diff --git a/src/coreclr/vm/genericdict.cpp b/src/coreclr/vm/genericdict.cpp
index 2a3e066d8adbac..4e512fa7cb38f6 100644
--- a/src/coreclr/vm/genericdict.cpp
+++ b/src/coreclr/vm/genericdict.cpp
@@ -848,7 +848,12 @@ Dictionary::PopulateEntry(
                 th = th.GetMethodTable()->GetMethodTableMatchingParentClass(declaringType.AsMethodTable());
             }
 
-            th.GetMethodTable()->EnsureInstanceActive();
+            if (!th.IsTypeDesc())
+            {
+                MethodTable* pMT = th.AsMethodTable();
+                _ASSERTE(pMT != NULL);
+                pMT->EnsureInstanceActive();
+            }
 
             result = (CORINFO_GENERIC_HANDLE)th.AsPtr();
             break;
diff --git a/src/coreclr/vm/unsafeaccessors.cpp b/src/coreclr/vm/unsafeaccessors.cpp
index 08a521d3ac3715..042fa4ebc1f853 100644
--- a/src/coreclr/vm/unsafeaccessors.cpp
+++ b/src/coreclr/vm/unsafeaccessors.cpp
@@ -1076,6 +1076,23 @@ bool MethodDesc::TryGenerateUnsafeAccessor(DynamicResolver** resolver, COR_ILMET
         context.TargetTypeSig = context.DeclarationMetaSig.GetArgProps();
         (void)context.TargetTypeSig.PeekElemType(&firstArgCorType);
         firstArgType = context.DeclarationMetaSig.GetLastTypeHandleThrowing();
+
+        // For instance member access, the first argument is the receiver ("this").
+        // For value types the receiver must be passed byref. A byref receiver can also occur for reference
+        // types depending on the declaration signature.
+        //
+        // However, when emitting the metadata token for the accessed member, the owning type must not be
+        // a byref. Keeping the byref here can lead to incorrect shared generic context lookups at runtime.
+        //
+        // No special handling is required for other forms of type parameterization here:
+        //  * Arrays and generic instantiations are part of the owning type identity and must not be stripped.
+        //  * Other forms (eg. pointers) are not valid target types and will be rejected by ValidateTargetType().
+        if ((context.Kind == UnsafeAccessorKind::Method || context.Kind == UnsafeAccessorKind::Field)
+            && firstArgCorType == ELEMENT_TYPE_BYREF)
+        {
+            // Consume byref token.
+            (void)context.TargetTypeSig.GetElemType(nullptr);
+        }
     }
 
     // Using the kind type, perform the following:
diff --git a/src/tests/baseservices/compilerservices/UnsafeAccessors/UnsafeAccessorsTests.Generics.cs b/src/tests/baseservices/compilerservices/UnsafeAccessors/UnsafeAccessorsTests.Generics.cs
index df95ad1bb194a5..0b46c2c0f09f77 100644
--- a/src/tests/baseservices/compilerservices/UnsafeAccessors/UnsafeAccessorsTests.Generics.cs
+++ b/src/tests/baseservices/compilerservices/UnsafeAccessors/UnsafeAccessorsTests.Generics.cs
@@ -9,7 +9,31 @@
 
 using Xunit;
 
-struct Struct { }
+struct Struct
+{
+    public Type Value;
+    private void SetType(Type type)
+    {
+        Value = type;
+    }
+    private void SetType<T>()
+    {
+        Value = typeof(T);
+    }
+}
+
+struct GenericStruct<T>
+{
+    public Type Value;
+    private void SetType(Type type)
+    {
+        Value = type;
+    }
+    private void SetType<U>()
+    {
+        Value = typeof(U);
+    }
+}
 
 interface I1 { }
 
@@ -112,6 +136,12 @@ static class Accessors<V>
         [UnsafeAccessor(UnsafeAccessorKind.Method, Name = "CreateMessage")]
         public extern static string CreateMessage(GenericBase<V> b, V v);
 
