diff --git a/python/lib/dependabot/python/package/package_registry_finder.rb b/python/lib/dependabot/python/package/package_registry_finder.rb
index 396bae16c0e..7c9873e0b68 100644
--- a/python/lib/dependabot/python/package/package_registry_finder.rb
+++ b/python/lib/dependabot/python/package/package_registry_finder.rb
@@ -59,6 +59,9 @@ def registry_urls
         sig { returns(T::Array[Dependabot::Credential]) }
         attr_reader :credentials
 
+        sig { returns(Dependabot::Dependency) }
+        attr_reader :dependency
+
         sig { returns(String) }
         def main_index_url
           url =
@@ -256,7 +259,17 @@ def pyproject
 
         sig { returns(T::Array[Dependabot::DependencyFile]) }
         def requirements_files
-          dependency_files.select { |f| f.name.match?(/requirements/x) }
+          # Get the list of requirement file names where this dependency appears
+          requirement_file_names = dependency.requirements
+                                             .map { |r| r[:file] }
+                                             .select { |f| f.match?(/requirements/x) }
+
+          # If the dependency has no requirements in any requirements files,
+          # return all requirements files (backward compatibility)
+          return dependency_files.select { |f| f.name.match?(/requirements/x) } if requirement_file_names.empty?
+
+          # Otherwise, only return the requirement files where this dependency appears
+          dependency_files.select { |f| requirement_file_names.include?(f.name) }
         end
 
         sig { returns(T::Array[Dependabot::DependencyFile]) }
diff --git a/python/spec/dependabot/python/package/package_registry_finder_spec.rb b/python/spec/dependabot/python/package/package_registry_finder_spec.rb
index b450d09fb4f..f29abc3c7ee 100644
--- a/python/spec/dependabot/python/package/package_registry_finder_spec.rb
+++ b/python/spec/dependabot/python/package/package_registry_finder_spec.rb
@@ -345,6 +345,102 @@
           expect(registry_urls).to contain_exactly("https://pypi.org/simple/", "https://pypi.weasyldev.com/weasyl/source/+simple/")
         end
       end
+
+      context "with multiple requirements files each having different extra-index-url" do
+        let(:requirements_cpu) do
+          Dependabot::DependencyFile.new(
+            name: "requirements_cpu.txt",
+            content: fixture("requirements", "torch_cpu.txt")
+          )
+        end
+        let(:requirements_gpu) do
+          Dependabot::DependencyFile.new(
+            name: "requirements_gpu.txt",
+            content: fixture("requirements", "torch_gpu.txt")
+          )
+        end
+
+        context "when dependency is only in requirements_cpu.txt" do
+          let(:dependency_files) { [requirements_cpu, requirements_gpu] }
+          let(:dependency) do
+            Dependabot::Dependency.new(
+              name: "torch",
+              version: "2.0.0+cpu",
+              requirements: [{
+                requirement: "==2.0.0+cpu",
+                file: "requirements_cpu.txt",
+                groups: ["dependencies"],
+                source: nil
+              }],
+              package_manager: "pip"
+            )
+          end
+
+          it "only uses the extra-index-url from requirements_cpu.txt" do
+            expect(registry_urls).to contain_exactly(
+              "https://pypi.org/simple/",
+              "https://download.pytorch.org/whl/cpu/"
+            )
+          end
+        end
+
+        context "when dependency is only in requirements_gpu.txt" do
+          let(:dependency_files) { [requirements_cpu, requirements_gpu] }
+          let(:dependency) do
+            Dependabot::Dependency.new(
+              name: "torch",
+              version: "2.0.0+cu118",
+              requirements: [{
+                requirement: "==2.0.0+cu118",
+                file: "requirements_gpu.txt",
+                groups: ["dependencies"],
+                source: nil
+              }],
+              package_manager: "pip"
+            )
+          end
+
+          it "only uses the extra-index-url from requirements_gpu.txt" do
+            expect(registry_urls).to contain_exactly(
+              "https://pypi.org/simple/",
+              "https://download.pytorch.org/whl/cu118/"
+            )
+          end
+        end
+
+        context "when dependency is in both files" do
+          let(:dependency_files) { [requirements_cpu, requirements_gpu] }
+          let(:dependency) do
+            Dependabot::Dependency.new(
+              name: "torch",
+              version: "2.0.0+cpu",
+              requirements: [
+                {
+                  requirement: "==2.0.0+cpu",
+                  file: "requirements_cpu.txt",
+                  groups: ["dependencies"],
+                  source: nil
+                },
+                {
+                  requirement: "==2.0.0+cu118",
+                  file: "requirements_gpu.txt",
+                  groups: ["dependencies"],
+                  source: nil
+                }
+              ],
+              package_manager: "pip"
+            )
+          end
+
+          it "uses extra-index-url from both files" do
+            expect(registry_urls).to contain_exactly(
+              "https://pypi.org/simple/",
+              "https://download.pytorch.org/whl/cpu/",
+              "https://download.pytorch.org/whl/cu118/"
+            )
+          end
+        end
+      end
     end
   end
 end
diff --git a/python/spec/fixtures/requirements/torch_cpu.txt b/python/spec/fixtures/requirements/torch_cpu.txt
new file mode 100644
index 00000000000..30e3683a920
--- /dev/null
+++ b/python/spec/fixtures/requirements/torch_cpu.txt
@@ -0,0 +1,2 @@
+--extra-index-url https://download.pytorch.org/whl/cpu
+torch==2.0.0+cpu
diff --git a/python/spec/fixtures/requirements/torch_gpu.txt b/python/spec/fixtures/requirements/torch_gpu.txt
new file mode 100644
index 00000000000..8ec296fb4bd
--- /dev/null
+++ b/python/spec/fixtures/requirements/torch_gpu.txt
@@ -0,0 +1,2 @@
+--extra-index-url https://download.pytorch.org/whl/cu118
+torch==2.0.0+cu118