Metamask is a Chrome web browser extension that allows users to visit webpages that interact with the ethereum blockchain. It allows users to access blockchain contracts without having to set up and run a full ethereum node. Metamask uses a consortium node run by the famous Consensys group and a Chrome browser plugin extension.
In principle, using the Ethereum Studio IDE one can deploy Dapps compatible with a Metamask enabled browser. It is beyond the scope of this document on how to prepare your web3 enabled Dapps to run in Metamask. However you can consult the metamask document: MetaMask Compatibility Guide for Developers.