+        [UnsafeAccessor(UnsafeAccessorKind.Method, Name = "SetType")]
+        public extern static void SetType(ref GenericStruct<V> s, Type type);
+
+        [UnsafeAccessor(UnsafeAccessorKind.Method, Name = "SetType")]
+        public extern static void SetType<U>(ref GenericStruct<V> s);
+
         [UnsafeAccessor(UnsafeAccessorKind.StaticMethod, Name = "ElementType")]
         public extern static Type ElementType(MyList<V> l);
 
@@ -128,6 +158,15 @@ static class Accessors<V>
         public extern static ref V GetPrivateStaticField(MyList<V> d);
     }
 
+    static class Accessors
+    {
+        [UnsafeAccessor(UnsafeAccessorKind.Method, Name = "SetType")]
+        public extern static void SetType<U>(ref Struct s);
+
+        [UnsafeAccessor(UnsafeAccessorKind.Method, Name = "SetType")]
+        public extern static void SetType(ref Struct s, Type type);
+    }
+
     [Fact]
     public static void Verify_Generic_AccessStaticFieldClass()
     {
@@ -459,6 +498,68 @@ public static void Verify_Generic_GenericTypeGenericStaticMethod()
         }
     }
 
+    [Fact]
+    public static void Verify_Generic_Structs()
+    {
+        Console.WriteLine($"Running {nameof(Verify_Generic_Structs)}");
+
+        {
+            Struct s = new();
+            Accessors.SetType(ref s, typeof(int));
+            Assert.Equal(typeof(int), s.Value);
+            Accessors.SetType(ref s, typeof(string));
+            Assert.Equal(typeof(string), s.Value);
+            Accessors.SetType(ref s, typeof(Struct));
+            Assert.Equal(typeof(Struct), s.Value);
+            Accessors.SetType(ref s, typeof(GenericStruct<int>));
+            Assert.Equal(typeof(GenericStruct<int>), s.Value);
+            Accessors.SetType(ref s, typeof(GenericStruct<string>));
+            Assert.Equal(typeof(GenericStruct<string>), s.Value);
+        }
+
+        {
+            Struct s = new();
+            Accessors.SetType<int>(ref s);
+            Assert.Equal(typeof(int), s.Value);
+            Accessors.SetType<string>(ref s);
+            Assert.Equal(typeof(string), s.Value);
+            Accessors.SetType<Struct>(ref s);
+            Assert.Equal(typeof(Struct), s.Value);
+            Accessors.SetType<GenericStruct<int>>(ref s);
+            Assert.Equal(typeof(GenericStruct<int>), s.Value);
+            Accessors.SetType<GenericStruct<string>>(ref s);
+            Assert.Equal(typeof(GenericStruct<string>), s.Value);
+        }
+
+        {
+            GenericStruct<int> s = new();
+            Accessors<int>.SetType(ref s, typeof(int));
+            Assert.Equal(typeof(int), s.Value);
+            Accessors<int>.SetType<string>(ref s);
+            Assert.Equal(typeof(string), s.Value);
+            Accessors<int>.SetType<Struct>(ref s);
+            Assert.Equal(typeof(Struct), s.Value);
+            Accessors<int>.SetType<GenericStruct<int>>(ref s);
+            Assert.Equal(typeof(GenericStruct<int>), s.Value);
+            Accessors<int>.SetType<GenericStruct<string>>(ref s);
+            Assert.Equal(typeof(GenericStruct<string>), s.Value);
+        }
+
+        {
+            GenericStruct<string> s = new();
+            Accessors<string>.SetType(ref s, typeof(int));
+            Assert.Equal(typeof(int), s.Value);
+            Accessors<string>.SetType<string>(ref s);
+            Assert.Equal(typeof(string), s.Value);
+            Accessors<string>.SetType<Struct>(ref s);
+            Assert.Equal(typeof(Struct), s.Value);
+            Accessors<string>.SetType<GenericStruct<int>>(ref s);
+            Assert.Equal(typeof(GenericStruct<int>), s.Value);
+            Accessors<string>.SetType<GenericStruct<string>>(ref s);
+            Assert.Equal(typeof(GenericStruct<string>), s.Value);
+        }
+    }
+
     class MethodWithConstraints
     {
         private string M<T, U>() where T : U, I2<T>