);for(let i=0;i({width:void 0,height:void 0})),this._shaderCache=new Map,this.rangeTextures=new WeakMap;const s=document.createElement("canvas");e.appendChild(s);const o=jA(s,{antialias:!0,depth:!1,premultipliedAlpha:!0,...i});if(!o)throw new Error("Unable to initialize WebGL. Your browser or machine may not support it.");if(!qr(o))throw new Error("Your web browser does not support WebGL 2.0. Chrome, Firefox, and Safari Tech Preview should work.");if(ip(o),o.blendFunc(o.ONE,o.ONE_MINUS_SRC_ALPHA),this.canvas=s,this.gl=o,this._pickingAttachmentOptions=[{format:o.RGBA,type:o.UNSIGNED_BYTE,minMag:o.LINEAR,wrap:o.CLAMP_TO_EDGE}],this._pickingBufferInfo=zA(o,this._pickingAttachmentOptions),o.bindFramebuffer(o.FRAMEBUFFER,null),this.adjustGl(),this._updateDpr(),this._clearColor=[0,0,0,0],r){const a=Kt(r).rgb();this._clearColor=[a.r/255,a.g/255,a.b/255,a.opacity]}}invalidateSize(){this._logicalCanvasSize=void 0,this._updateDpr(),this.adjustGl()}_updateDpr(){this.dpr=window.devicePixelRatio}compileShader(e,n){const r="#version 300 es",i="precision mediump float;";he(n)&&(n=n.join(` + +`));const s=this.gl,o=n.replaceAll(/ {2,}|^\s*\/\/.*$/gm,"");let a=this._shaderCache.get(o);if(!a){const c=[r,i,n].join(` + +`);a=s.createShader(e),s.shaderSource(a,c),s.compileShader(a),this._shaderCache.set(o,a)}return a}adjustGl(){const e=this.getLogicalCanvasSize();this.canvas.style.width=`${e.width}px`,this.canvas.style.height=`${e.height}px`;const n=this.getPhysicalCanvasSize(e);this.canvas.width=n.width,this.canvas.height=n.height,VA(this.gl,this._pickingBufferInfo,this._pickingAttachmentOptions)}finalize(){this.canvas.remove()}getPhysicalCanvasSize(e){return e=e||this.getLogicalCanvasSize(),{width:e.width*this.dpr,height:e.height*this.dpr}}getLogicalCanvasSize(){if(this._logicalCanvasSize)return this._logicalCanvasSize;const e=this._sizeSource(),n=window.getComputedStyle(this._container,null),r=e.width??this._container.clientWidth-parseFloat(n.paddingLeft)-parseFloat(n.paddingRight),i=e.height??this._container.clientHeight-parseFloat(n.paddingTop)-parseFloat(n.paddingBottom);return this._logicalCanvasSize={width:r,height:i},this._logicalCanvasSize}readPickingPixel(e,n){const r=this.gl;e*=this.dpr,n*=this.dpr;const i=this.getPhysicalCanvasSize().height,s=new Uint8Array(4);return r.bindFramebuffer(r.FRAMEBUFFER,this._pickingBufferInfo.framebuffer),r.readPixels(e,i-n-1,1,1,r.RGBA,r.UNSIGNED_BYTE,s),r.bindFramebuffer(r.FRAMEBUFFER,null),s}clearAll(){const e=this.gl,{width:n,height:r}=this.getPhysicalCanvasSize();e.viewport(0,0,n,r),e.disable(e.SCISSOR_TEST),e.clearColor(...this._clearColor),e.clear(e.COLOR_BUFFER_BIT)}createRangeTexture(e,n=!1){const r=this.rangeTextures.get(e);if(!n&&r)return;function i(o,a){return Zt(a.type)?a.domain().length:a.type=="threshold"?a.domain().length+1:a.type=="quantize"||a.type=="quantile"?o??4:o}const s=e.channel;if(en(s)){const o=e.scale,a=o.props,c=o.range();let u;if(a.scheme)if(o.type=="threshold"&&c)u=bu(c,this.gl,o.domain().length,r);else{let f=H(a.scheme)?void 0:a.scheme.count;f=i(f,o),u=LS(a.scheme,this.gl,f,r)}else qa(o.type)||ue(o.type)&&c.length>1?u=NS(c,a.interpolate,this.gl,r):u=bu(c,this.gl,o.domain().length,r);this.rangeTextures.set(e,u)}else{const o=e.scale;if(o.type==="ordinal"||Cn(o.type)){const a=ec(s)?Am(s):u=>u,c=o.range();this.rangeTextures.set(e,$S(c.map(a),this.gl,o.domain().length,r))}}}}function zS(t,e="",n=0){const r=/ERROR:\s*\d+:(\d+)/gi,i=[...e.matchAll(r)],s=new Map(i.map((o,a)=>{const c=parseInt(o[1]),u=i[a+1],f=u?u.index:e.length,l=e.substring(o.index,f);return[c-1,l]}));return t.split(` +`).map((o,a)=>{const c=s.get(a);return`${a+1+n}: ${o}${c?` + +^^^ ${c}`:""}`}).join(` +`)}function VS(t,e,n){const r=t.createProgram();t.attachShader(r,e),t.attachShader(r,n),t.linkProgram(r);function i(){let s,o;if(!t.getProgramParameter(r,t.LINK_STATUS)){s=t.getProgramInfoLog(r);for(const c of[e,n])t.getShaderParameter(c,t.COMPILE_STATUS)||(s=t.getShaderInfoLog(c),o=zS(t.getShaderSource(c),s,0)+` +Error compiling: ${s}`,t.deleteShader(c));t.deleteProgram(r)}if(s)return{message:s,detail:o}}return{program:r,getProgramErrors:i}}function nc(t,e,n,r){return r?S0(t,r,n,e):r=Li(t,{...e,src:n}),r}function Gh(...t){const e={get(n,r,i){for(const s of t){const a=s()[r];if(a!==void 0)return a}},has(n,r,i){for(const s of t){const o=s();if(r in o)return!0}return!1}};return new Proxy({},e)}function GS(t){return H(t)||Ce(t)||Ds(t)}class Gn extends Error{constructor(e,n){super(e),this.name="ViewError",this.view=n}}const HS="SAMPLE_FACET_UNIFORM",Hh="SAMPLE_FACET_TEXTURE";var at;class Ks{constructor(e){F(this,at,[]);this.unitView=e,this.encoders=void 0,this.bufferInfo=void 0,this.bytesPerElement=new Map,this.programInfo=void 0,this.vertexArrayInfo=void 0,this.viewUniformInfo=void 0,this.markUniformInfo=void 0,this.markUniformsAltered=!0,this.rangeMap=new WS,this.defaultProperties={get clip(){return["x","y"].map(n=>e.getScaleResolution(n)).some(n=>(n==null?void 0:n.isZoomable())??!1)},xOffset:0,yOffset:0,minBufferSize:0},this.properties=Gh(typeof this.unitView.spec.mark=="object"?()=>this.unitView.spec.mark:()=>({}),()=>this.defaultProperties)}augmentDefaultProperties(e){Object.defineProperties(this.defaultProperties,Object.getOwnPropertyDescriptors(e))}get opaque(){return!1}getAttributes(){throw new Error("Not implemented!")}getSupportedChannels(){return["sample","facetIndex","x","y","color","opacity","search","uniqueId"]}getDefaultEncoding(){const e={sample:void 0,uniqueId:void 0};return this.isPickingParticipant()&&(e.uniqueId={field:Qt}),e}fixEncoding(e){return e}setupExprRefsNeedingGraphicsUpdate(e){const n=this.getSupportedChannels(),r={};for(const s of e){const o=this.properties[s];if(o&&Ee(o)){const a=this.unitView.paramMediator.createExpression(o.expr);a.addListener(()=>{this.updateGraphicsData(),this.unitView.context.animator.requestRender()}),n.includes(s)||Object.defineProperty(r,s,{get(){return a()}})}}const i=this.properties;this.properties=Gh(()=>r,()=>i)}get encoding(){return tc(this,"encoding",()=>{var o;const e=this.getDefaultEncoding(),n=this.unitView.getEncoding(),r=a=>{const c=this.properties[a];return GS(c)||Ee(c)?{value:c}:void 0},i=Object.fromEntries(this.getSupportedChannels().map(a=>[a,r(a)]).filter(a=>Ye(a[1]))),s=this.fixEncoding({...e,...i,...n});for(const a of Object.keys(s))this.getSupportedChannels().includes(a)||delete s[a];return s.x&&((o=s.x).buildIndex??(o.buildIndex=!0)),s})}getContext(){return this.unitView.context}getType(){return this.unitView.getMarkType()}initializeData(){}initializeEncoders(){this.encoders=KC(this.unitView,this.encoding)}async initializeGraphics(){}updateGraphicsData(){}getSampleFacetMode(){if(this.encoders.facetIndex)return Hh;if(this.unitView.getLayoutAncestors().find(e=>"samples"in e.spec))return HS}createAndLinkShaders(e,n,r=[]){const i=this.getAttributes(),s=this.encoders,o=this.getSampleFacetMode();o&&r.push(`#define ${o}`);const a="// view: "+this.unitView.getPathString();let c=[];const u=new Set,f=_m(s),l=[],h=Object.values(s).flatMap(C=>C.accessors).map(C=>C.predicate).filter(C=>C.param),p=new Map;for(const C of h){const S=C.param,E=this.unitView.paramMediator.getValue(S);if(!E)throw new Error(`Cannot infer selection type as the parameter "${S}" has no value. Please ensure that the parameter is properly defined!`);if(pm(E)){if(!p.has(S)){const M=gu+Qa(S);p.set(S,"single"),l.push(" // Selection parameter"),l.push(` uniform highp uint ${M};`),b(this,at).push(()=>{this.registerMarkUniformValue(M,{expr:S},P=>P.uniqueId??0)})}}else throw new Error(`Unsupported selection (${S}) in condition: ${JSON.stringify(E)}`)}const d=(C,S,E,M)=>{const P=S.channelDef;if(Ye(P))if(Ee(P.value)){const{uniformName:O,uniformGlsl:R,accessorGlsl:q,adjuster:J}=fS(C,E);c.push(q),l.push(R),b(this,at).push(()=>{this.registerMarkUniformValue(O,P.value,J)})}else c.push(lS(C,E,P.value).accessorGlsl);else if(Hs(P)){const{uniformName:O,uniformGlsl:R,accessorGlsl:q}=hS(C,M,E);l.push(R),c.push(q);const{largeHp:J,discrete:we}=Ys(M,C),We=we&&"domain"in M?Ae=>M.domain().indexOf(Ae):J?Dm:Ae=>+Ae;b(this,at).push(()=>{this.registerMarkUniformValue(O,P.datum,We)})}else if(pn(P)){const O=f.get([P.field,!0]),{attributeGlsl:R,accessorGlsl:q}=Nh(C,M,E,O!=null&&O.includes(C)?O:void 0);u.add(R),c.push(q)}else if(Ws(P)){const{attributeGlsl:O,accessorGlsl:R}=Nh(C,M,E);u.add(O),c.push(R)}else throw new Gn(`Unsupported channel definition: ${JSON.stringify(P)}`,this.unitView)};for(const[C,S]of Object.entries(s)){if(!i.includes(C))continue;const{channelDef:E,accessors:M,scale:P}=S;for(let O=0;O{const Oe=this.createMarkUniformSetter(Ae),Te=()=>Oe(Im(P,C));R.addEventListener("range",Te),Te()}),J&&b(this,at).push(()=>{const Oe=this.createMarkUniformSetter(we),Te=()=>{const de=Zt(P.type)?[0,P.domain().length]:P.domain();Oe(Tm(P.type)?wS(de):de)};R.addEventListener("domain",Te),Te()})}c.push(pS(C,M))}const m=[...p.entries()].filter(([,C])=>C=="single").map(([C])=>`${gu}${C} == ${qs}uniqueId`);c.push("bool isPointSelected() {",this.encoders.uniqueId&&m.length>0?` return ${m.join(" || ")};`:" return false;","}");const g=`precision highp float; +precision highp int;`,y=C=>C.replace("#pragma markUniforms",l.join(` +`));r=r.map(y),e=y(e),n=y(n);const x=[g,a,...r,Vh,MS,[...u].join(` +`),...c,kS,BS,e],w=[g,a,...r,Vh,PS,n],v=this.gl;this.programStatus=VS(v,this.glHelper.compileShader(v.VERTEX_SHADER,x),this.glHelper.compileShader(v.FRAGMENT_SHADER,w))}finalizeGraphicsInitialization(){const e=this.programStatus.getProgramErrors();if(e){e.detail&&console.warn(e.detail);const n=new Error("Cannot create shader program: "+e.message);throw n.view=this.unitView,n}this.programInfo=EA(this.gl,this.programStatus.program),delete this.programStatus,this.viewUniformInfo=th(this.gl,this.programInfo,"View"),this.markUniformInfo=th(this.gl,this.programInfo,"Mark"),this.gl.useProgram(this.programInfo.program),fr(this.programInfo,{uSampleFacet:[0,1,0,1],uTransitionOffset:0,uZero:0});for(const n of b(this,at))n();k(this,at,void 0)}createMarkUniformSetter(e){const n=this.markUniformInfo.setters[e];if(!n)throw new Error(`Uniform "${e}" not found int the Mark block!`);return r=>{n(r),this.markUniformsAltered=!0,this.unitView.context.animator.requestRender()}}registerMarkUniformValue(e,n,r=i=>i){const i=this.createMarkUniformSetter(e),s=o=>{if(o==null)throw new Error(`Trying to set null/undefined value for uniform: ${e}${Ee(n)?`Expr: ${n.expr}`:""}`);i(o)};if(Ee(n)){const o=this.unitView.paramMediator.createExpression(n.expr),a=()=>s(r(o(null)));o.addListener(a),a()}else s(r(n))}deleteGraphicsData(){const e=this.gl;if(this.vertexArrayInfo&&(this.gl.bindVertexArray(null),e.deleteVertexArray(this.vertexArrayInfo.vertexArrayObject),this.vertexArrayInfo=void 0),this.bufferInfo){for(let n=0;n<8;n++)e.disableVertexAttribArray(n);Object.values(this.bufferInfo.attribs).forEach(n=>this.gl.deleteBuffer(n.buffer)),this.bufferInfo.indices&&this.gl.deleteBuffer(this.bufferInfo.indices),this.bufferInfo=void 0}}updateBufferInfo(e){if(this.gl.bindVertexArray(null),this.bufferInfo&&e.vertexCount<=this.bufferInfo.allocatedVertices)for(const[n,r]of Object.entries(e.arrays))r.data&&Ob(this.gl,this.bufferInfo.attribs[n],r.data,0);else{this.deleteGraphicsData(),this.bufferInfo=$b(this.gl,e.arrays,{numElements:e.vertexCount}),this.bufferInfo.allocatedVertices=e.allocatedVertices;for(const[n,r]of Object.entries(e.arrays))this.bytesPerElement.set(n,r.data.BYTES_PER_ELEMENT)}}get glHelper(){return this.getContext().glHelper}get gl(){return this.glHelper.gl}onBeforeSampleAnimation(){}onAfterSampleAnimation(){}isReady(){return this.bufferInfo&&this.programInfo}isPickingParticipant(){if(this.properties.tooltip===null&&!this.unitView.paramMediator.hasPointSelections())return!1;for(const e of this.unitView.getLayoutAncestors())if(!e.isPickingSupported())return!1;return!0}bindOrSetMarkUniformBlock(){this.markUniformsAltered?(nh(this.gl,this.programInfo,this.markUniformInfo),this.markUniformsAltered=!1):J0(this.gl,this.programInfo,this.markUniformInfo)}prepareRender(e){const n=this.glHelper,r=this.gl,i=[];i.push(()=>{this.vertexArrayInfo||(this.vertexArrayInfo=GA(this.gl,this.programInfo,this.bufferInfo)),r.useProgram(this.programInfo.program)});for(const[o,a]of Object.entries(this.encoding))if(He(a)){const c=He(a)&&a.resolutionChannel||o;if(Hi(c)){const u=this.unitView.getScaleResolution(c),f=n.rangeTextures.get(u);f&&i.push(()=>fr(this.programInfo,{[mu+o]:f}))}}this.getSampleFacetMode()==Hh&&i.push(()=>{let o;for(const a of this.unitView.getLayoutAncestors())if(o=a.getSampleFacetTexture(),o)break;if(!o)throw new Error("No facet texture available. This is bug.");fr(this.programInfo,{uSampleFacetTexture:o})});const s=(e.picking??!1)&&this.isPickingParticipant();return i.push(()=>Ni(this.viewUniformInfo,{uViewOpacity:this.unitView.getEffectiveOpacity(),uPickingEnabled:s})),this.opaque||e.picking?i.push(()=>r.disable(r.BLEND)):i.push(()=>r.enable(r.BLEND)),i}prepareSampleFacetRendering(e){const n=e.sampleFacetRenderingOptions,r=this.programInfo.uniformSetters.uSampleFacet;if(n&&r){const i=n.locSize?n.locSize.location:0,s=n.locSize?n.locSize.size:1;if(i>1||i+s<0)return!1;const o=n.targetLocSize?n.targetLocSize.location:i,a=n.targetLocSize?n.targetLocSize.size:s;this.gl.uniform4f(r.location,i,s,o,a)}return!0}render(e){}createRenderCallback(e,n){var l;if(!this.bufferInfo)return()=>{};const r=this;let i;const s=(l=this.unitView.getScaleResolution("x"))==null?void 0:l.scale,o=s&&ue(s.type),a=["index","locus"].includes(s==null?void 0:s.type)?-1:0,c=[0,0];i=h=>{if(o&&h.xIndex){const p=s.domain(),d=h.xIndex(p[0]+a,p[1],c),m=d[0],g=d[1]-m;g>0&&e(m,g)}else e(h.offset,h.count)};const u=this.rangeMap.get(void 0).count==0?n.facetId:void 0,f=this.rangeMap.get(u);return n.sampleFacetRenderingOptions?function(){f.count&&r.prepareSampleFacetRendering(n)&&i(f)}:function(){f.count&&i(f)}}setViewport(e,n){e=e.flatten();const r=this.unitView.context.devicePixelRatio,i=this.gl,s=this.properties,o=this.glHelper.getLogicalCanvasSize(),a=.5,c=(s.xOffset??0)+a,u=(s.yOffset??0)+a;let f,l=e;if(s.clip!=="never"&&(s.clip||n)){let h=0,p=0,d;if(n){if(l=e.intersect(n).flatten(),!l.isDefined())return!1;d=[e.width/l.width,e.height/l.height],p=Math.max(0,e.y2-n.y2),h=Math.min(0,e.x-n.x)}else d=[1,1];const m=[l.x,o.height-l.y2,l.width,l.height].map(w=>w*r),g=m.map(w=>Math.floor(w)),y=m[0]-g[0],x=m[1]-g[1];i.viewport(...g),i.scissor(...g),i.enable(i.SCISSOR_TEST),f={uViewOffset:[(c+h+y/r)/l.width,-(u+p-x/r)/l.height],uViewScale:d}}else{if(!e.isDefined())return!1;i.viewport(0,0,o.width*r,o.height*r),i.disable(i.SCISSOR_TEST),f={uViewOffset:[(e.x+c)/o.width,(o.height-e.y-u-e.height)/o.height],uViewScale:[e.width/o.width,e.height/o.height]}}return Ni(this.viewUniformInfo,{...f,uViewportSize:[e.width,e.height],uDevicePixelRatio:r}),nh(this.gl,this.programInfo,this.viewUniformInfo),!0}findDatumAt(e,n){}}at=new WeakMap;class WS extends Mt{constructor(){super([],JSON.stringify)}get(e){let n=super.get(e);return n===void 0&&(n={offset:0,count:0,xIndex:void 0},super.set(e,n)),n}migrateEntries(e){for(const[n,r]of this.entries())e.has(n)||(r.offset=0,r.count=0,r.xIndex=void 0);for(const[n,r]of e.entries())Object.assign(this.get(n),r)}}function wu(t,e){const n=rS(e);let r=t[e]&&{...t[e]},i=t[n]&&{...t[n]};if(!(Ye(r)||Ye(i))){if(r){if(!He(t[e]))return;if(i){if(r.type!="quantitative"){const s=(1-(r.band||1))/2;r.band=s,i.band=-s}}else if(r.type=="quantitative")i={datum:0,contributesToScaleDomain:!1};else{i={...r};const s=(1-(r.band??1))/2;r.band=0+s,i.band=1-s}}else r={value:0},i={value:1};t[e]=r,t[n]=i}}function Om(t,e){t.stroke||(e?t.stroke={value:null}:t.stroke={resolutionChannel:"color",...t.color}),Ye(t.stroke)&&t.stroke.value===null&&(t.strokeWidth={value:0}),t.strokeOpacity||(t.strokeOpacity={resolutionChannel:"opacity",...t.opacity})}function Lm(t,e){Ye(t.fill)&&t.fill.value===null?t.fillOpacity={value:0}:t.fill||(t.fill={resolutionChannel:"color",...t.color},!e&&!t.fillOpacity&&(t.fillOpacity={value:0})),t.fillOpacity||(e?t.fillOpacity={resolutionChannel:"opacity",...t.opacity}:t.fillOpacity={value:0})}var Xi,Au,Ki,vu;class qS extends Ks{constructor(n){super(n);F(this,Xi);F(this,Ki);this.augmentDefaultProperties({x2:void 0,y2:void 0,filled:!0,color:"#4c78a8",opacity:1,strokeWidth:3,cornerRadius:0,minWidth:.5,minHeight:.5,minOpacity:1})}getAttributes(){return["uniqueId","facetIndex","x","x2","y","y2","fill","stroke","fillOpacity","strokeOpacity","strokeWidth"]}getSupportedChannels(){return[...super.getSupportedChannels(),"x2","y2","fill","stroke","fillOpacity","strokeOpacity","strokeWidth"]}get opaque(){return tc(this,"opaque",()=>!D(this,Xi,Au).call(this)&&!D(this,Ki,vu).call(this)&&Ye(this.encoding.fillOpacity)&&this.encoding.fillOpacity.value==1&&this.properties.minOpacity==1)&&this.unitView.getEffectiveOpacity()==1}fixEncoding(n){return wu(n,"x"),wu(n,"y"),Om(n,this.properties.filled),Lm(n,this.properties.filled),delete n.color,delete n.opacity,n}onBeforeSampleAnimation(){}onAfterSampleAnimation(){}async initializeGraphics(){await super.initializeGraphics();const n=[];D(this,Xi,Au).call(this)&&n.push("ROUNDED_CORNERS"),D(this,Ki,vu).call(this)&&n.push("STROKED"),this.createAndLinkShaders(YA,XA,[KA,...n.map(r=>"#define "+r)])}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const n=this.properties;this.registerMarkUniformValue("uMinWidth",n.minWidth),this.registerMarkUniformValue("uMinHeight",n.minHeight),this.registerMarkUniformValue("uMinOpacity",n.minOpacity),this.registerMarkUniformValue("uCornerRadiusTopRight",n.cornerRadiusTopRight??n.cornerRadius??0),this.registerMarkUniformValue("uCornerRadiusBottomRight",n.cornerRadiusBottomRight??n.cornerRadius??0),this.registerMarkUniformValue("uCornerRadiusTopLeft",n.cornerRadiusTopLeft??n.cornerRadius??0),this.registerMarkUniformValue("uCornerRadiusBottomLeft",n.cornerRadiusBottomLeft??n.cornerRadius??0)}updateGraphicsData(){const n=this.unitView.getCollector();if(!n){console.debug("No collector");return}const r=n.getItemCount(),i=new TS({encoders:this.encoders,attributes:this.getAttributes(),numItems:r});i.addBatches(n.facetBatches);const s=i.toArrays();this.rangeMap.migrateEntries(s.rangeMap),this.updateBufferInfo(s)}prepareRender(n){const r=super.prepareRender(n);return r.push(()=>this.bindOrSetMarkUniformBlock()),r.push(()=>jn(this.gl,this.programInfo,this.vertexArrayInfo)),r}render(n){const r=this.gl;return this.createRenderCallback((i,s)=>{La(r,this.vertexArrayInfo,r.TRIANGLE_STRIP,s,i)},n)}findDatumAt(n,r){n=Be(n);const i=this.unitView.getCollector().facetBatches.get(n);if(!i)return;const s=this.encoders,o=s.x.scale.type;if(Zt(o)){const a=s.x.dataAccessor;return i.find(c=>r==a(c))}else{const a=s.x.dataAccessor,c=s.x2.dataAccessor;return i.find(u=>r>=a(u)&&r=uSemanticThreshold ? 1.0 : 0.0;}vec2 getDxDy(){ +#if defined(dx_DEFINED) || defined(dy_DEFINED) +return vec2(getScaled_dx(),getScaled_dy())/uViewportSize; +#else +return vec2(0.0,0.0); +#endif +}void main(void){float shapeAngle=0.0;float semanticThresholdFactor=computeSemanticThresholdFactor();if(semanticThresholdFactor<=0.0){gl_PointSize=0.0;gl_Position=vec4(100.0,0.0,0.0,0.0);return;}float size=getScaled_size();vec2 pos=vec2(getScaled_x(),getScaled_y())+getDxDy();gl_Position=unitToNdc(applySampleFacet(pos));float strokeWidth=getScaled_strokeWidth();float diameter=sqrt(size)*uScaleFactor*semanticThresholdFactor;float opacity=uViewOpacity;if(strokeWidth<=0.0||uInwardStroke){float minDiameter=1.0/uDevicePixelRatio;if(diameterTICK_UP&&vShape<=TICK_LEFT){shapeAngle=(vShape-TICK_UP)*90.0;vShape=TICK_UP;}else if(vShape>TRIANGLE_UP&&vShape<=TRIANGLE_LEFT){shapeAngle=(vShape-TRIANGLE_UP)*90.0;vShape=TRIANGLE_UP;}float angleInDegrees=getScaled_angle();float angle=-(shapeAngle+angleInDegrees)*PI/180.0;float sinTheta=sin(angle);float cosTheta=cos(angle);vRotationMatrix=mat2(cosTheta,sinTheta,-sinTheta,cosTheta);float roomForRotation=circle ? 1.0 : sin(mod(angle,PI/2.0)+PI/4.0)/sin(PI/4.0);float aaPadding=1.0/uDevicePixelRatio;float rotationPadding=(diameter*roomForRotation)-diameter;float strokePadding=uInwardStroke ? 0.0 : strokeWidth*(circle ? 1.0 : sqrt(3.0));float padding=rotationPadding+strokePadding+aaPadding;gl_PointSize=max((diameter+padding),uPickingEnabled ? uMinPickingSize : 0.0)*uDevicePixelRatio;vRadius=diameter/2.0;vRadiusWithPadding=vRadius+padding/2.0;vHalfStrokeWidth=strokeWidth/2.0;vFillColor=vec4(getScaled_fill()*fillOpa,fillOpa);vStrokeColor=vec4(getScaled_stroke()*strokeOpa,strokeOpa);setupPicking();}`,YS="const lowp vec4 white=vec4(1.0);const lowp vec4 black=vec4(0.0,0.0,0.0,1.0);in float vRadius;in float vRadiusWithPadding;in lowp vec4 vFillColor;in lowp vec4 vStrokeColor;in lowp float vShape;in lowp float vHalfStrokeWidth;in mat2 vRotationMatrix;out lowp vec4 fragColor;const float CIRCLE=0.0;const float SQUARE=1.0;const float CROSS=2.0;const float DIAMOND=3.0;const float TRIANGLE_UP=4.0;const float TICK_UP=8.0;float circle(vec2 p,float r){return length(p)-r;}float square(vec2 p,float r){p=abs(p);return max(p.x,p.y)-r;}float tickUp(vec2 p,float r){float halfR=r*0.5;p.y+=halfR;p=abs(p);return max(p.x-r*0.15,p.y-halfR);}float equilateralTriangle(vec2 p,float r){p.y=-p.y;float k=sqrt(3.0);float kr=k*r;p.y-=kr/2.0;return max((abs(p.x)*k+p.y)/2.0,-p.y-kr);}float crossShape(vec2 p,float r){p=abs(p);vec2 b=vec2(0.4,1.0)*r;vec2 v=abs(p)-b.xy;vec2 h=abs(p)-b.yx;return min(max(v.x,v.y),max(h.x,h.y));}float diamond(vec2 p,float r){p=abs(p);return(max(abs(p.x-p.y),abs(p.x+p.y))-r)/sqrt(2.0);}void main(){float d;vec2 p=vRotationMatrix*(2.0*gl_PointCoord-1.0)*vRadiusWithPadding;float r=vRadius;if(vShape==CIRCLE){d=circle(p,r);}else if(vShape==SQUARE){d=square(p,r);}else if(vShape==CROSS){d=crossShape(p,r);}else if(vShape==DIAMOND){d=diamond(p,r);}else if(vShape==TRIANGLE_UP){d=equilateralTriangle(p,r);}else if(vShape==TICK_UP){d=tickUp(p,r);}else{d=0.0;}if(!uPickingEnabled){lowp vec4 fillColor=mix(vFillColor,white,-d*uGradientStrength/vRadius);fragColor=distanceToColor(d+(uInwardStroke ? vHalfStrokeWidth : 0.0),fillColor,vStrokeColor,vHalfStrokeWidth);}else if(d-vHalfStrokeWidth<=0.0){fragColor=vPickingColor;}else{discard;}}",XS=`layout(std140)uniform Mark{/***The stroke should only grow inwards,e.g,the diameter/outline is not affected by the stroke width.*Thus,a point that has a zero size has no visible stroke. This allows strokes to be used with*geometric zoom,etc.*/uniform bool uInwardStroke;uniform float uMinPickingSize;uniform mediump float uScaleFactor;uniform mediump float uZoomLevel;uniform highp float uSemanticThreshold;uniform mediump float uGradientStrength; +#pragma markUniforms +};`;class Nm extends Z{constructor(e){super(),this.k=e.size||500,this.reset()}reset(){super.reset(),this.reservoir=[],this.W=void 0,this.ingester=this._initialIngester}_initialIngester(e){this.reservoir.push(e),this.reservoir.length==this.k&&(this.W=Math.exp(Math.log(Math.random())/this.k),this.i=this.k,this.next=this.i,this.ingester=this._finalIngester,this._setNextStop())}_finalIngester(e){++this.i==this.next&&(this.reservoir[Math.floor(Math.random()*this.k)]=e,this.W*=Math.exp(Math.log(Math.random())/this.k),this._setNextStop())}_setNextStop(){this.next+=Math.floor(Math.log(Math.random())/Math.log(1-this.W))+1}handle(e){this.ingester(e)}complete(){for(const e of this.reservoir)this._propagate(e);super.complete()}}function KS(t,e,n){const r=new Nm({type:"sample",size:t});for(const i of e)r.handle(n(i));return r.complete(),r.reservoir}const JS={};var gr,ia,$m;class ZS extends Ks{constructor(n){super(n);F(this,ia);F(this,gr,()=>0);this.augmentDefaultProperties({x:.5,y:.5,color:"#4c78a8",filled:!0,opacity:1,size:100,semanticScore:0,shape:"circle",strokeWidth:2,fillGradientStrength:0,dx:0,dy:0,angle:0,sampleFacetPadding:.1,semanticZoomFraction:.02,minPickingSize:2});const r=this.properties.semanticZoomFraction;if(r!=null)if(Ee(r)){const i=this.unitView.paramMediator.createExpression(r.expr);i.addListener(()=>this.getContext().animator.requestRender()),k(this,gr,i)}else k(this,gr,()=>r)}getAttributes(){return["uniqueId","facetIndex","x","y","size","semanticScore","shape","strokeWidth","dx","dy","fill","stroke","fillOpacity","strokeOpacity","angle"]}getSupportedChannels(){return[...super.getSupportedChannels(),"size","semanticScore","shape","strokeWidth","dx","dy","fill","stroke","fillOpacity","strokeOpacity","angle"]}getDefaultEncoding(){return{...super.getDefaultEncoding(),...JS}}fixEncoding(n){return Om(n,this.properties.filled),Lm(n,this.properties.filled),delete n.color,delete n.opacity,n}initializeData(){var r,i;super.initializeData();const n=(i=(r=this.encoders.semanticScore)==null?void 0:r.dataAccessor)==null?void 0:i.asNumberAccessor();n&&(this.sampledSemanticScores=Float32Array.from(KS(1e4,this.unitView.getCollector().getData(),n)),this.sampledSemanticScores.sort((s,o)=>s-o))}async initializeGraphics(){await super.initializeGraphics(),this.createAndLinkShaders(jS,YS,[XS])}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const n=this.properties;this.registerMarkUniformValue("uInwardStroke",n.inwardStroke,r=>!!r),this.registerMarkUniformValue("uGradientStrength",n.fillGradientStrength),this.registerMarkUniformValue("uMinPickingSize",n.minPickingSize)}updateGraphicsData(){const n=this.unitView.getCollector();if(!n){console.debug("No collector");return}const r=n.getItemCount(),i=new _S({encoders:this.encoders,attributes:this.getAttributes(),numItems:Math.max(r,this.properties.minBufferSize||0)});i.addBatches(n.facetBatches);const s=i.toArrays();this.rangeMap.migrateEntries(s.rangeMap),this.updateBufferInfo(s)}getSemanticThreshold(){if(this.sampledSemanticScores){const n=Math.max(0,1-b(this,gr).call(this)*this.unitView.getZoomLevel());if(n<=0)return-1/0;if(n>=1)return 1/0;{const r=this.sampledSemanticScores;return Ud(r,n)}}else return-1}prepareRender(n){const r=super.prepareRender(n);return r.push(()=>{Ni(this.markUniformInfo,{uScaleFactor:D(this,ia,$m).call(this),uSemanticThreshold:this.getSemanticThreshold()}),this.markUniformsAltered=!0}),r.push(()=>this.bindOrSetMarkUniformBlock()),r.push(()=>jn(this.gl,this.programInfo,this.vertexArrayInfo)),r}render(n){const r=this.gl;return this.createRenderCallback((i,s)=>{s&&La(r,this.vertexArrayInfo,r.POINTS,s,i)},n)}}gr=new WeakMap,ia=new WeakSet,$m=function(){const n=Math.pow(2,this.properties.geometricZoomBound||0);return Math.pow(Math.min(1,this.unitView.getZoomLevel()/n),1/3)};const QS="const int BUTT=0;const int SQUARE=1;const int ROUND=2;in float pos;in float side;out vec4 vColor;out float vSize;out float vNormalLengthInPixels;out highp vec2 vPosInPixels;void main(void){float pixelSize=1.0/uDevicePixelRatio;float size=getScaled_size();float opacity=getScaled_opacity()*uViewOpacity;if(size0.0||uStrokeCap!=BUTT){float len=length(tangent*uViewportSize);float diff=max(0.0,uMinLength-len);if(uStrokeCap!=BUTT){diff+=size;}relativeDiff=diff/len;offset=relativeDiff*(pos-0.5);}vec2 p=pos<1.0? a+tangent*(pos+offset): b+tangent*offset;float aaPadding=pixelSize;vec2 normal=normalize(vec2(-tangent.y,tangent.x)/uViewportSize);p+=normal*side*(size+aaPadding)/uViewportSize;gl_Position=unitToNdc(p);vColor=vec4(getScaled_color()*opacity,opacity);vSize=size;vNormalLengthInPixels=side*(size+aaPadding);vPosInPixels=vec2(pos,(1.0-pos))*(1.0+relativeDiff)*length(tangent*uViewportSize)-vec2(uStrokeCap!=BUTT ? size/2.0 : 0.0);setupPicking();}",e3="const int BUTT=0;const int SQUARE=1;const int ROUND=2;uniform sampler2D uDashTexture;in vec4 vColor;in float vSize;in vec2 vPosInPixels;in float vNormalLengthInPixels;out lowp vec4 fragColor;void main(void){float dpr=uDevicePixelRatio;float distanceFromEnd=-min(vPosInPixels[0],vPosInPixels[1]);float distance;if(distanceFromEnd>0.0&&uStrokeCap==ROUND){distance=length(vec2(distanceFromEnd,vNormalLengthInPixels));}else{distance=abs(vNormalLengthInPixels);}float opacity=clamp(((vSize/2.0-distance)*dpr),-0.5,0.5)+0.5;if(uDashTextureSize>0.0){float pos=(vPosInPixels[0]+uStrokeDashOffset)*dpr;float floored=floor(pos);vec2 texelPositions=(floored+vec2(0.5,1.5))/dpr/uDashTextureSize;opacity*=mix(texture(uDashTexture,vec2(texelPositions[0],0)).r,texture(uDashTexture,vec2(texelPositions[1],0)).r,clamp((pos-floored),0.0,1.0));}fragColor=vColor*opacity;if(uPickingEnabled){fragColor=vPickingColor;}}",t3=`layout(std140)uniform Mark{uniform mediump float uMinLength;uniform mediump float uDashTextureSize;uniform lowp int uStrokeCap;uniform mediump float uStrokeDashOffset; +#pragma markUniforms +};`;class n3 extends Ks{constructor(e){super(e),this.dashTextureSize=0,this.augmentDefaultProperties({x2:void 0,y2:void 0,size:1,color:"black",opacity:1,minLength:0,strokeDash:null,strokeDashOffset:0,strokeCap:"butt"})}getAttributes(){return["uniqueId","facetIndex","x","x2","y","y2","size","color","opacity"]}getSupportedChannels(){return[...super.getSupportedChannels(),"x2","y2","size"]}fixEncoding(e){if(!(e.x&&e.y&&e.x2&&e.y2))if(e.x&&e.x2&&!e.y)e.y={value:.5},e.y2=e.y;else if(e.y&&e.y2&&!e.x)e.x={value:.5},e.x2=e.x;else if(e.x&&!e.y)e.y={value:0},e.y2={value:1},e.x2=e.x;else if(e.y&&!e.x)e.x={value:0},e.x2={value:1},e.y2=e.y;else if(e.x&&e.y&&e.y2)e.x2=e.x;else if(e.y&&e.x&&e.x2)e.y2=e.y;else if(e.y&&e.x)if(!e.x2&&He(e.y)&&e.y.type=="quantitative")e.x2=e.x,e.y2={datum:0};else if(!e.y2&&He(e.x)&&e.x.type=="quantitative")e.y2=e.y,e.x2={datum:0};else throw new Error("A bug!");else throw new Error("Invalid x and y encodings for rule mark: "+JSON.stringify(e));return e}async initializeGraphics(){if(await super.initializeGraphics(),this.properties.strokeDash){const e=this.gl,n=r3(this.properties.strokeDash);this.dashTexture=Li(e,{mag:e.NEAREST,min:e.NEAREST,internalFormat:e.R8,format:e.RED,src:n,height:1}),this.dashTextureSize=n.length}this.createAndLinkShaders(QS,e3,[t3])}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const e=this.properties;this.registerMarkUniformValue("uMinLength",e.minLength),this.registerMarkUniformValue("uStrokeCap",e.strokeCap??"butt",n=>["butt","square","round"].indexOf(n)),Ni(this.markUniformInfo,{uDashTextureSize:+this.dashTextureSize}),this.markUniformsAltered=!0}updateGraphicsData(){const e=this.unitView.getCollector();if(!e){console.debug("No collector");return}const n=e.getItemCount(),r=new DS({encoders:this.encoders,attributes:this.getAttributes(),numItems:Math.max(n,this.properties.minBufferSize||0)});r.addBatches(e.facetBatches);const i=r.toArrays();this.rangeMap.migrateEntries(i.rangeMap),this.updateBufferInfo(i)}prepareRender(e){const n=super.prepareRender(e);return n.push(()=>this.bindOrSetMarkUniformBlock()),this.dashTexture&&n.push(()=>fr(this.programInfo,{uDashTexture:this.dashTexture})),n.push(()=>jn(this.gl,this.programInfo,this.vertexArrayInfo)),n}render(e){const n=this.gl;return this.createRenderCallback((r,i)=>La(n,this.vertexArrayInfo,n.TRIANGLE_STRIP,i,r),e)}}function r3(t){if(t.length==0||t.length%2||t.findIndex(s=>Math.round(s)!