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<meta charset="utf-8" />
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<meta name="author" content="María Alcázar-Fabra, Francisco Rodríguez-Sánchez, Eva Trevisson & Gloria Brea-Calvo" />
<title>Clinical manifestations of primary CoQ deficiencies</title>
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<h1 class="title toc-ignore">Clinical manifestations of primary CoQ deficiencies</h1>
<h4 class="author">María Alcázar-Fabra, Francisco Rodríguez-Sánchez, Eva Trevisson & Gloria Brea-Calvo</h4>
</div>
<hr />
<p><br></p>
<p>Primary coenzyme Q (CoQ) deficiencies are clinically heterogeneous and lack a clear genotype-phenotype correlation. With this platform, we aim to gain insight of the most common manifestations associated with the different COQ genes to improve the diagnosis of patients.</p>
<p><br></p>
<div id="section" class="section level2 tabset tabset-fade tabset-pills">
<h2></h2>
<div id="the-tool" class="section level3">
<h3>The tool</h3>
<p>Here you can search the frequency of clinical manifestations grouped by system for each gene.</p>
<p>Go to table to search the data by involved system, specific manifestation or COQ gene.</p>
</div>
<div id="csn" class="section level3">
<h3>CSN</h3>
<p><img src="index_files/figure-html/unnamed-chunk-3-1.png" width="100%" /></p>
</div>
<div id="heart" class="section level3">
<h3>Heart</h3>
<p><img src="index_files/figure-html/unnamed-chunk-4-1.png" width="100%" /></p>
</div>
<div id="kidney" class="section level3">
<h3>Kidney</h3>
<p><img src="index_files/figure-html/unnamed-chunk-5-1.png" width="100%" /></p>
</div>
<div id="liver" class="section level3">
<h3>Liver</h3>
<p><img src="index_files/figure-html/unnamed-chunk-6-1.png" width="100%" /></p>
</div>
<div id="lung" class="section level3">
<h3>Lung</h3>
<p><img src="index_files/figure-html/unnamed-chunk-7-1.png" width="100%" /></p>
</div>
<div id="muscle" class="section level3">
<h3>Muscle</h3>
<p><img src="index_files/figure-html/unnamed-chunk-8-1.png" width="100%" /></p>
</div>
<div id="pnssensory-organs" class="section level3">
<h3>PNS/Sensory organs</h3>
<p><img src="index_files/figure-html/unnamed-chunk-9-1.png" width="100%" /></p>
</div>
<div id="other" class="section level3">
<h3>Other</h3>
<p><img src="index_files/figure-html/unnamed-chunk-10-1.png" width="100%" /></p>
</div>
<div id="table" class="section level3">
<h3>Table</h3>
<p>In this table you can search by symptom (and link to symptom description). Numbers represent number of patients.</p>
<div id="htmlwidget-8638b79fb8a86dcdd1b1" style="width:100%;height:auto;" class="datatables html-widget"></div>
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<h2></h2>
<p>Last update: 2021-01-02</p>
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