diff --git a/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp b/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
index a5133023af6a..55f269881277 100644
--- a/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
+++ b/Source/Core/VideoBackends/OGL/ProgramShaderCache.cpp
@@ -135,6 +135,8 @@ void SHADER::SetProgramBindings(bool is_compute)
       // So we do support extended blending
       // So we need to set a few more things here.
       // Bind our out locations
+      // Note: on macOS, this can cause graphical issues if ocol1 exists in the fragment shader but
+      // we're not actually doing dual-source blending.
       glBindFragDataLocationIndexed(glprogid, 0, 0, "ocol0");
       glBindFragDataLocationIndexed(glprogid, 0, 1, "ocol1");
     }
diff --git a/Source/Core/VideoCommon/PixelShaderGen.cpp b/Source/Core/VideoCommon/PixelShaderGen.cpp
index 0ccfb09679c6..52e6468b1a12 100644
--- a/Source/Core/VideoCommon/PixelShaderGen.cpp
+++ b/Source/Core/VideoCommon/PixelShaderGen.cpp
@@ -16,6 +16,7 @@
 #include "VideoCommon/DriverDetails.h"
 #include "VideoCommon/LightingShaderGen.h"
 #include "VideoCommon/NativeVertexFormat.h"
+#include "VideoCommon/RenderState.h"
 #include "VideoCommon/VertexLoaderManager.h"
 #include "VideoCommon/VideoCommon.h"
 #include "VideoCommon/VideoConfig.h"
@@ -177,6 +178,11 @@ PixelShaderUid GetPixelShaderUid()
   uid_data->dither = bpmem.blendmode.dither && uid_data->rgba6_format;
   uid_data->uint_output = bpmem.blendmode.UseLogicOp();
 
+  BlendingState state{};
+  state.Generate(bpmem);
+  uid_data->blendEnable = state.blendenable;
+  uid_data->useDualSource = state.usedualsrc;
+
   u32 numStages = uid_data->genMode_numtevstages + 1;
 
   const bool forced_early_z =
@@ -516,7 +522,7 @@ ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host
 
   // Only use dual-source blending when required on drivers that don't support it very well.
   const bool use_dual_source =
-      host_config.backend_dual_source_blend &&
+      uid_data->blendEnable && uid_data->useDualSource && host_config.backend_dual_source_blend &&
       (!DriverDetails::HasBug(DriverDetails::BUG_BROKEN_DUAL_SOURCE_BLENDING) ||
        uid_data->useDstAlpha);
 
diff --git a/Source/Core/VideoCommon/PixelShaderGen.h b/Source/Core/VideoCommon/PixelShaderGen.h
index b480777c41a0..d98cb107ab12 100644
--- a/Source/Core/VideoCommon/PixelShaderGen.h
+++ b/Source/Core/VideoCommon/PixelShaderGen.h
@@ -44,7 +44,9 @@ struct pixel_shader_uid_data
   u32 rgba6_format : 1;
   u32 dither : 1;
   u32 uint_output : 1;
-  u32 pad : 15;
+  u32 blendEnable : 1;
+  u32 useDualSource : 1;
+  u32 pad : 13;
 
   u32 texMtxInfo_n_projection : 8;  // 8x1 bit
   u32 tevindref_bi0 : 3;