=s||s<1||s>1e3)>=0)throw new Error("Invalid stroke dash pattern: "+JSON.stringify(t));const e=t.reduce((s,o)=>s+o),n=new Uint8Array(e);let r=!0,i=0;for(let s of t){for(;s;)n[i++]=r&&255||0,s--;r=!r}return n}const i3="out vec4 vColor;out float vSize;out float vNormalLengthInPixels;out float vGamma;const int SHAPE_ARC=0;const int SHAPE_DOME=1;const int SHAPE_DIAGONAL=2;const int SHAPE_LINE=3;const int ORIENT_VERTICAL=0;const int ORIENT_HORIZONTAL=1;float distanceFromLine(vec2 pointOnLine1,vec2 pointOnLine2,vec2 point){vec2 a=point-pointOnLine1;vec2 b=pointOnLine2-pointOnLine1;vec2 proj=dot(a,b)/dot(b,b)*b;return length(a-proj);}bool isInsideViewport(vec2 point,float marginFactor){vec2 margin=uViewportSize*vec2(marginFactor);return point.x>=-margin.x&&point.x<=uViewportSize.x+margin.x&&point.y>=-margin.y&&point.y<=uViewportSize.y+margin.y;}void main(void){float pixelSize=1.0/uDevicePixelRatio;float opacity=getScaled_opacity()*uViewOpacity;vec2 p1,p2,p3,p4;vec2 a=applySampleFacet(vec2(getScaled_x(),getScaled_y()))*uViewportSize;vec2 b=applySampleFacet(vec2(getScaled_x2(),getScaled_y2()))*uViewportSize;if(uShape<=SHAPE_DOME){if(uShape==SHAPE_DOME){vec2 height=vec2(0.0);if(uOrient==ORIENT_VERTICAL){p1=vec2(min(a.x,b.x),b.y);p4=vec2(max(a.x,b.x),b.y);height=vec2(0.0,a.y-b.y);if(uClampApex){if(p4.x>0.0){p1.x=max(p1.x,-p4.x);}if(p1.x0.0){p1.y=max(p1.y,-p4.y);}if(p1.yuMaxChordLength){if(isInsideViewport(p1,2.0)){chordLength=uMaxChordLength;p4=p1+unitChordVector*uMaxChordLength;}else if(isInsideViewport(p4,2.0)){chordLength=uMaxChordLength;p1=p4-unitChordVector*uMaxChordLength;}}float height=max(chordLength/2.0*uArcHeightFactor,uMinArcHeight);vec2 controlOffset=chordNormal*height/0.75;p2=p1+controlOffset;p3=p4+controlOffset;}}else if(uShape==SHAPE_DIAGONAL){if(uOrient==ORIENT_VERTICAL){p1=a;p2=vec2(a.x,(a.y+b.y)/2.0);p3=vec2(b.x,(a.y+b.y)/2.0);p4=b;}else{p1=a;p2=vec2((a.x+b.x)/2.0,a.y);p3=vec2((a.x+b.x)/2.0,b.y);p4=b;}}else if(uShape==SHAPE_LINE){p1=a;p2=(a+b)/2.0;p3=p2;p4=b;}vec2 strip=vec2(float(gl_VertexID/2)/float(uSegmentBreaks),float(gl_VertexID % 2)-0.5);float t=smoothstep(0.0,1.0,strip.x);vec2 C1=p4-3.0*p3+3.0*p2-p1;vec2 C2=3.0*p3-6.0*p2+3.0*p1;vec2 C3=3.0*p2-3.0*p1;vec2 C4=p1;vec2 p;if(t==0.0){p=p1;}else if(t==1.0){p=p4;}else{p=C1*t*t*t+C2*t*t+C3*t+C4;}vec2 tangent=normalize(3.0*C1*t*t+2.0*C2*t+C3);vec2 normal=vec2(-tangent.y,tangent.x);float size=getScaled_size();if(size0.0&&uArcFadingDistance[1]>0.0&&(!uNoFadingOnPointSelection||!isPointSelected())){float d=distanceFromLine(p1,p4,p);float distanceOpacity=smoothstep(uArcFadingDistance[1],uArcFadingDistance[0],d);opacity*=distanceOpacity;if(distanceOpacity<=0.0){vNormalLengthInPixels=0.0;}}p+=normal*vNormalLengthInPixels;gl_Position=pixelsToNdc(p);vec3 color=getScaled_color();vColor=vec4(color*opacity,opacity);vGamma=getGammaForColor(color);vSize=paddedSize;setupPicking();}",s3="in vec4 vColor;in float vSize;in float vNormalLengthInPixels;in float vGamma;out lowp vec4 fragColor;void main(void){float dpr=uDevicePixelRatio;float distance=abs(vNormalLengthInPixels);float opacity=clamp(((vSize/2.0-distance)*dpr),0.0,1.0);opacity=pow(opacity,vGamma);fragColor=vColor*opacity;if(uPickingEnabled){fragColor=vPickingColor;}}",o3=`layout(std140)uniform Mark{uniform float uArcHeightFactor;uniform float uMinArcHeight;uniform float uMinPickingSize;uniform int uShape;uniform int uOrient;uniform bool uClampApex;uniform float uMaxChordLength;uniform vec2 uArcFadingDistance;uniform bool uNoFadingOnPointSelection;uniform int uSegmentBreaks; +#pragma markUniforms +};`,a3=["arc","dome","diagonal","line"],c3=["vertical","horizontal"];class u3 extends Ks{constructor(e){super(e),this.augmentDefaultProperties({x:0,x2:void 0,y:0,y2:void 0,size:1,color:"black",opacity:1,segments:101,arcHeightFactor:1,minArcHeight:1.5,minPickingSize:3,clampApex:!1,maxChordLength:5e4,arcFadingDistance:!1,noFadingOnPointSelection:!0,linkShape:"arc",orient:"vertical"}),this._baseInstanceExt=this.gl.getExtension("WEBGL_draw_instanced_base_vertex_base_instance")}getAttributes(){return["uniqueId","facetIndex","x","x2","y","y2","size","color","opacity"]}getSupportedChannels(){return[...super.getSupportedChannels(),"x2","y2","size"]}fixEncoding(e){return e.x2||(He(e.x)?e.x2={datum:0}:e.x2=e.x),e.y2||(He(e.y)?e.y2={datum:0}:e.y2=e.y),e}async initializeGraphics(){await super.initializeGraphics(),this.createAndLinkShaders(i3,s3,[o3])}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const e=this.properties;this.registerMarkUniformValue("uArcFadingDistance",e.arcFadingDistance,n=>n||[0,0]),this.registerMarkUniformValue("uArcHeightFactor",e.arcHeightFactor),this.registerMarkUniformValue("uMinArcHeight",e.minArcHeight),this.registerMarkUniformValue("uMinPickingSize",e.minPickingSize),this.registerMarkUniformValue("uShape",e.linkShape,n=>a3.indexOf(n)),this.registerMarkUniformValue("uOrient",e.orient,n=>c3.indexOf(n)),this.registerMarkUniformValue("uClampApex",e.clampApex,n=>!!n),this.registerMarkUniformValue("uMaxChordLength",e.maxChordLength),this.registerMarkUniformValue("uSegmentBreaks",e.segments,n=>n),this.registerMarkUniformValue("uNoFadingOnPointSelection",e.noFadingOnPointSelection,n=>!!n)}updateGraphicsData(){const e=this.unitView.getCollector();if(!e){console.debug("No collector");return}const n=e.getItemCount(),r=new IS({encoders:this.encoders,attributes:this.getAttributes(),numItems:n});r.addBatches(e.facetBatches);const i=r.toArrays();this.rangeMap.migrateEntries(i.rangeMap),this.arrays=Object.fromEntries(Object.entries(i.arrays).map(([s,o])=>[s,{...o,data:void 0}])),this.updateBufferInfo(i)}prepareRender(e){const n=super.prepareRender(e);return n.push(()=>this.bindOrSetMarkUniformBlock()),this._baseInstanceExt?n.push(()=>jn(this.gl,this.programInfo,this.vertexArrayInfo)):n.push(()=>this.gl.bindVertexArray(null)),n}render(e){const n=this.gl,r=()=>(this.markUniformInfo.uniforms.uSegmentBreaks[0]+1)*2;return this._baseInstanceExt?this.createRenderCallback((i,s)=>{this._baseInstanceExt.drawArraysInstancedBaseInstanceWEBGL(n.TRIANGLE_STRIP,0,r(),s,i)},e):this.createRenderCallback((i,s)=>{for(const o of Object.entries(this.bufferInfo.attribs)){const[a,c]=o;c.buffer&&c.numComponents&&c.divisor&&(c.offset=i*this.arrays[a].numComponents*this.bytesPerElement.get(a))}jn(n,this.programInfo,this.bufferInfo),n.drawArraysInstanced(n.TRIANGLE_STRIP,0,r(),s)},e)}}const l3=`in mediump vec2 vertexCoord;in lowp vec2 textureCoord;in float width;out vec2 vTexCoord;out vec4 vColor;out float vSlope;out float vEdgeFadeOpacity;out float vGamma;struct RangeResult{float pos;float scale;};float minValue(vec4 v){return min(min(v.x,v.y),min(v.z,v.w));}float maxValue(vec4 v){return max(max(v.x,v.y),max(v.z,v.w));}/***All measures are in[0,1]*/RangeResult positionInsideRange(float a,float b,float width,float padding,int align,bool flush){float span=b-a;float paddedWidth=width+2.0*padding;if(a>1.0||b<0.0){return RangeResult(0.0,0.0);}float extra=max(0.0,span-paddedWidth);float pos;if(align==0){float centre=a+b;if(flush){float leftOver=max(0.0,paddedWidth-centre);centre+=min(leftOver,extra);float rightOver=max(0.0,paddedWidth+centre-2.0);centre-=min(rightOver,extra);}pos=centre/2.0;}else if(align<0){float edge=a;if(flush){float over=max(0.0,-edge);edge+=min(over,extra);}pos=edge+padding;}else{float edge=b;if(flush){float over=max(0.0,edge-1.0);edge-=min(over,extra);}pos=edge-padding;}float scale=clamp((span-padding)/paddedWidth,0.0,1.0);return RangeResult(pos,scale);}vec2 calculateRotatedDimensions(float width,mat2 rotationMatrix){vec2 a=abs(rotationMatrix*vec2(width/2.0,0.5));vec2 b=abs(rotationMatrix*vec2(width/2.0,-0.5));return vec2(max(a.x,b.x),max(a.y,b.y))*2.0;}ivec2 fixAlignForAngle(ivec2 align,float angleInDegrees){float a=mod(angleInDegrees+45.0,360.0);int x=align.x;int y=-align.y;if(a<90.0){return ivec2(x,y);}else if(a<180.0){return ivec2(y,-x);}else if(a<270.0){return ivec2(-x,y);}else{return ivec2(-y,x);}}void main(void){float opacity=getScaled_opacity()*uViewOpacity;vec2 size=vec2(getScaled_size());float x=getScaled_x();float y=getScaled_y();float scale=1.0;float angleInDegrees=getScaled_angle();float angle=-angleInDegrees*PI/180.0;float sinTheta=sin(angle);float cosTheta=cos(angle);mat2 rotationMatrix=mat2(cosTheta,sinTheta,-sinTheta,cosTheta);vec2 flushSize=calculateRotatedDimensions(width,rotationMatrix); +#if defined(x2_DEFINED) || defined(y2_DEFINED) +ivec2 align=fixAlignForAngle(uAlign,angleInDegrees); +#else +ivec2 align=uAlign; +#endif +#ifdef x2_DEFINED +float x2=getScaled_x2();if(uLogoLetter){size.x=(x2-x)*uViewportSize.x;x+=(x2-x)/2.0;}else{float x2=getScaled_x2();RangeResult result=positionInsideRange(min(x,x2),max(x,x2),size.x*scale*flushSize.x/uViewportSize.x,uPaddingX/uViewportSize.x,align.x,uFlushX);x=result.pos;scale*=result.scale;} +#endif +vec2 pos=applySampleFacet(vec2(x,y)); +#ifdef y2_DEFINED +float y2=getScaled_y2();vec2 pos2=applySampleFacet(vec2(x,y2));if(uLogoLetter){size.y=(pos2.y-pos.y)*uViewportSize.y;pos.y+=(pos2.y-pos.y)/2.0;}else{RangeResult result=positionInsideRange(min(pos.y,pos2.y),max(pos.y,pos2.y),size.y*scale*flushSize.y/uViewportSize.y,uPaddingY/uViewportSize.y,align.y,uFlushY);pos.y=result.pos;scale*=result.scale;} +#endif +if(scale<1.0){if(uSqueeze){vec2 scaleFadeExtent=vec2(3.0,6.0)/size;if(scale-pow(10.0,10.0)){vEdgeFadeOpacity=minValue(((vec4(1.0,1.0,0.0,0.0)+vec4(-1.0,-1.0,1.0,1.0)*unitPos.yxyx)*uViewportSize.yxyx-uViewportEdgeFadeDistance)/uViewportEdgeFadeWidth);}else{vEdgeFadeOpacity=1.0;}setupPicking();}`,f3="uniform sampler2D uTexture;in vec2 vTexCoord;in float vEdgeFadeOpacity;in vec4 vColor;in float vSlope;in float vGamma;out lowp vec4 fragColor;float median(float r,float g,float b){return max(min(r,g),min(max(r,g),b));}void main(){vec3 c=texture(uTexture,vTexCoord).rgb;float sigDist=1.0-median(c.r,c.g,c.b);float slope=uLogoLetter? 0.7/length(vec2(dFdy(sigDist),dFdx(sigDist))): vSlope;float opa=clamp((sigDist-0.5)*slope+0.5,0.0,1.0);opa*=clamp(vEdgeFadeOpacity,0.0,1.0);opa=pow(opa,vGamma);fragColor=vColor*opa;if(uPickingEnabled){fragColor=vPickingColor;}}",h3=`layout(std140)uniform Mark{uniform mediump float uSdfNumerator;uniform mediump vec2 uD;uniform mediump vec4 uViewportEdgeFadeWidth;uniform mediump vec4 uViewportEdgeFadeDistance;uniform bool uSqueeze;uniform bool uLogoLetter;uniform lowp ivec2 uAlign;uniform mediump float uPaddingX;uniform bool uFlushX;uniform mediump float uPaddingY;uniform bool uFlushY; +#pragma markUniforms +};`,d3={left:-1,center:0,right:1},p3={top:-1,middle:0,bottom:1,alphabetic:1};class m3 extends Ks{constructor(e){super(e),this.augmentDefaultProperties({x:.5,y:.5,x2:void 0,y2:void 0,text:"",size:11,color:"black",opacity:1,font:void 0,fontStyle:void 0,fontWeight:void 0,align:"center",baseline:"middle",dx:0,dy:0,angle:0,fitToBand:!1,squeeze:!0,paddingX:0,paddingY:0,flushX:!0,flushY:!0,logoLetters:!1,viewportEdgeFadeWidthTop:0,viewportEdgeFadeWidthRight:0,viewportEdgeFadeWidthBottom:0,viewportEdgeFadeWidthLeft:0,viewportEdgeFadeDistanceTop:-1/0,viewportEdgeFadeDistanceRight:-1/0,viewportEdgeFadeDistanceBottom:-1/0,viewportEdgeFadeDistanceLeft:-1/0}),this.font=this.properties.font?e.context.fontManager.getFont(this.properties.font,this.properties.fontStyle,this.properties.fontWeight):e.context.fontManager.getDefaultFont(),this.setupExprRefsNeedingGraphicsUpdate(["text","fitToBand","logoLetters"])}getAttributes(){return["uniqueId","facetIndex","x","x2","y","y2","color","size","opacity","angle"]}getSupportedChannels(){return[...super.getSupportedChannels(),"x2","y2","size","text","angle"]}fixEncoding(e){for(const n of Kr)this.properties.fitToBand&&wu(e,n);return e}async initializeGraphics(){await super.initializeGraphics(),this.createAndLinkShaders(l3,f3,[h3])}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const e=this.properties;this.registerMarkUniformValue("uSdfNumerator",{expr:"devicePixelRatio"},n=>{let r=.35;return this.properties.logoLetters&&(r/=2),this.font.metrics.common.base/(n/r)}),this.registerMarkUniformValue("uPaddingX",e.paddingX),this.registerMarkUniformValue("uPaddingY",e.paddingY),this.registerMarkUniformValue("uFlushX",e.flushX,n=>!!n),this.registerMarkUniformValue("uFlushY",e.flushY,n=>!!n),this.registerMarkUniformValue("uSqueeze",e.squeeze,n=>!!n),Ni(this.markUniformInfo,{uAlign:[d3[e.align],p3[e.baseline]],uD:[e.dx,-e.dy],uLogoLetter:!!e.logoLetters,uViewportEdgeFadeWidth:[e.viewportEdgeFadeWidthTop,e.viewportEdgeFadeWidthRight,e.viewportEdgeFadeWidthBottom,e.viewportEdgeFadeWidthLeft],uViewportEdgeFadeDistance:[e.viewportEdgeFadeDistanceTop,e.viewportEdgeFadeDistanceRight,e.viewportEdgeFadeDistanceBottom,e.viewportEdgeFadeDistanceLeft]})}updateGraphicsData(){const e=this.unitView.getCollector();if(!e){console.debug("No collector");return}const n=e.getData(),r=this.encoding,i=this.encoders.text;let s=0;const o="format"in r.text?fe(r.text.format):u=>u;for(const u of n){const f=o(i(u)),l=H(f)?f:f===null?"":""+f;s+=l&&l.length||0}const a=new RS({encoders:this.encoders,attributes:this.getAttributes(),properties:this.properties,fontMetrics:this.font.metrics,numCharacters:Math.max(s,this.properties.minBufferSize||1024)});a.addBatches(e.facetBatches);const c=a.toArrays();this.rangeMap.migrateEntries(c.rangeMap),this.updateBufferInfo(c)}prepareRender(e){const n=super.prepareRender(e);return n.push(()=>{fr(this.programInfo,{uTexture:this.font.texture})}),n.push(()=>this.bindOrSetMarkUniformBlock()),n.push(()=>jn(this.gl,this.programInfo,this.vertexArrayInfo)),n}render(e){const n=this.gl;return this.createRenderCallback((r,i)=>La(n,this.vertexArrayInfo,n.TRIANGLES,i,r),e)}}const Wh=1;function Jl(){let t=[0,1],e=[0,1],n=1,r=1,i=0,s=0,o=.5,a=0;const u=f=>(f+o-t[0])/n*r+e[0];return u.invert=f=>(f-e[0])/r*n+t[0]-o,u.domain=function(f){if(arguments.length){t=ny(f),n=t[1]-t[0];const l=t[0]===0&&t[0]===0;if(nr/n,u.bandwidth=()=>u.step(),u.ticks=f=>{const l=u.align(),h=u.numberingOffset();return Bo(t[0]-l+h,t[1]-l+h,Math.min(f,Math.ceil(n))).filter(Number.isInteger).map(p=>p-a)},u.tickFormat=(f,l)=>{if(l)throw new Error("Index scale's tickFormat does not support a specifier!");const p=qt(t[0],t[1],Math.min(f,Math.ceil(n)))<1e5?fe(","):fe(".3s");return d=>p(d+a)},u.copy=()=>Jl().domain(t).range(e).paddingInner(i).paddingOuter(s).numberingOffset(a),u}function g3(){const t=Jl().numberingOffset(1);let e;t.genome=function(r){return arguments.length?(e=r,t):e},t.ticks=r=>{if(!e)return[];const i=t.domain(),s=t.numberingOffset(),[o,a]=[Math.max(i[0],0),Math.min(i[1],e.totalSize-1)].map(f=>e.toChromosome(f)),c=Math.max(1,qt(i[0],i[1],r)),u=[];for(let f=o.index;f<=a.index;f++){const l=e.chromosomes[f],h=Math.max(l.continuousStart+c,i[0]-(i[0]-l.continuousStart)%c),p=Math.min(l.continuousEnd-c/4,i[1]+1);for(let d=h;d<=p;d+=c){const m=d-s;m>=i[0]&&m{if(!e)return;if(i)throw new Error("Locus scale's tickFormat does not support a specifier!");const s=t.domain(),o=s[1]-s[0],a=t.numberingOffset(),u=qt(s[0],s[1],Math.min(r,Math.ceil(o)))<1e6?fe(","):fe(".3s"),f=l=>l-e.toChromosome(l).continuousStart;return l=>u(f(l)+a)};const n=t.copy;return t.copy=()=>n().genome(e),t}function y3(t){return t.type=="locus"}function Xo(t,e,n){if(n=n||[],t.some(o=>o===null)){if(t.every(o=>o===null))return null;throw console.warn(t),new Error("Cannot merge objects with nulls!")}const r={},i=(o,a)=>o===a||ar(o)&&ar(a)||ar(o)&&a===!0||o===!0&&be(a),s=o=>{for(let a in o){const c=o[a];if(!n.includes(a)&&c!==void 0)if(r[a]!==void 0&&!i(r[a],c))console.warn(`Conflicting property ${a} of ${e}: (${JSON.stringify(r[a])} and ${JSON.stringify(o[a])}). Using ${JSON.stringify(r[a])}.`);else{const u=r[a];if(ar(u))ar(c)&&(r[a]=Xo([u,c],a));else if(ar(c)){if(!(u===!0||u===void 0))throw new Error("Bug in merge! Target is: "+u);r[a]=Xo([{},c],a)}else r[a]=c}}};for(const o of t)s(o);return r}function ar(t){return be(t)&&!Array.isArray(t)}/*! + * Adapted from vega-encode: + * https://github.com/vega/vega/blob/master/packages/vega-encode/src/ticks.js + * + * Copyright (c) 2015-2018, University of Washington Interactive Data Lab + * All rights reserved. + * + * BSD-3-Clause License: https://github.com/vega/vega-lite/blob/master/LICENSE + */function Um(t,e,n){return Ce(e)&&n!=null&&(e=Math.min(e,~~(Ro(t.domain())/n)||1)),be(e)&&(e.step,e=e.interval),e}function zm(t,e,n){var r=t.range(),i=Math.floor(r[0]),s=Math.ceil(nt(r));if(i>s&&(r=s,s=i,i=r),e=e.filter(function(a){return a=t(a),i<=a&&a<=s}),n>0&&e.length>1){for(var o=[e[0],nt(e)];e.length>n&&e.length>=3;)e=e.filter(function(a,c){return!(c%2)});e.length<3&&(e=o)}return e}function x3(t,e){return t.bins?zm(t,b3(t.bins,e)):t.ticks?t.ticks(e):t.domain()}function b3(t,e){var n=t.length,r=~~(n/(e||n));return r<2?t.slice():t.filter(function(i,s){return!(s%r)})}function w3(t,e,n){var r=t.tickFormat?t.tickFormat(e,n):n?fe(n):String;if(Qp(t.type)){var i=v3(n);r=t.bins?i:A3(r,i)}return r}function A3(t,e){return function(n){return t(n)?e(n):""}}function v3(t){var e=jt(t||",");if(e.precision==null){switch(e.precision=12,e.type){case"%":e.precision-=2;break;case"e":e.precision-=1;break}return E3(fe(e),fe(".1f")(1)[1])}else return fe(e)}function E3(t,e){return function(n){var r=t(n),i=r.indexOf(e),s,o;if(i<0)return r;for(s=C3(r,i),o=si;)if(r[s]!=="0"){++s;break}return r.slice(0,s)+o}}function C3(t,e){var n=t.lastIndexOf("e"),r;if(n>0)return n;for(n=t.length;--n>e;)if(r=t.charCodeAt(n),r>=48&&r<=57)return n+1}/*! + * Adapted from vega-encode: + * https://github.com/vega/vega/blob/master/packages/vega-encode/src/Scale.js + * + * Copyright (c) 2015-2018, University of Washington Interactive Data Lab + * All rights reserved. + * + * BSD-3-Clause License: https://github.com/vega/vega-lite/blob/master/LICENSE + */const S3="locus",F3="index";var T3=5;function D3(t){const e=t.type;return!t.bins&&(e===Vr||e===Os||e===Ls)}function Vm(t){return ue(t)&&![ht,F3,S3].includes(t)}function Gm(t){return t||{warn:(e,...n)=>console.warn(e,...n)}}var _3=Mo(["set","modified","clear","type","scheme","schemeExtent","schemeCount","domain","domainMin","domainMid","domainMax","domainRaw","domainImplicit","nice","zero","bins","range","rangeStep","round","reverse","interpolate","interpolateGamma","zoom","fp64","name"]);function Hm(t,e,n){n=Gm(n);for(const r in t)if(!_3[r]){if(r==="padding"&&Vm(e.type))continue;je(e[r])?e[r](t[r]):n.warn("Unsupported scale property: "+r)}L3(e,t,O3(e,t,k3(e,t,n)))}function I3(t,e){const n=R3(t),r=V(n);if(!r)throw new Error("Unknown scale type: "+n);const i=r();return!t.domain&&ue(i.type)&&(t.domain=[0,0]),Hm(t,i,e),i}function R3(t){var e=t.type,n="",r;return e===ht?ht+"-"+Vr:(M3(t)&&(r=t.rawDomain?t.rawDomain.length:t.domain?t.domain.length+ +(t.domainMid!=null):0,n=r===2?ht+"-":r===3?Xr+"-":""),(n+e||Vr).toLowerCase())}function M3(t){const e=t.type;return ue(e)&&e!==Wp&&e!==qp&&(t.scheme||t.range&&t.range.length&&t.range.every(H))}function k3(t,e,n){if(!t.domain)return 0;n=Gm(n);var r=B3(t,e.domainRaw,n);if(r>-1)return r;var i=e.domain,s=t.type,o=e.zero||e.zero===void 0&&D3(t),a,c;return i?(Vm(s)&&e.padding&&i[0]!==nt(i)&&(i=P3(s,i,e.range,e.padding,e.exponent,e.constant)),(o||e.domainMin!=null||e.domainMax!=null||e.domainMid!=null)&&(a=(i=i.slice()).length-1||1,o&&(i[0]>0&&(i[0]=0),i[a]<0&&(i[a]=0)),e.domainMin!=null&&(i[0]=e.domainMin),e.domainMax!=null&&(i[a]=e.domainMax),e.domainMid!=null&&(c=e.domainMid,(ci[a])&&n.warn("Scale domainMid exceeds domain min or max.",c),i.splice(a,0,c))),t.domain(Wm(s,i,n)),s===zl&&t.unknown(e.domainImplicit?eu:void 0),e.nice&&t.nice&&t.nice(e.nice!==!0&&Um(t,e.nice)||null),i.length):0}function B3(t,e,n){return e?(t.domain(Wm(t.type,e,n)),e.length):-1}function P3(t,e,n,r,i,s){n??(n=[0,1]);var o=Math.abs(nt(n)-n[0]),a=o/(o-2*r),c=t===Jt?_d(e,null,a):t===Ls?Nc(e,null,a,.5):t===Os?Nc(e,null,a,i||1):t===Wa?y1(e,null,a,s||1):Dd(e,null,a);return e=e.slice(),e[0]=c[0],e[e.length-1]=c[1],e}function Wm(t,e,n){if(Qp(t)){var r=Math.abs(e.reduce(function(i,s){return i+(s<0?-1:s>0?1:0)},0));r!==e.length&&n.warn("Log scale domain includes zero: "+Ku(e))}return e}function O3(t,e,n){let r=e.bins;if(r&&!he(r)){const i=(r.start==null||r.stop==null)&&t.domain(),s=r.start==null?i[0]:r.start,o=r.stop==null?nt(i):r.stop,a=r.step;a||te("Scale bins parameter missing step property."),r=Ci(s,o+a,a)}return r?t.bins=r:t.bins&&delete t.bins,t.type===Vl&&(r?!e.domain&&!e.domainRaw&&(t.domain(r),n=r.length):t.bins=t.domain()),n}function L3(t,e,n){var r=t.type,i=e.round||!1,s=e.range;if(e.rangeStep!=null)s=N3(r,e,n);else if(e.scheme&&(s=$3(r,e,n),je(s))){if(t.interpolator)return t.interpolator(s);te(`Scale type ${r} does not support interpolating color schemes.`)}if(s&&qa(r))return t.interpolator(ja(Eu(s,e.reverse),e.interpolate,e.interpolateGamma));s&&e.interpolate&&t.interpolate?t.interpolate(em(e.interpolate,e.interpolateGamma)):je(t.round)?t.round(i):je(t.rangeRound)&&t.interpolate(i?Bs:ln),s&&t.range(Eu(s,e.reverse))}function N3(t,e,n){t!==Xp&&t!==fu&&te("Only band and point scales support rangeStep.");var r=(e.paddingOuter!=null?e.paddingOuter:e.padding)||0,i=t===fu?1:(e.paddingInner!=null?e.paddingInner:e.padding)||0;return[0,e.rangeStep*Ul(n,i,r)]}function $3(t,e,n){var r=e.schemeExtent,i,s;return he(e.scheme)?s=ja(e.scheme,e.interpolate,e.interpolateGamma):(i=e.scheme.toLowerCase(),s=Hl(i),s||te(`Unrecognized scheme name: ${e.scheme}`)),n=t===Yp?n+1:t===Vl?n-1:t===lu||t===jp?+e.schemeCount||T3:n,qa(t)?qh(s,r,e.reverse):je(s)?vE(qh(s,r),n):t===zl?s:s.slice(0,n)}function qh(t,e,n){return je(t)&&(e||n)?AE(t,Eu(e||[0,1],n)):t}function Eu(t,e){return e?t.slice().reverse():t}const jh=fe(",d");function U3(t,e){return t.chrom+":"+jh(Math.floor(t.pos+1))+"-"+(t.chrom!=e.chrom?e.chrom+":":"")+jh(Math.ceil(e.pos))}const z3=`chr3R 32079331 +chr3L 28110227 +chr2R 25286936 +chrX 23542271 +chr2L 23513712 +chrY 3667352 +chr4 1348131 +chrM 19524`,V3=`chr1 247249719 +chr2 242951149 +chr3 199501827 +chr4 191273063 +chr5 180857866 +chr6 170899992 +chr7 158821424 +chr8 146274826 +chr9 140273252 +chr10 135374737 +chr11 134452384 +chr12 132349534 +chr13 114142980 +chr14 106368585 +chr15 100338915 +chr16 88827254 +chr17 78774742 +chr18 76117153 +chr19 63811651 +chr20 62435964 +chr21 46944323 +chr22 49691432 +chrX 154913754 +chrY 57772954 +chrM 16571`,G3=`chr1 249250621 +chr2 243199373 +chr3 198022430 +chr4 191154276 +chr5 180915260 +chr6 171115067 +chr7 159138663 +chr8 146364022 +chr9 141213431 +chr10 135534747 +chr11 135006516 +chr12 133851895 +chr13 115169878 +chr14 107349540 +chr15 102531392 +chr16 90354753 +chr17 81195210 +chr18 78077248 +chr19 59128983 +chr20 63025520 +chr21 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+chr11 122082543 +chr12 120129022 +chr13 120421639 +chr14 124902244 +chr15 104043685 +chr16 98207768 +chr17 94987271 +chr18 90702639 +chr19 61431566 +chrX 171031299 +chrY 91744698 +chrM 16299`,Yh={dm6:z3,hg18:V3,hg19:G3,hg38:H3,mm9:W3,mm10:q3};function j3(t){if(!(t in Yh))throw new Error(`Unknown assembly: ${t}`);return Yh[t].split(` +`).map(e=>{const n=e.split(" ");return{name:n[0],size:parseInt(n[1])}})}const Y3=/^([A-Za-z]+:)?\/\//;function qi(t,e){if(e&&Y3.test(e))return e;const n=typeof t=="function"?t():t;if(!n)return e;if(!e)return n;if(/[#?]/.test(n))throw new Error(`Cannot append to a url with query or hash. Append: ${e}, base: ${n}`);return qm(n)+e}function qm(t){const e=t.replace(/[^/]*$/,"");return e===""?void 0:e.endsWith("://")?t+"/":e}class X3{constructor(e){if(this.config={name:"custom",...e},"baseUrl"in e)throw new Error("The `baseUrl` property in genome config has been removed in GenomeSpy v0.52.0. Use `url` instead. See https://genomespy.app/docs/genomic-data/genomic-coordinates/.");if(!Zl(e))throw new Error("Not a genome configuration: "+JSON.stringify(e));if(this.chromosomes=[],this.cumulativeChromPositions=new Map,this.chromosomesByName=new Map,this.startByIndex=[],this.totalSize=0,Ym(this.config))this.setChromSizes(this.config.contigs);else if(!Cu(this.config)){const n=j3(this.config.name);if(n)this.setChromSizes(n);else throw new Error(`Unknown genome: ${this.config.name}. Please provide contigs or a URL. 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Reason: ${n.message}`)}}hasChrPrefix(){return this.chromosomes.some(e=>e.name.startsWith("chr"))}setChromSizes(e){let n=0;this.startByIndex=[0];for(let r=0;rthis.totalSize)return;e=Math.floor(e);const n=Wr(this.startByIndex,e)-1;if(n>0&&n<=this.chromosomes.length)return this.chromosomes[n-1]}toChromosomal(e){const n=this.toChromosome(e);if(n)return{chrom:n.name,pos:Math.floor(e)-n.continuousStart}}getChromosome(e){return this.chromosomesByName.get(e)}formatInterval(e){return U3(...this.toChromosomalInterval(e))}toChromosomalInterval(e){const n=this.toChromosomal(e[0]+.5),r=this.toChromosomal(e[1]-.5);return r.pos+=1,[n,r]}toContinuousInterval(e){var i;let[n,r]=e;return r||(r=n),[this.toContinuous(n.chrom,n.pos??0),this.toContinuous(r.chrom,r.pos??((i=this.chromosomesByName.get(r.chrom))==null?void 0:i.size))]}toDiscreteChromosomeIntervals(e){const n=e[0],r=e[1],i=[];if(n.chrom===r.chrom)i.push({chrom:n.chrom,startPos:n.pos,endPos:r.pos});else{const s=this.chromosomes.findIndex(a=>a.name===n.chrom),o=this.chromosomes.findIndex(a=>a.name===r.chrom);i.push({chrom:n.chrom,startPos:n.pos,endPos:this.chromosomes[s].size});for(let a=s+1;aa===void 0)){const a=this.getChromosome(r);return a?[a.continuousStart,a.continuousEnd]:void 0}const i=n[3]||r,s=parseInt(n[2].replace(/,/g,"")),o=n[4]!==void 0?parseInt(n[4].replace(/,/g,"")):s;return[this.toContinuous(r,s-1),this.toContinuous(i,o)]}}}function K3(t){return s1(t).map(([e,n])=>({name:e,size:parseInt(n)}))}function jm(t){return be(t)&&"chrom"in t}function J3(t){return t.every(jm)}function Zl(t){return be(t)&&("name"in t||Cu(t)||Ym(t))}function Cu(t){return Zl(t)&&"url"in t}function Ym(t){return Zl(t)&&"contigs"in t}class Js extends Array{constructor(){super(),this.type=void 0}extend(e){return this}extendAll(e){if(e instanceof Js&&e.type!=this.type)throw new Error(`Cannot combine different types of domains: ${this.type} and ${e.type}`);for(const n of e)this.extend(n);return this}extendAllWithAccessor(e,n){for(const r of e)this.extend(n(r));return this}}class Rc extends Js{constructor(){super(),this.type="quantitative"}extend(e){return e==null||Number.isNaN(e)?this:(e=+e,this.length?ethis[1]&&(this[1]=e):(this.push(e),this.push(e)),this)}}class Xm extends Js{constructor(){super(),this.type="ordinal",this.uniqueValues=new Set}extend(e){return e==null||Number.isNaN(e)?this:(this.uniqueValues.has(e)||(this.uniqueValues.add(e),this.push(e)),this)}}class Km extends Xm{constructor(){super(),this.type="nominal"}}class Z3 extends Js{constructor(e){super();let n=0;for(let r=1;rthis.push(r))}extend(e){if(this.includes(e))return this;throw new Error("Piecewise domains are immutable and cannot be unioned!")}}const Xh={quantitative:Rc,index:Rc,locus:Rc,nominal:Km,ordinal:Xm};function Jm(t,e){if(t=="quantitative"&&Q3(e)){const n=new Z3(e);return n.type=t,n}else if(Xh[t]){const n=new Xh[t];return n.type=t,e&&n.extendAll(e),n}throw new Error("Unknown type: "+t)}function Q3(t){return t&&t.length>0&&t.length!=2&&t.every(e=>typeof e=="number")}function e4(t){return((t*=2)<=1?t*t*t:(t-=2)*t*t+2)/2}function t4(t,e,n){return t*Math.pow(e/t,n)}V("index",Jl,["continuous"]);V("locus",g3,["continuous"]);V("null",Xl,[]);const Kh="quantitative",Zm="ordinal",Qm="nominal",eg="locus",n4="index";var vt,yr,Ue,Ji,Zi,Su,Qi,Fu,Qe,wt,es,Tu,sa,tg,oa,ng,ts,Du,ns,_u,xr,So,rs,Iu,Et,vn,is,Ru,aa,rg;class r4{constructor(e){F(this,Zi);F(this,Qi);F(this,Qe);F(this,es);F(this,sa);F(this,oa);F(this,ts);F(this,ns);F(this,xr);F(this,rs);F(this,Et);F(this,is);F(this,aa);F(this,vt,void 0);F(this,yr,{domain:new Set,range:new Set});F(this,Ue,void 0);F(this,Ji,new Set);this.channel=e,this.members=[],this.type=null,this.name=void 0}addEventListener(e,n){b(this,yr)[e].add(n)}removeEventListener(e,n){b(this,yr)[e].delete(n)}addMember(e){var o;const{channel:n,channelDef:r}=e,i=r.type,s=(o=r==null?void 0:r.scale)==null?void 0:o.name;if(s){if(this.name!==void 0&&s!=this.name)throw new Error(`Shared scales have conflicting names: "${s}" vs. "${this.name}"!`);this.name=s}if(!this.type)this.type=i;else if(i!==this.type&&!wm(n))throw new Error(`Can not use shared scale for different data types: ${this.type} vs. ${i}. Use "resolve: independent" for channel ${this.channel}`);this.members.push(e)}getDataDomain(){return this.members.map(e=>{var n;return(n=e.dataDomainSource)==null?void 0:n.call(e,e.channel,this.type)}).filter(e=>!!e).reduce((e,n)=>e.extendAll(n))}reconfigure(){const e=b(this,Ue);if(!e||e.type=="null")return;const n=D(this,sa,tg).call(this),r=e.domain(),i=D(this,ts,Du).call(this,!0);if(Hm({...i,range:void 0},e),e.props=i,D(this,ns,_u).call(this),ue(e.type)&&k(this,vt,D(this,is,Ru).call(this)),!n){D(this,Qe,wt).call(this,"domain");return}const s=e.domain();No(s,r)||(this.isZoomable()?e.domain(r):D(this,Et,vn).call(this)?(e.domain(r),this.zoomTo(s,500)):D(this,Qe,wt).call(this,"domain"))}get scale(){if(b(this,Ue))return b(this,Ue);const e=D(this,ts,Du).call(this),n=I3({...e,range:void 0});n.props=e,"unknown"in n&&n.unknown(null),k(this,Ue,n),D(this,ns,_u).call(this),y3(n)&&n.genome(this.getGenome()),ue(n.type)&&k(this,vt,D(this,is,Ru).call(this));const r=n.range;if(r){const i=()=>D(this,Qe,wt).call(this,"range");n.range=function(s){if(arguments.length)r(s),i();else return r()},i()}return n}getDomain(){return this.scale.domain()}getComplexDomain(){var e;return((e=this.getGenome())==null?void 0:e.toChromosomalInterval(this.getDomain()))??this.getDomain()}isZoomed(){return D(this,Et,vn).call(this)&&No(D(this,xr,So).call(this),this.getDomain())}isZoomable(){return D(this,Et,vn).call(this)&&!!this.scale.props.zoom}zoom(e,n,r){if(!D(this,Et,vn).call(this))return!1;const i=this.scale,s=i.domain();let o=[...s],a=i.invert(n);switch(i.props.reverse&&(r=-r),"align"in i&&(a+=i.align()),i.type){case"linear":case"index":case"locus":o=p1(o,r||0),o=Dd(o,a,e);break;case"log":o=m1(o,r||0),o=_d(o,a,e);break;case"pow":case"sqrt":{const c=i;o=g1(o,r||0,c.exponent()),o=Nc(o,a,e,c.exponent());break}default:throw new Error("Zooming is not implemented for: "+i.type)}return b(this,vt)&&(o=x1(o,b(this,vt)[0],b(this,vt)[1])),[0,1].some(c=>o[c]!=s[c])?(i.domain(o),D(this,Qe,wt).call(this,"domain"),!0):!1}async zoomTo(e,n=!1){if(Ds(n)&&(n=n?700:0),!D(this,Et,vn).call(this))throw new Error("Not a zoomable scale!");const r=this.fromComplexInterval(e),i=b(this,Qi,Fu).animator,s=this.scale,o=s.domain();if(n>0&&o.length==2){const a=o[1]-o[0],c=r[1]-r[0],u=o[0]+a/2,f=r[0]+c/2,l=o[0]==r[0],h=o[1]==r[1];await i.transition({duration:n,easingFunction:e4,onUpdate:p=>{const d=t4(a,c,p),m=a==c?p:(a-d)/(a-c),g=m*f+(1-m)*u,y=[l?o[0]:g-d/2,h?o[1]:g+d/2];s.domain(y),D(this,Qe,wt).call(this,"domain")}}),s.domain(r),D(this,Qe,wt).call(this,"domain")}else s.domain(r),i==null||i.requestRender(),D(this,Qe,wt).call(this,"domain")}resetZoom(){if(!D(this,Et,vn).call(this))throw new Error("Not a zoomable scale!");const e=this.getDomain(),n=D(this,xr,So).call(this);return[0,1].some(r=>n[r]!=e[r])?(b(this,Ue).domain(n),D(this,Qe,wt).call(this,"domain"),!0):!1}getZoomLevel(){return this.isZoomable()?Ro(b(this,vt))/Ro(this.scale.domain()):1}getAxisLength(){if(this.channel!=="x"&&this.channel!=="y")throw new Error("Axis length is only defined for x and y channels!");const e=this.members.map(n=>{var r;return(r=n.view.coords)==null?void 0:r[this.channel==="x"?"width":"height"]}).filter(n=>n>0);return e.length?e.reduce((n,r)=>Math.min(n,r),1e4):0}getGenome(){var n;if(this.type!=="locus")return;const e=(n=b(this,Qi,Fu).genomeStore)==null?void 0:n.getGenome();if(!e)throw new Error("No genome has been defined!");return e}invertToComplex(e){const n=this.scale;if("invert"in n){const r=n.invert(e);return this.toComplex(r)}else throw new Error("The scale does not support inverting!")}toComplex(e){const n=this.getGenome();return n?n.toChromosomal(e):e}fromComplex(e){return jm(e)?this.getGenome().toContinuous(e.chrom,e.pos):e}fromComplexInterval(e){return this.type==="locus"&&J3(e)?this.getGenome().toContinuousInterval(e):e}}vt=new WeakMap,yr=new WeakMap,Ue=new WeakMap,Ji=new WeakMap,Zi=new WeakSet,Su=function(){return this.members[0].view},Qi=new WeakSet,Fu=function(){return b(this,Zi,Su).context},Qe=new WeakSet,wt=function(e){for(const n of b(this,yr)[e].values())n({type:e,scaleResolution:this})},es=new WeakSet,Tu=function(){return!!D(this,rs,Iu).call(this)},sa=new WeakSet,tg=function(){const e=b(this,Ue);if(!e)return!1;const n=e.domain();return ue(e.type)?n.length>2||n.length==2&&(n[0]!==0||n[1]!==0):n.length>0},oa=new WeakSet,ng=function(){const e=this.members.map(n=>n.channelDef.scale).filter(n=>n!==void 0);return Xo(e,"scale",["domain"])},ts=new WeakSet,Du=function(e=!1){const n=D(this,oa,ng).call(this);if(n===null||n.type=="null")return{type:"null"};const r={...D(this,aa,rg).call(this,this.type),...n};r.type||(r.type=i4(this.channel,this.type));const i=D(this,xr,So).call(this,e);return i&&i.length>0?r.domain=i:Zt(r.type)&&(r.domain=new Km),!r.domain&&r.domainMid!==void 0&&(r.domain=[r.domainMin??0,r.domainMax??1]),this.channel=="y"&&Zt(r.type)&&r.reverse==null&&(r.reverse=!0),r.range&&r.scheme&&delete r.scheme,!("zoom"in r)&&["index","locus"].includes(r.type)&&(r.zoom=!0),s4(r,this.channel),r},ns=new WeakSet,_u=function(){const e=b(this,Ue).props,n=e.range;if(b(this,Ji).forEach(i=>i.invalidate()),!n||!he(n))return;const r=(i,s)=>s?i.slice().reverse():i;if(n.some(Ee)){let i;const s=()=>{b(this,Ue).range(r(i.map(o=>o()),e.reverse))};i=n.map(o=>{if(Ee(o)){const a=b(this,Zi,Su).paramMediator.createExpression(o.expr);return a.addListener(s),b(this,Ji).add(a),()=>a(null)}else return()=>o}),s()}else b(this,Ue).range(r(n,e.reverse))},xr=new WeakSet,So=function(e=!1){return D(this,rs,Iu).call(this)??(this.type==eg?this.getGenome().getExtent():e?this.getDataDomain():[])},rs=new WeakSet,Iu=function(){const e=this.members.map(n=>n.channelDef).filter(n=>{var r;return(r=n.scale)==null?void 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i,s;r.firstFacet&&this.facetCoords.clear(),this.facetCoords.set(r.facetId,r.clipRect?n.intersect(r.clipRect):n),(i=b(this,cs))==null||i.call(this,n.width),(s=b(this,us))==null||s.call(this,n.height)}getEncoding(){const e=this.dataParent&&!this.options.blockEncodingInheritance?this.dataParent.getEncoding():{},n=this.spec.encoding||{},r={...e,...n};for(const[i,s]of Object.entries(r))s===null&&delete r[i];return r}getFacetAccessor(e){if(this.layoutParent)return this.layoutParent.getFacetAccessor(this)}getFacetFields(e){var r;const n=this.getEncoding().sample;return pn(n)?[n.field]:(r=this.layoutParent)==null?void 0:r.getFacetFields(this)}getSampleFacetTexture(){}getScaleResolution(e){const n=Jn(e);return this.getDataAncestors().map(r=>r.resolutions.scale[n]).find(r=>r)}getAxisResolution(e){const n=Jn(e);return this.getDataAncestors().map(r=>r.resolutions.axis[n]).find(r=>r)}getConfiguredResolution(e,n){var r,i;return(i=(r=this.spec.resolve)==null?void 0:r[n])==null?void 0:i[e]}getConfiguredOrDefaultResolution(e,n){return this.getConfiguredResolution(e,n)??this.getConfiguredResolution("default",n)??this.getDefaultResolution(e,n)}getDefaultResolution(e,n){return"independent"}getBaseUrl(){return qi(()=>{var e;return(e=this.dataParent)==null?void 0:e.getBaseUrl()},l4(this.spec.baseUrl))}isPickingSupported(){return!0}getTitleText(){const e=this.spec.title;if(e)return H(e)?e:Ee(e.text)?this.paramMediator.evaluateAndGet(e.text.expr):e.text}_cache(e,n){return tc(this,e,n)}_invalidateCacheByPrefix(e,n="self"){switch(n){case"self":Co(this,e);break;case"ancestors":for(const r of this.getLayoutAncestors())Co(r,e);break;case"progeny":this.visit(r=>Co(r,e));break}}invalidateSizeCache(){this._invalidateCacheByPrefix("size/","ancestors")}propagateInteractionEvent(e){}}br=new WeakMap,os=new WeakMap,as=new WeakMap,cs=new WeakMap,us=new WeakMap,Mn=new WeakSet,li=function(e){var i;let n=this.spec[e];const r=e=="viewportWidth"||e=="viewportHeight";if(og(n)){if(r)throw new Gn(`Cannot use step-based size with "${e}"!`,this);const s=n.step,o=(i=this.getScaleResolution(e=="width"?"x":"y"))==null?void 0:i.scale;if(o){let a=0;if(Zt(o.type))a=o.domain().length;else if(["locus","index"].includes(o.type)){const u=o.domain();a=Rs(u)-u[0]}else throw new Gn(`Cannot use step-based size with "${o.type}" scale!`,this);const c=o;return a=Ul(a,c.paddingInner(),c.paddingOuter()),{px:a*s,grow:0}}else throw new Gn("Cannot use 'step' size with missing scale!",this)}else return(n&&ig(n))??(r?void 0:{px:0,grow:1})},ls=new WeakSet,Pu=function(e){const n=[];let r=this;do n.push(r),r=r[e];while(r);return n};function h4(t){return"unitsPerPixel"in t}function d4(t){const e="opacity"in t.spec?t.spec.opacity:void 0;if(e!==void 0){if(Ce(e))return n=>n*e;if(h4(e)){const n=s=>{var a;const o=(a=t.getScaleResolution(s))==null?void 0:a.scale;if(["linear","index","locus"].includes(o==null?void 0:o.type))return o},r=e.channel?n(e.channel):n("x")??n("y");if(!r)throw new Gn("Cannot find a resolved quantitative scale for dynamic opacity!",t);const i=Ml().domain(e.unitsPerPixel).range(e.values).clamp(!0);return s=>{const a=Ro(r.domain())/1e3;return i(a)*s}}else if(Ee(e)){const n=t.paramMediator.createExpression(e.expr);return n.addListener(()=>t.context.animator.requestRender()),r=>n(null)*r}}return n=>n}const og=t=>!!(t!=null&&t.step),p4={point:ZS,rect:qS,rule:n3,link:u3,text:m3};var fs,ca,ag;class Ge extends sg{constructor(n,r,i,s,o,a){super(n,r,i,s,o,a);F(this,ca);F(this,fs,void 0);this.spec=n;const c=p4[this.getMarkType()];if(c)this.mark=new c(this);else throw new Error(`No such mark: ${this.getMarkType()}`);this.resolve(),k(this,fs,this.paramMediator.allocateSetter("zoomLevel",1)),["x","y"].forEach(u=>{var f;return(f=this.getScaleResolution(u))==null?void 0:f.addEventListener("domain",()=>b(this,fs).call(this,Math.sqrt(this.getZoomLevel())))}),this.needsAxes={x:!0,y:!0},D(this,ca,ag).call(this)}render(n,r,i={}){super.render(n,r,i),this.isConfiguredVisible()&&(n.pushView(this,r),n.renderMark(this.mark,i),n.popView(this))}getMarkType(){return typeof this.spec.mark=="object"?this.spec.mark.type:this.spec.mark}resolve(n){n||(this.resolve("scale"),this.resolve("axis"));const r=this.mark.encoding;for(const[i,s]of Object.entries(r)){if(!He(s))continue;const o=Jn(s.resolutionChannel??i);if(!Hi(o)||n=="axis"&&!Gi(o))continue;let a=this;for(;(a.getConfiguredOrDefaultResolution(o,n)=="forced"||a.dataParent&&["shared","excluded","forced"].includes(a.dataParent.getConfiguredOrDefaultResolution(o,n)))&&a.getConfiguredOrDefaultResolution(o,n)!="excluded";)a=a.dataParent;if(n=="axis"&&Gi(i)&&ym(o))a.resolutions[n][o]||(a.resolutions[n][o]=new a4(o)),a.resolutions[n][o].addMember({view:this,channel:i,channelDef:s});else if(n=="scale"&&Hi(i)){if(!a.resolutions[n][o]){const u=new r4(o);a.resolutions[n][o]=u,u.addEventListener("range",f=>{var l;(l=this.context.glHelper)==null||l.createRangeTexture(f.scaleResolution,!0)})}const c=this.getLayoutAncestors().some(u=>!u.options.contributesToScaleDomain)||He(s)&&s.contributesToScaleDomain===!1?void 0:this.extractDataDomain.bind(this);a.resolutions[n][o].addMember({view:this,channel:i,channelDef:s,dataDomainSource:c})}}}getDataAccessor(n){var r;return(r=this.mark.encoders[n])==null?void 0:r.dataAccessor}getFacetAccessor(n){const r=this.getDataAccessor("sample");return r||super.getFacetAccessor(this)}getCollector(){return this.context.dataFlow.findCollectorByKey(this)}extractDataDomain(n,r){var s;let i=Jm(r);return(((s=this.mark.encoders[n])==null?void 0:s.accessors)??[]).filter(o=>o.scaleChannel).forEach(o=>{if(o.constant)i.extend(o({}));else{const a=this.getCollector();a!=null&&a.completed&&a.visitData(c=>i.extend(o(c)))}}),i}getZoomLevel(){const n=r=>{var i;return((i=this.getScaleResolution(r))==null?void 0:i.getZoomLevel())??1};return Kr.map(n).reduce((r,i)=>r*i,1)}propagateInteractionEvent(n){this.handleInteractionEvent(void 0,n,!0),n.target=this,!n.stopped&&this.handleInteractionEvent(void 0,n,!1)}getDefaultResolution(n,r){return n=="x"?"shared":"independent"}}fs=new WeakMap,ca=new WeakSet,ag=function(){for(const[n,r]of this.paramMediator.paramConfigs){if(!("select"in r))continue;const i=r.select;if((H(i)?i:i.type)==="point"){let a=-1;const c=this.paramMediator.getSetter(n),u=()=>{var h;const l=this.context.getCurrentHover();return((h=l==null?void 0:l.mark)==null?void 0:h.unitView)===this?l.datum:null},f=!H(i)&&"on"in i?i.on:"click";this.addInteractionEventListener(["mouseover","pointerover"].includes(f)?"mousemove":"click",(l,h)=>{const p=u(),d=p?p[Qt]:-1;if(d!=a){a=d;const m=hm(u());c(m)}})}}};function*Ql(t,e=[]){for(const[n,r]of t.entries())if(r instanceof Map)for(const i of Ql(r,[...e,n]))yield i;else yield[[...e,n],r]}const cg=2147483647,m4=ug([cg]);function ug(t){let e=0;for(let n=0,r=t.length;no),r=new Array(t.length);const i=new Array(16);for(let s=0;s{const f=t[n[u]];return s>=m4?f>cg?Math.floor(f/a)%16:0:f>>o&15};for(let u=0;u=0;u--)r[--i[c(u)]]=n[u];[n,r]=[r,n]}return n}var Ct,hs,kn,Bn,ds,Ou,ps,Lu,ms,Nu,ua,fg;class lg extends Z{constructor(n){super();F(this,ds);F(this,ps);F(this,ms);F(this,ua);F(this,Ct,[]);F(this,hs,W(Qt));F(this,kn,[]);F(this,Bn,void 0);this.params=n??{type:"collect"},this.observers=[],this.facetBatches=new Mt([],JSON.stringify),D(this,ds,Ou).call(this)}get behavior(){return Yl}reset(){super.reset(),D(this,ds,Ou).call(this)}handle(n){b(this,Ct).push(n)}beginBatch(n){$C(n)&&(k(this,Ct,[]),this.facetBatches.set(Be(n.facetId),b(this,Ct)))}complete(){var s,o;k(this,Ct,[]);const n=(s=this.params)==null?void 0:s.sort,r=n?Id(n.field,n.order):void 0,i=a=>{r&&a.sort(r)};if((o=this.params.groupby)!=null&&o.length){if(this.facetBatches.size>1)throw new Error("TODO: Support faceted data!");const a=this.facetBatches.get(void 0),c=this.params.groupby.map(f=>W(f)),u=c.length>1?wa(a,...c):y4(a,c[0]);this.facetBatches.clear();for(const[f,l]of Ql(u))this.facetBatches.set(f,l)}for(const a of this.facetBatches.values())i(a);D(this,ua,fg).call(this),D(this,ps,Lu).call(this),super.complete();for(const a of this.observers)a(this)}repropagate(){for(const n of this.children)n.reset();D(this,ps,Lu).call(this);for(const n of this.children)n.complete()}getData(){switch(D(this,ms,Nu).call(this),this.facetBatches.size){case 0:return[];case 1:return[...this.facetBatches.values()][0];default:{const n=this.facetBatches;return{[Symbol.iterator]:function*(){for(const i of n.values())yield*i}}}}}visitData(n){D(this,ms,Nu).call(this);for(const r of this.facetBatches.values())for(let i=0;ic.start).right,i=b(this,hs),s=Br(c=>i(o(c))).left,o=c=>{const u=r(b(this,Bn),c),f=b(this,Bn)[u-1];return!f||c>=f.stop?void 0:this.facetBatches.get(f.facetId)[c-f.start]},a=s(b(this,kn),n);if(a>=0){const c=o(b(this,kn)[a]);if(c&&i(c)===n)return c}}}Ct=new WeakMap,hs=new WeakMap,kn=new WeakMap,Bn=new WeakMap,ds=new WeakSet,Ou=function(){k(this,Ct,[]),this.facetBatches.clear(),this.facetBatches.set(void 0,b(this,Ct))},ps=new WeakSet,Lu=function(){if(this.children.length)for(const[n,r]of this.facetBatches.entries()){if(n){const i={type:"facet",facetId:n};for(const s of this.children)s.beginBatch(i)}for(let i=0,s=r.length;i0;){const i=r-1>>1,s=this.values[i];if(n>=s)break;this.ids[r]=this.ids[i],this.values[r]=s,r=i}this.ids[r]=e,this.values[r]=n}pop(){if(this.length===0)return;const e=this.ids[0];if(this.length--,this.length>0){const n=this.ids[0]=this.ids[this.length],r=this.values[0]=this.values[this.length],i=this.length>>1;let s=0;for(;s=r)break;this.ids[s]=c,this.values[s]=u,s=o}this.ids[s]=n,this.values[s]=r}return e}peek(){if(this.length!==0)return this.ids[0]}peekValue(){if(this.length!==0)return this.values[0]}shrink(){this.ids.length=this.values.length=this.length}}class x4 extends Z{get behavior(){return xt}constructor(e){super(),this.params=e,this.startAccessor=W(e.start),this.endAccessor=W(e.end),this.chromAccessor=e.chrom?W(e.chrom):n=>{},this.weightAccessor=e.weight?W(e.weight):n=>1,this.as={coverage:e.as??"coverage",start:e.asStart??e.start,end:e.asEnd??e.end,chrom:e.asChrom??e.chrom},this.createSegment=new Function("start","end","coverage","chrom","return {"+Object.entries(this.as).filter(([n,r])=>r).map(([n,r])=>`${JSON.stringify(r)}: ${n}`).join(", ")+"};"),this.ends=new Ko}reset(){super.reset(),this.initialize()}initialize(){const e=this.as.coverage,n=this.as.end,r=this.as.chrom,i=this.startAccessor,s=this.endAccessor,o=this.chromAccessor,a=this.weightAccessor;let c,u,f,l=0,h=NaN;const p=this.ends;p.clear();const d=y=>{this._propagate(y),c=null},m=(y,x,w)=>{if(y==x)return;let v=!1;c&&(c[e]===w?(c[n]=x,v=!0):c[e]!=0&&d(c)),v||(c=this.createSegment(y,x,w,f))},g=()=>{let y=0;for(;(y=p.peekValue())!==void 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Map,this.resolution=n.getScaleResolution(this.channel);const r=()=>this._filterAndPropagate();this.schedule=()=>n.context.animator.requestTransition(r),this.resolution.addEventListener("domain",i=>this.schedule()),n._addBroadcastHandler("layoutComputed",()=>this.schedule())}complete(){const e=this.posAccessor;this._data.sort((n,r)=>e(n)-e(r)),this._scores=this._data.map(this.scoreAccessor);for(const n of new Set(this._data.map(this.laneAccessor)))this.reservationMaps.set(n,new w4(200));this.schedule(),super.complete()}_filterAndPropagate(){super.reset();const e=this.resolution.scale,n=this.resolution.getAxisLength();if(!n)return;for(const o of this.reservationMaps.values())o.reset();const r=e.domain(),i=70,s=b4(this._scores,i,this.posBisector.left(this._data,r[0]),this.posBisector.right(this._data,r[1]));for(const o of s){const 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Reason: ${c.message}`)}},o=(a,c)=>{try{const u=r0(a,r);this.beginBatch({type:"file",url:c});for(const f of u)this._propagate(f)}catch(u){throw new Error(`Cannot parse: ${c}: ${u.message}`)}};this.setLoadingStatus("loading"),this.reset();try{await Promise.all(n.map(a=>s(a).then(o))),this.setLoadingStatus("complete")}catch(a){this.setLoadingStatus("error",a.message)}this.complete()}}function tF(t){return"sequence"in t}class nF extends Jr{constructor(e,n){if(super(n),this.sequence=Za(n.paramMediator,e.sequence,()=>this.loadSynchronously()),!("start"in this.sequence))throw new Error("'start' is missing from sequence parameters!");if(!("stop"in this.sequence))throw new Error("'stop' is missing from sequence parameters!")}loadSynchronously(){const e=Ve(this.sequence.as)??"data",n=Ve(this.sequence.start)??0,r=Ve(this.sequence.step)??1,i=Ve(this.sequence.stop);this.reset(),this.beginBatch({type:"file"});for(let s=n;s{this.view.isVisible()&&this.onDomainChanged(this.scaleResolution.getDomain(),this.scaleResolution.getComplexDomain())};this.scaleResolution.addEventListener("domain",i),this.view.context.addBroadcastListener("layoutComputed",i)}get genome(){return this.scaleResolution.getGenome()}onDomainChanged(n,r){}requestRender(){this.view.context.animator.requestRender()}async load(){this.reset(),this.complete()}publishData(n){this.reset(),this.beginBatch({type:"file"});for(const r of n)for(const i of r)this._propagate(i);this.complete(),Mu(this.view)}}class rF extends ef{constructor(n,r){const i={axis:{},...n};super(r,i.channel);ve(this,"ticks",[]);this.params=n}async load(){this.ticks=null,this.onDomainChanged()}onDomainChanged(){const n=this.scaleResolution.scale,r=this.scaleResolution.getAxisLength(),i=this.params.axis,s=u=>25+60*lm(100,700,u),o=Ce(i.tickCount)?i.tickCount:Math.round(r/s(r)),a=Um(n,o,i.tickMinStep),c=i.values?zm(n,i.values,a):x3(n,a);if(this.ticks==null||!No(c,this.ticks)){this.ticks=c;const u=w3(n,o,i.format);this.publishData([c.map(f=>({value:f,label:u(f)}))])}}}class iF extends ef{constructor(e,n){super(n,e.channel)}async load(){this.publishData([this.genome.chromosomes])}}const sF="modulepreload",oF=function(t,e){return new URL(t,e).href},td={},Pe=function(e,n,r){if(!n||n.length===0)return e();const i=document.getElementsByTagName("link");return Promise.all(n.map(s=>{if(s=oF(s,r),s in td)return;td[s]=!0;const o=s.endsWith(".css"),a=o?'[rel="stylesheet"]':"";if(!!r)for(let f=i.length-1;f>=0;f--){const l=i[f];if(l.href===s&&(!o||l.rel==="stylesheet"))return}else if(document.querySelector(`link[href="${s}"]${a}`))return;const u=document.createElement("link");if(u.rel=o?"stylesheet":sF,o||(u.as="script",u.crossOrigin=""),u.href=s,document.head.appendChild(u),o)return new Promise((f,l)=>{u.addEventListener("load",f),u.addEventListener("error",()=>l(new Error(`Unable to preload CSS for ${s}`)))})})).then(()=>e()).catch(s=>{const o=new Event("vite:preloadError",{cancelable:!0});if(o.payload=s,window.dispatchEvent(o),!o.defaultPrevented)throw s})};function Jo(t,e,n=!0){let r,i=o=>{};return function(...a){return new Promise((c,u)=>{const f=()=>{clearTimeout(r),i=l=>{},c(t(...a))};n&&i("debounced"),clearTimeout(r),i=u,r=window.setTimeout(f,typeof e=="function"?e():e)})}}var wr,Ar,vr,gs;class Qs extends ef{constructor(){super(...arguments);F(this,wr,new AbortController);F(this,Ar,[0,0]);F(this,vr,[0,0]);F(this,gs,0);ve(this,"params")}setupDebouncing(n){const r=()=>Ve(n.debounce),i=n.debounceMode;if(i=="domain")this.onDomainChanged=Jo(this.onDomainChanged.bind(this),r,!1);else if(i=="window")this.loadInterval=Jo(this.loadInterval.bind(this),r,!1);else throw new Error("Invalid debounceMode: "+i)}onDomainChanged(n){var i;k(this,vr,n);const r=Ve((i=this.params)==null?void 0:i.windowSize)??-1;n[1]-n[0]>r||this.callIfWindowsChanged(n,r,async s=>{await this.initializedPromise,this.loadInterval(s)})}reloadLastDomain(){const n=b(this,vr);k(this,vr,[0,0]),k(this,Ar,[0,0]),this.onDomainChanged(n)}async loadInterval(n){}async discretizeAndLoad(n,r){b(this,wr).abort(),this.setLoadingStatus("loading"),k(this,wr,new AbortController);const i=b(this,wr).signal,s=this.genome.continuousToDiscreteChromosomeIntervals(n);try{const o=await Promise.all(s.map(async a=>r(a,i)));if(!i.aborted)return this.setLoadingStatus("complete"),o}catch(o){if(!i.aborted)throw this.setLoadingStatus("error",o.message),o}}callIfWindowsChanged(n,r,i){const s=[Math.max(Math.floor(n[0]/r)*r,0),Math.min(Math.ceil(n[1]/r)*r,this.genome.totalSize)],o=b(this,Ar);(r!==b(this,gs)||s[0]o[1])&&(k(this,Ar,s),k(this,gs,r),i(s))}}wr=new WeakMap,Ar=new WeakMap,vr=new WeakMap,gs=new WeakMap;class aF extends Qs{constructor(e,n){const r={channel:"x",windowSize:7e3,debounce:200,debounceMode:"window",...e};if(super(n,r.channel),this.params=r,!this.params.url)throw new Error("No URL provided for IndexedFastaSource");this.setupDebouncing(this.params),this.initializedPromise=new Promise(i=>{Promise.all([Pe(()=>import("./index-462333f7.js").then(s=>s.i),["./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url),Pe(()=>import("./index-f8b9b7f4.js"),["./index-f8b9b7f4.js","./__vite-browser-external-d053bc6e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js","./long-c1fdf4ae.js"],import.meta.url),Pe(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([{Buffer:s},{IndexedFasta:o},{RemoteFile:a}])=>{typeof window<"u"&&(window.Buffer??(window.Buffer=s));const c=u=>new a(Zs(u,this.view.getBaseUrl()));this.fasta=new o({fasta:c(this.params.url),fai:c(this.params.indexUrl??this.params.url+".fai")}),i()})})}async loadInterval(e){const n=await this.discretizeAndLoad(e,async(r,i)=>this.fasta.getSequence(r.chrom,r.startPos,r.endPos,{signal:i}).then(s=>({chrom:r.chrom,start:r.startPos,sequence:s})));n&&this.publishData([n])}}var Er,Cr,ys,$u;class cF extends Qs{constructor(n,r){const i={pixelsPerBin:2,channel:"x",debounce:200,debounceMode:"window",...n},s=Za(r.paramMediator,i,o=>{o.includes("url")?D(this,ys,$u).call(this).then(()=>this.reloadLastDomain()):o.includes("pixelsPerBin")&&this.reloadLastDomain()});super(r,s.channel);F(this,ys);F(this,Er,[]);F(this,Cr,void 0);if(this.params=s,!this.params.url)throw new Error("No URL provided for BigWigSource");this.setupDebouncing(this.params),D(this,ys,$u).call(this)}async onDomainChanged(n){await this.initializedPromise;const r=this.scaleResolution.getAxisLength()||700,i=uF(n,r,b(this,Er)),s=Math.max(i*r,5e3);this.callIfWindowsChanged(n,s,o=>this.loadInterval(o,i))}async loadInterval(n,r){const i=.5/r/Ve(this.params.pixelsPerBin),s=await this.discretizeAndLoad(n,(o,a)=>b(this,Cr).getFeatures(o.chrom,o.startPos,o.endPos,{scale:i,signal:a}).then(c=>c.map(u=>({chrom:o.chrom,start:u.start,end:u.end,score:u.score}))));s&&this.publishData(s)}}Er=new WeakMap,Cr=new WeakMap,ys=new WeakSet,$u=function(){return this.initializedPromise=new Promise((n,r)=>{Promise.all([Pe(()=>import("./index-712d95de.js"),["./index-712d95de.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js","./index-d89cadd6.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js"],import.meta.url),Pe(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([{BigWig:i},{RemoteFile:s}])=>{k(this,Cr,new i({filehandle:new s(Zs(Ve(this.params.url),this.view.getBaseUrl()))})),this.setLoadingStatus("loading"),b(this,Cr).getHeader().then(o=>{k(this,Er,o.zoomLevels.map(a=>a.reductionLevel).reverse()),b(this,Er).push(1),this.setLoadingStatus("complete"),n()}).catch(o=>{this.load(),this.setLoadingStatus("error",`${Ve(this.params.url)}: ${o.message}`),r(o)})})}),this.initializedPromise};function uF(t,e,n){const r=(t[1]-t[0])/e;return n.find(i=>i{o.includes("url")?D(this,xs,Uu).call(this).then(()=>this.reloadLastDomain()):o.includes("windowSize")&&this.reloadLastDomain()});super(r,s.channel);F(this,xs);ve(this,"parser");ve(this,"bbi");ve(this,"parseLine");if(this.params=s,!this.params.url)throw new Error("No URL provided for BigBedSource");this.setupDebouncing(this.params),D(this,xs,Uu).call(this)}async loadInterval(n){const r=await this.discretizeAndLoad(n,async(i,s)=>this.bbi.getFeatures(i.chrom,i.startPos,i.endPos,{signal:s}).then(o=>o.map(a=>this.parseLine(i.chrom,a))));r&&this.publishData(r)}}xs=new WeakSet,Uu=function(){return this.initializedPromise=new Promise((n,r)=>{Promise.all([Pe(()=>import("./index-7a37a249.js"),["./index-7a37a249.js","./_commonjsHelpers-de833af9.js"],import.meta.url),Pe(()=>import("./index-712d95de.js"),["./index-712d95de.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js","./index-d89cadd6.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js"],import.meta.url),Pe(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([i,{BigBed:s},{RemoteFile:o}])=>{const a=i.default;this.bbi=new s({filehandle:new o(Zs(Ve(this.params.url),this.view.getBaseUrl()))}),this.setLoadingStatus("loading"),this.bbi.getHeader().then(async c=>{this.parser=new a({autoSql:c.autoSql});try{const u=fF(this.parser);this.parseLine=(f,l)=>u(f,l.start,l.end,l.rest)}catch{this.parseLine=(f,l)=>this.parser.parseLine(`${f} ${l.start} ${l.end} ${l.rest}`)}this.setLoadingStatus("complete"),n()}).catch(c=>{this.load(),this.setLoadingStatus("error",`${Ve(this.params.url)}: ${c.message}`),r(c)})})}),this.initializedPromise};function fF(t){const e=t.autoSql.fields.filter(x=>x.type).slice(3);let n=0,r="",i=0,s={};const o=" ",a=o.charCodeAt(0),c="0".charCodeAt(0),u="-".charCodeAt(0);function f(){let x=r.indexOf(o,n);x<0&&(x=i);const w=r.substring(n,x);return n=x+1,w}function l(){let x=0,w=r.charCodeAt(n),v=1;w===u&&(v=-1,n++,w=r.charCodeAt(n));do{if(w===a){n++;break}x=x*10+w-c,w=r.charCodeAt(++n)}while(n`${JSON.stringify(x.name)}: ${x.isNumeric?"0":"emptyString"}`),p=new Function(` + const emptyString = ""; + return function makeTemplate(chrom, chromStart, chromEnd) { + return { + chrom, + chromStart, + chromEnd, + ${h.join(`, +`)} + } + };`)(),d=e.map(x=>{const w=x.type,v=JSON.stringify(x.name);if(["ubyte","int","uint"].includes(w))return`d[${v}] = parseInt();`;if(x.isNumeric)return`d[${v}] = Number(parseString());`;if(["char","string","lstring"].includes(w))return`d[${v}] = parseString();`;throw new Error("Unsupported type: "+w)}),m=hF(d,50).map((x,w)=>Function("parseInt","parseString",`return function parseFieldChunk${w}(d) { + ${x.join(` +`)} + }`)(l,f));function g(x){r=x,i=x.length,n=0}function y(x,w,v,C){g(C),s=p(x,w,v);for(const S of m)S(s);return s}return y}function hF(t,e){return Array.from({length:Math.ceil(t.length/e)},(n,r)=>t.slice(r*e,r*e+e))}var Pn;class dF extends Qs{constructor(n,r){const i={channel:"x",windowSize:2e4,debounce:200,debounceMode:"domain",...n};super(r,i.channel);F(this,Pn,void 0);ve(this,"chrPrefixFixer",n=>n);if(this.params=i,!this.params.url)throw new Error("No URL provided for BamSource");this.setupDebouncing(this.params),this.initializedPromise=new Promise(s=>{Promise.all([Pe(()=>import("./index-234835b1.js"),["./index-234835b1.js","./long-c1fdf4ae.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-d89cadd6.js"],import.meta.url),Pe(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([{BamFile:o},{RemoteFile:a}])=>{const c=u=>new a(Zs(u,this.view.getBaseUrl()));k(this,Pn,new o({bamFilehandle:c(this.params.url),baiFilehandle:c(this.params.indexUrl??this.params.url+".bai")})),b(this,Pn).getHeader().then(u=>{var h,p;const f=this.genome.hasChrPrefix(),l=(p=(h=b(this,Pn).indexToChr)==null?void 0:h[0])==null?void 0:p.refName.startsWith("chr");f&&!l?this.chrPrefixFixer=d=>d.replace("chr",""):!f&&l&&(this.chrPrefixFixer=d=>"chr"+d),s()})})})}async loadInterval(n){const r=await this.discretizeAndLoad(n,async(i,s)=>b(this,Pn).getRecordsForRange(this.chrPrefixFixer(i.chrom),i.startPos,i.endPos,{signal:s}).then(o=>o.map(a=>({chrom:i.chrom,start:a.get("start"),end:a.get("end"),name:a.get("name"),MD:a.get("MD"),cigar:a.get("cigar"),mapq:a.get("mq"),strand:a.get("strand")===1?"+":"-"}))));r&&this.publishData(r)}}Pn=new WeakMap;var bs;class pF extends Qs{constructor(n,r){const i={channel:"x",windowSize:3e6,debounce:200,debounceMode:"domain",...n};super(r,i.channel);F(this,bs,void 0);if(this.params=i,!this.params.url)throw new Error("No URL provided for TabixSource");this.setupDebouncing(this.params),this.initializedPromise=new Promise(s=>{Promise.all([Pe(()=>import("./index-462333f7.js").then(o=>o.i),["./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url),Pe(()=>import("./index-9e6f36fd.js"),["./index-9e6f36fd.js","./index-d89cadd6.js","./_commonjsHelpers-de833af9.js","./index-462333f7.js","./__vite-browser-external-d053bc6e.js","./long-c1fdf4ae.js"],import.meta.url),Pe(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([{Buffer:o},{TabixIndexedFile:a},{RemoteFile:c}])=>{typeof window<"u"&&(window.Buffer??(window.Buffer=o));const u=f=>new c(Zs(f,this.view.getBaseUrl()));k(this,bs,new a({filehandle:u(this.params.url),tbiFilehandle:u(this.params.indexUrl??this.params.url+".tbi")})),s()})})}async loadInterval(n){const r=await this.discretizeAndLoad(n,async(i,s)=>{const o=[];return await b(this,bs).getLines(i.chrom,i.startPos,i.endPos,{lineCallback:a=>{o.push(a)},signal:s}),this._parseFeatures(o)});r&&this.publishData(r)}_parseFeatures(n){return[]}}bs=new WeakMap;var ws;class mF extends pF{constructor(n,r){super(n,r);F(this,ws,void 0);Pe(()=>import("./index-ba6a6d03.js"),["./index-ba6a6d03.js","./_commonjsHelpers-de833af9.js","./index-462333f7.js","./__vite-browser-external-d053bc6e.js"],import.meta.url).then(i=>{k(this,ws,i.default)})}_parseFeatures(n){var i;return(i=b(this,ws))==null?void 0:i.parseStringSync(n.join(` +`),{parseSequences:!1})}}ws=new WeakMap;function gF(t,e){if(gg(t))return new Z4(t,e);if(Q4(t))return new eF(t,e);if(tF(t))return new nF(t,e);if(yF(t))return SF(t.lazy,e);throw new Error("Cannot figure out the data source type: "+JSON.stringify(t))}function yF(t){return"lazy"in t}function xF(t){return(t==null?void 0:t.type)=="axisTicks"}function bF(t){return(t==null?void 0:t.type)=="axisGenome"}function wF(t){return(t==null?void 0:t.type)=="indexedFasta"}function AF(t){return(t==null?void 0:t.type)=="bigwig"}function vF(t){return(t==null?void 0:t.type)=="bigbed"}function EF(t){return(t==null?void 0:t.type)=="bam"}function CF(t){return(t==null?void 0:t.type)=="gff3"}function SF(t,e){if(xF(t))return new rF(t,e);if(bF(t))return new iF(t,e);if(wF(t))return new aF(t,e);if(AF(t))return new cF(t,e);if(vF(t))return new lF(t,e);if(EF(t))return new dF(t,e);if(CF(t))return new mF(t,e);throw new Error("Cannot figure out the data source type: "+JSON.stringify(t))}function FF(t){const e=yg(t).filter(r=>typeof r=="string"),n=new Function("source","return { "+e.map(r=>JSON.stringify(r)).map(r=>`${r}: source[${r}]`).join(`, +`)+" };");return n.properties=e,n}function yg(t){let e=[];do e=e.concat(Object.keys(t)),t=Object.getPrototypeOf(t);while(t&&t!==Object.prototype);return Array.from(new Set(e))}var Sr,As;class Zo extends Z{constructor(){super();F(this,Sr,void 0);F(this,As,n=>n);const n=r=>{const i=yg(r);(!b(this,Sr)||!No(i,b(this,Sr)))&&(k(this,Sr,i),k(this,As,FF(r)));const s=b(this,As);this.handle=o=>this._propagate(s(o)),this.handle(r)};this.handle=n,this.beginBatch=r=>{fm(r)&&(this.handle=n),super.beginBatch(r)}}get behavior(){return xt}}Sr=new WeakMap,As=new WeakMap;function TF(t){return"name"in t}var vs;class xg extends Jr{constructor(n,r,i){super(r);F(this,vs,void 0);this.provider=i,this.params=n}get identifier(){return this.params.name}updateDynamicData(n){k(this,vs,n),this.loadSynchronously()}loadSynchronously(){const n=b(this,vs)??this.provider(this.params.name)??[];let r=i=>i;if(Array.isArray(n))n.length>0&&(r=mg(n[0]));else throw new Error(`Named data "${this.params.name}" is not an array!`);this.reset(),this.beginBatch({type:"file"});for(const i of n)this._propagate(r(i));this.complete()}async load(){this.loadSynchronously()}}vs=new WeakMap;class bg{constructor(){this._dataSourcesByHost=new Map,this._collectorsByHost=new Map,this._observers=new Map}get dataSources(){return[...new Set(this._dataSourcesByHost.values()).values()]}get collectors(){return[...this._collectorsByHost.values()]}addObserver(e,n){let r=this._observers.get(n);r||(r=[],this._observers.set(n,r)),r.push(e)}_relayObserverCallback(e,n){const r=this._observers.get(n);if(r)for(const i of r)i(e)}addDataSource(e,n){this._dataSourcesByHost.set(n,e)}findDataSourceByKey(e){return this._dataSourcesByHost.get(e)}findNamedDataSource(e){let n,r=[];for(const[i,s]of this._dataSourcesByHost.entries())if(s instanceof xg&&e==s.identifier){if(n&&n!==s)throw new Error(`Found multiple instances of named data: ${e}. 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e?this===e||this.x===e.x&&this.y===e.y&&this.width===e.width&&this.height===e.height:!1}modify(e){if(!Object.keys(e).length)return this;const n=r=>{const i=e[r];return typeof i=="number"?bt(i):typeof i=="function"?i:this._passThrough(r)};return new Ze(n("x"),n("y"),n("width"),n("height"))}translate(e,n){return e===0&&n===0?this:new Ze(this._offset("x",e),this._offset("y",n),this._passThrough("width"),this._passThrough("height"))}translateBy(e){return this.translate(e.x,e.y)}expand(e,n=1){return e.left==0&&e.top==0&&e.right==0&&e.bottom==0?this:new Ze(e.left?this._offset("x",-e.left*n):this._passThrough("x"),e.top?this._offset("y",-e.top*n):this._passThrough("y"),e.width?this._offset("width",e.width*n):this._passThrough("width"),e.height?this._offset("height",e.height*n):this._passThrough("height"))}shrink(e){return this.expand(e,-1)}intersect(e){return this===e||e==null?this:new 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Promise.all(this.spec.layer.map((n,r)=>this.context.createOrImportView(n,this,this,"grid"+r,i=>{if(!ju(i)&&!qu(i))throw new Gn("LayerView accepts only unit or layer specs as children!",this)}))))}get children(){return b(this,St).slice()}*[Symbol.iterator](){for(const n of b(this,St))yield n}render(n,r,i={}){if(super.render(n,r,i),!!this.isConfiguredVisible()){n.pushView(this,r);for(const s of b(this,St))s.render(n,r,i);n.popView(this)}}propagateInteractionEvent(n){this.handleInteractionEvent(void 0,n,!0);for(let r=b(this,St).length-1;r>=0;r--)if(b(this,St)[r].propagateInteractionEvent(n),n.stopped)return;this.handleInteractionEvent(void 0,n,!1)}}St=new WeakMap;class sd{constructor(e,n){this.n=e,this.maxCols=n??1/0}get nRows(){return this.maxCols==1/0?1:Math.ceil(this.n/this.maxCols)}get nCols(){return Math.min(this.n,this.maxCols)}get rowIndices(){const e=[],n=this.nCols,r=this.nRows;for(let i=0;i=this.maxCols)return;r=n*this.nCols+e}return r=this.n))return[e%this.nCols,Math.floor(e/this.nCols)]}}const aT="chromosome_ticks_and_labels",cT={x:"width",y:"height"};function Vu(t){return t=="x"?"y":"x"}const Qo={x:["bottom","top"],y:["left","right"]},nf=Object.fromEntries(Object.entries(Qo).map(([t,e])=>e.map(n=>[n,t])).flat(1));function nn(t){return nf[t]}class Cg extends to{constructor(e,n,r,i,s,o){const a=n=="locus",c={...a?lT:Sg,...uT(n,e),...e};super(a?fT(c,n):Fg(c,n),r,i,s,`axis_${e.orient}`,{blockEncodingInheritance:!0,contributesToScaleDomain:!1,...o}),this.axisProps=c}getSize(){const e={px:this.getPerpendicularSize()},n={grow:1};return nf[this.axisProps.orient]=="x"?new tn(n,e):new tn(e,n)}getPerpendicularSize(){return rf(this.axisProps)}isPickingSupported(){return!1}}function rf(t){const e=nn(t.orient);let n=t.ticks&&t.tickSize||0;return t.labels&&(n+=t.labelPadding,e=="x"?n+=t.labelFontSize:n+=30),t.title&&(n+=t.titlePadding+t.titleFontSize),n=Math.min(t.maxExtent||1/0,Math.max(t.minExtent||0,n)),n}const Sg={values:null,minExtent:20,maxExtent:1/0,offset:0,domain:!0,domainWidth:1,domainColor:"gray",domainDash:null,domainDashOffset:0,domainCap:"square",ticks:!0,tickSize:5,tickWidth:1,tickColor:"gray",tickDash:null,tickDashOffset:0,tickCap:"square",tickCount:null,tickMinStep:null,labels:!0,labelAlign:"center",labelBaseline:"middle",labelPadding:4,labelFontSize:10,labelLimit:180,labelColor:"black",format:null,titleColor:"black",titleFont:"sans-serif",titleFontSize:10,titlePadding:3};function uT(t,e){const n=e.orient,r=t=="nominal"||t=="ordinal";let i="center",s="middle",o=e.labelAngle??((n=="top"||n=="bottom")&&r?-90:0);switch(n){case"left":i="right";break;case"right":i="left";break;case"top":case"bottom":Math.abs(o)>30?(i=o>0==(n=="bottom")?"left":"right",s="middle"):s=n=="top"?"alphabetic":"top";break}return{labelAlign:i,labelAngle:o,labelBaseline:s}}function Fg(t,e){const n={...t,extent:rf(t)},r=nn(n.orient),i=Vu(r),s=n.orient=="bottom"||n.orient=="right"?1:-1,o=n.orient=="bottom"||n.orient=="left"?1:0,a=()=>({name:"domain",data:{values:[0]},mark:{type:"rule",clip:!1,strokeDash:n.domainDash,strokeCap:n.domainCap,color:n.domainColor,[i]:o,size:n.domainWidth}}),c=()=>({name:"labels",mark:{type:"text",clip:!1,align:n.labelAlign,angle:n.labelAngle,baseline:n.labelBaseline,[i+"Offset"]:(n.tickSize+n.labelPadding)*s,[i]:o,size:n.labelFontSize,color:n.labelColor,minBufferSize:1500},encoding:{[r]:{field:"value",type:e},text:{field:"label"}}}),u=()=>({name:"ticks",mark:{type:"rule",clip:!1,strokeDash:n.tickDash,strokeCap:n.tickCap,color:n.tickColor,size:n.tickWidth,minBufferSize:300},encoding:{[i]:{value:o},[i+"2"]:{value:o-n.tickSize/n.extent*(o?1:-1)}}}),f=()=>({name:"title",data:{values:[0]},mark:{type:"text",clip:!1,align:"center",baseline:n.orient=="bottom"?"bottom":"top",angle:[0,90,0,-90][["top","right","bottom","left"].indexOf(n.orient)],text:n.title,color:n.titleColor,[r]:.5,[i]:1-o}}),l=()=>{const p={name:"ticks_and_labels",encoding:{[r]:{field:"value",type:e}},layer:[]};return n.ticks&&p.layer.push(u()),n.labels&&p.layer.push(c()),p},h={resolve:{scale:{[r]:"forced"}},[cT[Vu(r)]]:n.extent,data:{lazy:{type:"axisTicks",channel:r,axis:t}},layer:[]};return n.domain&&h.layer.push(a()),(n.ticks||n.labels)&&h.layer.push(l()),n.title&&h.layer.push(f()),h}const lT={...Sg,chromTicks:!0,chromTickSize:18,chromTickWidth:1,chromTickColor:"#989898",chromTickDash:[4,2],chromTickDashOffset:1,chromLabels:!0,chromLabelFontSize:13,chromLabelFontWeight:"normal",chromLabelFontStyle:"normal",chromLabelColor:"black",chromLabelAlign:"left",chromLabelPadding:7};function fT(t,e){const n={...t,extent:rf(t)},r=nn(n.orient),i=Vu(r),s=n.orient=="bottom"||n.orient=="left"?1:0,o=()=>({name:"chromosome_ticks",mark:{type:"rule",strokeDash:t.chromTickDash,strokeDashOffset:t.chromTickDashOffset,[i]:s,[i+"2"]:s-n.chromTickSize/n.extent*(s?1:-1),color:t.chromTickColor,size:n.chromTickWidth}}),a=()=>{let f;switch(n.orient){case"top":f={y:0,angle:0,paddingX:4,dy:-n.chromLabelPadding,viewportEdgeFadeWidthLeft:20,viewportEdgeFadeWidthRight:20,viewportEdgeFadeDistanceRight:-10,viewportEdgeFadeDistanceLeft:-20};break;case"bottom":f={y:1,angle:0,paddingX:4,dy:n.chromLabelPadding+n.chromLabelFontSize*.73,viewportEdgeFadeWidthLeft:20,viewportEdgeFadeWidthRight:20,viewportEdgeFadeDistanceRight:-10,viewportEdgeFadeDistanceLeft:-20};break;case"left":f={x:1,angle:-90,paddingY:4,dy:-n.chromLabelPadding,viewportEdgeFadeWidthBottom:20,viewportEdgeFadeWidthTop:20,viewportEdgeFadeDistanceBottom:-20,viewportEdgeFadeDistanceTop:-10};break;case"right":f={x:0,angle:90,align:"right",paddingY:4,dy:-n.chromLabelPadding};break;default:f={}}return{name:"chromosome_labels",mark:{type:"text",size:n.chromLabelFontSize,font:n.chromLabelFont,fontWeight:n.chromLabelFontWeight,fontStyle:n.chromLabelFontStyle,color:n.chromLabelColor,align:t.chromLabelAlign,baseline:"alphabetic",clip:!1,...f},encoding:{[r+"2"]:{field:"continuousEnd",type:e},text:{field:"name"}}}};let c;switch(n.orient){case"bottom":case"top":c={};break;case"left":c={labelAngle:-90,labelAlign:"center",labelPadding:6};break;case"right":c={labelAngle:90,labelAlign:"center",labelPadding:6};break;default:c={}}const u=Fg({...t,...c},e);if(t.chromTicks||t.chromLabels){const f={name:aT,data:{lazy:{type:"axisGenome",channel:nn(n.orient)}},encoding:{[r]:{field:"continuousStart",type:e,band:0}},layer:[]};if(t.chromTicks&&f.layer.push(o()),t.chromLabels){f.layer.push(a());let l;u.layer.filter(h=>h.name=="ticks_and_labels").forEach(h=>h.layer.filter(p=>p.name=="labels").forEach(p=>{l=p.mark})),l&&(n.orient=="top"||n.orient=="bottom"?(l.viewportEdgeFadeWidthLeft=30,l.viewportEdgeFadeDistanceLeft=40):(l.viewportEdgeFadeWidthBottom=30,l.viewportEdgeFadeDistanceBottom=40))}u.layer.push(f)}return u}class hT extends to{constructor(e,n,r,i,s,o){const c={...n=="locus"?dT:Tg,...e};super(yT(c,n),r,i,s,`axisGrid_${e.orient}`,{blockEncodingInheritance:!0,contributesToScaleDomain:!1,...o}),this.axisProps=c}getOrient(){return this.axisProps.orient}isPickingSupported(){return!1}}const Tg={values:null,grid:!1,gridCap:"butt",gridColor:"lightgray",gridDash:null,gridOpacity:1,gridWidth:1,tickCount:null,tickMinStep:null},dT={...Tg,chromGrid:!1,chromGridCap:"butt",chromGridColor:"gray",chromGridDash:[1,5],chromGridOpacity:1,chromGridWidth:1};function pT(t,e){const n=t,r=nn(n.orient);return{name:"grid_lines",data:{lazy:{type:"axisTicks",channel:r,axis:t}},mark:{type:"rule",strokeDash:n.gridDash,strokeCap:n.gridCap,color:n.gridColor,size:n.gridWidth,opacity:n.gridOpacity,minBufferSize:300},encoding:{[r]:{field:"value",type:e}}}}function mT(t,e){const n=t,r=nn(n.orient);return{name:"chromosome_lines",data:{lazy:{type:"axisGenome",channel:r}},mark:{type:"rule",strokeDash:n.chromGridDash,strokeCap:n.chromGridCap,color:n.chromGridColor,size:n.chromGridWidth,opacity:n.chromGridOpacity},encoding:{[r]:{field:"continuousStart",type:e,band:0}}}}function gT(t,e){const n=t,r=nn(n.orient);return{name:"chromosome_fill",data:{lazy:{type:"axisGenome",channel:r}},mark:{type:"rect"},encoding:{[r]:{field:"continuousStart",type:e,band:0},[r+"2"]:{field:"continuousEnd",band:0},fill:{field:"odd",type:"nominal",scale:{domain:[!1,!0],range:[n.chromGridFillEven??"white",n.chromGridFillOdd??"white"]}},opacity:{field:"odd",type:"nominal",scale:{type:"ordinal",domain:[!1,!0],range:[n.chromGridFillEven?1:0,n.chromGridFillOdd?1:0]}}}}}function yT(t,e){const n={...t},r=[];return n.chromGrid&&(n.chromGridFillOdd||n.chromGridFillEven)&&r.push(gT(n,e)),n.chromGrid&&n.chromGridOpacity>0&&r.push(mT(n,e)),n.grid&&n.gridOpacity>0&&r.push(pT(n,e)),{name:"grid_layers",configurableVisibility:!1,resolve:{scale:{[nn(t.orient)]:"forced",fill:"independent",opacity:"independent"}},layer:r}}const od={anchor:"middle",frame:"group",offset:10,orient:"top",align:void 0,angle:0,baseline:"alphabetic",dx:0,dy:0,color:void 0,font:void 0,fontSize:12,fontStyle:"normal",fontWeight:"normal"},xT={orient:"left",anchor:"middle",align:"right",baseline:"middle",angle:0,fontSize:12},bT={orient:"top",anchor:"start",align:"left",baseline:"top",offset:-10,dx:10,fontSize:12},wT={start:0,middle:.5,end:1},AT={start:"left",middle:"center",end:"right"};function vT(t){if(!t)return;const e=H(t)?{text:t}:t;if(!e.text||e.orient=="none")return;const n={"track-title":xT,overlay:bT}[e.style]??{},r={...od,...n,...e};let i={},s={x:0,y:0};const o=wT[r.anchor??"middle"];switch(r.orient){case"top":s={x:o,y:1},i={baseline:"alphabetic",angle:0};break;case"right":s={x:1,y:1-o},i={baseline:"alphabetic",angle:90};break;case"bottom":s={x:o,y:0},i={baseline:"top",angle:0};break;case"left":s={x:0,y:o},i={baseline:"alphabetic",angle:-90};break}const a={...od,...i,...n,...e},c={xOffset:0,yOffset:0};switch(r.orient){case"top":c.yOffset=-a.offset;break;case"right":c.xOffset=a.offset;break;case"bottom":c.yOffset=a.offset;break;case"left":c.xOffset=-a.offset;break}return{configurableVisibility:!1,data:{values:[{}]},mark:{type:"text",tooltip:null,clip:!1,...s,...c,text:a.text,align:a.align??AT[a.anchor],angle:a.angle,baseline:a.baseline,dx:a.dx,dy:a.dy,color:a.color,font:a.font,size:a.fontSize,fontStyle:a.fontStyle,fontWeight:a.fontWeight}}}var On,Ut,zt;class ET{constructor(e){F(this,On,void 0);F(this,Ut,0);F(this,zt,0);k(this,On,new Array(e))}push(e){b(this,On)[b(this,Ut)]=e,k(this,Ut,(b(this,Ut)+1)%this.size),k(this,zt,Math.min(b(this,zt)+1,this.size))}get(){const e=b(this,On);return b(this,zt){const h=ct.fromMouseEvent(l);s.push({point:h,timestamp:performance.now()});const p=h.subtract(a);n({x:a.x,y:a.y,xDelta:p.x,yDelta:p.y,zDelta:0}),a=h},u=()=>{const h=performance.now(),p=s.get().filter(w=>h-w.timestamp<160);if(p.length<5||!i||FT(p))return;const d=p.at(-1),m=p[0],g=d.point.subtract(m.point).multiply(1/(d.timestamp-m.timestamp));let y=a.x,x=a.y;An=tf(i,w=>{n({x:w.x,y:w.y,xDelta:y-w.x,yDelta:x-w.y,zDelta:0}),y=w.x,x=w.y},150,.5,{x:y,y:x}),An({x:a.x-g.x*250,y:a.y-g.y*250})},f=()=>{document.removeEventListener("mousemove",c),document.removeEventListener("mouseup",f),u()};document.addEventListener("mouseup",f,!1),document.addEventListener("mousemove",c,!1)}}function FT(t){const e=t[Math.floor(t.length/2)],n=e.point.subtract(t[0].point).multiply(e.timestamp-t[0].timestamp),r=t.at(-1).point.subtract(e.point).multiply(t.at(-1).timestamp-e.timestamp),i=n.length,s=r.length,o=.4;return s/is.view==n);if(i>=0)b(this,ze)[i]=new ud(r,this,b(this,Dr));else throw new Error("Not my child view!")}get children(){return b(this,ze).map(n=>n.view)}get childCount(){return b(this,ze).length}async createAxes(){const n=[];for(const r of Kr){const i=this.resolutions.axis[r];if(i){const s=i.getAxisProps();if(s){const o={title:i.getTitle(),orient:Qo[r][0],...s},a=new Cg(o,i.scaleResolution.type,this.context,this,this);n.push(a.initializeChildren()),b(this,Ln)[r]=a}}}return Promise.all([...n,...b(this,ze).map(r=>r.createAxes())])}*[Symbol.iterator](){for(const n of b(this,ze))yield*n.getChildren();for(const n of Object.values(b(this,Ln)))yield n}getOverhang(){return D(this,fa,Ig).call(this).union(D(this,_r,Fo).call(this))}getSize(){return this._cache("size",()=>new tn(D(this,Cs,Hu).call(this,"column"),D(this,Cs,Hu).call(this,"row")).addPadding(D(this,_r,Fo).call(this)))}render(n,r,i={}){if(super.render(n,r,i),!this.isConfiguredVisible())return;this.layoutParent||(r=r.shrink(this.getPadding())),r=r.shrink(D(this,_r,Fo).call(this)),n.pushView(this,r);const s={devicePixelRatio:this.context.devicePixelRatio},o=Jh(D(this,Es,Gu).call(this,"column"),r.width,s),a=Jh(D(this,Es,Gu).call(this,"row"),r.height,s),c=new sd(b(this,Ft,En).length,b(this,Fr)??1/0),u=f=>Math.round(f*devicePixelRatio)/devicePixelRatio;for(const[f,l]of b(this,Ft,En).entries()){const{view:h,axes:p,gridLines:d,background:m,backgroundStroke:g,title:y}=l,[x,w]=c.getCellCoords(f),v=o[D(this,Ss,Wu).call(this,"column",x)],C=a[D(this,Ss,Wu).call(this,"row",w)],S=h.getViewportSize(),E=h.getSize(),M=h.getOverhang(),P=v.location-M.left,O=C.location-M.top,R=(ce,st)=>(ce[st].grow?(st=="width"?v:C).size:ce[st].px)+M[st],q=R(S,"width"),J=R(S,"height"),we=R(E,"width"),We=R(E,"height"),Ae=l.scrollbars.horizontal,Oe=l.scrollbars.vertical,Te=Ae?()=>u(Ae.viewportOffset):()=>0,de=Oe?()=>u(Oe.viewportOffset):()=>0,Le=new Rt(()=>r.x+P,()=>r.y+O,()=>q,()=>J),no=h.isScrollable(),mn=no?new Rt(()=>r.x+P-Te(),()=>r.y+O-de(),()=>we,()=>We):Le;l.coords=Le;const Zr=i.clipRect?Le.intersect(i.clipRect):Le;m==null||m.render(n,Zr,{...i,clipRect:void 0});for(const ce of Object.values(d))ce.render(n,Le,i);const ro=RT(h)||no;ro&&h.render(n,mn,{...i,clipRect:Zr}),g==null||g.render(n,Zr,{...i,clipRect:void 0});for(const[ce,st]of Object.entries(p)){const Ke=ce=="left"||ce=="right"?"vertical":"horizontal",Qr=l.scrollbars[Ke],_=Qr?Le.modify(Ke=="vertical"?{y:()=>mn.y,height:We}:{x:()=>mn.x,width:we}):Le,L=cd(_,ce,st);let N=i.clipRect;Qr&&(N=L.intersect(N).intersect(Qr?Le.modify(Ke=="vertical"?{x:-1e5,width:2e5}:{y:-1e5,height:2e5}):void 0)),st.render(n,L,{...i,clipRect:N})}for(const ce of Object.values(b(this,Ln))){const Ke=ce.axisProps.orient;(Ke=="left"&&x==0||Ke=="right"&&x==c.nCols-1||Ke=="top"&&w==0||Ke=="bottom"&&w==c.nRows-1)&&ce.render(n,cd(Le.shrink(l.view.getOverhang()),Ke,ce),i)}ro||h.render(n,mn,i);for(const ce of Object.values(l.scrollbars))ce.updateScrollbar(Le,mn),ce.render(n,r,i);y==null||y.render(n,Le,i)}n.popView(this)}propagateInteractionEvent(n){if(this.handleInteractionEvent(void 0,n,!0),n.stopped)return;const r=b(this,Ft,En).find(s=>s.coords.containsPoint(n.point.x,n.point.y));for(const s of Object.values((r==null?void 0:r.scrollbars)??{}))if(s.coords.containsPoint(n.point.x,n.point.y)&&(s.propagateInteractionEvent(n),n.stopped))return;const i=r==null?void 0:r.view;i&&(i.propagateInteractionEvent(n),(i instanceof Ge||i instanceof to)&&ST(n,r.coords,s=>D(this,ha,Rg).call(this,r.coords,r.view,s),this.context.getCurrentHover(),this.context.animator)),!n.stopped&&this.handleInteractionEvent(void 0,n,!1)}getDefaultResolution(n,r){return"independent"}}Fr=new WeakMap,Tr=new WeakMap,ze=new WeakMap,Ln=new WeakMap,Dr=new WeakMap,Ft=new WeakSet,En=function(){return b(this,ze).filter(n=>n.view.isConfiguredVisible())},la=new WeakSet,_g=function(){return new sd(b(this,Ft,En).length,b(this,Fr)??1/0)},Nn=new WeakSet,fi=function(n){const r=n=="column"?"width":"height",i=(s,o)=>s.map(a=>{const u=b(this,Ft,En)[a].getOverhangAndPadding();return n=="column"?o?u.right:u.left:o?u.bottom:u.top}).reduce((a,c)=>Math.max(a,c),0);return this._cache(`size/directionSizes/${n}`,()=>b(this,la,_g)[n=="column"?"colIndices":"rowIndices"].map(s=>({axisBefore:i(s,0),axisAfter:i(s,1),view:c4(s.map(o=>b(this,Ft,En)[o].view.getViewportSize()[r]))})))},Es=new WeakSet,Gu=function(n){const r=D(this,Nn,fi).call(this,n),i=[];i.push(gi);for(const[s,o]of r.entries())s>0&&i.push({px:b(this,Tr),grow:0}),(s==0||this.wrappingFacet)&&i.push(gi),i.push({px:o.axisBefore,grow:0}),i.push(o.view),i.push({px:o.axisAfter,grow:0}),(s==r.length-1||this.wrappingFacet)&&i.push(gi);return i},Cs=new WeakSet,Hu=function(n){let r=0,i=0;const s=n=="row"?this.spec.height:this.spec.width;if(s||s===0)return ig(s);const o=D(this,Nn,fi).call(this,n);for(const[a,c]of o.entries())a>0&&(i+=b(this,Tr)),(a==0||this.wrappingFacet)&&(i+=0),i+=c.axisBefore,i+=c.view.px??0,r+=c.view.grow??0,i+=c.axisAfter,(a==o.length-1||this.wrappingFacet)&&(i+=0);return{px:i,grow:r}},Ss=new WeakSet,Wu=function(n,r){return n=="row"&&this.wrappingFacet?1+6*r+2:2+4*r+1},fa=new WeakSet,Ig=function(){const n=D(this,Nn,fi).call(this,"column"),r=D(this,Nn,fi).call(this,"row");return!n.length||!r.length?me.zero():new me(r.at(0).axisBefore,n.at(-1).axisAfter,r.at(-1).axisAfter,n.at(0).axisBefore)},_r=new WeakSet,Fo=function(){const n=r=>{const i=nf[r],s=b(this,Ln)[i];return(s==null?void 0:s.axisProps.orient)!==r?0:Math.max(s.getPerpendicularSize()+s.axisProps.offset,0)};return new me(n("top"),n("right"),n("bottom"),n("left"))},ha=new WeakSet,Rg=function(n,r,i){for(const[s,o]of Object.entries(IT(r))){if(o.size<=0)continue;const a=n.normalizePoint(i.x,i.y),c=n.normalizePoint(i.x+i.xDelta,i.y+i.yDelta),u={x:c.x-a.x,y:c.y-a.y};for(const f of o)f.zoom(2**i.zDelta,s=="y"?1-a[s]:a[s],s=="x"?u.x:-u.y)}this.context.animator.requestRender()};function DT(t){if(!(!t||!t.fill||t.fillOpacity===0))return{configurableVisibility:!1,data:{values:[{}]},mark:{color:t.fill,opacity:t.fillOpacity??1,type:"rect",clip:!1,tooltip:null,minHeight:1,minOpacity:0}}}function _T(t){if(!(!t||!t.stroke||t.strokeWidth===0||t.strokeOpacity===0))return{configurableVisibility:!1,resolve:{scale:{x:"excluded",y:"excluded"},axis:{x:"excluded",y:"excluded"}},data:{values:[{x:0,y:0,x2:1,y2:0},{x:1,y:0,x2:1,y2:1},{x:1,y:1,x2:0,y2:1},{x:0,y:1,x2:0,y2:0}]},mark:{size:t.strokeWidth??1,color:t.stroke??"lightgray",strokeCap:"square",opacity:t.strokeOpacity??1,type:"rule",clip:!1,tooltip:null},encoding:{x:{field:"x",type:"quantitative",scale:null},y:{field:"y",type:"quantitative",scale:null},x2:{field:"x2"},y2:{field:"y2"}}}}function IT(t){const e={x:new Set,y:new Set};return t.visit(n=>{for(const[r,i]of Object.entries(e)){const s=n.getScaleResolution(r);s&&s.isZoomable()&&i.add(s)}}),e}function RT(t){let e=!0;return t.visit(n=>{n instanceof Ge&&e&&(e=n.mark.properties.clip===!0)}),e}function cd(t,e,n){const r=n.axisProps,i=n.getPerpendicularSize();if(e=="bottom")return t.translate(0,t.height+r.offset).modify({height:i});if(e=="top")return t.translate(0,-i-r.offset).modify({height:i});if(e=="left")return t.translate(-i-r.offset,0).modify({width:i});if(e=="right")return t.translate(t.width+r.offset,0).modify({width:i})}class ud{constructor(e,n,r){if(this.layoutParent=n,this.view=e,this.serial=r,this.background=void 0,this.backgroundStroke=void 0,this.axes={},this.gridLines={},this.scrollbars={},this.title=void 0,this.coords=Rt.ZERO,e.needsAxes.x||e.needsAxes.y){const i=e.spec,s="view"in i?i==null?void 0:i.view:void 0,o=DT(s);o&&(this.background=new Ge(o,n.context,n,e,"background"+r,{blockEncodingInheritance:!0}));const a=_T(s);a&&(this.backgroundStroke=new Ge(a,n.context,n,e,"backgroundStroke"+r,{blockEncodingInheritance:!0}));const c=vT(e.spec.title);if(c){const u=new Ge(c,n.context,n,e,"title"+r,{blockEncodingInheritance:!0});this.title=u}}e.spec.viewportWidth!=null&&(this.scrollbars.horizontal=new ld(this,"horizontal")),e.spec.viewportHeight!=null&&(this.scrollbars.vertical=new ld(this,"vertical"))}*getChildren(){this.background&&(yield this.background),this.backgroundStroke&&(yield this.backgroundStroke),this.title&&(yield this.title),yield*Object.values(this.axes),yield*Object.values(this.gridLines),yield this.view,yield*Object.values(this.scrollbars)}async createAxes(){const{view:e,axes:n,gridLines:r}=this,i=(a,c)=>{const u=a.getAxisProps();if(u===null)return;const f=u?{...u}:{};if(!f.orient){for(const l of Qo[c])if(!n[l]){f.orient=l;break}if(!f.orient)throw new Error("No slots available for an axis! Perhaps a LayerView has more than two children?")}if(f.title??(f.title=a.getTitle()),!Qo[c].includes(f.orient))throw new Error(`Invalid axis orientation "${f.orient}" on channel "${c}"!`);return f},s=async(a,c,u)=>{const f=i(a,c);if(f){if(n[f.orient])throw new Error(`An axis with the orient "${f.orient}" already exists!`);const l=new Cg(f,a.scaleResolution.type,this.layoutParent.context,this.layoutParent,u);n[f.orient]=l,await l.initializeChildren()}},o=async(a,c,u)=>{const f=i(a,c);if(f&&(f.grid||f.chromGrid)){const l=new hT(f,a.scaleResolution.type,this.layoutParent.context,this.layoutParent,u);r[f.orient]=l,await l.initializeChildren()}};for(const a of["x","y"])if(e.needsAxes[a]){const c=e.resolutions.axis[a];if(!c)continue;await s(c,a,e)}for(const a of["x","y"])if(e.needsAxes[a]){const c=e.getAxisResolution(a);if(!c)continue;await o(c,a,e)}if(e instanceof to){for(const a of e)for(const[c,u]of Object.entries(a.resolutions.axis)){const f=u.getAxisProps();f&&f.orient&&await s(u,c,a)}for(const a of e)for(const[c,u]of Object.entries(a.resolutions.axis)){const f=u.getAxisProps();f&&!f.orient&&await s(u,c,a)}}[...Object.values(n),...Object.values(r)].forEach(a=>a.visit(c=>{c instanceof Ge&&c.resolve("scale")}))}getOverhang(){const e=n=>{const r=this.axes[n];return r?Math.max(r.getPerpendicularSize()+r.axisProps.offset,0):0};return new me(e("top"),e("right"),e("bottom"),e("left")).add(this.view.getOverhang())}getOverhangAndPadding(){return this.getOverhang().add(this.view.getPadding())}}var Ir,Fs,Vt,$n;class ld extends Ge{constructor(n,r){const i={scrollbarSize:8,scrollbarPadding:2};super({data:{values:[{}]},mark:{type:"rect",fill:"#b0b0b0",fillOpacity:.6,stroke:"white",strokeWidth:1,strokeOpacity:1,cornerRadius:5,clip:!1},configurableVisibility:!1},n.layoutParent.context,n.layoutParent,n.view,"scrollbar-"+r,{blockEncodingInheritance:!0});F(this,Ir,void 0);F(this,Fs,Rt.ZERO);F(this,Vt,0);F(this,$n,0);ve(this,"viewportOffset",0);this.config=i,k(this,Ir,r),this.interpolateViewportOffset=tf(this.context.animator,s=>{this.viewportOffset=s.x},50,.4,{x:this.viewportOffset}),this.addInteractionEventListener("mousedown",(s,o)=>{if(o.stopPropagation(),b(this,Vt)<=0)return;const a=p=>r=="vertical"?p.clientY:p.clientX,c=o.uiEvent;c.preventDefault();const u=this.scrollOffset,f=a(c),l=p=>{const d=Gr(a(p)-f+u,0,b(this,Vt));this.interpolateViewportOffset({x:d/b(this,Vt)*b(this,$n)})},h=()=>{document.removeEventListener("mousemove",l),document.removeEventListener("mouseup",h)};document.addEventListener("mouseup",h,!1),document.addEventListener("mousemove",l,!1)})}get scrollOffset(){return this.viewportOffset/b(this,$n)*b(this,Vt)}render(n,r,i){super.render(n,b(this,Fs),i)}updateScrollbar(n,r){const i=this.config.scrollbarPadding,s=this.config.scrollbarSize,o=b(this,Ir)=="horizontal"?"width":"height",a=Math.min(1,n[o]/r[o]),c=n[o]-2*i,u=a*c;k(this,Vt,c-u),k(this,$n,r[o]-n[o]),this.viewportOffset=Gr(this.viewportOffset,0,b(this,$n)),k(this,Fs,b(this,Ir)=="vertical"?new Rt(()=>n.x+n.width-s-i,()=>n.y+i+this.scrollOffset,()=>s,()=>u):new Rt(()=>n.x+i+this.scrollOffset,()=>n.y+n.height-s-i,()=>u,()=>s))}}Ir=new WeakMap,Fs=new WeakMap,Vt=new WeakMap,$n=new WeakMap;class Bc extends TT{constructor(e,n,r,i,s){super(e,n,r,i,s,Yu(e)?e.columns:To(e)?1:1/0),this.spec=e}async initializeChildren(){const e=this.spec,n=Yu(e)?e.concat:To(e)?e.vconcat:e.hconcat;this.setChildren(await Promise.all(n.map((r,i)=>this.context.createOrImportView(r,this,this,"grid"+i)))),await this.createAxes()}getDefaultResolution(e,n){return n=="axis"?"independent":To(this.spec)&&e==="x"||Bg(this.spec)&&e==="y"?"shared":"independent"}}const Mg="viewRoot";var Rr;class MT{constructor(e={}){F(this,Rr,new Map);this.options={allowImport:!0,wrapRoot:!0,...e};const n=r=>(i,s,o,a,c)=>new r(i,s,o,a,i.name??c);this.addViewType(ju,n(to)),this.addViewType(qu,n(Ge)),this.addViewType(To,n(Bc)),this.addViewType(Bg,n(Bc)),this.addViewType(Yu,n(Bc)),this.addViewType(PT,()=>{throw new Error("SampleView is not supported by the @genome-spy/core package. Use @genome-spy/app instead!")})}addViewType(e,n){b(this,Rr).set(e,n)}createView(e,n,r,i,s){for(const[o,a]of b(this,Rr))if(o(e))return a(e,n,r,i,s);throw new Error("Invalid spec, cannot figure out the view type from the properties: "+JSON.stringify([...Object.keys(e)]))}isViewSpec(e){const n=[...b(this,Rr).keys()].filter(r=>r(e));if(n.length>1)throw new Error("Ambiguous spec. Cannot create a view!");return n.length==1}async createOrImportView(e,n,r,i,s,o){let a;if(BT(e)){let u;if("url"in e.import)if(this.options.allowImport)u=await NF(e,i.getBaseUrl(),n);else throw new Gn("Importing views is not allowed!",r);else if("template"in e.import)u=kg(e.import.template,i);else throw new Error("Invalid import: "+JSON.stringify(e));o==null||o(u),kT(u,e),a=u}else a=e;!i&&this.options.wrapRoot&&(qu(a)||ju(a))&&s===Mg&&(a={name:"implicitRoot",vconcat:[a]});const c=this.createView(a,n,r,i,s);return c instanceof eo&&await c.initializeChildren(),c}}Rr=new WeakMap;function kg(t,e){var r,i;const n=(i=(r=e.spec)==null?void 0:r.templates)==null?void 0:i[t];if(n)return structuredClone(n);if(e.dataParent)return kg(t,e.dataParent);throw new Error(`Cannot find template "${t}" in current view or its ancestors!`)}function kT(t,e){e.name!=null&&(t.name=e.name);const n=he(e.params)?e.params:be(e.params)?Object.entries(e.params).map(([r,i])=>({name:r,value:i})):[];if(n.length){t.params??(t.params=[]);for(const r of n){const i=t.params.findIndex(s=>s.name==r.name);i>=0&&(t.params[i]=r)}for(const r of n)t.params.some(i=>i.name==r.name)||t.params.push(r)}}function qu(t){return"mark"in t&&(H(t.mark)||be(t.mark))}function ju(t){return"layer"in t&&be(t.layer)}function BT(t){return"import"in t}function To(t){return"vconcat"in t&&he(t.vconcat)}function Bg(t){return"hconcat"in t&&he(t.hconcat)}function Yu(t){return"concat"in t&&he(t.concat)}function PT(t){return"samples"in t&&be(t.samples)&&"spec"in t&&be(t.spec)}function OT(t){const e=Math.floor(Math.random()*16777215).toString(16),n=[];for(const r of t.paramConfigs.values()){if(!qC(r))continue;const i=r.bind;if(!i||!("input"in i))continue;const s=r.name,o=t.getSetter(s),a=t.getValue(s),c=i.name??s,u=i.debounce?Jo(o,i.debounce,!1):o,f=`${e}-param-${s}`;if(i.input=="range")n.push(z`
${a}
`);else if(i.input=="checkbox")n.push(z` `);else if(i.input=="radio")n.push(z`${c}
${i.options.map((l,h)=>{var p;return z``})}
`);else if(i.input=="select")n.push(z` `);else if(i.input=="text"||i.input=="number"||i.input=="color")n.push(z`
`);else throw new Error("Unsupported input type: "+i.input);i.description&&n.push(z`
${i.description}
`)}return n}ol("fasta",JF);var Mr,Do,da,Pg,pa,Og,ma,Lg;class LT{constructor(e,n,r={}){F(this,Mr);F(this,da);F(this,pa);F(this,ma);this.container=e,this.options=r,r.inputBindingContainer??(r.inputBindingContainer="default"),this._destructionCallbacks=[],this.spec=n,this.viewFactory=new MT,this.namedDataProviders=[],this.animator=new HF(()=>this.renderAll()),this.genomeStore=void 0,this.viewVisibilityPredicate=i=>i.isVisibleInSpec(),this._renderingContext=void 0,this._pickingContext=void 0,this._dirtyPickingBuffer=!1,this._currentHover=void 0,this._wheelInertia=new ZF(this.animator),this._keyboardListeners=new Map,this._eventListeners=new Map,this._extraBroadcastListeners=new Map,this.tooltipHandlers={default:oT,refseqgene:eT,...r.tooltipHandlers??{}},this.viewRoot=void 0,this._loadingViews=new Map,this._inputBindingContainer=void 0,this._mouseDownCoords=void 0}registerNamedDataProvider(e){this.namedDataProviders.unshift(e)}getNamedDataFromProvider(e){for(const n of this.namedDataProviders){const r=n(e);if(r)return r}}updateNamedData(e,n){const r=this.viewRoot.context.dataFlow.findNamedDataSource(e);if(!r)throw new Error("No such named data source: "+e);r.dataSource.updateDynamicData(n),Mu(r.hosts),this.animator.requestRender()}broadcast(e,n){var i;const r={type:e,payload:n};this.viewRoot.visit(s=>s.handleBroadcast(r)),(i=this._extraBroadcastListeners.get(e))==null||i.forEach(s=>s(r))}_updateLoadingIndicators(){const e=[],n=()=>[...this._loadingViews.values()].some(r=>r.status=="loading"||r.status=="error");for(const[r,i]of this._loadingViews){const s=r.coords;if(s){const o={left:`${s.x}px`,top:`${s.y}px`,width:`${s.width}px`,height:`${s.height}px`};e.push(z`
${i.status=="error"?z`Loading failed${i.detail?z`: ${i.detail}`:Q}`:z` Loading...`}
`)}}n()?this.loadingIndicatorsElement.style.display="block":setTimeout(()=>{n()||(this.loadingIndicatorsElement.style.display="none")},3e3),qn(e,this.loadingIndicatorsElement)}destroy(){var n;const e=b(this,Mr,Do);this.container.classList.remove("genome-spy"),e.classList.remove("loading");for(const[r,i]of this._keyboardListeners)for(const s of i)document.removeEventListener(r,s);for(this._destructionCallbacks.forEach(r=>r()),this._glHelper.finalize(),(n=this._inputBindingContainer)==null||n.remove();this.container.firstChild;)this.container.firstChild.remove()}async _prepareViewsAndData(){this.spec.genome&&(this.genomeStore=new WF(this.spec.baseUrl),await this.genomeStore.initialize(this.spec.genome));const e=this,n={dataFlow:new bg,glHelper:this._glHelper,animator:this.animator,genomeStore:this.genomeStore,fontManager:new YF(this._glHelper),get devicePixelRatio(){return e._glHelper.dpr},requestLayoutReflow:()=>{},updateTooltip:this.updateTooltip.bind(this),getNamedDataFromProvider:this.getNamedDataFromProvider.bind(this),getCurrentHover:()=>this._currentHover,setDataLoadingStatus:(c,u,f)=>{this._loadingViews.set(c,{status:u,detail:f}),this._updateLoadingIndicators()},addKeyboardListener:(c,u)=>{document.addEventListener(c,u);let f=this._keyboardListeners.get(c);f||(f=[],this._keyboardListeners.set(c,f)),f.push(u)},addBroadcastListener(c,u){const f=e._extraBroadcastListeners;let l=f.get(c);l||(l=new Set,f.set(c,l)),l.add(u)},removeBroadcastListener(c,u){var l;(l=e._extraBroadcastListeners.get(c))==null||l.delete(u)},isViewConfiguredVisible:e.viewVisibilityPredicate,isViewSpec:c=>e.viewFactory.isViewSpec(c),createView:function(c,u,f,l){return e.viewFactory.createView(c,n,u,f,l)},createOrImportView:async function(c,u,f,l,h){return e.viewFactory.createOrImportView(c,n,u,f,l,h)}},r=this.spec;r.datasets&&this.registerNamedDataProvider(c=>r.datasets[c]),this.viewRoot=await n.createOrImportView(r,null,null,Mg),b(this,Mr,Do).style.flexGrow=this.viewRoot.getSize().height.grow>0?"1":"0",D(this,da,Pg).call(this),OF(this.viewRoot),LF(this.viewRoot);const i=this.viewRoot.getDescendants();i.forEach(c=>c.configureViewOpacity()),this._glHelper.invalidateSize(),D(this,pa,Og).call(this);const s=i.filter(c=>c instanceof Ge),o=IF(this.viewRoot,n.dataFlow);PF(o),this.broadcast("dataFlowBuilt",o),s.forEach(c=>c.mark.initializeEncoders());const a=Promise.all(s.map(c=>c.mark.initializeGraphics()));for(const c of s)o.addObserver(u=>{c.mark.initializeData(),c.mark.updateGraphicsData(),n.animator.requestRender()},c);await n.fontManager.waitUntilReady(),o.initialize(),await Promise.all(o.dataSources.map(c=>c.load())),Mu(this.viewRoot),this.broadcast("dataLoaded"),await a;for(const c of s)c.mark.finalizeGraphicsInitialization();n.requestLayoutReflow=this.computeLayout.bind(this),this.viewRoot.visit(c=>Co(c,"size")),this._glHelper.invalidateSize()}async launch(){try{return D(this,ma,Lg).call(this),await this._prepareViewsAndData(),this.registerMouseEvents(),this.computeLayout(),this.animator.requestRender(),!0}catch(e){const n=`${e.view?`At "${e.view.getPathString()}": `:""}${e.toString()}`;return console.error(e.stack),NT(this.container,n),!1}finally{b(this,Mr,Do).classList.remove("loading"),window.setTimeout(()=>{this.loadingMessageElement.style.display="none"},2e3)}}registerMouseEvents(){const e=this._glHelper.canvas;let n=performance.now();const r=i=>{var a,c;const s=performance.now(),o=s-n<200;if(i instanceof MouseEvent){const u=e.getBoundingClientRect(),f=new ct(i.clientX-u.left-e.clientLeft,i.clientY-u.top-e.clientTop);i.type=="mousemove"&&!o&&(this.tooltip.handleMouseMove(i),this._tooltipUpdateRequested=!1,i.buttons==0&&!ad()&&(this.renderPickingFramebuffer(),this._handlePicking(f.x,f.y)));const l=h=>{this.viewRoot.propagateInteractionEvent(new zF(f,h)),this._tooltipUpdateRequested||this.tooltip.clear()};if(i.type!="wheel"&&this._wheelInertia.cancel(),(i.type=="mousedown"||i.type=="mouseup")&&!ad())this.renderPickingFramebuffer();else if(i.type=="wheel"){n=s,this._tooltipUpdateRequested=!1;const h=i;if(Math.abs(h.deltaX)>Math.abs(h.deltaY))this._currentHover=null,this._wheelInertia.cancel();else{const p=QF(h);this._wheelInertia.setMomentum(h.deltaY*(h.deltaMode?80:1),d=>{const m=new WheelEvent("wheel",{...p,deltaMode:0,deltaX:0,deltaY:d});l(m)}),h.preventDefault();return}}if(i.type=="click"){const h=this._currentHover?{type:i.type,viewPath:this._currentHover.mark.unitView.getLayoutAncestors().map(p=>p.name).reverse(),datum:this._currentHover.datum}:{type:i.type,viewPath:null,datum:null};(a=this._eventListeners.get("click"))==null||a.forEach(p=>p(h))}(i.type!="click"||((c=this._mouseDownCoords)==null?void 0:c.subtract(ct.fromMouseEvent(i)).length)<3)&&l(i)}};["mousedown","mouseup","wheel","click","mousemove","gesturechange","contextmenu"].forEach(i=>e.addEventListener(i,r)),e.addEventListener("mousedown",i=>{this._mouseDownCoords=ct.fromMouseEvent(i),document.addEventListener("mouseup",()=>this.tooltip.popEnabledState(),{once:!0}),this.tooltip.pushEnabledState(!1)}),e.addEventListener("dragstart",i=>i.stopPropagation())}_handlePicking(e,n){var s;const r=this._glHelper.readPickingPixel(e,n),i=r[0]|r[1]<<8|r[2]<<16|r[3]<<24;if(i==0){this._currentHover=null;return}if(i!==((s=this._currentHover)==null?void 0:s.uniqueId)&&(this._currentHover=null),this._currentHover||this.viewRoot.visit(o=>{if(o instanceof Ge){if(o.mark.isPickingParticipant()&&[...o.facetCoords.values()].some(a=>a.containsPoint(e,n))){const a=o.getCollector().findDatumByUniqueId(i);a&&(this._currentHover={mark:o.mark,datum:a,uniqueId:i})}if(this._currentHover)return yi}}),this._currentHover){const o=this._currentHover.mark;this.updateTooltip(this._currentHover.datum,async a=>{if(!o.isPickingParticipant())return;const c=o.properties.tooltip;if(c!==null){const u=(c==null?void 0:c.handler)??"default",f=this.tooltipHandlers[u];if(!f)throw new Error("No such tooltip handler: "+u);return f(a,o,c==null?void 0:c.params)}})}}updateTooltip(e,n){if(!this._tooltipUpdateRequested||!e)this.tooltip.updateWithDatum(e,n),this._tooltipUpdateRequested=!0;else throw new Error("Tooltip has already been updated! Duplicate event handler?")}computeLayout(){const e=this.viewRoot;if(!e)return;this.broadcast("layout");const n=this._glHelper.getLogicalCanvasSize();if(isNaN(n.width)||isNaN(n.height)){console.log(`NaN in canvas size: ${n.width}x${n.height}. Skipping computeLayout().`);return}this._renderingContext=new nd({picking:!1},this._glHelper),this._pickingContext=new nd({picking:!0},this._glHelper),e.render(new UF(this._renderingContext,this._pickingContext),Rt.create(0,0,n.width,n.height)),this._updateLoadingIndicators(),this.broadcast("layoutComputed")}renderAll(){var e;(e=this._renderingContext)==null||e.render(),this._dirtyPickingBuffer=!0}renderPickingFramebuffer(){this._dirtyPickingBuffer&&(this._pickingContext.render(),this._dirtyPickingBuffer=!1)}getSearchableViews(){const e=[];return this.viewRoot.visit(n=>{n instanceof Ge&&n.getDataAccessor("search")&&e.push(n)}),e}getNamedScaleResolutions(){const e=new Map;return this.viewRoot.visit(n=>{for(const r of Object.values(n.resolutions.scale))r.name&&e.set(r.name,r)}),e}}Mr=new WeakSet,Do=function(){return this.container.querySelector(".canvas-wrapper")},da=new WeakSet,Pg=function(){const e=[];this.viewRoot.visit(r=>{const i=r.paramMediator;e.push(...OT(i))});const n=this.options.inputBindingContainer;if(!(!n||n=="none"||!e.length)){if(this._inputBindingContainer=bo("div",{className:"gs-input-bindings"}),n=="default")this.container.appendChild(this._inputBindingContainer);else if(n instanceof HTMLElement)n.appendChild(this._inputBindingContainer);else throw new Error("Invalid inputBindingContainer");e.length&&qn(z`
${e}
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`;return z`${(()=>z`

1. Choose a genome assembly or a sequence dictionary

Choosing a genome assembly instead of a sequence dictionary activates cytoband, GC content, and RefSeq gene tracks.

${e()}

2. Select files

Please provide at least one of the following files to start visualizing. File types are detected from the TSV header row.

N.B. All data processing takes place in your web browser. Nothing is uploaded anywhere.

${Object.values(ge).filter(r=>r!==ge.DICT||!Hn).map(t)}
or drag and drop here.

No files to play with?

Try the example data sets:

${bi?z` Loading...`:""}

3. Explore the data

Zoom with the mouse wheel or touchpad, pan by dragging or with the touchpad. Hover an item to get details.
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Disabling binned index."));const A=n(g),E=r(g),F=l(A,!1),C=l(E,!0);for(let w=F;w<=C;w++)i[w]>x&&(i[w]=x),a[w]{const A=l(g,!1),E=l(x,!0),F=i[A],C=Math.max(a[E],F);return b[0]=F,b[1]=C,b},m=()=>{for(let x=1;x0;x--)g&&i[x]==sf?(i[x]=a[x],g=!1):i[x-1]>i[x]&&(i[x-1]=i[x]);return d};if(h.getIndex=m,p.getIndex=m,!o)return n==r?h:p}class Xi{constructor({encoders:e,numVertices:n=void 0,attributes:r=[]}){this.encoders=e,this.variableEncoders=Object.fromEntries(Object.entries(e).filter(([i,s])=>r.includes(i)&&s&&s.scale&&!s.constant)),this.allocatedVertices=n,this.variableBuilder=new kv(n);for(const[i,s]of Object.entries(this.variableEncoders)){const o=s.accessor,a=[0,0],c=qs(s.scale.type),u=s.indexer,f=u?l=>u(o(l)):c?l=>Md(o(l),a):o;this.variableBuilder.addConverter(i,{f,numComponents:c?2:1,arrayReference:c?a:void 0})}this.lastOffset=0,this.rangeMap=new Sn([],JSON.stringify)}registerBatch(e){var s;const n=this.lastOffset,r=this.variableBuilder.vertexCount,i=r-n;i&&this.rangeMap.set(e,{offset:n,count:i,xIndex:(s=this.xIndexer)==null?void 0:s.getIndex()}),this.lastOffset=r}addBatches(e){for(const[n,r]of e)this.addBatch(n,r)}addBatch(e,n,r=0,i=n.length){this.prepareXIndexer(n,r,i);for(let s=r;s{this.addToXIndex=c=>{},this.xIndexer=void 0};if(!e.length||r-n<0){i();return}const s=c=>{var u;return c&&me((u=c.scale)==null?void 0:u.type)&&c},o=s(this.variableEncoders.x),a=s(this.variableEncoders.x2);if(o){const c=o.accessor,u=a?a.accessor:c,f=[c(e[n]),u(e[r-1])];if(f[1]>f[0]){this.xIndexer=Pv(50,f,c,u);let l=this.variableBuilder.vertexCount;this.addToXIndex=h=>{let p=this.variableBuilder.vertexCount;this.xIndexer(h,l,p),l=p}}else i()}else i()}addToXIndex(e){}toArrays(){return{arrays:this.variableBuilder.arrays,vertexCount:this.variableBuilder.vertexCount,allocatedVertices:this.allocatedVertices,rangeMap:this.rangeMap}}}class Lv extends Xi{constructor({encoders:e,attributes:n,tessellationThreshold:r=1/0,visibleRange:i=[-1/0,1/0],numItems:s}){super({encoders:e,attributes:n,numVertices:r==1/0?s*6:void 0}),this.visibleRange=i,this.tessellationThreshold=r||1/0,this.updateFrac=this.variableBuilder.createUpdater("frac",2)}addBatch(e,n,r=0,i=n.length){if(i<=r)return;const s=this.encoders,[o,a]=this.visibleRange,c=h=>h.accessor||(p=>0),u=c(s.x),f=c(s.x2);this.prepareXIndexer(n,r,i);const l=[0,0];this.updateFrac(l);for(let h=r;hm&&([d,m]=[m,d]),ma)continue;da&&(m=a),this.variableBuilder.updateFromDatum(p),l[0]=0,l[1]=0;const g=1;this.variableBuilder.pushAll();for(let x=0;x<=g;x++)l[0]=x/g,l[1]=0,this.variableBuilder.pushAll(),l[1]=1,this.variableBuilder.pushAll();this.variableBuilder.pushAll(),this.addToXIndex(p)}this.registerBatch(e)}}class Nv extends Xi{constructor({encoders:e,attributes:n,tessellationThreshold:r=1/0,visibleRange:i=[-1/0,1/0],numItems:s}){super({encoders:e,attributes:n,numVertices:r==1/0?s*6:void 0}),this.visibleRange=i,this.tessellationThreshold=r||1/0,this.updateSide=this.variableBuilder.createUpdater("side",1),this.updatePos=this.variableBuilder.createUpdater("pos",1)}addBatch(e,n,r=0,i=n.length){this.prepareXIndexer(n,r,i);for(let s=r;sc,this.updateVertexCoord=this.variableBuilder.createUpdater("vertexCoord",2),this.updateTextureCoord=this.variableBuilder.createUpdater("textureCoord",2),this.updateWidth=this.variableBuilder.createUpdater("width",1)}addBatch(e,n,r=0,i=n.length){const s=this.properties.align||"left",o=this.properties.logoLetters??!1,a=this.metadata.common.base,c=this.metadata.common.scaleH;let u=-Wn;switch(this.properties.baseline){case"top":u+=this.metrics.capHeight;break;case"middle":u+=this.metrics.capHeight/2;break;case"bottom":u-=this.metrics.descent;break}const f=this.encoders.text.accessor||this.encoders.text,l=[0,0];this.updateVertexCoord(l);const h=[0,0];this.updateTextureCoord(h),this.prepareXIndexer(n,r,i);for(let p=r;p0.0){float sd=abs(d)-halfStrokeWidth;return mix(stroke,d<=0.0 ? fill : vec4(0.0),distanceToRatio(sd));}else{return fill*distanceToRatio(-d);}}`,Vv="uniform highp float uZero;vec3 getDiscreteColor(sampler2D s,int index){return texelFetch(s,ivec2(index % textureSize(s,0).x,0),0).rgb;}vec3 getInterpolatedColor(sampler2D s,float unitValue){return texture(s,vec2(unitValue,0.0)).rgb;}float clampToRange(float value,vec2 range){return clamp(value,min(range[0],range[1]),max(range[0],range[1]));}float scaleIdentity(float value){return value;}float scaleLinear(float value,vec2 domain,vec2 range){float domainSpan=domain[1]-domain[0];float rangeSpan=range[1]-range[0];return(value-domain[0])/domainSpan*rangeSpan+range[0];}float scaleLog(float value,vec2 domain,vec2 range,float base){return scaleLinear(log(value)/log(base),log(domain)/log(base),range);}float symlog(float value,float constant){return sign(value)*log(abs(value/constant)+1.0);}float scaleSymlog(float value,vec2 domain,vec2 range,float constant){return scaleLinear(symlog(value,constant),vec2(symlog(domain[0],constant),symlog(domain[1],constant)),range);}float scalePow(float value,vec2 domain,vec2 range,float exponent){return scaleLinear(pow(abs(value),exponent)*sign(value),pow(abs(domain),vec2(exponent))*sign(domain),range);}float scaleBand(float value,vec2 domainExtent,vec2 range,float paddingInner,float paddingOuter,float align,float band){float start=range[0];float stop=range[1];float rangeSpan=stop-start;float n=domainExtent[1]-domainExtent[0];paddingInner=int(n)>1 ? paddingInner : 0.0;float step=rangeSpan/max(1.0,n-paddingInner+paddingOuter*2.0);start+=(rangeSpan-step*(n-paddingInner))*align;float bandwidth=step*(1.0-paddingInner);return start+(value-domainExtent[0])*step+bandwidth*band;}float scaleBandHp(vec2 value,vec3 domainExtent,vec2 range,float paddingInner,float paddingOuter,float align,float band){float start=range[0];float stop=range[1];float rangeSpan=stop-start;vec2 domainStart=domainExtent.xy;float n=domainExtent[2];float step=rangeSpan/max(1.0,n-paddingInner+paddingOuter*2.0);start+=(rangeSpan-step*(n-paddingInner))*align;float bandwidth=step*(1.0-paddingInner);float inf=1.0/uZero;float hi=max(value[0]-domainStart[0],-inf);float lo=max(value[1]-domainStart[1],-inf);return dot(vec4(start,hi,lo,bandwidth),vec4(1.0,step,step,band));}",Gv=`/***Describes where a sample facet should be shown. Interpolating between the*current and target positions/heights allows for transitioning between facet*configurations.*/struct SampleFacetPosition{float pos;float height;float targetPos;float targetHeight;};/***Trasition fraction[0,1]between the current and target configurations.*/uniform float uTransitionOffset; -#if !defined(SAMPLE_FACET_UNIFORM) && !defined(SAMPLE_FACET_TEXTURE) -SampleFacetPosition getSampleFacetPos(){return SampleFacetPosition(0.0,1.0,0.0,1.0);} -#elif defined(SAMPLE_FACET_UNIFORM) -/***Location and height of the band on the Y axis on a normalized[0,1]scale.*Elements: curr pos,curr height,target pos,target height*/uniform vec4 uSampleFacet;SampleFacetPosition getSampleFacetPos(){return SampleFacetPosition(1.0-uSampleFacet.x-uSampleFacet.y,uSampleFacet.y,1.0-uSampleFacet.z-uSampleFacet.w,uSampleFacet.w);} -#elif defined(SAMPLE_FACET_TEXTURE) -uniform sampler2D uSampleFacetTexture;SampleFacetPosition getSampleFacetPos(){vec4 texel=texelFetch(uSampleFacetTexture,ivec2(int(attr_facetIndex),0),0);return SampleFacetPosition(1.0-texel.r-texel.g,texel.g,1.0-texel.r-texel.g,texel.g);} -#endif -bool isFacetedSamples(SampleFacetPosition facetPos){return facetPos!=SampleFacetPosition(0.0,1.0,0.0,1.0);}bool isFacetedSamples(){return isFacetedSamples(getSampleFacetPos());}bool isInTransit(){return uTransitionOffset>0.0;}float getTransitionFraction(float xPos){return smoothstep(0.0,0.7+uTransitionOffset,(xPos-uTransitionOffset)*2.0);}vec2 applySampleFacet(vec2 pos){SampleFacetPosition facetPos=getSampleFacetPos();if(!isFacetedSamples(facetPos)){return pos;}else if(isInTransit()){vec2 interpolated=mix(vec2(facetPos.pos,facetPos.height),vec2(facetPos.targetPos,facetPos.targetHeight),getTransitionFraction(pos.x));return vec2(pos.x,interpolated[0]+pos.y*interpolated[1]);}else{return vec2(pos.x,facetPos.pos+pos.y*facetPos.height);}}float getSampleFacetHeight(vec2 pos){SampleFacetPosition facetPos=getSampleFacetPos();if(!isFacetedSamples(facetPos)){return 1.0;}else if(isInTransit()){return mix(facetPos.height,facetPos.targetHeight,getTransitionFraction(pos.x));}else{return facetPos.height;}}`,Hv=`/**Based on concepts presented at:*https:*https:*/out highp vec4 vPickingColor;/***Passes the unique id to the fragment shader as a color if picking is enabled.*Returns true if picking is enabled.*/bool setupPicking(){if(uPickingEnabled){ -#ifdef uniqueId_DEFINED -int id=int(getScaled_uniqueId());vPickingColor=vec4(ivec4(id>>0,id>>8,id>>16,0xFF)&0xFF)/float(0xFF); -#else -vPickingColor=vec4(1.0); -#endif -return true;}return false;}`,qv="in highp vec4 vPickingColor;",bs=Symbol("cacheMap");function pr(t,e,n){let r=pi(t).get(e);return r===void 0&&(r=n(e),pi(t).set(e,r)),r}function Bd(t,e){pi(t).delete(e)}function As(t,e){const n=pi(t);for(const r of n.keys())r.startsWith(e)&&n.delete(r);pi(t).delete(e)}function kd(t){t[bs]=new Map}function pi(t){return t[bs]||kd(t),t[bs]}function Wv(t,e,n,r){const i=V(t)?t:t.name,s=!V(t)&&t.extent||[0,1];if(n===void 0&&!V(t)&&(n=t.count),i){const o=su(i);if(Ie(o)){const a=Od(o,{extent:s,count:n});return qo(e,{minMag:e.LINEAR,format:e.RGB,height:1,wrap:e.CLAMP_TO_EDGE},a,r)}else{if(Me(o))return ac(o,e);throw new Error("Unknown scheme: "+i)}}}function jv(t,e="rgb",n,r){const i=Ro(t,V(e)?e:e.type,V(e)?void 0:e.gamma),s=Od(i);return qo(n,{minMag:n.LINEAR,format:n.RGB,height:1,wrap:n.CLAMP_TO_EDGE},s,r)}function Yv(t,e,n,r){const i=Math.max(t.length,n||0),s=new Float32Array(i);for(let o=0;oa/(r-1)).map(a=>i+a/s).map(t);return n&&o.reverse(),Pd(o)}function Pd(t,e){const n=Math.max(t.length,e||0),r=new Uint8Array(n*3);for(let i=0;i{this.invalidateSize(),this._emit("resize")}),this._resizeObserver.observe(this._container),this._updateDpr(),this._clearColor=[0,0,0,0],r){const o=Bt(r).rgb();this._clearColor=[o.r/255,o.g/255,o.b/255,o.opacity]}}invalidateSize(){this._logicalCanvasSize=void 0,this._updateDpr(),this.adjustGl()}_updateDpr(){this.dpr=window.devicePixelRatio}compileShader(e,n){const r="#version 300 es",i="precision mediump float;";Me(n)&&(n=n.join(` - -`));const s=this.gl,o=n.replaceAll(/ {2,}|^\s*\/\/.*$/gm,"");let a=this._shaderCache.get(o);if(!a){const c=[r,i,n].join(` - -`);a=s.createShader(e),s.shaderSource(a,c),s.compileShader(a),this._shaderCache.set(o,a)}return a}adjustGl(){const e=this.getLogicalCanvasSize();this.canvas.style.width=`${e.width}px`,this.canvas.style.height=`${e.height}px`;const n=this.getPhysicalCanvasSize(e);this.canvas.width=n.width,this.canvas.height=n.height,xv(this.gl,this._pickingBufferInfo,this._pickingAttachmentOptions)}finalize(){this._resizeObserver.unobserve(this._container),this.canvas.remove()}getPhysicalCanvasSize(e){return e=e||this.getLogicalCanvasSize(),{width:e.width*this.dpr,height:e.height*this.dpr}}getLogicalCanvasSize(){var s;if(this._logicalCanvasSize)return this._logicalCanvasSize;const e=((s=this._sizeSource)==null?void 0:s.call(this))??{width:void 0,height:void 0},n=window.getComputedStyle(this._container,null),r=e.width??this._container.clientWidth-parseFloat(n.paddingLeft)-parseFloat(n.paddingRight),i=e.height??this._container.clientHeight-parseFloat(n.paddingTop)-parseFloat(n.paddingBottom);return this._logicalCanvasSize={width:r,height:i},this._logicalCanvasSize}addEventListener(e,n){this._listeners.push({type:e,listener:n})}_emit(e){for(const n of this._listeners)n.type===e&&n.listener()}readPickingPixel(e,n){const r=this.gl;e*=this.dpr,n*=this.dpr;const i=this.getPhysicalCanvasSize().height,s=new Uint8Array(4);return r.bindFramebuffer(r.FRAMEBUFFER,this._pickingBufferInfo.framebuffer),r.readPixels(e,i-n-1,1,1,r.RGBA,r.UNSIGNED_BYTE,s),r.bindFramebuffer(r.FRAMEBUFFER,null),s}clearAll(){const e=this.gl,{width:n,height:r}=this.getPhysicalCanvasSize();e.viewport(0,0,n,r),e.disable(e.SCISSOR_TEST),e.clearColor(...this._clearColor),e.clear(e.COLOR_BUFFER_BIT)}createRangeTexture(e,n=!1){const r=this.rangeTextures.get(e);if(!n&&r)return;function i(o,a){return Ot(a.type)?a.domain().length:a.type=="threshold"?a.domain().length+1:a.type=="quantize"||a.type=="quantile"?o??4:o}const s=e.channel;if(An(s)){const o=e.getScaleProps(),a=e.getScale(),c=a.range();let u;if(o.scheme)if(a.type=="threshold"&&c)u=ac(c,this.gl,a.domain().length,r);else{let f=V(o.scheme)?void 0:o.scheme.count;f=i(f,a),u=Wv(o.scheme,this.gl,f,r)}else _o(a.type)||me(a.type)&&c.length>2?u=jv(c,o.interpolate,this.gl,r):u=ac(c,this.gl,a.domain().length,r);this.rangeTextures.set(e,u)}else{const o=e.getScale();if(o.type==="ordinal"||Hn(o.type)){const a=Bo(s)?D0(s):u=>u,c=e.getScale().range();this.rangeTextures.set(e,Yv(c.map(a),this.gl,o.domain().length,r))}}}}function Kv(t,e="",n=0){const r=/ERROR:\s*\d+:(\d+)/gi,i=[...e.matchAll(r)],s=new Map(i.map((o,a)=>{const c=parseInt(o[1]),u=i[a+1],f=u?u.index:e.length,l=e.substring(o.index,f);return[c-1,l]}));return t.split(` -`).map((o,a)=>{const c=s.get(a);return`${a+1+n}: ${o}${c?` - -^^^ ${c}`:""}`}).join(` -`)}function Jv(t,e,n){const r=t.createProgram();t.attachShader(r,e),t.attachShader(r,n),t.linkProgram(r);function i(){let s,o;if(!t.getProgramParameter(r,t.LINK_STATUS)){s=t.getProgramInfoLog(r);for(const c of[e,n])t.getShaderParameter(c,t.COMPILE_STATUS)||(s=t.getShaderInfoLog(c),o=Kv(t.getShaderSource(c),s,0)+` -Error compiling: ${s}`,t.deleteShader(c));t.deleteProgram(r)}if(s)return{message:s,detail:o}}return{program:r,getProgramErrors:i}}function qo(t,e,n,r){return r?X0(t,r,n,e):r=di(t,{...e,src:n}),r}function Zv(...t){const e={get(n,r,i){for(const s of t){const a=s()[r];if(a!==void 0)return a}},has(n,r,i){for(const s of t){const o=s();if(r in o)return!0}return!1}};return new Proxy({},e)}function Qv(t){return V(t)||be(t)||_i(t)}class vn extends Error{constructor(e,n){super(e),this.name="ViewError",this.view=n}}const eE="SAMPLE_FACET_UNIFORM",af="SAMPLE_FACET_TEXTURE";class Ki{constructor(e){this.unitView=e,this.encoders=void 0,this.bufferInfo=void 0,this.programInfo=void 0,this.vertexArrayInfo=void 0,this.domainUniformInfo=void 0,this.viewUniformInfo=void 0,this.markUniformInfo=void 0,this.markUniformsAltered=!0,this.rangeMap=new tE,this.defaultProperties={get clip(){return["x","y"].map(n=>e.getScaleResolution(n)).some(n=>(n==null?void 0:n.isZoomable())??!1)},xOffset:0,yOffset:0,minBufferSize:0},this.properties=Zv(typeof this.unitView.spec.mark=="object"?()=>this.unitView.spec.mark:()=>({}),()=>this.defaultProperties)}get opaque(){return!1}getAttributes(){throw new Error("Not implemented!")}getSupportedChannels(){return["sample","facetIndex","x","y","color","opacity","search","uniqueId"]}getDefaultEncoding(){const e={sample:void 0,uniqueId:void 0};return this.isPickingParticipant()&&(e.uniqueId={field:"_uniqueId"}),e}fixEncoding(e){return e}get encoding(){return pr(this,"encoding",()=>{const e=this.getDefaultEncoding(),n=this.unitView.getEncoding(),r=o=>{const a=this.properties[o];return Qv(a)&&{value:a}},i=Object.fromEntries(this.getSupportedChannels().map(o=>[o,r(o)]).filter(o=>o[1].value!==void 0)),s=this.fixEncoding({...e,...i,...n});for(const o of Object.keys(s))this.getSupportedChannels().includes(o)||delete s[o];return s})}getContext(){return this.unitView.context}getType(){return this.unitView.getMarkType()}initializeData(){}initializeEncoders(){this.encoders=Tb(this)}async initializeGraphics(){}updateGraphicsData(){}getSampleFacetMode(){if(this.encoders.facetIndex)return af;if(this.unitView.getLayoutAncestors().find(e=>"samples"in e.spec))return eE}createAndLinkShaders(e,n,r=[]){const i=this.getAttributes(),s="// view: "+this.unitView.getPathString();this.domainUniforms=[];let o=[];const a=this.getSampleFacetMode();a&&r.push(`#define ${a}`);for(const p of i){let d;if(p in this.encoding)d=p;else continue;const m=this.encoding[d];if(m)if(Xe(m))o.push(Tv(d,m.value));else{const g=De(m)&&m.resolutionChannel||d,x=wn(g)?this.unitView.getScaleResolution(g).getScale():Mo(),b=Dv(d,x,m);o.push(b.glsl),b.domainUniform&&this.domainUniforms.push(b.domainUniform)}}const c=this.domainUniforms.length?`layout(std140) uniform Domains { -`+this.domainUniforms.map(p=>` ${p} -`).join("")+`}; - -`:"",f=[`precision highp float; -`,s,...r,of,Vv,c,...o,Gv,Hv,e],l=[s,...r,of,qv,n],h=this.gl;this.programStatus=Jv(h,this.glHelper.compileShader(h.VERTEX_SHADER,f),this.glHelper.compileShader(h.FRAGMENT_SHADER,l))}finalizeGraphicsInitialization(){const e=this.programStatus.getProgramErrors();if(e){e.detail&&console.warn(e.detail);const n=new Error("Cannot create shader program: "+e.message);throw n.view=this.unitView,n}this.programInfo=Zw(this.gl,this.programStatus.program),delete this.programStatus,this.domainUniforms.length&&(this.domainUniformInfo=ya(this.gl,this.programInfo,"Domains")),this.viewUniformInfo=ya(this.gl,this.programInfo,"View"),this.markUniformInfo=ya(this.gl,this.programInfo,"Mark"),this.gl.useProgram(this.programInfo.program),this._setDatums(),cn(this.programInfo,{uSampleFacet:[0,1,0,1],uTransitionOffset:0,uZero:0})}registerMarkUniform(e,n,r=i=>i){const i=this.markUniformInfo.setters[e];if(Ld(n)){const s=this.unitView.context.paramBroker.createExpression(n.expr),o=()=>{i(r(s(null))),this.markUniformsAltered=!0};s.addListener(o),o()}else i(r(n)),this.markUniformsAltered=!0}_setDatums(){for(const[e,n]of Object.entries(this.encoding))if(Wi(n)){const r=this.encoders[e],i=r.indexer?r.indexer(n.datum):qs(r.scale.type)?Md(+n.datum):+n.datum;cn(this.programInfo,{[Fu+e]:i})}}deleteGraphicsData(){if(this.bufferInfo){const e=this.gl;for(let n=0;n<8;n++)e.disableVertexAttribArray(n);Object.values(this.bufferInfo.attribs).forEach(n=>this.gl.deleteBuffer(n.buffer)),this.bufferInfo.indices&&this.gl.deleteBuffer(this.bufferInfo.indices),this.bufferInfo=void 0}}updateBufferInfo(e){if(this.gl.bindVertexArray(null),this.bufferInfo&&e.vertexCount<=this.bufferInfo.allocatedVertices)for(const[n,r]of Object.entries(e.arrays))r.data&&f2(this.gl,this.bufferInfo.attribs[n],r.data,0);else this.deleteGraphicsData(),this.bufferInfo=p2(this.gl,e.arrays,{numElements:e.vertexCount}),this.bufferInfo.allocatedVertices=e.allocatedVertices,this.vertexArrayInfo=void 0}get glHelper(){return this.getContext().glHelper}get gl(){return this.glHelper.gl}onBeforeSampleAnimation(){}onAfterSampleAnimation(){}isReady(){return this.bufferInfo&&this.programInfo}isPickingParticipant(){if(this.properties.tooltip===null)return!1;for(const e of this.unitView.getLayoutAncestors())if(!e.isPickingSupported())return!1;return!0}bindOrSetMarkUniformBlock(){this.markUniformsAltered?(ba(this.gl,this.programInfo,this.markUniformInfo),this.markUniformsAltered=!1):wd(this.gl,this.programInfo,this.markUniformInfo)}prepareRender(e){const n=this.glHelper,r=this.gl,i=[];if(i.push(()=>{this.vertexArrayInfo||(this.vertexArrayInfo=yv(this.gl,this.programInfo,this.bufferInfo)),r.useProgram(this.programInfo.program)}),this.domainUniformInfo){for(const[o,a]of Object.entries(this.domainUniformInfo.setters)){const c=o.substring(Id.length),u=this.encoding[c],f=De(u)&&u.resolutionChannel||c;if(wn(f)){const l=this.unitView.getScaleResolution(f).getScale();i.push(()=>{const h=Ot(l.type)?[0,l.domain().length]:l.domain();a(qs(l.type)?Bv(h):h)})}}i.push(()=>ba(r,this.programInfo,this.domainUniformInfo))}for(const[o,a]of Object.entries(this.encoding))if(De(a)){const c=De(a)&&a.resolutionChannel||o;if(wn(c)){const u=this.unitView.getScaleResolution(c),f=n.rangeTextures.get(u);f&&i.push(()=>cn(this.programInfo,{[ic+o]:f}))}}this.getSampleFacetMode()==af&&i.push(()=>{let o;for(const a of this.unitView.getLayoutAncestors())if(o=a.getSampleFacetTexture(),o)break;if(!o)throw new Error("No facet texture available. This is bug.");cn(this.programInfo,{uSampleFacetTexture:o})});const s=(e.picking??!1)&&this.isPickingParticipant();return i.push(()=>Rn(this.viewUniformInfo,{uViewOpacity:this.unitView.getEffectiveOpacity(),uPickingEnabled:s})),this.opaque||e.picking?i.push(()=>r.disable(r.BLEND)):i.push(()=>r.enable(r.BLEND)),i}prepareSampleFacetRendering(e){const n=e.sampleFacetRenderingOptions,r=this.programInfo.uniformSetters.uSampleFacet;if(n&&r){const i=n.locSize?n.locSize.location:0,s=n.locSize?n.locSize.size:1;if(i>1||i+s<0)return!1;const o=n.targetLocSize?n.targetLocSize.location:i,a=n.targetLocSize?n.targetLocSize.size:s;this.gl.uniform4f(r.location,i,s,o,a)}return!0}render(e){}createRenderCallback(e,n){var l;if(!this.bufferInfo)throw new vn(`${this.getType()} mark has no data. This is bug.`,this.unitView);const r=this;let i;const s=(l=this.unitView.getScaleResolution("x"))==null?void 0:l.getScale(),o=s&&me(s.type),a=["index","locus"].includes(s==null?void 0:s.type)?-1:0,c=[0,0];i=h=>{if(o&&h.xIndex){const p=s.domain(),d=h.xIndex(p[0]+a,p[1],c),m=d[0],g=d[1]-m;g>0&&e(m,g)}else e(h.offset,h.count)};const u=this.rangeMap.get(void 0).count==0?n.facetId:void 0,f=this.rangeMap.get(u);return n.sampleFacetRenderingOptions?function(){f.count&&r.prepareSampleFacetRendering(n)&&i(f)}:function(){f.count&&i(f)}}setViewport(e,n){e=e.flatten();const r=this.unitView.context.devicePixelRatio,i=this.gl,s=this.properties,o=this.glHelper.getLogicalCanvasSize(),a=.5,c=(s.xOffset??0)+a,u=(s.yOffset??0)+a;let f,l=e;if(s.clip!=="never"&&(s.clip||n)){let h=0,p=0,d;if(n){if(l=e.intersect(n).flatten(),!l.isDefined())return!1;d=[e.width/l.width,e.height/l.height],p=Math.max(0,e.y2-n.y2),h=Math.min(0,e.x-n.x)}else d=[1,1];const m=[l.x,o.height-l.y2,l.width,l.height].map(A=>A*r),g=m.map(A=>Math.round(A)),[x,b]=m.map((A,E)=>A-g[E]);i.viewport(...g),i.scissor(...g),i.enable(i.SCISSOR_TEST),f={uViewOffset:[(c+h+x/r)/l.width,-(u+p-b/r)/l.height],uViewScale:d}}else{if(!e.isDefined())return!1;i.viewport(0,0,o.width*r,o.height*r),i.disable(i.SCISSOR_TEST),f={uViewOffset:[(e.x+c)/o.width,(o.height-e.y-u-e.height)/o.height],uViewScale:[e.width/o.width,e.height/o.height]}}return Rn(this.viewUniformInfo,{...f,uViewportSize:[e.width,e.height],uDevicePixelRatio:r}),ba(this.gl,this.programInfo,this.viewUniformInfo),!0}findDatumAt(e,n){}}class tE extends Sn{constructor(){super([],JSON.stringify)}get(e){let n=super.get(e);return n===void 0&&(n={offset:0,count:0,xIndex:void 0},super.set(e,n)),n}migrateEntries(e){for(const[n,r]of e.entries())Object.assign(this.get(n),r)}}function Ld(t){return typeof t=="object"&&"expr"in t&&V(t.expr)}function cc(t,e){const n=Rb(e);let r=t[e]&&{...t[e]},i=t[n]&&{...t[n]};if(!(Xe(r)||Xe(i))){if(r){if(!De(t[e]))return;if(i){if(r.type!="quantitative"){const s=(1-(r.band||1))/2;r.band=s,i.band=-s}}else if(r.type=="quantitative")i={datum:0};else{i={...r};const s=(1-(r.band??1))/2;r.band=0+s,i.band=1-s}}else r={value:0},i={value:1};t[e]=r,t[n]=i}}function Nd(t,e){t.stroke||(e?t.stroke={value:null}:t.stroke={resolutionChannel:"color",...t.color}),Xe(t.stroke)&&t.stroke.value===null&&(t.strokeWidth={value:0}),t.strokeOpacity||(t.strokeOpacity={resolutionChannel:"opacity",...t.opacity})}function zd(t,e){Xe(t.fill)&&t.fill.value===null?t.fillOpacity={value:0}:t.fill||(t.fill={resolutionChannel:"color",...t.color},!e&&!t.fillOpacity&&(t.fillOpacity={value:0})),t.fillOpacity||(e?t.fillOpacity={resolutionChannel:"opacity",...t.opacity}:t.fillOpacity={value:0})}var mi,uc,gi,lc;class nE extends Ki{constructor(n){super(n);M(this,mi);M(this,gi);Object.defineProperties(this.defaultProperties,Object.getOwnPropertyDescriptors({x2:void 0,y2:void 0,filled:!0,color:"#4c78a8",opacity:1,strokeWidth:3,cornerRadius:0,minWidth:.5,minHeight:.5,minOpacity:1,tessellationZoomThreshold:10,tessellationTiles:35}))}getAttributes(){return["uniqueId","facetIndex","x","x2","y","y2","fill","stroke","fillOpacity","strokeOpacity","strokeWidth"]}getSupportedChannels(){return[...super.getSupportedChannels(),"x2","y2","fill","stroke","fillOpacity","strokeOpacity","strokeWidth"]}get opaque(){return pr(this,"opaque",()=>!I(this,mi,uc).call(this)&&!I(this,gi,lc).call(this)&&Xe(this.encoding.fillOpacity)&&this.encoding.fillOpacity.value==1&&this.properties.minOpacity==1)&&this.unitView.getEffectiveOpacity()==1}fixEncoding(n){return cc(n,"x"),cc(n,"y"),Nd(n,this.properties.filled),zd(n,this.properties.filled),delete n.color,delete n.opacity,n}onBeforeSampleAnimation(){}onAfterSampleAnimation(){}async initializeGraphics(){await super.initializeGraphics();const n=[];I(this,mi,uc).call(this)&&n.push("ROUNDED_CORNERS"),I(this,gi,lc).call(this)&&n.push("STROKED"),this.createAndLinkShaders(Ev,Cv,n.map(r=>"#define "+r))}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const n=this.properties;this.registerMarkUniform("uMinWidth",n.minWidth),this.registerMarkUniform("uMinHeight",n.minHeight),this.registerMarkUniform("uMinOpacity",n.minOpacity),this.registerMarkUniform("uCornerRadiusTopRight",n.cornerRadiusTopRight??n.cornerRadius??0),this.registerMarkUniform("uCornerRadiusBottomRight",n.cornerRadiusBottomRight??n.cornerRadius??0),this.registerMarkUniform("uCornerRadiusTopLeft",n.cornerRadiusTopLeft??n.cornerRadius??0),this.registerMarkUniform("uCornerRadiusBottomLeft",n.cornerRadiusBottomLeft??n.cornerRadius??0)}updateGraphicsData(){const n=this.unitView.getCollector(),r=n.getItemCount(),i=new Lv({encoders:this.encoders,attributes:this.getAttributes(),numItems:r});i.addBatches(n.facetBatches);const s=i.toArrays();this.rangeMap.migrateEntries(s.rangeMap),this.updateBufferInfo(s)}prepareRender(n){const r=super.prepareRender(n);return r.push(()=>this.bindOrSetMarkUniformBlock()),r.push(()=>vr(this.gl,this.programInfo,this.vertexArrayInfo)),r}render(n){const r=this.gl;return this.createRenderCallback((i,s)=>{Yi(r,this.vertexArrayInfo,r.TRIANGLE_STRIP,s,i)},n)}findDatumAt(n,r){n=ze(n);const i=this.unitView.getCollector().facetBatches.get(n);if(!i)return;const s=this.encoders,o=s.x.scale.type;if(Ot(o)){const a=s.x.accessor;return i.find(c=>r==a(c))}else{const a=s.x.accessor,c=s.x2.accessor;return i.find(u=>r>=a(u)&&r=uSemanticThreshold ? 1.0 : 0.0;}/***Computes a scaling factor for the points in a sample-faceted view.*/float getDownscaleFactor(vec2 pos){if(!isFacetedSamples()){return 1.0;}float sampleFacetHeight=getSampleFacetHeight(pos);float maxPointDiameter=sqrt(uMaxPointSize);float factor=sampleFacetHeight*uViewportSize.y*uMaxRelativePointDiameter;return clamp(0.0,maxPointDiameter,factor)/maxPointDiameter;}vec2 getDxDy(){ -#if defined(dx_DEFINED) || defined(dy_DEFINED) -return vec2(getScaled_dx(),getScaled_dy())/uViewportSize; -#else -return vec2(0.0,0.0); -#endif -}void main(void){float shapeAngle=0.0;float semanticThresholdFactor=computeSemanticThresholdFactor();if(semanticThresholdFactor<=0.0){gl_PointSize=0.0;gl_Position=vec4(100.0,0.0,0.0,0.0);return;}float size=getScaled_size();vec2 pos=vec2(getScaled_x(),getScaled_y())+getDxDy();gl_Position=unitToNdc(applySampleFacet(pos));float strokeWidth=getScaled_strokeWidth();float diameter=sqrt(size)*uScaleFactor*semanticThresholdFactor*getDownscaleFactor(pos);float opacity=uViewOpacity;if(strokeWidth<=0.0||uInwardStroke){float minDiameter=1.0/uDevicePixelRatio;if(diameterTICK_UP&&vShape<=TICK_LEFT){shapeAngle=(vShape-TICK_UP)*90.0;vShape=TICK_UP;}else if(vShape>TRIANGLE_UP&&vShape<=TRIANGLE_LEFT){shapeAngle=(vShape-TRIANGLE_UP)*90.0;vShape=TRIANGLE_UP;}float angleInDegrees=getScaled_angle();float angle=-(shapeAngle+angleInDegrees)*PI/180.0;float sinTheta=sin(angle);float cosTheta=cos(angle);vRotationMatrix=mat2(cosTheta,sinTheta,-sinTheta,cosTheta);float roomForRotation=circle ? 1.0 : sin(mod(angle,PI/2.0)+PI/4.0)/sin(PI/4.0);float aaPadding=1.0/uDevicePixelRatio;float rotationPadding=(diameter*roomForRotation)-diameter;float strokePadding=uInwardStroke ? 0.0 : strokeWidth*(circle ? 1.0 : sqrt(3.0));float padding=rotationPadding+strokePadding+aaPadding;gl_PointSize=(diameter+padding)*uDevicePixelRatio;vRadius=diameter/2.0;vRadiusWithPadding=vRadius+padding/2.0;vHalfStrokeWidth=strokeWidth/2.0;vFillColor=vec4(getScaled_fill()*fillOpa,fillOpa);vStrokeColor=vec4(getScaled_stroke()*strokeOpa,strokeOpa);setupPicking();}`,iE="const lowp vec4 white=vec4(1.0);const lowp vec4 black=vec4(0.0,0.0,0.0,1.0);in float vRadius;in float vRadiusWithPadding;in lowp vec4 vFillColor;in lowp vec4 vStrokeColor;in lowp float vShape;in lowp float vHalfStrokeWidth;in mat2 vRotationMatrix;out lowp vec4 fragColor;const float CIRCLE=0.0;const float SQUARE=1.0;const float CROSS=2.0;const float DIAMOND=3.0;const float TRIANGLE_UP=4.0;const float TICK_UP=8.0;float circle(vec2 p,float r){return length(p)-r;}float square(vec2 p,float r){p=abs(p);return max(p.x,p.y)-r;}float tickUp(vec2 p,float r){float halfR=r*0.5;p.y+=halfR;p=abs(p);return max(p.x-r*0.15,p.y-halfR);}float equilateralTriangle(vec2 p,float r){p.y=-p.y;float k=sqrt(3.0);float kr=k*r;p.y-=kr/2.0;return max((abs(p.x)*k+p.y)/2.0,-p.y-kr);}float crossShape(vec2 p,float r){p=abs(p);vec2 b=vec2(0.4,1.0)*r;vec2 v=abs(p)-b.xy;vec2 h=abs(p)-b.yx;return min(max(v.x,v.y),max(h.x,h.y));}float diamond(vec2 p,float r){p=abs(p);return(max(abs(p.x-p.y),abs(p.x+p.y))-r)/sqrt(2.0);}void main(){float d;vec2 p=vRotationMatrix*(2.0*gl_PointCoord-1.0)*vRadiusWithPadding;float r=vRadius;if(vShape==CIRCLE){d=circle(p,r);}else if(vShape==SQUARE){d=square(p,r);}else if(vShape==CROSS){d=crossShape(p,r);}else if(vShape==DIAMOND){d=diamond(p,r);}else if(vShape==TRIANGLE_UP){d=equilateralTriangle(p,r);}else if(vShape==TICK_UP){d=tickUp(p,r);}else{d=0.0;}if(!uPickingEnabled){lowp vec4 fillColor=mix(vFillColor,white,-d*uGradientStrength/vRadius);fragColor=distanceToColor(d+(uInwardStroke ? vHalfStrokeWidth : 0.0),fillColor,vStrokeColor,vHalfStrokeWidth);}else if(d-vHalfStrokeWidth<=0.0){fragColor=vPickingColor;}else{discard;}}",sE="uniform Mark{/***The stroke should only grow inwards,e.g,the diameter/outline is not affected by the stroke width.*Thus,a point that has a zero size has no visible stroke. This allows strokes to be used with*geometric zoom,etc.*/uniform bool uInwardStroke;uniform lowp float uMaxRelativePointDiameter;uniform mediump float uScaleFactor;uniform mediump float uMaxPointSize;uniform mediump float uZoomLevel;uniform highp float uSemanticThreshold;uniform mediump float uGradientStrength;};",ut=1,Xt=2,Tu=4,oE={};class X{get behavior(){return 0}constructor(){this.children=[],this.parent=void 0,this.completed=!1}reset(){this.completed=!1;for(const e of this.children)e.reset()}initialize(){}_updatePropagator(){this._propagate=Function("children",Yr(this.children.length).map(e=>`const child${e} = children[${e}];`).join(` -`)+`return function propagate(datum) {${Yr(this.children.length).map(e=>`child${e}.handle(datum);`).join(` -`)}}`)(this.children)}setParent(e){this.parent=e}addChild(e){if(e.parent)throw new Error("Cannot add the child! It already has a parent.");return this.children.push(e),e.setParent(this),this._updatePropagator(),this}adopt(e){e.parent&&e.parent.removeChild(e),this.addChild(e)}adoptChildrenOf(e){for(const n of e.children)this.adopt(n)}insertAsParent(e){if(this.isRoot())throw new Error("Cannot insert a new parent for a root node!");e.parent=this.parent,this.parent.children[this.parent.children.indexOf(this)]=e,this.parent._updatePropagator(),this.parent=void 0,e.addChild(this)}removeChild(e){const n=this.children.indexOf(e);if(n>-1)this.children.splice(n,1),e.parent=void 0,this._updatePropagator();else throw new Error("Trying to remove an unknown child node!")}excise(){if(this.isRoot())throw new Error("Cannot excise root node!");if(this.isTerminal())this.parent.removeChild(this);else if(this.children.length==1){const e=this.children[0];e.setParent(this.parent),this.parent.children[this.parent.children.indexOf(this)]=e,this.parent._updatePropagator(),this.setParent(void 0),this.children.length=0}else throw new Error("Cannot excise a node that has multiple children!")}isRoot(){return!this.parent}isBranching(){return this.children.length>1}isTerminal(){return this.children.length==0}visit(e){e(this);for(const n of this.children)n.visit(e);e.afterChildren&&e.afterChildren(this)}subtreeToString(e=0){const n=this.children.map(r=>r.subtreeToString(e+1)).join("");return`${" ".repeat(e*2)}* ${this.constructor.name}${("identifier"in this&&this.identifier?": "+this.identifier:"")??""} -${n}`}getGlobalObject(){return this.parent?this.parent.getGlobalObject():oE}handle(e){this._propagate(e)}complete(){this.completed=!0;for(const e of this.children)e.complete()}beginBatch(e){for(const n of this.children)n.beginBatch(e)}_propagate(e){}}function Ud(t){return t.type=="file"}function aE(t){return t.type=="facet"}class $d extends X{constructor(e){super(),this.k=e.size||500,this.reset()}reset(){super.reset(),this.reservoir=[],this.W=void 0,this.ingester=this._initialIngester}_initialIngester(e){this.reservoir.push(e),this.reservoir.length==this.k&&(this.W=Math.exp(Math.log(Math.random())/this.k),this.i=this.k,this.next=this.i,this.ingester=this._finalIngester,this._setNextStop())}_finalIngester(e){++this.i==this.next&&(this.reservoir[Math.floor(Math.random()*this.k)]=e,this.W*=Math.exp(Math.log(Math.random())/this.k),this._setNextStop())}_setNextStop(){this.next+=Math.floor(Math.log(Math.random())/Math.log(1-this.W))+1}handle(e){this.ingester(e)}complete(){for(const e of this.reservoir)this._propagate(e);super.complete()}}function cE(t,e,n){const r=new $d({type:"sample",size:t});for(const i of e)r.handle(n(i));return r.complete(),r.reservoir}const uE={};class lE extends Ki{constructor(e){super(e),Object.defineProperties(this.defaultProperties,Object.getOwnPropertyDescriptors({x:.5,y:.5,color:"#4c78a8",filled:!0,opacity:1,size:100,semanticScore:0,shape:"circle",strokeWidth:2,fillGradientStrength:0,dx:0,dy:0,angle:0,sampleFacetPadding:.1,semanticZoomFraction:.02}))}getAttributes(){return["inwardStroke","uniqueId","facetIndex","x","y","size","semanticScore","shape","strokeWidth","gradientStrength","dx","dy","fill","stroke","fillOpacity","strokeOpacity","angle"]}getSupportedChannels(){return[...super.getSupportedChannels(),"size","semanticScore","shape","strokeWidth","dx","dy","fill","stroke","fillOpacity","strokeOpacity","angle"]}getDefaultEncoding(){return{...super.getDefaultEncoding(),...uE}}fixEncoding(e){return Nd(e,this.properties.filled),zd(e,this.properties.filled),delete e.color,delete e.opacity,e}initializeData(){super.initializeData();const e=this.unitView.getAccessor("semanticScore");e&&(this.sampledSemanticScores=Float32Array.from(cE(1e4,this.unitView.getCollector().getData(),e)),this.sampledSemanticScores.sort((n,r)=>n-r))}async initializeGraphics(){await super.initializeGraphics(),this.createAndLinkShaders(rE,iE,[sE])}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const e=this.properties;Rn(this.markUniformInfo,{uInwardStroke:!!e.inwardStroke,uGradientStrength:+e.fillGradientStrength,uMaxRelativePointDiameter:1-2*e.sampleFacetPadding})}updateGraphicsData(){const e=this.unitView.getCollector(),n=e.getItemCount(),r=new zv({encoders:this.encoders,attributes:this.getAttributes(),numItems:Math.max(n,this.properties.minBufferSize||0)});r.addBatches(e.facetBatches);const i=r.toArrays();this.rangeMap.migrateEntries(i.rangeMap),this.updateBufferInfo(i)}_getGeometricScaleFactor(){const e=Math.pow(2,this.properties.geometricZoomBound||0);return Math.pow(Math.min(1,this.unitView.getZoomLevel()/e),1/3)}_getMaxPointSize(){const e=this.encoders.size;return e.constant?e(null):e.scale.range().reduce((n,r)=>Math.max(n,r))}getSemanticThreshold(){if(this.sampledSemanticScores){const e=Math.max(0,1-this.properties.semanticZoomFraction*this.unitView.getZoomLevel());if(e<=0)return-1/0;if(e>=1)return 1/0;{const n=this.sampledSemanticScores;return Qf(n,e)}}else return-1}prepareRender(e){const n=super.prepareRender(e);return n.push(()=>{Rn(this.markUniformInfo,{uMaxPointSize:this._getMaxPointSize(),uScaleFactor:this._getGeometricScaleFactor(),uSemanticThreshold:this.getSemanticThreshold()}),this.markUniformsAltered=!0}),n.push(()=>this.bindOrSetMarkUniformBlock()),n.push(()=>vr(this.gl,this.programInfo,this.vertexArrayInfo)),n}render(e){const n=this.gl;return this.createRenderCallback((r,i)=>{i&&Yi(n,this.vertexArrayInfo,n.POINTS,i,r)},e)}}const fE="const int BUTT=0;const int SQUARE=1;const int ROUND=2;in float pos;in float side;out vec4 vColor;out float vSize;out float vNormalLengthInPixels;out highp vec2 vPosInPixels;void main(void){float pixelSize=1.0/uDevicePixelRatio;float size=getScaled_size();float opacity=getScaled_opacity()*uViewOpacity;if(size0.0||uStrokeCap!=BUTT){float len=length(tangent*uViewportSize);float diff=max(0.0,uMinLength-len);if(uStrokeCap!=BUTT){diff+=size;}relativeDiff=diff/len;offset=relativeDiff*(pos-0.5);}vec2 p=pos<1.0? a+tangent*(pos+offset): b+tangent*offset;float aaPadding=pixelSize;vec2 normal=normalize(vec2(-tangent.y,tangent.x)/uViewportSize);p+=normal*side*(size+aaPadding)/uViewportSize;gl_Position=unitToNdc(p);vColor=vec4(getScaled_color()*opacity,opacity);vSize=size;vNormalLengthInPixels=side*(size+aaPadding);vPosInPixels=vec2(pos,(1.0-pos))*(1.0+relativeDiff)*length(tangent*uViewportSize)-vec2(uStrokeCap!=BUTT ? size/2.0 : 0.0);setupPicking();}",hE="const int BUTT=0;const int SQUARE=1;const int ROUND=2;uniform sampler2D uDashTexture;in vec4 vColor;in float vSize;in vec2 vPosInPixels;in float vNormalLengthInPixels;out lowp vec4 fragColor;void main(void){float dpr=uDevicePixelRatio;float distanceFromEnd=-min(vPosInPixels[0],vPosInPixels[1]);float distance;if(distanceFromEnd>0.0&&uStrokeCap==ROUND){distance=length(vec2(distanceFromEnd,vNormalLengthInPixels));}else{distance=abs(vNormalLengthInPixels);}float opacity=clamp(((vSize/2.0-distance)*dpr),-0.5,0.5)+0.5;if(uDashTextureSize>0.0){float pos=(vPosInPixels[0]+uStrokeDashOffset)*dpr;float floored=floor(pos);vec2 texelPositions=(floored+vec2(0.5,1.5))/dpr/uDashTextureSize;opacity*=mix(texture(uDashTexture,vec2(texelPositions[0],0)).r,texture(uDashTexture,vec2(texelPositions[1],0)).r,clamp((pos-floored),0.0,1.0));}fragColor=vColor*opacity;if(uPickingEnabled){fragColor=vPickingColor;}}",dE="uniform Mark{uniform mediump float uMinLength;uniform mediump float uDashTextureSize;uniform lowp int uStrokeCap;uniform mediump float uStrokeDashOffset;};";class pE extends Ki{constructor(e){super(e),this.dashTextureSize=0,Object.defineProperties(this.defaultProperties,Object.getOwnPropertyDescriptors({x2:void 0,y2:void 0,size:1,color:"black",opacity:1,minLength:0,strokeDash:null,strokeDashOffset:0,strokeCap:"butt"}))}getAttributes(){return["uniqueId","facetIndex","x","x2","y","y2","size","color","opacity"]}getSupportedChannels(){return[...super.getSupportedChannels(),"x2","y2","size"]}fixEncoding(e){if(!(e.x&&e.y&&e.x2&&e.y2))if(e.x&&e.x2&&!e.y)e.y={value:.5},e.y2=e.y;else if(e.y&&e.y2&&!e.x)e.x={value:.5},e.x2=e.x;else if(e.x&&!e.y)e.y={value:0},e.y2={value:1},e.x2=e.x;else if(e.y&&!e.x)e.x={value:0},e.x2={value:1},e.y2=e.y;else if(e.x&&e.y&&e.y2)e.x2=e.x;else if(e.y&&e.x&&e.x2)e.y2=e.y;else if(e.y&&e.x)if(!e.x2&&De(e.y)&&e.y.type=="quantitative")e.x2=e.x,e.y2={datum:0};else if(!e.y2&&De(e.x)&&e.x.type=="quantitative")e.y2=e.y,e.x2={datum:0};else throw new Error("A bug!");else throw new Error("Invalid x and y encodings for rule mark: "+JSON.stringify(e));return e}async initializeGraphics(){if(await super.initializeGraphics(),this.properties.strokeDash){const e=this.gl,n=mE(this.properties.strokeDash);this.dashTexture=di(e,{mag:e.NEAREST,min:e.NEAREST,internalFormat:e.R8,format:e.RED,src:n,height:1}),this.dashTextureSize=n.length}this.createAndLinkShaders(fE,hE,[dE])}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const e=this.properties;this.registerMarkUniform("uMinLength",e.minLength),this.registerMarkUniform("uStrokeCap",e.strokeCap??"butt",n=>["butt","square","round"].indexOf(n)),Rn(this.markUniformInfo,{uDashTextureSize:+this.dashTextureSize}),this.markUniformsAltered=!0}updateGraphicsData(){const e=this.unitView.getCollector(),n=e.getItemCount(),r=new Nv({encoders:this.encoders,attributes:this.getAttributes(),numItems:Math.max(n,this.properties.minBufferSize||0)});r.addBatches(e.facetBatches);const i=r.toArrays();this.rangeMap.migrateEntries(i.rangeMap),this.updateBufferInfo(i)}prepareRender(e){const n=super.prepareRender(e);return n.push(()=>this.bindOrSetMarkUniformBlock()),this.dashTexture&&n.push(()=>cn(this.programInfo,{uDashTexture:this.dashTexture})),n.push(()=>vr(this.gl,this.programInfo,this.vertexArrayInfo)),n}render(e){const n=this.gl;return this.createRenderCallback((r,i)=>Yi(n,this.vertexArrayInfo,n.TRIANGLE_STRIP,i,r),e)}}function mE(t){if(t.length==0||t.length%2||t.findIndex(s=>Math.round(s)!=s||s<1||s>1e3)>=0)throw new Error("Invalid stroke dash pattern: "+JSON.stringify(t));const e=t.reduce((s,o)=>s+o),n=new Uint8Array(e);let r=!0,i=0;for(let s of t){for(;s;)n[i++]=r&&255||0,s--;r=!r}return n}const gE="uniform Mark{uniform float uArcHeightFactor;uniform float uMinArcHeight;uniform float uMinPickingSize;uniform int uShape;uniform int uOrient;uniform bool uClampApex;uniform float uMaxChordLength;uniform vec2 uArcFadingDistance;};in vec2 strip;out vec4 vColor;out float vSize;out float vNormalLengthInPixels;const int SHAPE_ARC=0;const int SHAPE_DOME=1;const int SHAPE_DIAGONAL=2;const int SHAPE_LINE=3;const int ORIENT_VERTICAL=0;const int ORIENT_HORIZONTAL=1;float distanceFromLine(vec2 pointOnLine1,vec2 pointOnLine2,vec2 point){vec2 a=point-pointOnLine1;vec2 b=pointOnLine2-pointOnLine1;vec2 proj=dot(a,b)/dot(b,b)*b;return length(a-proj);}bool isInsideViewport(vec2 point,float marginFactor){vec2 margin=uViewportSize*vec2(marginFactor);return point.x>=-margin.x&&point.x<=uViewportSize.x+margin.x&&point.y>=-margin.y&&point.y<=uViewportSize.y+margin.y;}void main(void){float pixelSize=1.0/uDevicePixelRatio;float opacity=getScaled_opacity()*uViewOpacity;vec2 p1,p2,p3,p4;vec2 a=applySampleFacet(vec2(getScaled_x(),getScaled_y()))*uViewportSize;vec2 b=applySampleFacet(vec2(getScaled_x2(),getScaled_y2()))*uViewportSize;if(uShape<=SHAPE_DOME){if(uShape==SHAPE_DOME){vec2 height=vec2(0.0);if(uOrient==ORIENT_VERTICAL){p1=vec2(min(a.x,b.x),b.y);p4=vec2(max(a.x,b.x),b.y);height=vec2(0.0,a.y-b.y);if(uClampApex){if(p4.x>0.0){p1.x=max(p1.x,-p4.x);}if(p1.x0.0){p1.y=max(p1.y,-p4.y);}if(p1.yuMaxChordLength){if(isInsideViewport(p1,2.0)){chordLength=uMaxChordLength;p4=p1+unitChordVector*uMaxChordLength;}else if(isInsideViewport(p4,2.0)){chordLength=uMaxChordLength;p1=p4-unitChordVector*uMaxChordLength;}}float height=max(chordLength/2.0*uArcHeightFactor,uMinArcHeight);vec2 controlOffset=chordNormal*height/0.75;p2=p1+controlOffset;p3=p4+controlOffset;}}else if(uShape==SHAPE_DIAGONAL){if(uOrient==ORIENT_VERTICAL){p1=a;p2=vec2(a.x,(a.y+b.y)/2.0);p3=vec2(b.x,(a.y+b.y)/2.0);p4=b;}else{p1=a;p2=vec2((a.x+b.x)/2.0,a.y);p3=vec2((a.x+b.x)/2.0,b.y);p4=b;}}else if(uShape==SHAPE_LINE){p1=a;p2=(a+b)/2.0;p3=p2;p4=b;}float t=smoothstep(0.0,1.0,strip.x);vec2 C1=p4-3.0*p3+3.0*p2-p1;vec2 C2=3.0*p3-6.0*p2+3.0*p1;vec2 C3=3.0*p2-3.0*p1;vec2 C4=p1;vec2 p;if(t==0.0){p=p1;}else if(t==1.0){p=p4;}else{p=C1*t*t*t+C2*t*t+C3*t+C4;}vec2 tangent=normalize(3.0*C1*t*t+2.0*C2*t+C3);vec2 normal=vec2(-tangent.y,tangent.x);float size=getScaled_size();if(size0.0&&uArcFadingDistance[1]>0.0){float d=distanceFromLine(p1,p4,p);float distanceOpacity=smoothstep(uArcFadingDistance[1],uArcFadingDistance[0],d);opacity*=distanceOpacity;if(distanceOpacity<=0.0){vNormalLengthInPixels=0.0;}}p+=normal*vNormalLengthInPixels;gl_Position=pixelsToNdc(p);vec3 color=getScaled_color();vColor=vec4(color*opacity,opacity);vSize=paddedSize;setupPicking();}",xE="in vec4 vColor;in float vSize;in float vNormalLengthInPixels;out lowp vec4 fragColor;void main(void){float dpr=uDevicePixelRatio;float distance=abs(vNormalLengthInPixels);float opacity=clamp(((vSize/2.0-distance)*dpr),0.0,1.0);fragColor=vColor*opacity;if(uPickingEnabled){fragColor=vPickingColor;}}",yE=["arc","dome","diagonal","line"],bE=["vertical","horizontal"];class AE extends Ki{constructor(e){super(e),Object.defineProperties(this.defaultProperties,Object.getOwnPropertyDescriptors({x:0,x2:void 0,y:0,y2:void 0,size:1,color:"black",opacity:1,segments:101,arcHeightFactor:1,minArcHeight:1.5,minPickingSize:3,clampApex:!1,maxChordLength:5e4,arcFadingDistance:!1,linkShape:"arc",orient:"vertical"}))}getAttributes(){return["uniqueId","facetIndex","x","x2","y","y2","size","height","color","opacity"]}getSupportedChannels(){return[...super.getSupportedChannels(),"x2","y2","size"]}fixEncoding(e){return e.x2||(De(e.x)?e.x2={datum:0}:e.x2=e.x),e.y2||(De(e.y)?e.y2={datum:0}:e.y2=e.y),e}async initializeGraphics(){await super.initializeGraphics(),this.createAndLinkShaders(gE,xE)}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const e=this.properties;this.registerMarkUniform("uArcFadingDistance",e.arcFadingDistance,n=>n||[0,0]),this.registerMarkUniform("uArcHeightFactor",e.arcHeightFactor),this.registerMarkUniform("uMinArcHeight",e.minArcHeight),this.registerMarkUniform("uMinPickingSize",e.minPickingSize),this.registerMarkUniform("uShape",e.linkShape,n=>yE.indexOf(n)),this.registerMarkUniform("uOrient",e.orient,n=>bE.indexOf(n)),this.registerMarkUniform("uClampApex",e.clampApex,n=>!!n),this.registerMarkUniform("uMaxChordLength",e.maxChordLength)}updateGraphicsData(){const e=this.unitView.getCollector(),n=e.getItemCount(),r=new Uv({encoders:this.encoders,attributes:this.getAttributes(),numItems:n});r.addBatches(e.facetBatches);const i=r.toArrays();i.arrays.strip={data:wE(this.properties.segments),numComponents:2},this.rangeMap.migrateEntries(i.rangeMap),this.arrays=Object.fromEntries(Object.entries(i.arrays).map(([s,o])=>[s,{...o,data:void 0}])),this.updateBufferInfo(i)}prepareRender(e){const n=super.prepareRender(e);return n.push(()=>this.bindOrSetMarkUniformBlock()),n}render(e){const n=this.gl;return this.createRenderCallback((r,i)=>{this.gl.bindVertexArray(this.vertexArrayInfo.vertexArrayObject);for(const s of Object.entries(this.bufferInfo.attribs)){const[o,a]=s;a.buffer&&a.numComponents&&a.divisor&&(a.offset=r*this.arrays[o].numComponents*4)}vr(n,this.programInfo,this.bufferInfo),Yi(n,this.bufferInfo,n.TRIANGLE_STRIP,(this.properties.segments+1)*2,0,i)},e)}}function wE(t){let e=0;const n=[];for(;e<=t;e++)n.push(e/t,.5),n.push(e/t,-.5);return n}const vE=`in mediump vec2 vertexCoord;in lowp vec2 textureCoord;in float width;out vec2 vTexCoord;out vec4 vColor;out float vSlope;out float vEdgeFadeOpacity;struct RangeResult{float pos;float scale;};float minValue(vec4 v){return min(min(v.x,v.y),min(v.z,v.w));}float maxValue(vec4 v){return max(max(v.x,v.y),max(v.z,v.w));}/***All measures are in[0,1]*/RangeResult positionInsideRange(float a,float b,float width,float padding,int align,bool flush){float span=b-a;float paddedWidth=width+2.0*padding;if(a>1.0||b<0.0){return RangeResult(0.0,0.0);}float extra=max(0.0,span-paddedWidth);float pos;if(align==0){float centre=a+b;if(flush){float leftOver=max(0.0,paddedWidth-centre);centre+=min(leftOver,extra);float rightOver=max(0.0,paddedWidth+centre-2.0);centre-=min(rightOver,extra);}pos=centre/2.0;}else if(align<0){float edge=a;if(flush){float over=max(0.0,-edge);edge+=min(over,extra);}pos=edge+padding;}else{float edge=b;if(flush){float over=max(0.0,edge-1.0);edge-=min(over,extra);}pos=edge-padding;}float scale=clamp((span-padding)/paddedWidth,0.0,1.0);return RangeResult(pos,scale);}vec2 calculateRotatedDimensions(float width,mat2 rotationMatrix){vec2 a=abs(rotationMatrix*vec2(width/2.0,0.5));vec2 b=abs(rotationMatrix*vec2(width/2.0,-0.5));return vec2(max(a.x,b.x),max(a.y,b.y))*2.0;}ivec2 fixAlignForAngle(ivec2 align,float angleInDegrees){float a=mod(angleInDegrees+45.0,360.0);int x=align.x;int y=-align.y;if(a<90.0){return ivec2(x,y);}else if(a<180.0){return ivec2(y,-x);}else if(a<270.0){return ivec2(-x,y);}else{return ivec2(-y,x);}}void main(void){float opacity=getScaled_opacity()*uViewOpacity;vec2 size=vec2(getScaled_size());float x=getScaled_x();float y=getScaled_y();float scale=1.0;float angleInDegrees=getScaled_angle();float angle=-angleInDegrees*PI/180.0;float sinTheta=sin(angle);float cosTheta=cos(angle);mat2 rotationMatrix=mat2(cosTheta,sinTheta,-sinTheta,cosTheta);vec2 flushSize=calculateRotatedDimensions(width,rotationMatrix); -#if defined(x2_DEFINED) || defined(y2_DEFINED) -ivec2 align=fixAlignForAngle(uAlign,angleInDegrees); -#else -ivec2 align=uAlign; -#endif -#ifdef x2_DEFINED -float x2=getScaled_x2();if(uLogoLetter){size.x=(x2-x)*uViewportSize.x;x+=(x2-x)/2.0;}else{float x2=getScaled_x2();RangeResult result=positionInsideRange(min(x,x2),max(x,x2),size.x*scale*flushSize.x/uViewportSize.x,uPaddingX/uViewportSize.x,align.x,uFlushX);x=result.pos;scale*=result.scale;} -#endif -vec2 pos=applySampleFacet(vec2(x,y)); -#ifdef y2_DEFINED -float y2=getScaled_y2();vec2 pos2=applySampleFacet(vec2(x,y2));if(uLogoLetter){size.y=(pos2.y-pos.y)*uViewportSize.y;pos.y+=(pos2.y-pos.y)/2.0;}else{RangeResult result=positionInsideRange(min(pos.y,pos2.y),max(pos.y,pos2.y),size.y*scale*flushSize.y/uViewportSize.y,uPaddingY/uViewportSize.y,align.y,uFlushY);pos.y=result.pos;scale*=result.scale;} -#endif -if(scale<1.0){if(uSqueeze){vec2 scaleFadeExtent=vec2(3.0,6.0)/size;if(scale-pow(10.0,10.0)){vEdgeFadeOpacity=minValue(((vec4(1.0,1.0,0.0,0.0)+vec4(-1.0,-1.0,1.0,1.0)*unitPos.yxyx)*uViewportSize.yxyx-uViewportEdgeFadeDistance)/uViewportEdgeFadeWidth);}else{vEdgeFadeOpacity=1.0;}setupPicking();}`,EE="uniform sampler2D uTexture;in vec2 vTexCoord;in float vEdgeFadeOpacity;in vec4 vColor;in float vSlope;out lowp vec4 fragColor;float median(float r,float g,float b){return max(min(r,g),min(max(r,g),b));}void main(){vec3 c=texture(uTexture,vTexCoord).rgb;float sigDist=1.0-median(c.r,c.g,c.b);float slope=uLogoLetter? 0.7/length(vec2(dFdy(sigDist),dFdx(sigDist))): vSlope;float opa=clamp((sigDist-0.5)*slope+0.5,0.0,1.0);opa*=pow(clamp(vEdgeFadeOpacity,0.0,1.0),2.2);fragColor=vColor*opa;if(uPickingEnabled){fragColor=vPickingColor;}}",CE="uniform Mark{uniform mediump float uSdfNumerator;uniform mediump vec2 uD;uniform mediump vec4 uViewportEdgeFadeWidth;uniform mediump vec4 uViewportEdgeFadeDistance;uniform bool uSqueeze;uniform bool uLogoLetter;uniform lowp ivec2 uAlign;uniform mediump float uPaddingX;uniform bool uFlushX;uniform mediump float uPaddingY;uniform bool uFlushY;};",SE={left:-1,center:0,right:1},FE={top:-1,middle:0,bottom:1,alphabetic:1};class TE extends Ki{constructor(e){super(e),Object.defineProperties(this.defaultProperties,Object.getOwnPropertyDescriptors({x:.5,y:.5,x2:void 0,y2:void 0,text:"",size:11,color:"black",opacity:1,font:void 0,fontStyle:void 0,fontWeight:void 0,align:"center",baseline:"middle",dx:0,dy:0,angle:0,fitToBand:!1,squeeze:!0,paddingX:0,paddingY:0,flushX:!0,flushY:!0,logoLetters:!1,viewportEdgeFadeWidthTop:0,viewportEdgeFadeWidthRight:0,viewportEdgeFadeWidthBottom:0,viewportEdgeFadeWidthLeft:0,viewportEdgeFadeDistanceTop:-1/0,viewportEdgeFadeDistanceRight:-1/0,viewportEdgeFadeDistanceBottom:-1/0,viewportEdgeFadeDistanceLeft:-1/0})),this.font=this.properties.font?e.context.fontManager.getFont(this.properties.font,this.properties.fontStyle,this.properties.fontWeight):e.context.fontManager.getDefaultFont()}getAttributes(){return["uniqueId","facetIndex","x","x2","y","y2","color","size","opacity","angle"]}getSupportedChannels(){return[...super.getSupportedChannels(),"x2","y2","size","text","angle"]}fixEncoding(e){for(const n of br)this.properties.fitToBand&&cc(e,n);return e}async initializeGraphics(){await super.initializeGraphics(),this.createAndLinkShaders(vE,EE,[CE])}finalizeGraphicsInitialization(){super.finalizeGraphicsInitialization(),this.gl.useProgram(this.programInfo.program);const e=this.properties;Rn(this.markUniformInfo,{uPaddingX:e.paddingX,uPaddingY:e.paddingY,uFlushX:!!e.flushX,uFlushY:!!e.flushY,uAlign:[SE[e.align],FE[e.baseline]],uD:[e.dx,-e.dy],uLogoLetter:!!e.logoLetters,uSqueeze:!!e.squeeze,uViewportEdgeFadeWidth:[e.viewportEdgeFadeWidthTop,e.viewportEdgeFadeWidthRight,e.viewportEdgeFadeWidthBottom,e.viewportEdgeFadeWidthLeft],uViewportEdgeFadeDistance:[e.viewportEdgeFadeDistanceTop,e.viewportEdgeFadeDistanceRight,e.viewportEdgeFadeDistanceBottom,e.viewportEdgeFadeDistanceLeft]})}updateGraphicsData(){const e=this.unitView.getCollector(),n=e.getData(),r=this.encoding,i=this.encoders.text.accessor||this.encoders.text;let s=0;const o="format"in r.text?ue(r.text.format):u=>u;for(const u of n){const f=o(i(u)),l=V(f)?f:f===null?"":""+f;s+=l&&l.length||0}const a=new 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not support interpolating color schemes.`)}if(s&&_o(r))return t.interpolator(Ro(pc(s,e.reverse),e.interpolate,e.interpolateGamma));s&&e.interpolate&&t.interpolate?t.interpolate(v0(e.interpolate,e.interpolateGamma)):Ie(t.round)?t.round(i):Ie(t.rangeRound)&&t.interpolate(i?Ni:Ht),s&&t.range(pc(s,e.reverse))}function iC(t,e,n){t!==x0&&t!==ja&&W("Only band and point scales support rangeStep.");var r=(e.paddingOuter!=null?e.paddingOuter:e.padding)||0,i=t===ja?1:(e.paddingInner!=null?e.paddingInner:e.padding)||0;return[0,e.rangeStep*tu(n,i,r)]}function sC(t,e,n){var r=e.schemeExtent,i,s;return Me(e.scheme)?s=Ro(e.scheme,e.interpolate,e.interpolateGamma):(i=e.scheme.toLowerCase(),s=su(i),s||W(`Unrecognized scheme name: ${e.scheme}`)),n=t===g0?n+1:t===ru?n-1:t===Wa||t===m0?+e.schemeCount||jE:n,_o(t)?hf(s,r,e.reverse):Ie(s)?vb(hf(s,r),n):t===nu?s:s.slice(0,n)}function hf(t,e,n){return Ie(t)&&(e||n)?wb(t,pc(e||[0,1],n)):t}function pc(t,e){return e?t.slice().reverse():t}const df=ue(",d");function oC(t,e){return t.chrom+":"+df(Math.floor(t.pos+1))+"-"+(t.chrom!=e.chrom?e.chrom+":":"")+df(Math.ceil(e.pos))}const aC="https://genomespy.app/data/genomes/";class cC{constructor(e){if(this.config=e,!this.config.contigs&&typeof this.config.name!="string")throw new Error("No name has been defined for the genome assembly!");this.chromosomes=[],this.cumulativeChromPositions=new Map,this.chromosomesByName=new Map,this.startByIndex=[],this.totalSize=0,this.config.contigs&&this.setChromSizes(this.config.contigs)}get name(){return this.config.name}async load(e){if(!this.config.contigs){this.config.baseUrl?this.baseUrl=/^http(s)?/.test(this.config.baseUrl)?this.config.baseUrl:e+"/"+this.config.baseUrl:this.baseUrl=aC;try{this.setChromSizes(uC(await xo({baseURL:this.baseUrl}).load(`${this.config.name}/${this.name}.chrom.sizes`)))}catch(n){throw new Error(`Could not load chrom sizes: ${n.message}`)}}}hasChrPrefix(){return this.chromosomes.some(e=>e.name.startsWith("chr"))}setChromSizes(e){let n=0;this.startByIndex=[0];for(let r=0;rthis.totalSize)return;e=Math.floor(e);const n=gr(this.startByIndex,e)-1;if(n>0&&n<=this.chromosomes.length)return this.chromosomes[n-1]}toChromosomal(e){const n=this.toChromosome(e);if(n)return{chrom:n.name,pos:Math.floor(e)-n.continuousStart}}getChromosome(e){return this.chromosomesByName.get(e)}formatInterval(e){return oC(...this.toChromosomalInterval(e))}toChromosomalInterval(e){const n=this.toChromosomal(e[0]+.5),r=this.toChromosomal(e[1]-.5);return r.pos+=1,[n,r]}toContinuousInterval(e){var i;let[n,r]=e;return r||(r=n),[this.toContinuous(n.chrom,n.pos??0),this.toContinuous(r.chrom,r.pos??((i=this.chromosomesByName.get(r.chrom))==null?void 0:i.size))]}toDiscreteChromosomeIntervals(e){const n=e[0],r=e[1],i=[];if(n.chrom===r.chrom)i.push({chrom:n.chrom,startPos:n.pos,endPos:r.pos});else{const s=this.chromosomes.findIndex(a=>a.name===n.chrom),o=this.chromosomes.findIndex(a=>a.name===r.chrom);i.push({chrom:n.chrom,startPos:n.pos,endPos:this.chromosomes[s].size});for(let a=s+1;aa===void 0)){const a=this.getChromosome(r);return a?[a.continuousStart,a.continuousEnd]:void 0}const i=n[3]||r,s=parseInt(n[2].replace(/,/g,"")),o=n[4]!==void 0?parseInt(n[4].replace(/,/g,"")):s;return[this.toContinuous(r,s-1),this.toContinuous(i,o)]}}}function uC(t){return Xp(t).filter(e=>/^chr[0-9A-Z]+$/.test(e[0])).map(([e,n])=>({name:e,size:parseInt(n)}))}function Kd(t){return Re(t)&&"chrom"in t}function lC(t){return t.every(Kd)}class Ji extends Array{constructor(){super(),this.type=void 0}extend(e){return this}extendAll(e){if(e instanceof Ji&&e.type!=this.type)throw new Error(`Cannot combine different types of domains: ${this.type} and ${e.type}`);for(const n of e)this.extend(n);return this}extendAllWithAccessor(e,n){for(const r of e)this.extend(n(r));return this}}class va extends Ji{constructor(){super(),this.type="quantitative"}extend(e){return e==null||Number.isNaN(e)?this:(e=+e,this.length?ethis[1]&&(this[1]=e):(this.push(e),this.push(e)),this)}}class Jd extends Ji{constructor(){super(),this.type="ordinal",this.uniqueValues=new Set}extend(e){return e==null||Number.isNaN(e)?this:(this.uniqueValues.has(e)||(this.uniqueValues.add(e),this.push(e)),this)}}class Zd extends Jd{constructor(){super(),this.type="nominal"}}class fC extends Ji{constructor(e){super();let n=0;for(let r=1;rthis.push(r))}extend(e){if(this.includes(e))return this;throw new Error("Piecewise domains are immutable and cannot be unioned!")}}const pf={quantitative:va,index:va,locus:va,nominal:Zd,ordinal:Jd};function mf(t,e){if(t=="quantitative"&&hC(e)){const n=new fC(e);return n.type=t,n}else if(pf[t]){const n=new pf[t];return n.type=t,e&&n.extendAll(e),n}throw new Error("Unknown type: "+t)}function hC(t){return t&&t.length>0&&t.length!=2&&t.every(e=>typeof e=="number")}function dC(t){return((t*=2)<=1?t*t*t:(t-=2)*t*t+2)/2}function pC(t,e,n){return t*Math.pow(e/t,n)}N("index",Du,["continuous"]);N("locus",PE,["continuous"]);N("null",Mo,[]);const gf="quantitative",Qd="ordinal",ep="nominal",tp="locus",mC="index";var pt,Kn,ae,et,It,Zs,np,Jn,ws,mt,rn,wi,mc,Qs,rp,Fc,xC,vi,gc;class gC{constructor(e){M(this,et);M(this,Zs);M(this,Jn);M(this,mt);M(this,wi);M(this,Qs);M(this,Fc);M(this,vi);M(this,pt,void 0);M(this,Kn,new Set);M(this,ae,void 0);this.channel=e,this.members=[],this.type=null,this.name=void 0}addEventListener(e,n){if(e!="domain")throw new Error("Unsupported event type: "+e);S(this,Kn).add(n)}removeEventListener(e,n){if(e!="domain")throw new Error("Unsupported event type: "+e);S(this,Kn).delete(n)}pushUnitView(e,n){var o;const r=Ya(e,n),i=r.type,s=(o=r==null?void 0:r.scale)==null?void 0:o.name;if(s){if(this.name!==void 0&&s!=this.name)throw new Error(`Shared scales have conflicting names: "${s}" vs. "${this.name}"!`);this.name=s}if(!this.type)this.type=i;else if(i!==this.type&&!zr(n))throw new Error(`Can not use shared scale for different data types: ${this.type} vs. ${i}. Use "resolve: independent" for channel ${this.channel}`);this.members.push({view:e,channel:n})}isExplicitDomain(){return!!this.getConfiguredDomain()}isDomainInitialized(){const e=S(this,ae);if(!e)return!1;const n=e.domain();return me(e.type)?n.length>2||n.length==2&&(n[0]!==0||n[1]!==0):n.length>0}getScaleProps(){return pr(this,"scaleProps",()=>{const e=I(this,Zs,np).call(this);if(e===null||e.type=="null")return{type:"null"};const n={...I(this,Qs,rp).call(this,this.type),...e};n.type||(n.type=yC(this.channel,this.type));const r=I(this,Jn,ws).call(this);return r&&r.length>0?n.domain=r:Ot(n.type)&&(n.domain=new Zd),!n.domain&&n.domainMid!==void 0&&(n.domain=[n.domainMin??0,n.domainMax??1]),this.channel=="y"&&Ot(n.type)&&n.reverse==null&&(n.reverse=!0),n.range&&n.scheme&&delete n.scheme,!("zoom"in n)&&["index","locus"].includes(n.type)&&(n.zoom=!0),bC(n,this.channel),n})}getConfiguredDomain(){return I(this,vi,gc).call(this,e=>zr(e.channel)?void 0:e.view.getConfiguredDomain(e.channel))}getDataDomain(){return I(this,vi,gc).call(this,e=>zr(e.channel)?void 0:e.view.extractDataDomain(e.channel))}reconfigure(){if(S(this,ae)&&S(this,ae).type!="null"){const e=this.isDomainInitialized(),n=S(this,ae).domain();Bd(this,"scaleProps");const r=this.getScaleProps();if(Yd(r,S(this,ae)),me(S(this,ae).type)&&he(this,pt,I(this,wi,mc).call(this)),!e){I(this,et,It).call(this);return}const i=S(this,ae).domain();ks(i,n)||(this.isZoomable()?S(this,ae).domain(n):I(this,mt,rn).call(this)?(S(this,ae).domain(n),this.zoomTo(i,500)):I(this,et,It).call(this))}}getScale(){if(S(this,ae))return S(this,ae);const e=this.getScaleProps(),n=KE(e);return he(this,ae,n),LE(n)&&n.genome(this.getGenome()),me(n.type)&&he(this,pt,I(this,wi,mc).call(this)),n}getDomain(){return this.getScale().domain()}getComplexDomain(){var e;return((e=this.getGenome())==null?void 0:e.toChromosomalInterval(this.getDomain()))??this.getDomain()}isZoomed(){return I(this,mt,rn).call(this)&&ks(I(this,Jn,ws).call(this),this.getDomain())}isZoomable(){return I(this,mt,rn).call(this)&&!!this.getScaleProps().zoom}zoom(e,n,r){if(!I(this,mt,rn).call(this))return!1;const i=this.getScale(),s=i.domain();let o=[...s],a=i.invert(n);switch(this.getScaleProps().reverse&&(r=-r),"align"in i&&(a+=i.align()),i.type){case"linear":case"index":case"locus":o=rm(o,r||0),o=Gf(o,a,e);break;case"log":o=im(o,r||0),o=Hf(o,a,e);break;case"pow":case"sqrt":{const c=i;o=sm(o,r||0,c.exponent()),o=Da(o,a,e,c.exponent());break}default:throw new Error("Zooming is not implemented for: "+i.type)}return S(this,pt)&&(o=am(o,S(this,pt)[0],S(this,pt)[1])),[0,1].some(c=>o[c]!=s[c])?(i.domain(o),I(this,et,It).call(this),!0):!1}async zoomTo(e,n=!1){var a;if(_i(n)&&(n=n?700:0),!I(this,mt,rn).call(this))throw new Error("Not a zoomable scale!");const r=this.fromComplexInterval(e),i=(a=this.members[0])==null?void 0:a.view.context.animator,s=this.getScale(),o=s.domain();if(n>0&&o.length==2){const c=o[1]-o[0],u=o[0]+c/2,f=r[1]-r[0],l=r[0]+f/2;await i.transition({duration:n,easingFunction:dC,onUpdate:h=>{const p=pC(c,f,h),d=(c-p)/(c-f),m=d*l+(1-d)*u;s.domain([m-p/2,m+p/2]),I(this,et,It).call(this)}}),s.domain(r),I(this,et,It).call(this)}else s.domain(r),i==null||i.requestRender(),I(this,et,It).call(this)}resetZoom(){if(!I(this,mt,rn).call(this))throw new Error("Not a zoomable scale!");const e=this.getDomain(),n=I(this,Jn,ws).call(this);return[0,1].some(r=>n[r]!=e[r])?(S(this,ae).domain(n),I(this,et,It).call(this),!0):!1}getZoomLevel(){return this.isZoomable()?Ts(S(this,pt))/Ts(this.getScale().domain()):1}getGenome(){var n;if(this.type!=="locus")return;const e=(n=this.members[0].view.context.genomeStore)==null?void 0:n.getGenome();if(!e)throw new Error("No genome has been defined!");return e}invertToComplex(e){const n=this.getScale();if("invert"in n){const r=n.invert(e);return this.toComplex(r)}else throw new Error("The scale does not support inverting!")}toComplex(e){const n=this.getGenome();return n?n.toChromosomal(e):e}fromComplex(e){return Kd(e)?this.getGenome().toContinuous(e.chrom,e.pos):e}fromComplexInterval(e){return this.type==="locus"&&lC(e)?this.getGenome().toContinuousInterval(e):e}}pt=new WeakMap,Kn=new WeakMap,ae=new WeakMap,et=new WeakSet,It=function(){for(const e of S(this,Kn).values())e({type:"domain",scaleResolution:this})},Zs=new WeakSet,np=function(){return pr(this,"mergedScaleProps",()=>{const e=this.members.map(n=>Ya(n.view,n.channel).scale).filter(n=>n!==void 0);return Ws(e,"scale",["domain"])})},Jn=new WeakSet,ws=function(){return this.getConfiguredDomain()??(this.type==tp?this.getGenome().getExtent():this.getDataDomain())},mt=new WeakSet,rn=function(){const e=this.getScale().type;return me(e)},wi=new WeakSet,mc=function(){const e=this.getScaleProps(),n=e.zoom;if(AC(n)&&Me(n.extent))return this.fromComplexInterval(n.extent);if(n)return e.type=="locus"?this.getGenome().getExtent():S(this,ae).domain()},Qs=new WeakSet,rp=function(e){const n=this.channel,r={};return this.isExplicitDomain()&&(r.zero=!1),li(n)?r.nice=!this.isExplicitDomain():An(n)?r.scheme=e==ep?"tableau10":e==Qd?"blues":"viridis":Bo(n)?r.range=n=="shape"?["circle","square","triangle-up","cross","diamond"]:[]:n=="size"?r.range=[0,400]:n=="angle"&&(r.range=[0,360]),r},Fc=new WeakSet,xC=function(){return this.members.map(e=>e.view.getPathString()).join(", ")},vi=new WeakSet,gc=function(e){const n=this.members.filter(r=>!r.view.getLayoutAncestors().some(i=>!i.options.contributesToScaleDomain)).map(e).filter(r=>!!r);if(n.length)return n.reduce((r,i)=>r.extendAll(i))};function yC(t,e){if(e==mC||e==tp){if(F0(t))return e;throw new Error(`${t} does not support ${e} data type. Only positional channels do.`)}const n={x:["band","band","linear"],y:["band","band","linear"],size:[void 0,"point","linear"],opacity:[void 0,"point","linear"],fillOpacity:[void 0,"point","linear"],strokeOpacity:[void 0,"point","linear"],color:["ordinal","ordinal","linear"],fill:["ordinal","ordinal","linear"],stroke:["ordinal","ordinal","linear"],strokeWidth:[void 0,void 0,"linear"],shape:["ordinal","ordinal",void 0],dx:[void 0,void 0,"null"],dy:[void 0,void 0,"null"],angle:[void 0,void 0,"linear"]},i=["sample"].includes(t)?"null":n[t]?n[t][[ep,Qd,gf].indexOf(e)]:e==gf?"linear":"ordinal";if(i===void 0)throw new Error(`Channel "${t}" is not compatible with "${e}" data type. Use of a proper scale may be needed.`);return i}function bC(t,e){li(e)&&t.type!=="ordinal"&&(t.range=[0,1]),e=="opacity"&&me(t.type)&&(t.clamp=!0)}function AC(t){return Re(t)}function xc(t){const e=new Set;function n(r){for(const i of Object.values(r.resolutions.scale))e.add(i)}for(const r of ze(t)){r.visit(n);for(const i of r.getDataAncestors()){if(!i.options.contributesToScaleDomain)break;n(i)}}e.forEach(r=>r.reconfigure())}function Ea(...t){for(const e of t)if(e!==void 0)return e}class wC{constructor(e){this.channel=e,this.members=[]}get scaleResolution(){var e;return(e=Bi(this.members))==null?void 0:e.view.getScaleResolution(this.channel)}pushUnitView(e,n){const r=e.getScaleResolution(this.channel);if(!r)throw new Error("Cannot find a scale resolution!");if(this.scaleResolution&&r!==this.scaleResolution)throw new Error("Shared axes must have a shared scale!");this.members.push({view:e,channel:n})}getAxisProps(){return pr(this,"axisProps",()=>{const e=this.members.map(n=>{const r=n.view.mark.encoding[n.channel];return"axis"in r&&r.axis});return e.length>0&&e.some(n=>n===null)?null:Ws(e.filter(n=>n!==void 0),"axis",["title"])})}getTitle(){const e=s=>{var a;const o=Ya(s.view,s.channel);if(!Xe(o))return{member:s,explicitTitle:Ea("axis"in o?(a=o.axis)==null?void 0:a.title:void 0,o.title),implicitTitle:Ea(qi(o)?o.field:void 0,ou(o)?o.expr:void 0)}},n=this.members.map(e),r=n.filter(s=>{var o;if(zr(s.member.channel)&&!s.explicitTitle){const a=_n(s.member.channel);return((o=n.find(c=>c.member.view==s.member.view&&c.member.channel==a))==null?void 0:o.explicitTitle)===void 0}return!0}),i=new Set(r.map(s=>Ea(s.explicitTitle,s.implicitTitle)).filter(V));return i.size?[...i].join(", "):null}}const vC={point:lE,rect:nE,rule:pE,link:AE,text:TE};class Ne extends Mn{constructor(e,n,r,i,s,o){super(e,n,r,i,s,o),this.spec=e;const a=vC[this.getMarkType()];if(a)this.mark=new a(this);else throw new Error(`No such mark: ${this.getMarkType()}`);this.resolve(),this.coords=void 0,this.needsAxes={x:!0,y:!0}}render(e,n,r={}){this.isConfiguredVisible()&&(this.coords=n,e.pushView(this,n),e.renderMark(this.mark,r),e.popView(this))}getMarkType(){return typeof this.spec.mark=="object"?this.spec.mark.type:this.spec.mark}resolve(e){e||(this.resolve("scale"),this.resolve("axis"));const n=this.mark.encoding;for(const[r,i]of Object.entries(n)){if(!De(i))continue;const s=_n(i.resolutionChannel??r);if(!wn(s)||e=="axis"&&!li(s))continue;let o=this;for(;(o.getConfiguredOrDefaultResolution(s,e)=="forced"||o.dataParent instanceof Mn&&["shared","excluded","forced"].includes(o.dataParent.getConfiguredOrDefaultResolution(s,e)))&&o.getConfiguredOrDefaultResolution(s,e)!="excluded";)o=o.dataParent;e=="axis"&&li(r)&&F0(s)?(o.resolutions[e][s]||(o.resolutions[e][s]=new wC(s)),o.resolutions[e][s].pushUnitView(this,r)):e=="scale"&&wn(r)&&(o.resolutions[e][s]||(o.resolutions[e][s]=new gC(s)),o.resolutions[e][s].pushUnitView(this,r))}}getAccessor(e){return this._cache("accessor/"+e,()=>{const n=this.mark.encoding;if(n&&n[e])return this.context.accessorFactory.createAccessor(n[e])})}getFacetAccessor(e){const n=this.getAccessor("sample");return n||super.getFacetAccessor(this)}getCollector(){return this.context.dataFlow.findCollectorByKey(this)}_validateDomainQuery(e){if(zr(e))throw new Error(`getDomain(${e}), must only be called for primary channels!`);const n=this.mark.encoding[e];if(!De(n))throw new Error("The channel has no scale, cannot get domain!");return n}getConfiguredDomain(e){const n=this._validateDomainQuery(e),r=n&&n.scale&&n.scale.domain;if(r){const i=this.getScaleResolution(n.resolutionChannel??e);return mf(n.type??"nominal",i.fromComplexInterval(r))}}extractDataDomain(e){const r=this._validateDomainQuery(e).type??"nominal",i=a=>{let c;const u=this.mark.encoding[a];if(u){const f=this.context.accessorFactory.createAccessor(u);if(f)if(c=mf(r),f.constant)c.extend(f({}));else{const l=this.getCollector();l!=null&&l.completed&&l.visitData(h=>c.extend(f(h)))}}return c};let s=i(e);const o=au[e];if(o){const a=i(o);a&&s.extendAll(a)}return s}getZoomLevel(){const e=n=>{var r;return((r=this.getScaleResolution(n))==null?void 0:r.getZoomLevel())??1};return br.map(e).reduce((n,r)=>n*r,1)}propagateInteractionEvent(e){this.handleInteractionEvent(void 0,e,!0),e.target=this,!e.stopped&&this.handleInteractionEvent(void 0,e,!1)}getDefaultResolution(e,n){return e=="x"?"shared":"independent"}}function*Iu(t,e=[]){for(const[n,r]of t.entries())if(r instanceof Map)for(const i of Iu(r,[...e,n]))yield i;else yield[[...e,n],r]}class ip extends X{get behavior(){return Tu}constructor(e){super(),this.params=e??{type:"collect"},this.observers=[],this.facetBatches=void 0,this._init()}_init(){this._data=[],this.facetBatches=new Sn([],JSON.stringify),this.facetBatches.set(void 0,this._data)}reset(){super.reset(),this._init()}handle(e){this._data.push(e)}beginBatch(e){aE(e)&&(this._data=[],this.facetBatches.set(ze(e.facetId),this._data))}complete(){var i,s;const e=(i=this.params)==null?void 0:i.sort,n=e?qf(e.field,e.order):void 0,r=o=>{n&&o.sort(n)};if((s=this.params.groupby)!=null&&s.length){if(this.facetBatches.size>1)throw new Error("TODO: Support faceted data!");const o=this.params.groupby.map(c=>U(c)),a=uo(this._data,...o);this.facetBatches.clear();for(const[c,u]of Iu(a))this.facetBatches.set(c,u)}for(const o of this.facetBatches.values())r(o);if(this.children.length)for(const[o,a]of this.facetBatches.entries()){if(o){const c={type:"facet",facetId:o};for(const u of this.children)u.beginBatch(c)}for(const c of a)this._propagate(c)}super.complete();for(const o of this.observers)o(this)}getData(){switch(this._checkStatus(),this.facetBatches.size){case 0:return[];case 1:return[...this.facetBatches.values()][0];default:{const e=this.facetBatches;return{[Symbol.iterator]:function*(){for(const r of e.values())for(let i=0;i0;){const i=r-1>>1,s=this.values[i];if(n>=s)break;this.ids[r]=this.ids[i],this.values[r]=s,r=i}this.ids[r]=e,this.values[r]=n}pop(){if(this.length===0)return;const e=this.ids[0];if(this.length--,this.length>0){const n=this.ids[0]=this.ids[this.length],r=this.values[0]=this.values[this.length],i=this.length>>1;let s=0;for(;s=r)break;this.ids[s]=c,this.values[s]=u,s=o}this.ids[s]=n,this.values[s]=r}return e}peek(){if(this.length!==0)return this.ids[0]}peekValue(){if(this.length!==0)return this.values[0]}shrink(){this.ids.length=this.values.length=this.length}}class EC extends X{get behavior(){return ut}constructor(e){super(),this.params=e,this.startAccessor=U(e.start),this.endAccessor=U(e.end),this.chromAccessor=e.chrom?U(e.chrom):n=>{},this.weightAccessor=e.weight?U(e.weight):n=>1,this.as={coverage:e.as||"coverage",start:e.asStart||e.start,end:e.asEnd||e.end,chrom:e.asChrom||e.chrom},this.createSegment=new Function("start","end","coverage","chrom","return {"+Object.entries(this.as).filter(([n,r])=>r).map(([n,r])=>`${JSON.stringify(r)}: ${n}`).join(", ")+"};"),this.ends=new js}reset(){super.reset(),this.initialize()}initialize(){const e=this.as.coverage,n=this.as.end,r=this.as.chrom,i=this.startAccessor,s=this.endAccessor,o=this.chromAccessor,a=this.weightAccessor;let c,u,f,l=0,h;const p=this.ends;p.clear();const d=(g,x,b)=>{if(g==x)return;let A=!1;c&&(c[e]===b?(c[n]=x,A=!0):c[e]!=0&&this._propagate(c)),A||(c=this.createSegment(g,x,b,f))},m=()=>{let g;for(;(g=p.peekValue())!==void 0;)d(h,g,l),h=g,l-=p.pop();h=void 0,c&&(this._propagate(c),c=void 0)};this.handle=g=>{const x=i(g);let b;for(;(b=p.peekValue())!==void 0&&b{m(),super.complete()}}}function CC(t,e,n=0,r=t.length){const i=new js,s=r-n;let o;for(o=0;o=i.peekValue()&&(i.push(o,u),i.pop())}const a=[];let c;for(;(c=i.pop())!==void 0;)a.push(n+c);return a.reverse()}class SC{constructor(e,n=-1/0,r=1/0){this.maxSize=e,this.lowerLimit=n,this.upperLimit=r;const i=this.maxSize*2+1;this.lowerLimits=new Float64Array(i),this.upperLimits=new Float64Array(i),this.lowerChildren=new Int32Array(i),this.upperChildren=new Int32Array(i),this.reset()}reset(){this.lowerLimits.fill(0),this.upperLimits.fill(0),this.lowerChildren.fill(0),this.upperChildren.fill(0),this.n=1,this.lowerLimits[0]=this.lowerLimit,this.upperLimits[0]=this.upperLimit}_findSlot(e,n,r=0){if(e>=this.lowerLimits[r]&&n<=this.upperLimits[r]){const i=this.lowerChildren[r];if(i){const s=this._findSlot(e,n,i);return s>=0?s:this._findSlot(e,n,this.upperChildren[r])}else return r}else return-1}reserve(e,n){if(n-e<=0)throw new Error("Cannot reserve an empty or negative-size slot!");if(this.n+1>this.lowerLimits.length)return!1;const r=this._findSlot(e,n);if(r<0)return!1;const i=this.n++,s=this.n++;return this.lowerLimits[i]=this.lowerLimits[r],this.upperLimits[i]=e,this.lowerLimits[s]=n,this.upperLimits[s]=this.upperLimits[r],this.lowerChildren[r]=i,this.upperChildren[r]=s,!0}}class FC extends X{get behavior(){return Tu}constructor(e,n){if(super(),this.params=e,this._data=[],this.channel=e.channel??"x",!["x","y"].includes(this.channel))throw new Error("Invalid channel: "+this.channel);this.posAccessor=U(this.params.pos),this.posBisector=co(this.posAccessor),this.scoreAccessor=U(this.params.score),this.widthAccessor=U(this.params.width),this.laneAccessor=this.params.lane?U(this.params.lane):i=>0,this.padding=this.params.padding??0,this.reservationMaps=new Map,this.resolution=n.getScaleResolution(this.channel);const r=()=>this._filterAndPropagate();this.schedule=()=>n.context.animator.requestTransition(r),this.resolution.addEventListener("domain",i=>this.schedule()),n._addBroadcastHandler("layoutComputed",()=>this.schedule())}complete(){const e=this.posAccessor;this._data.sort((n,r)=>e(n)-e(r)),this._scores=this._data.map(this.scoreAccessor);for(const n of new Set(this._data.map(this.laneAccessor)))this.reservationMaps.set(n,new SC(200));this.schedule(),super.complete()}_filterAndPropagate(){var o;super.reset();const e=this.resolution.getScale(),n=(o=this.resolution.members[0].view.coords)==null?void 0:o[this.channel=="x"?"width":"height"];if(!n)return;for(const a of this.reservationMaps.values())a.reset();const r=e.domain(),i=70,s=CC(this._scores,i,this.posBisector.left(this._data,r[0]),this.posBisector.right(this._data,r[1]));for(const a of s){const c=this._data[a],u=e(this.posAccessor(c))*n,f=this.widthAccessor(c)/2+this.padding;this.reservationMaps.get(this.laneAccessor(c)).reserve(u-f,u+f)&&this._propagate(c)}super.complete()}reset(){super.reset(),this._data=[],this.groups=new Map}handle(e){this._data.push(e)}}class TC extends X{constructor(e){super(),this.params=e,this.predicate=void 0}initialize(){this.predicate=vo(this.params.expr,this.getGlobalObject())}handle(e){this.predicate(e)&&this._propagate(e)}}class DC extends X{get behavior(){return ut}constructor(e){super();const n=e.index;if(e.fields){const r=ze(e.fields).map(s=>U(s)),i=ze(e.as||e.fields);if(r.length!==i.length)throw new Error(`Lengths of "fields" (${r.length}), and "as" (${i.length}) do not match!`);this.handle=s=>{const o=r.map((c,u)=>c(s)??[]),a=o[0].length;for(let c=0;c{for(let i=0;i{let a=r(o),c=a,u=!0;const f=n(o);for(const l of _C(f)){if(u)c=a+l;else{a=c+l;const h=Object.assign({},o);h[i]=c,h[s]=a,this._propagate(h)}u=!u}}}}class MC extends X{get behavior(){return ut}constructor(e){super();const n=ze(e.field).map(s=>U(s)),r=ze(e.separator),i=ze(e.as||e.field);if(n.length!==r.length||n.length!==i.length)throw new Error(`Lengths of "separator" (${r.length}), "fields" (${n.length}), and "as" (${i.length}) do not match!`);this.handle=s=>{if(n.some(c=>!c(s)))return;const o=n.map((c,u)=>c(s).split(r[u]));BC(o,s);const a=o[0].length;for(let c=0;cr.length);if(!n.every(r=>r==n[0]))throw new Error("Mismatching number of elements in the fields to be split: "+JSON.stringify(e))}class kC extends X{get behavior(){return Xt}constructor(e){super(),this.params=e,this.as=e.as,this.fn=void 0}initialize(){this.fn=vo(this.params.expr,this.getGlobalObject())}handle(e){e[this.as]=this.fn(e),this._propagate(e)}}class sp extends X{get behavior(){return Xt}constructor(e,n){super();const r=e.channel??"x";if(!["x","y"].includes(r))throw new Error("Invalid channel: "+r);const i=n.getScaleResolution(r).getGenome();if(!i)throw new Error("LinearizeGenomicCoordinate transform requires a locus scale!");const s=U(e.chrom),o=ze(e.pos).map(d=>U(d)),a=ze(e.as);if(o.length!=a.length)throw new Error('The number of "pos" and "as" elements must be equal!');const c=ze(e.offset);let u;if(c.length==0)u=new Array(o.length).fill(0);else if(c.length==1)u=new Array(o.length).fill(c[0]);else if(c.length==o.length)u=c;else throw new Error(`Invalid "offset" parameter: ${JSON.stringify(e.offset)}!`);const f=new Function("datum","chromOffset","posAccessors",a.map((d,m)=>`datum[${JSON.stringify(d)}] = chromOffset + +posAccessors[${m}](datum) - ${u[m]};`).join(` -`));let l,h=0;const p=d=>{if(d!==l){if(h=i.cumulativeChromPositions.get(d),h===void 0)throw new Error("Unknown chromosome/contig: "+d);l=d}return h};this.handle=d=>{f(d,p(s(d)),o),this._propagate(d)}}}const 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JSON.stringify({params:this.params,baseUrl:this.baseUrl})}async load(){const e=this.params.url,n=Array.isArray(e)?e:[e],r=async s=>xo({baseURL:this.baseUrl}).load(s).catch(o=>{throw new Error(`Cannot fetch: ${this.baseUrl}${s}: ${o.message}`)}),i=(s,o)=>{try{const a=xh(s,cp(this.params));this.beginBatch({type:"file",url:o});for(const c of a)this._propagate(c)}catch(a){throw new Error(`Cannot parse: ${o}: ${a.message}`)}};this.reset(),await Promise.all(n.map(s=>r(s).then(i))),this.complete()}}function iS(t){return"sequence"in t}class sS extends Zi{constructor(e,n){if(super(),this.sequence=e.sequence,!("start"in this.sequence))throw new Error("'start' is missing from sequence parameters!");if(!("stop"in this.sequence))throw new Error("'stop' is missing from sequence parameters!")}loadSynchronously(){const e=this.sequence.as||"data",n=this.sequence.step||1,r=this.sequence.stop;this.reset(),this.beginBatch({type:"file"});for(let 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n=this.scaleResolution.getScale(),r=this.params.axis,i=this.getAxisLength(),s=u=>25+60*Sh(100,700,u),o=be(r.tickCount)?r.tickCount:Math.round(i/s(i)),a=Hd(n,o,r.tickMinStep),c=r.values?qd(n,r.values,a):NE(n,a);if(!ks(c,this.ticks)){this.ticks=c;const u=UE(n,o,r.format);this.publishData(c.map(f=>({value:f,label:u(f)})))}}}class aS extends Ln{constructor(e,n){super(n,e.channel)}async load(){this.publishData(this.genome.chromosomes)}}const cS="modulepreload",uS=function(t,e){return new URL(t,e).href},Af={},_e=function(e,n,r){if(!n||n.length===0)return e();const i=document.getElementsByTagName("link");return Promise.all(n.map(s=>{if(s=uS(s,r),s in Af)return;Af[s]=!0;const o=s.endsWith(".css"),a=o?'[rel="stylesheet"]':"";if(!!r)for(let f=i.length-1;f>=0;f--){const l=i[f];if(l.href===s&&(!o||l.rel==="stylesheet"))return}else if(document.querySelector(`link[href="${s}"]${a}`))return;const u=document.createElement("link");if(u.rel=o?"stylesheet":cS,o||(u.as="script",u.crossOrigin=""),u.href=s,document.head.appendChild(u),o)return new Promise((f,l)=>{u.addEventListener("load",f),u.addEventListener("error",()=>l(new Error(`Unable to preload CSS for ${s}`)))})})).then(()=>e()).catch(s=>{const o=new Event("vite:preloadError",{cancelable:!0});if(o.payload=s,window.dispatchEvent(o),!o.defaultPrevented)throw s})};function Qi(t){return class extends t{constructor(){super(...arguments);fe(this,"lastQuantizedInterval",[0,0])}quantizeInterval(r,i){return[Math.max(Math.floor(r[0]/i-1)*i,0),Math.min(Math.ceil(r[1]/i+1)*i,this.genome.totalSize)]}checkAndUpdateLastInterval(r){return ks(this.lastQuantizedInterval,r)?!1:(this.lastQuantizedInterval=r,!0)}}}function es(t,e){return!e||/^(data:|([A-Za-z]+:)?\/\/)/.test(t)||t.startsWith("/")?t:(e.endsWith("/")||(e+="/"),e+t)}class lS extends Qi(Ln){constructor(e,n){const r={channel:"x",windowSize:7e3,...e};if(super(n,r.channel),this.params=r,!this.params.url)throw new Error("No URL provided for IndexedFastaSource");this.initializedPromise=new Promise(i=>{Promise.all([_e(()=>import("./index-462333f7.js").then(s=>s.i),["./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url),_e(()=>import("./index-f8b9b7f4.js"),["./index-f8b9b7f4.js","./__vite-browser-external-d053bc6e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js","./long-c1fdf4ae.js"],import.meta.url),_e(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([{Buffer:s},{IndexedFasta:o},{RemoteFile:a}])=>{typeof window<"u"&&(window.Buffer??(window.Buffer=s));const c=u=>new a(es(u,this.view.getBaseUrl()));this.fasta=new o({fasta:c(this.params.url),fai:c(this.params.indexUrl??this.params.url+".fai")}),i()})})}async onDomainChanged(e){const n=this.params.windowSize;if(e[1]-e[0]>n)return;await this.initializedPromise;const r=this.quantizeInterval(e,n);if(this.checkAndUpdateLastInterval(r)){const i=this.genome.continuousToDiscreteChromosomeIntervals(r),s=await Promise.all(i.map(o=>this.fasta.getSequence(o.chrom,o.startPos,o.endPos).then(a=>({chrom:o.chrom,start:o.startPos,sequence:a}))));this.publishData(s)}}}function Wo(t,e,n=!0){let r,i=o=>{};return function(...a){return new Promise((c,u)=>{const f=()=>{clearTimeout(r),i=l=>{},c(t(...a))};n&&i("debounced"),clearTimeout(r),i=u,r=window.setTimeout(f,e)})}}class fS extends Qi(Ln){constructor(n,r){const i={pixelsPerBin:2,channel:"x",...n};super(r,i.channel);fe(this,"reductionLevels",[]);fe(this,"lastRequestId",0);fe(this,"bbi");if(this.params=i,!this.params.url)throw new Error("No URL provided for BigWigSource");this.doDebouncedRequest=Wo(this.doRequest.bind(this),200,!1),this.initializedPromise=new Promise(s=>{Promise.all([_e(()=>import("./index-396a8699.js"),["./index-396a8699.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js","./index-d89cadd6.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js"],import.meta.url),_e(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([{BigWig:o},{RemoteFile:a}])=>{this.bbi=new o({filehandle:new a(es(this.params.url,this.view.getBaseUrl()))}),this.bbi.getHeader().then(c=>{this.reductionLevels=c.zoomLevels.map(u=>u.reductionLevel).reverse(),this.reductionLevels.push(1),s()})})})}async onDomainChanged(n){await this.initializedPromise;const r=this.getAxisLength()||700,i=hS(n,r,this.reductionLevels),s=Math.max(i*r,5e3),o=this.quantizeInterval(n,s);this.checkAndUpdateLastInterval(o)&&this.doDebouncedRequest(o,i)}async doRequest(n,r){const i=await this.getFeatures(n,.5/r/this.params.pixelsPerBin);i.requestIdthis.bbi.getFeatures(c.chrom,c.startPos,c.endPos,{scale:r,signal:s.signal}).then(u=>u.map(f=>({chrom:c.chrom,start:f.start,end:f.end,score:f.score})))));return{requestId:i,abort:()=>s.abort(),features:a.flat()}}}function hS(t,e,n){const r=(t[1]-t[0])/e;return n.find(i=>i{Promise.all([_e(()=>import("./index-7a37a249.js"),["./index-7a37a249.js","./_commonjsHelpers-de833af9.js"],import.meta.url),_e(()=>import("./index-396a8699.js"),["./index-396a8699.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js","./index-d89cadd6.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js"],import.meta.url),_e(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([o,{BigBed:a},{RemoteFile:c}])=>{const u=o.default;this.bbi=new a({filehandle:new c(es(this.params.url,this.view.getBaseUrl()))}),this.headerPromise=this.bbi.getHeader(),this.headerPromise.then(async f=>{this.parser=new u({autoSql:f.autoSql}),s()})})})}async onDomainChanged(n){await this.initializedPromise;const r=this.params.windowSize;if(n[1]-n[0]>r)return;const i=this.quantizeInterval(n,r);this.checkAndUpdateLastInterval(i)&&this.doDebouncedRequest(i)}async doRequest(n){const r=await this.getFeatures(n);r.requestIdthis.bbi.getFeatures(a.chrom,a.startPos,a.endPos,{signal:i.signal}).then(c=>c.map(u=>this.parser.parseLine(`${a.chrom} ${u.start} ${u.end} ${u.rest}`,{uniqueId:u.uniqueId})))));return{requestId:r,abort:()=>i.abort(),features:o.flat()}}}class pS extends Qi(Ln){constructor(n,r){const i={channel:"x",windowSize:2e4,...n};super(r,i.channel);fe(this,"lastRequestId",0);fe(this,"bam");fe(this,"chrPrefixFixer",n=>n);if(this.params=i,!this.params.url)throw new Error("No URL provided for BamSource");this.initializedPromise=new Promise(s=>{Promise.all([_e(()=>import("./index-234835b1.js"),["./index-234835b1.js","./long-c1fdf4ae.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-d89cadd6.js"],import.meta.url),_e(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([{BamFile:o},{RemoteFile:a}])=>{const c=u=>new a(es(u,this.view.getBaseUrl()));this.bam=new o({bamFilehandle:c(this.params.url),baiFilehandle:c(this.params.indexUrl??this.params.url+".bai")}),this.bam.getHeader().then(u=>{var h,p;const f=this.genome.hasChrPrefix(),l=(p=(h=this.bam.indexToChr)==null?void 0:h[0])==null?void 0:p.refName.startsWith("chr");f&&!l?this.chrPrefixFixer=d=>d.replace("chr",""):!f&&l&&(this.chrPrefixFixer=d=>"chr"+d),s()})})})}async onDomainChanged(n){const r=this.params.windowSize;if(n[1]-n[0]>r)return;await this.initializedPromise;const i=this.quantizeInterval(n,r);if(this.checkAndUpdateLastInterval(i)){const s=this.genome.continuousToDiscreteChromosomeIntervals(i),o=await Promise.all(s.map(a=>this.bam.getRecordsForRange(this.chrPrefixFixer(a.chrom),a.startPos,a.endPos).then(c=>c.map(u=>({chrom:a.chrom,start:u.get("start"),end:u.get("end"),name:u.get("name"),MD:u.get("MD"),cigar:u.get("cigar"),mapq:u.get("mq"),strand:u.get("strand")===1?"+":"-"})))));this.publishData(o.flat())}}}class mS extends Qi(Ln){constructor(n,r){const i={channel:"x",windowSize:3e6,debounceDomainChange:200,...n};super(r,i.channel);fe(this,"lastRequestId",0);fe(this,"tbiIndex");if(this.params=i,!this.params.url)throw new Error("No URL provided for TabixSource");this.params.debounceDomainChange>0&&(this.onDomainChanged=Wo(this.onDomainChanged.bind(this),this.params.debounceDomainChange,!1)),this.initializedPromise=new Promise(s=>{Promise.all([_e(()=>import("./index-462333f7.js").then(o=>o.i),["./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url),_e(()=>import("./index-4e587624.js"),["./index-4e587624.js","./index-d89cadd6.js","./_commonjsHelpers-de833af9.js","./index-462333f7.js","./__vite-browser-external-d053bc6e.js","./long-c1fdf4ae.js"],import.meta.url),_e(()=>import("./index-5c802462.js"),["./index-5c802462.js","./__vite-browser-external-d053bc6e.js","./remoteFile-1948951e.js","./index-462333f7.js","./_commonjsHelpers-de833af9.js"],import.meta.url)]).then(([{Buffer:o},{TabixIndexedFile:a},{RemoteFile:c}])=>{typeof window<"u"&&(window.Buffer??(window.Buffer=o));const u=f=>new c(es(f,this.view.getBaseUrl()));this.tbiIndex=new a({filehandle:u(this.params.url),tbiFilehandle:u(this.params.indexUrl??this.params.url+".tbi")}),s()})})}async onDomainChanged(n){const r=this.params.windowSize;if(n[1]-n[0]>r)return;const i=this.quantizeInterval(n,r);this.checkAndUpdateLastInterval(i)&&this.doRequest(i)}async doRequest(n){const r=await this.getFeatures(n);r.requestId{const c=[];return await this.tbiIndex.getLines(a.chrom,a.startPos,a.endPos,{lineCallback:u=>{c.push(u)},signal:i.signal}),this._parseFeatures(c)}));return{requestId:r,abort:()=>i.abort(),features:o.flat()}}_parseFeatures(n){return[]}}var Ei;class gS extends mS{constructor(n,r){super(n,r);M(this,Ei,void 0);_e(()=>import("./index-ba6a6d03.js"),["./index-ba6a6d03.js","./_commonjsHelpers-de833af9.js","./index-462333f7.js","./__vite-browser-external-d053bc6e.js"],import.meta.url).then(i=>{he(this,Ei,i.default)})}_parseFeatures(n){var i;return(i=S(this,Ei))==null?void 0:i.parseStringSync(n.join(` -`),{parseSequences:!1})}}Ei=new WeakMap;function xS(t,e){if(lp(t))return new tS(t,e);if(nS(t))return new rS(t,e);if(iS(t))return new sS(t,e);if(yS(t))return FS(t.lazy,e);throw new Error("Cannot figure out the data source type: "+JSON.stringify(t))}function yS(t){return"lazy"in t}function bS(t){return(t==null?void 0:t.type)=="axisTicks"}function AS(t){return(t==null?void 0:t.type)=="axisGenome"}function wS(t){return(t==null?void 0:t.type)=="indexedFasta"}function vS(t){return(t==null?void 0:t.type)=="bigwig"}function ES(t){return(t==null?void 0:t.type)=="bigbed"}function CS(t){return(t==null?void 0:t.type)=="bam"}function SS(t){return(t==null?void 0:t.type)=="gff3"}function FS(t,e){if(bS(t))return new oS(t,e);if(AS(t))return new aS(t,e);if(wS(t))return new lS(t,e);if(vS(t))return new fS(t,e);if(ES(t))return new dS(t,e);if(CS(t))return new pS(t,e);if(SS(t))return new gS(t,e);throw new Error("Cannot figure out the data source type: "+JSON.stringify(t))}function TS(t){const e=Object.keys(t).filter(r=>typeof r=="string"),n=new Function("source","return { "+e.map(r=>JSON.stringify(r)).map(r=>`${r}: source[${r}]`).join(`, -`)+" };");return n.properties=e,n}class Ys extends X{get behavior(){return 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cC(e);return this.genomes.set(n.name,n),Promise.all([...this.genomes.values()].map(r=>r.load(this.baseUrl)))}getGenome(e){if(!this.genomes.size)throw new Error("No genomes have been configured!");if(e){const n=this.genomes.get(e);if(!n)throw new Error(`No genome with the name ${e} has been configured!`);return n}else{if(this.genomes.size>1)throw new Error("Cannot pick a default genome! 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Math.min(this.n,this.maxCols)}get rowIndices(){const e=[],n=this.nCols,r=this.nRows;for(let i=0;i=this.maxCols)return;r=n*this.nCols+e}return r=this.n))return[e%this.nCols,Math.floor(e/this.nCols)]}}const u3="chromosome_ticks_and_labels",l3={x:"width",y:"height"};function bc(t){return t=="x"?"y":"x"}const Xs={x:["bottom","top"],y:["left","right"]},_u=Object.fromEntries(Object.entries(Xs).map(([t,e])=>e.map(n=>[n,t])).flat(1));function zt(t){return _u[t]}class xp extends ts{constructor(e,n,r,i,s,o){const a=n=="locus",c={...a?h3:yp,...f3(n,e),...e};super(a?d3(c,n):bp(c,n),r,i,s,`axis_${e.orient}`,{blockEncodingInheritance:!0,contributesToScaleDomain:!1,...o}),this.axisProps=c}getSize(){const e={px:this.getPerpendicularSize()},n={grow:1};return _u[this.axisProps.orient]=="x"?new Nt(n,e):new Nt(e,n)}getPerpendicularSize(){return Ru(this.axisProps)}isPickingSupported(){return!1}}function Ru(t){const e=zt(t.orient);let n=t.ticks&&t.tickSize||0;return t.labels&&(n+=t.labelPadding,e=="x"?n+=t.labelFontSize:n+=30),t.title&&(n+=t.titlePadding+t.titleFontSize),n=Math.min(t.maxExtent||1/0,Math.max(t.minExtent||0,n)),n}const yp={values:null,minExtent:20,maxExtent:1/0,offset:0,domain:!0,domainWidth:1,domainColor:"gray",domainDash:null,domainDashOffset:0,domainCap:"square",ticks:!0,tickSize:5,tickWidth:1,tickColor:"gray",tickDash:null,tickDashOffset:0,tickCap:"square",tickCount:null,tickMinStep:null,labels:!0,labelAlign:"center",labelBaseline:"middle",labelPadding:4,labelFontSize:10,labelLimit:180,labelColor:"black",format:null,titleColor:"black",titleFont:"sans-serif",titleFontSize:10,titlePadding:3};function f3(t,e){const n=e.orient,r=t=="nominal"||t=="ordinal";let i="center",s="middle",o=e.labelAngle??((n=="top"||n=="bottom")&&r?-90:0);switch(n){case"left":i="right";break;case"right":i="left";break;case"top":case"bottom":Math.abs(o)>30?(i=o>0==(n=="bottom")?"left":"right",s="middle"):s=n=="top"?"alphabetic":"top";break}return{labelAlign:i,labelAngle:o,labelBaseline:s}}function bp(t,e){const n={...t,extent:Ru(t)},r=zt(n.orient),i=bc(r),s=n.orient=="bottom"||n.orient=="right"?1:-1,o=n.orient=="bottom"||n.orient=="left"?1:0,a=()=>({name:"domain",data:{values:[0]},mark:{type:"rule",clip:!1,strokeDash:n.domainDash,strokeCap:n.domainCap,color:n.domainColor,[i]:o,size:n.domainWidth}}),c=()=>({name:"labels",mark:{type:"text",clip:!1,align:n.labelAlign,angle:n.labelAngle,baseline:n.labelBaseline,[i+"Offset"]:(n.tickSize+n.labelPadding)*s,[i]:o,size:n.labelFontSize,color:n.labelColor,minBufferSize:1500},encoding:{[r]:{field:"value",type:e},text:{field:"label"}}}),u=()=>({name:"ticks",mark:{type:"rule",clip:!1,strokeDash:n.tickDash,strokeCap:n.tickCap,color:n.tickColor,size:n.tickWidth,minBufferSize:300},encoding:{[i]:{value:o},[i+"2"]:{value:o-n.tickSize/n.extent*(o?1:-1)}}}),f=()=>({name:"title",data:{values:[0]},mark:{type:"text",clip:!1,align:"center",baseline:n.orient=="bottom"?"bottom":"top",angle:[0,90,0,-90][["top","right","bottom","left"].indexOf(n.orient)],text:n.title,color:n.titleColor,[r]:.5,[i]:1-o}}),l=()=>{const p={name:"ticks_and_labels",encoding:{[r]:{field:"value",type:e}},layer:[]};return n.ticks&&p.layer.push(u()),n.labels&&p.layer.push(c()),p},h={resolve:{scale:{[r]:"forced"}},[l3[bc(r)]]:n.extent,data:{lazy:{type:"axisTicks",channel:r,axis:t}},layer:[]};return n.domain&&h.layer.push(a()),(n.ticks||n.labels)&&h.layer.push(l()),n.title&&h.layer.push(f()),h}const h3={...yp,chromTicks:!0,chromTickSize:18,chromTickWidth:1,chromTickColor:"#989898",chromTickDash:[4,2],chromTickDashOffset:1,chromLabels:!0,chromLabelFontSize:13,chromLabelFontWeight:"normal",chromLabelFontStyle:"normal",chromLabelColor:"black",chromLabelAlign:"left",chromLabelPadding:7};function d3(t,e){const n={...t,extent:Ru(t)},r=zt(n.orient),i=bc(r),s=n.orient=="bottom"||n.orient=="left"?1:0,o=()=>({name:"chromosome_ticks",mark:{type:"rule",strokeDash:t.chromTickDash,strokeDashOffset:t.chromTickDashOffset,[i]:s,[i+"2"]:s-n.chromTickSize/n.extent*(s?1:-1),color:t.chromTickColor,size:n.chromTickWidth}}),a=()=>{let f;switch(n.orient){case"top":f={y:0,angle:0,paddingX:4,dy:-n.chromLabelPadding,viewportEdgeFadeWidthLeft:20,viewportEdgeFadeWidthRight:20,viewportEdgeFadeDistanceRight:-10,viewportEdgeFadeDistanceLeft:-20};break;case"bottom":f={y:1,angle:0,paddingX:4,dy:n.chromLabelPadding+n.chromLabelFontSize*.73,viewportEdgeFadeWidthLeft:20,viewportEdgeFadeWidthRight:20,viewportEdgeFadeDistanceRight:-10,viewportEdgeFadeDistanceLeft:-20};break;case"left":f={x:1,angle:-90,paddingY:4,dy:-n.chromLabelPadding,viewportEdgeFadeWidthBottom:20,viewportEdgeFadeWidthTop:20,viewportEdgeFadeDistanceBottom:-20,viewportEdgeFadeDistanceTop:-10};break;case"right":f={x:0,angle:90,align:"right",paddingY:4,dy:-n.chromLabelPadding};break;default:f={}}return{name:"chromosome_labels",mark:{type:"text",size:n.chromLabelFontSize,font:n.chromLabelFont,fontWeight:n.chromLabelFontWeight,fontStyle:n.chromLabelFontStyle,color:n.chromLabelColor,align:t.chromLabelAlign,baseline:"alphabetic",clip:!1,...f},encoding:{[r+"2"]:{field:"continuousEnd",type:e},text:{field:"name"}}}};let c;switch(n.orient){case"bottom":case"top":c={};break;case"left":c={labelAngle:-90,labelAlign:"center",labelPadding:6};break;case"right":c={labelAngle:90,labelAlign:"center",labelPadding:6};break;default:c={}}const u=bp({...t,...c},e);if(t.chromTicks||t.chromLabels){const f={name:u3,data:{lazy:{type:"axisGenome",channel:zt(n.orient)}},encoding:{[r]:{field:"continuousStart",type:e,band:0}},layer:[]};if(t.chromTicks&&f.layer.push(o()),t.chromLabels){f.layer.push(a());let l;u.layer.filter(h=>h.name=="ticks_and_labels").forEach(h=>h.layer.filter(p=>p.name=="labels").forEach(p=>{l=p.mark})),l&&(n.orient=="top"||n.orient=="bottom"?(l.viewportEdgeFadeWidthLeft=30,l.viewportEdgeFadeDistanceLeft=40):(l.viewportEdgeFadeWidthBottom=30,l.viewportEdgeFadeDistanceBottom=40))}u.layer.push(f)}return u}class p3 extends ts{constructor(e,n,r,i,s,o){const c={...n=="locus"?m3:Ap,...e};super(b3(c,n),r,i,s,`axisGrid_${e.orient}`,{blockEncodingInheritance:!0,contributesToScaleDomain:!1,...o}),this.axisProps=c}getOrient(){return this.axisProps.orient}isPickingSupported(){return!1}}const Ap={values:null,grid:!1,gridCap:"butt",gridColor:"lightgray",gridDash:null,gridOpacity:1,gridWidth:1,tickCount:null,tickMinStep:null},m3={...Ap,chromGrid:!1,chromGridCap:"butt",chromGridColor:"gray",chromGridDash:[1,5],chromGridOpacity:1,chromGridWidth:1};function g3(t,e){const n=t,r=zt(n.orient);return{name:"grid_lines",data:{lazy:{type:"axisTicks",channel:r,axis:t}},mark:{type:"rule",strokeDash:n.gridDash,strokeCap:n.gridCap,color:n.gridColor,size:n.gridWidth,opacity:n.gridOpacity,minBufferSize:300},encoding:{[r]:{field:"value",type:e}}}}function x3(t,e){const n=t,r=zt(n.orient);return{name:"chromosome_lines",data:{lazy:{type:"axisGenome",channel:r}},mark:{type:"rule",strokeDash:n.chromGridDash,strokeCap:n.chromGridCap,color:n.chromGridColor,size:n.chromGridWidth,opacity:n.chromGridOpacity},encoding:{[r]:{field:"continuousStart",type:e,band:0}}}}function y3(t,e){const n=t,r=zt(n.orient);return{name:"chromosome_fill",data:{lazy:{type:"axisGenome",channel:r}},mark:{type:"rect"},encoding:{[r]:{field:"continuousStart",type:e,band:0},[r+"2"]:{field:"continuousEnd",band:0},fill:{field:"odd",type:"nominal",scale:{domain:[!1,!0],range:[n.chromGridFillEven??"white",n.chromGridFillOdd??"white"]}},opacity:{field:"odd",type:"nominal",scale:{type:"ordinal",domain:[!1,!0],range:[n.chromGridFillEven?1:0,n.chromGridFillOdd?1:0]}}}}}function b3(t,e){const n={...t},r=[];return n.chromGrid&&(n.chromGridFillOdd||n.chromGridFillEven)&&r.push(y3(n,e)),n.chromGrid&&n.chromGridOpacity>0&&r.push(x3(n,e)),n.grid&&n.gridOpacity>0&&r.push(g3(n,e)),{name:"grid_layers",configurableVisibility:!1,resolve:{scale:{[zt(t.orient)]:"forced",fill:"independent",opacity:"independent"}},layer:r}}const Sf={anchor:"middle",frame:"group",offset:10,orient:"top",align:void 0,angle:0,baseline:"alphabetic",dx:0,dy:0,color:void 0,font:void 0,fontSize:12,fontStyle:"normal",fontWeight:"normal"},A3={orient:"left",anchor:"middle",align:"right",baseline:"middle",angle:0,fontSize:12},w3={orient:"top",anchor:"start",align:"left",baseline:"top",offset:-10,dx:10,fontSize:12},v3={start:0,middle:.5,end:1},E3={start:"left",middle:"center",end:"right"};function C3(t){if(!t)return;const e=V(t)?{text:t}:t;if(!e.text||e.orient=="none")return;const n={"track-title":A3,overlay:w3}[e.style]??{},r={...Sf,...n,...e};let i={},s={x:0,y:0};const o=v3[r.anchor??"middle"];switch(r.orient){case"top":s={x:o,y:1},i={baseline:"alphabetic",angle:0};break;case"right":s={x:1,y:1-o},i={baseline:"alphabetic",angle:90};break;case"bottom":s={x:o,y:0},i={baseline:"top",angle:0};break;case"left":s={x:0,y:o},i={baseline:"alphabetic",angle:-90};break}const a={...Sf,...i,...n,...e},c={xOffset:0,yOffset:0};switch(r.orient){case"top":c.yOffset=-a.offset;break;case"right":c.xOffset=a.offset;break;case"bottom":c.yOffset=a.offset;break;case"left":c.xOffset=-a.offset;break}return{configurableVisibility:!1,data:{values:[{}]},mark:{type:"text",tooltip:null,clip:!1,...s,...c,text:a.text,align:a.align??E3[a.anchor],angle:a.angle,baseline:a.baseline,dx:a.dx,dy:a.dy,color:a.color,font:a.font,size:a.fontSize,fontStyle:a.fontStyle,fontWeight:a.fontWeight}}}function S3(t,e,n,r){if(t.type=="wheel"){t.uiEvent.preventDefault();const i=t.uiEvent,s=i.deltaMode?120:1;let{x:o,y:a}=t.point;if(r){const c=r.mark.encoders;c.x&&!c.x2&&!c.x.constantValue&&(o=+c.x(r.datum)*e.width+e.x),c.y&&!c.y2&&!c.y.constantValue&&(a=(1-+c.y(r.datum))*e.height+e.y)}Math.abs(i.deltaX){n({x:s.clientX,y:s.clientY,xDelta:c.clientX-s.clientX,yDelta:c.clientY-s.clientY,zDelta:0}),s=c},a=c=>{document.removeEventListener("mousemove",o),document.removeEventListener("mouseup",a)};document.addEventListener("mouseup",a,!1),document.addEventListener("mousemove",o,!1)}}var Zn,Qn,Le,dn,er,xt,sn,eo,wp,pn,Or,Si,Ac,Fi,wc,Ti,vc,to,vp,tr,vs,no,Ep;class F3 extends Mn{constructor(n,r,i,s,o,a,c){super(n,r,i,s,o,c);M(this,xt);M(this,eo);M(this,pn);M(this,Si);M(this,Fi);M(this,Ti);M(this,to);M(this,tr);M(this,no);M(this,Zn,1/0);M(this,Qn,10);M(this,Le,[]);M(this,dn,{});M(this,er,0);this.spec=n,he(this,Qn,n.spacing??10),he(this,Zn,a),he(this,Le,[]),this.wrappingFacet=!1}appendChild(n){n.layoutParent??(n.layoutParent=this),S(this,Le).push(new Tf(n,this,S(this,er))),Ou(this,er)._++}setChildren(n){he(this,Le,[]);for(const r of n)this.appendChild(r)}replaceChild(n,r){const i=S(this,Le).findIndex(s=>s.view==n);if(i>=0)S(this,Le)[i]=new Tf(r,this,S(this,er));else throw new Error("Not my child view!")}get children(){return S(this,Le).map(n=>n.view)}get childCount(){return S(this,Le).length}async createAxes(){const n=[];for(const r of br){const i=this.resolutions.axis[r];if(i){const s=i.getAxisProps();if(s){const o={title:i.getTitle(),orient:Xs[r][0],...s},a=new xp(o,i.scaleResolution.type,this.context,this,this);n.push(a.initializeChildren()),S(this,dn)[r]=a}}}return Promise.all([...n,...S(this,Le).map(r=>r.createAxes())])}*[Symbol.iterator](){for(const n of S(this,Le))yield*n.getChildren();for(const n of Object.values(S(this,dn)))yield n}getOverhang(){return I(this,to,vp).call(this).union(I(this,tr,vs).call(this))}getSize(){return this._cache("size",()=>new Nt(I(this,Fi,wc).call(this,"column"),I(this,Fi,wc).call(this,"row")).addPadding(I(this,tr,vs).call(this)))}render(n,r,i={}){if(!this.isConfiguredVisible())return;this.layoutParent||(r=r.shrink(this.getPadding())),r=r.shrink(I(this,tr,vs).call(this)),n.pushView(this,r);const s={devicePixelRatio:this.context.devicePixelRatio},o=cf(I(this,Si,Ac).call(this,"column"),r.width,s),a=cf(I(this,Si,Ac).call(this,"row"),r.height,s),c=new Cf(S(this,xt,sn).length,S(this,Zn)??1/0),u=f=>Math.round(f*devicePixelRatio)/devicePixelRatio;for(const[f,l]of S(this,xt,sn).entries()){const{view:h,axes:p,gridLines:d,background:m,backgroundStroke:g,title:x}=l,[b,A]=c.getCellCoords(f),E=o[I(this,Ti,vc).call(this,"column",b)],F=a[I(this,Ti,vc).call(this,"row",A)],C=h.getViewportSize(),w=h.getSize(),L=h.getOverhang(),Y=E.location-L.left,j=F.location-L.top,_=(oe,Ze)=>(oe[Ze].grow?(Ze=="width"?E:F).size:oe[Ze].px)+L[Ze],ee=_(C,"width"),le=_(C,"height"),Ve=_(w,"width"),Kt=_(w,"height"),lt=l.scrollbars.horizontal,ft=l.scrollbars.vertical,Tt=lt?()=>u(lt.viewportOffset):()=>0,Be=ft?()=>u(ft.viewportOffset):()=>0,ke=new vt(()=>r.x+Y,()=>r.y+j,()=>ee,()=>le),ns=h.isScrollable(),Jt=ns?new vt(()=>r.x+Y-Tt(),()=>r.y+j-Be(),()=>Ve,()=>Kt):ke;l.coords=ke;const Er=i.clipRect?ke.intersect(i.clipRect):ke;m==null||m.render(n,Er,{...i,clipRect:void 0});for(const oe of Object.values(d))oe.render(n,ke,i);const rs=_3(h)||ns;rs&&h.render(n,Jt,{...i,clipRect:Er}),g==null||g.render(n,Er,{...i,clipRect:void 0});for(const[oe,Ze]of Object.entries(p)){const Ge=oe=="left"||oe=="right"?"vertical":"horizontal",Cr=l.scrollbars[Ge],T=Cr?ke.modify(Ge=="vertical"?{y:()=>Jt.y,height:Kt}:{x:()=>Jt.x,width:Ve}):ke,B=Ff(T,oe,Ze);let k=i.clipRect;Cr&&(k=B.intersect(k).intersect(Cr?ke.modify(Ge=="vertical"?{x:-1e5,width:2e5}:{y:-1e5,height:2e5}):void 0)),Ze.render(n,B,{...i,clipRect:k})}for(const oe of Object.values(S(this,dn))){const Ge=oe.axisProps.orient;(Ge=="left"&&b==0||Ge=="right"&&b==c.nCols-1||Ge=="top"&&A==0||Ge=="bottom"&&A==c.nRows-1)&&oe.render(n,Ff(ke.shrink(l.view.getOverhang()),Ge,oe),i)}rs||h.render(n,Jt,i);for(const oe of Object.values(l.scrollbars))oe.updateScrollbar(ke,Jt),oe.render(n,r,i);x==null||x.render(n,ke,i)}n.popView(this)}propagateInteractionEvent(n){if(this.handleInteractionEvent(void 0,n,!0),n.stopped)return;const r=S(this,xt,sn).find(s=>s.coords.containsPoint(n.point.x,n.point.y));for(const s of Object.values((r==null?void 0:r.scrollbars)??{}))if(s.coords.containsPoint(n.point.x,n.point.y)&&(s.propagateInteractionEvent(n),n.stopped))return;const i=r==null?void 0:r.view;i&&(i.propagateInteractionEvent(n),(i instanceof Ne||i instanceof ts)&&S3(n,r.coords,s=>I(this,no,Ep).call(this,r.coords,r.view,s),this.context.getCurrentHover())),!n.stopped&&this.handleInteractionEvent(void 0,n,!1)}getDefaultResolution(n,r){return"independent"}}Zn=new WeakMap,Qn=new WeakMap,Le=new WeakMap,dn=new WeakMap,er=new WeakMap,xt=new WeakSet,sn=function(){return S(this,Le).filter(n=>n.view.isConfiguredVisible())},eo=new WeakSet,wp=function(){return new Cf(S(this,xt,sn).length,S(this,Zn)??1/0)},pn=new WeakSet,Or=function(n){const r=n=="column"?"width":"height",i=(s,o)=>s.map(a=>{const u=S(this,xt,sn)[a].getOverhangAndPadding();return n=="column"?o?u.right:u.left:o?u.bottom:u.top}).reduce((a,c)=>Math.max(a,c),0);return this._cache(`size/directionSizes/${n}`,()=>S(this,eo,wp)[n=="column"?"colIndices":"rowIndices"].map(s=>({axisBefore:i(s,0),axisAfter:i(s,1),view:DE(s.map(o=>S(this,xt,sn)[o].view.getViewportSize()[r]))})))},Si=new WeakSet,Ac=function(n){const r=I(this,pn,Or).call(this,n),i=[];i.push(Ur);for(const[s,o]of r.entries())s>0&&i.push({px:S(this,Qn),grow:0}),(s==0||this.wrappingFacet)&&i.push(Ur),i.push({px:o.axisBefore,grow:0}),i.push(o.view),i.push({px:o.axisAfter,grow:0}),(s==r.length-1||this.wrappingFacet)&&i.push(Ur);return i},Fi=new WeakSet,wc=function(n){let r=0,i=0;const s=n=="row"?this.spec.height:this.spec.width;if(s||s===0)return Vd(s);const o=I(this,pn,Or).call(this,n);for(const[a,c]of o.entries())a>0&&(i+=S(this,Qn)),(a==0||this.wrappingFacet)&&(i+=0),i+=c.axisBefore,i+=c.view.px??0,r+=c.view.grow??0,i+=c.axisAfter,(a==o.length-1||this.wrappingFacet)&&(i+=0);return{px:i,grow:r}},Ti=new WeakSet,vc=function(n,r){return n=="row"&&this.wrappingFacet?1+6*r+2:2+4*r+1},to=new WeakSet,vp=function(){const n=I(this,pn,Or).call(this,"column"),r=I(this,pn,Or).call(this,"row");return!n.length||!r.length?pe.zero():new pe(r.at(0).axisBefore,n.at(-1).axisAfter,r.at(-1).axisAfter,n.at(0).axisBefore)},tr=new WeakSet,vs=function(){const n=r=>{const i=_u[r],s=S(this,dn)[i];return(s==null?void 0:s.axisProps.orient)!==r?0:Math.max(s.getPerpendicularSize()+s.axisProps.offset,0)};return new pe(n("top"),n("right"),n("bottom"),n("left"))},no=new WeakSet,Ep=function(n,r,i){for(const[s,o]of Object.entries(I3(r))){if(o.size<=0)continue;const a=n.normalizePoint(i.x,i.y),c=n.normalizePoint(i.x+i.xDelta,i.y+i.yDelta),u={x:c.x-a.x,y:c.y-a.y};for(const f of o)f.zoom(2**i.zDelta,s=="y"?1-a[s]:a[s],s=="x"?u.x:-u.y)}this.context.animator.requestRender()};function T3(t){if(!(!t||!t.fill||t.fillOpacity===0))return{configurableVisibility:!1,data:{values:[{}]},mark:{color:t.fill,opacity:t.fillOpacity??1,type:"rect",clip:!1,tooltip:null,minHeight:1,minOpacity:0}}}function D3(t){if(!(!t||!t.stroke||t.strokeWidth===0||t.strokeOpacity===0))return{configurableVisibility:!1,resolve:{scale:{x:"excluded",y:"excluded"},axis:{x:"excluded",y:"excluded"}},data:{values:[{x:0,y:0,x2:1,y2:0},{x:1,y:0,x2:1,y2:1},{x:1,y:1,x2:0,y2:1},{x:0,y:1,x2:0,y2:0}]},mark:{size:t.strokeWidth??1,color:t.stroke??"lightgray",strokeCap:"square",strokeOpacity:t.strokeOpacity??1,type:"rule",clip:!1,tooltip:null},encoding:{x:{field:"x",type:"quantitative",scale:null},y:{field:"y",type:"quantitative",scale:null},x2:{field:"x2"},y2:{field:"y2"}}}}function I3(t){const e={x:new Set,y:new Set};return t.visit(n=>{for(const[r,i]of Object.entries(e)){const s=n.getScaleResolution(r);s&&s.isZoomable()&&i.add(s)}}),e}function _3(t){let e=!0;return t.visit(n=>{n instanceof Ne&&e&&(e=n.mark.properties.clip===!0)}),e}function Ff(t,e,n){const r=n.axisProps,i=n.getPerpendicularSize();if(e=="bottom")return t.translate(0,t.height+r.offset).modify({height:i});if(e=="top")return t.translate(0,-i-r.offset).modify({height:i});if(e=="left")return t.translate(-i-r.offset,0).modify({width:i});if(e=="right")return t.translate(t.width+r.offset,0).modify({width:i})}class Tf{constructor(e,n,r){if(this.layoutParent=n,this.view=e,this.serial=r,this.background=void 0,this.backgroundStroke=void 0,this.axes={},this.gridLines={},this.scrollbars={},this.title=void 0,this.coords=vt.ZERO,e.needsAxes.x||e.needsAxes.y){const i=e.spec,s="view"in i?i==null?void 0:i.view:void 0,o=T3(s);o&&(this.background=new Ne(o,n.context,n,e,"background"+r,{blockEncodingInheritance:!0}));const a=D3(s);a&&(this.backgroundStroke=new Ne(a,n.context,n,e,"backgroundStroke"+r,{blockEncodingInheritance:!0}));const c=C3(e.spec.title);if(c){const u=new Ne(c,n.context,n,e,"title"+r,{blockEncodingInheritance:!0});this.title=u}}e.spec.viewportWidth!=null&&(this.scrollbars.horizontal=new Df(this,"horizontal")),e.spec.viewportHeight!=null&&(this.scrollbars.vertical=new Df(this,"vertical"))}*getChildren(){this.background&&(yield this.background),this.backgroundStroke&&(yield this.backgroundStroke),this.title&&(yield this.title),yield*Object.values(this.axes),yield*Object.values(this.gridLines),yield this.view,yield*Object.values(this.scrollbars)}async createAxes(){const{view:e,axes:n,gridLines:r}=this,i=(a,c)=>{const u=a.getAxisProps();if(u===null)return;const f=u?{...u}:{};if(!f.orient){for(const l of Xs[c])if(!n[l]){f.orient=l;break}if(!f.orient)throw new Error("No slots available for an axis! Perhaps a LayerView has more than two children?")}if(f.title??(f.title=a.getTitle()),!Xs[c].includes(f.orient))throw new Error(`Invalid axis orientation "${f.orient}" on channel "${c}"!`);return f},s=async(a,c,u)=>{const f=i(a,c);if(f){if(n[f.orient])throw new Error(`An axis with the orient "${f.orient}" already exists!`);const l=new xp(f,a.scaleResolution.type,this.layoutParent.context,this.layoutParent,u);n[f.orient]=l,await l.initializeChildren()}},o=async(a,c,u)=>{const f=i(a,c);if(f&&(f.grid||f.chromGrid)){const l=new p3(f,a.scaleResolution.type,this.layoutParent.context,this.layoutParent,u);r[f.orient]=l,await l.initializeChildren()}};for(const a of["x","y"])if(e.needsAxes[a]){const c=e.resolutions.axis[a];if(!c)continue;await s(c,a,e)}for(const a of["x","y"])if(e.needsAxes[a]){const c=e.getAxisResolution(a);if(!c)continue;await o(c,a,e)}if(e instanceof ts){for(const a of e)for(const[c,u]of Object.entries(a.resolutions.axis)){const f=u.getAxisProps();f&&f.orient&&await s(u,c,a)}for(const a of e)for(const[c,u]of Object.entries(a.resolutions.axis)){const f=u.getAxisProps();f&&!f.orient&&await s(u,c,a)}}[...Object.values(n),...Object.values(r)].forEach(a=>a.visit(c=>{c instanceof Ne&&c.resolve("scale")}))}getOverhang(){const e=n=>{const r=this.axes[n];return r?Math.max(r.getPerpendicularSize()+r.axisProps.offset,0):0};return new pe(e("top"),e("right"),e("bottom"),e("left")).add(this.view.getOverhang())}getOverhangAndPadding(){return this.getOverhang().add(this.view.getPadding())}}class Df extends Ne{constructor(e,n){const r={scrollbarSize:8,scrollbarPadding:2};super({data:{values:[{}]},mark:{type:"rect",fill:"#b0b0b0",fillOpacity:.6,stroke:"white",strokeWidth:1,strokeOpacity:1,cornerRadius:5,clip:!1},configurableVisibility:!1},e.layoutParent.context,e.layoutParent,e.view,"scrollbar-"+n,{blockEncodingInheritance:!0}),this.config=r,this.scrollDirection=n,this.viewportOffset=0,this.maxScrollOffset=0,this.scrollbarCoords=vt.ZERO,this.addInteractionEventListener("mousedown",(i,s)=>{if(s.stopPropagation(),this.maxScrollOffset<=0)return;const o=h=>n=="vertical"?h.clientY:h.clientX,a=s.uiEvent;a.preventDefault();const c=this.getScrollOffset(),u=o(a),f=h=>{const p=ai(o(h)-u+c,0,this.maxScrollOffset);this.viewportOffset=p/this.maxScrollOffset*this.maxViewportOffset,this.context.animator.requestRender()},l=()=>{document.removeEventListener("mousemove",f),document.removeEventListener("mouseup",l)};document.addEventListener("mouseup",l,!1),document.addEventListener("mousemove",f,!1)})}getScrollOffset(){return this.viewportOffset/this.maxViewportOffset*this.maxScrollOffset}render(e,n,r){super.render(e,this.scrollbarCoords,r)}updateScrollbar(e,n){const r=this.config.scrollbarPadding,i=this.config.scrollbarSize,s=this.scrollDirection=="horizontal"?"width":"height",o=Math.min(1,e[s]/n[s]),a=e[s]-2*r,c=o*a;this.maxScrollOffset=a-c,this.maxViewportOffset=n[s]-e[s],this.viewportOffset=ai(this.viewportOffset,0,this.maxViewportOffset),this.scrollbarCoords=this.scrollDirection=="vertical"?new vt(()=>e.x+e.width-i-r,()=>e.y+r+this.getScrollOffset(),()=>i,()=>c):new vt(()=>e.x+r+this.getScrollOffset(),()=>e.y+e.height-i-r,()=>c,()=>i)}}class Ca extends F3{constructor(e,n,r,i,s){super(e,n,r,i,s,Sc(e)?e.columns:Es(e)?1:1/0),this.spec=e}async initializeChildren(){const e=this.spec,n=Sc(e)?e.concat:Es(e)?e.vconcat:e.hconcat;this.setChildren(await Promise.all(n.map((r,i)=>this.context.createOrImportView(r,this,this,"grid"+i)))),await this.createAxes()}getDefaultResolution(e,n){return n=="axis"?"independent":Es(this.spec)&&e==="x"||Sp(this.spec)&&e==="y"?"shared":"independent"}}const Cp="viewRoot";var nr;class R3{constructor(e={}){M(this,nr,new Map);this.options={allowImport:!0,wrapRoot:!0,...e};const n=r=>(i,s,o,a,c)=>new r(i,s,o,a,i.name??c);this.addViewType(Cc,n(ts)),this.addViewType(Ec,n(Ne)),this.addViewType(Es,n(Ca)),this.addViewType(Sp,n(Ca)),this.addViewType(Sc,n(Ca)),this.addViewType(B3,()=>{throw new Error("SampleView is not supported by the @genome-spy/core package. Use @genome-spy/app instead!")})}addViewType(e,n){S(this,nr).set(e,n)}createView(e,n,r,i,s){for(const[o,a]of S(this,nr))if(o(e))return a(e,n,r,i,s);throw new Error("Invalid spec, cannot figure out the view type from the properties: "+JSON.stringify([...Object.keys(e)]))}isViewSpec(e){const n=[...S(this,nr).keys()].filter(r=>r(e));if(n.length>1)throw new Error("Ambiguous spec. Cannot create a view!");return n.length==1}async createOrImportView(e,n,r,i,s,o){let a;if(M3(e))if(this.options.allowImport)a=await zS(e,i.getBaseUrl(),n),o&&o(a);else throw new vn("Importing views is not allowed!",r);else a=e;!i&&this.options.wrapRoot&&(Ec(a)||Cc(a))&&s===Cp&&(a={name:"implicitRoot",vconcat:[a]});const c=this.createView(a,n,r,i,s);return c instanceof Mn&&await c.initializeChildren(),c}}nr=new WeakMap;function Ec(t){return"mark"in t&&(V(t.mark)||Re(t.mark))}function Cc(t){return"layer"in t&&Re(t.layer)}function M3(t){return"import"in t}function Es(t){return"vconcat"in t&&Me(t.vconcat)}function Sp(t){return"hconcat"in t&&Me(t.hconcat)}function Sc(t){return"concat"in t&&Me(t.concat)}function B3(t){return"samples"in t&&Re(t.samples)&&"spec"in t&&Re(t.spec)}var rr,mn,Di,gn;class k3{constructor(){M(this,rr,void 0);M(this,mn,void 0);M(this,Di,void 0);M(this,gn,void 0);he(this,rr,new Map),he(this,mn,new Set),he(this,gn,new Map),he(this,Di,new Proxy(S(this,rr),{get(e,n){return V(n)?e.get(n):void 0}}))}allocateSetter(e){if(S(this,mn).has(e))throw new Error("Setter already allocated for parameter: "+e);return S(this,mn).add(e),n=>{S(this,rr).set(e,n);const r=S(this,gn).get(e);if(r)for(const i of r)i()}}createExpression(e){const n=vo(e,S(this,Di));for(const r of n.globals)if(!S(this,mn).has(r))throw new Error(`Unknown variable "${r}" in expression: ${e}`);return n.addListener=r=>{for(const i of n.globals){const s=S(this,gn).get(i)??new Set;S(this,gn).set(i,s),s.add(r)}},n}}rr=new WeakMap,mn=new WeakMap,Di=new WeakMap,gn=new WeakMap;gh("fasta",QS);class O3{constructor(e,n,r={}){this.container=e;const i=document.createElement("style");i.innerHTML=V1,e.appendChild(i),this.spec=n,this.accessorFactory=new Bb,this.viewFactory=new R3,this.namedDataProviders=[],this.animator=new WS(()=>this.renderAll()),this.genomeStore=void 0,this.viewVisibilityPredicate=s=>s.isVisibleInSpec(),this._renderingContext=void 0,this._pickingContext=void 0,this._dirtyPickingBuffer=!1,this._currentHover=void 0,this._wheelInertia=new e3(this.animator),this._keyboardListeners=new Map,this._eventListeners=new Map,this._extraBroadcastListeners=new Map,this.tooltipHandlers={default:c3,refseqgene:n3,...r.tooltipHandlers??{}},this.viewRoot=void 0,this._paramBroker=new k3}registerNamedDataProvider(e){this.namedDataProviders.unshift(e)}getNamedDataFromProvider(e){for(const n of this.namedDataProviders){const r=n(e);if(r)return r}}updateNamedData(e,n){const r=this.viewRoot.context.dataFlow.findNamedDataSource(e);if(!r)throw new Error("No such named data source: "+e);r.dataSource.updateDynamicData(n),xc(r.hosts),this.animator.requestRender()}broadcast(e,n){var i;const r={type:e,payload:n};this.viewRoot.visit(s=>s.handleBroadcast(r)),(i=this._extraBroadcastListeners.get(e))==null||i.forEach(s=>s(r))}_prepareContainer(){this.container.classList.add("genome-spy"),this.container.classList.add("loading"),this._glHelper=new Xv(this.container,()=>this.viewRoot?US(this.viewRoot):{width:void 0,height:void 0},this.spec.background),this.loadingMessageElement=document.createElement("div"),this.loadingMessageElement.className="loading-message",this.loadingMessageElement.innerHTML='
Loading...
',this.container.appendChild(this.loadingMessageElement),this.tooltip=new H1(this.container),this.loadingMessageElement.querySelector(".message").addEventListener("transitionend",()=>{this.loadingMessageElement.style.display="none"})}destroy(){this.container.classList.remove("genome-spy"),this.container.classList.remove("loading");for(const[e,n]of this._keyboardListeners)for(const r of n)document.removeEventListener(e,r);for(this._glHelper.finalize();this.container.firstChild;)this.container.firstChild.remove()}async _prepareViewsAndData(){this.spec.genome&&(this.genomeStore=new jS(this.spec.baseUrl),await this.genomeStore.initialize(this.spec.genome));const e=this,n={dataFlow:new hp,accessorFactory:this.accessorFactory,glHelper:this._glHelper,animator:this.animator,genomeStore:this.genomeStore,fontManager:new KS(this._glHelper),get devicePixelRatio(){return e._glHelper.dpr},paramBroker:this._paramBroker,requestLayoutReflow:()=>{},updateTooltip:this.updateTooltip.bind(this),getNamedDataFromProvider:this.getNamedDataFromProvider.bind(this),getCurrentHover:()=>this._currentHover,addKeyboardListener:(c,u)=>{document.addEventListener(c,u);let f=this._keyboardListeners.get(c);f||(f=[],this._keyboardListeners.set(c,f)),f.push(u)},addBroadcastListener(c,u){const f=e._extraBroadcastListeners;let l=f.get(c);l||(l=new Set,f.set(c,l)),l.add(u)},removeBroadcastListener(c,u){var l;(l=e._extraBroadcastListeners.get(c))==null||l.delete(u)},isViewConfiguredVisible:e.viewVisibilityPredicate,isViewSpec:c=>e.viewFactory.isViewSpec(c),createView:function(c,u,f,l){return e.viewFactory.createView(c,n,u,f,l)},createOrImportView:async function(c,u,f,l,h){return e.viewFactory.createOrImportView(c,n,u,f,l,h)}},r=this.spec;r.datasets&&this.registerNamedDataProvider(c=>r.datasets[c]),this.viewRoot=await n.createOrImportView(r,null,null,Cp),LS(this.viewRoot),NS(this.viewRoot);const i=this.viewRoot.getDescendants();i.forEach(c=>c.configureViewOpacity()),this._glHelper.invalidateSize();const s=i.filter(c=>c instanceof Ne),o=RS(this.viewRoot,n.dataFlow);PS(o),this.broadcast("dataFlowBuilt",o),s.forEach(c=>c.mark.initializeEncoders());const a=Promise.all(s.map(c=>c.mark.initializeGraphics()));for(const c of s)o.addObserver(u=>{c.mark.initializeData(),c.mark.updateGraphicsData()},c);await n.fontManager.waitUntilReady(),o.initialize(),await Promise.all(o.dataSources.map(c=>c.load())),xc(this.viewRoot),this.broadcast("dataLoaded"),await a,this.viewRoot.visit(c=>{for(const u of Object.values(c.resolutions.scale))this._glHelper.createRangeTexture(u)});for(const c of s)c.mark.finalizeGraphicsInitialization();n.requestLayoutReflow=this.computeLayout.bind(this),this.viewRoot.visit(c=>As(c,"size")),this._glHelper.invalidateSize()}async launch(){try{return this._prepareContainer(),await this._prepareViewsAndData(),this.registerMouseEvents(),this.computeLayout(),this.animator.requestRender(),this._glHelper.addEventListener("resize",()=>{this.computeLayout(),this.renderAll()}),!0}catch(e){const n=`${e.view?`At "${e.view.getPathString()}": `:""}${e.toString()}`;return console.error(e.stack),P3(this.container,n),!1}finally{this.container.classList.remove("loading"),window.setTimeout(()=>{this.loadingMessageElement.style.display="none"},2e3)}}registerMouseEvents(){const e=this._glHelper.canvas,n=r=>{var i;if(r instanceof MouseEvent){r.type=="mousemove"&&(this.tooltip.handleMouseMove(r),this._tooltipUpdateRequested=!1,r.buttons==0&&this.renderPickingFramebuffer());const s=e.getBoundingClientRect(),o=new GS(r.clientX-s.left-e.clientLeft,r.clientY-s.top-e.clientTop),a=c=>{this.viewRoot.propagateInteractionEvent(new VS(o,c)),this._tooltipUpdateRequested||this.tooltip.clear()};if(r.type!="wheel"&&this._wheelInertia.cancel(),r.type=="mousemove")this._handlePicking(o.x,o.y);else if(r.type=="mousedown"||r.type=="mouseup")this.renderPickingFramebuffer();else if(r.type=="wheel"){this._tooltipUpdateRequested=!1;const c=r;if(Math.abs(c.deltaX)>Math.abs(c.deltaY))this._currentHover=null,this._wheelInertia.cancel();else{const u=t3(c);this._wheelInertia.setMomentum(c.deltaY*(c.deltaMode?80:1),f=>{const l=new WheelEvent("wheel",{...u,deltaMode:0,deltaX:0,deltaY:f});a(l)}),c.preventDefault();return}}if(r.type=="click"){const c=this._currentHover?{type:r.type,viewPath:this._currentHover.mark.unitView.getLayoutAncestors().map(u=>u.name).reverse(),datum:this._currentHover.datum}:{type:r.type,viewPath:null,datum:null};(i=this._eventListeners.get("click"))==null||i.forEach(u=>u(c))}a(r)}};["mousedown","mouseup","wheel","click","mousemove","gesturechange","contextmenu"].forEach(r=>e.addEventListener(r,n)),e.addEventListener("mousedown",()=>{document.addEventListener("mouseup",()=>this.tooltip.popEnabledState(),{once:!0}),this.tooltip.pushEnabledState(!1)}),e.addEventListener("dragstart",r=>r.stopPropagation())}_handlePicking(e,n){var s;const r=this._glHelper.readPickingPixel(e,n),i=r[0]|r[1]<<8|r[2]<<16;if(i==0){this._currentHover=null;return}if(i!==((s=this._currentHover)==null?void 0:s.uniqueId)&&(this._currentHover=null),this._currentHover||this.viewRoot.visit(o=>{if(o instanceof Ne){if(o.mark.isPickingParticipant()){const a=o.mark.encoders.uniqueId.accessor;o.getCollector().visitData(c=>{a(c)==i&&(this._currentHover={mark:o.mark,datum:c,uniqueId:i})})}if(this._currentHover)return $r}}),this._currentHover){const o=this._currentHover.mark;this.updateTooltip(this._currentHover.datum,async a=>{if(!o.isPickingParticipant())return;const c=o.properties.tooltip;if(c!==null){const u=(c==null?void 0:c.handler)??"default",f=this.tooltipHandlers[u];if(!f)throw new Error("No such tooltip handler: "+u);return f(a,o,c==null?void 0:c.params)}})}}updateTooltip(e,n){if(!this._tooltipUpdateRequested||!e)this.tooltip.updateWithDatum(e,n),this._tooltipUpdateRequested=!0;else throw new Error("Tooltip has already been updated! Duplicate event handler?")}computeLayout(){const e=this.viewRoot;if(!e)return;this.broadcast("layout");const n=this._glHelper.getLogicalCanvasSize();if(isNaN(n.width)||isNaN(n.height)){console.log(`NaN in canvas size: ${n.width}x${n.height}. 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`;return te`${(()=>te`

1. Choose a genome assembly or a sequence dictionary

Choosing a genome assembly instead of a sequence dictionary activates cytoband, GC content, and RefSeq gene tracks.

${e()}

2. Select files

Please provide at least one of the following files to start visualizing. File types are detected from the TSV header row.

N.B. All data processing takes place in your web browser. Nothing is uploaded anywhere.

${Object.values(ge).filter(r=>r!==ge.DICT||!En).map(t)}
or drag and drop here.

No files to play with?

Try the example data sets:

${Gr?te` Loading...`:""}

3. Explore the data

Zoom with the mouse wheel or touchpad, pan by dragging or with the touchpad. Hover an item to get details.
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