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mLLMCelltype is an R package that leverages various large language models (LLMs) for automated cell type annotation in single-cell RNA sequencing data. The package implements a **multi-LLM consensus architecture** where multiple LLMs collaborate through structured deliberation that aims to improve annotation reliability by combining multiple model predictions.
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The mLLMCelltype paper was published online in *Communications Biology* on June 8, 2026.
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### Key Features
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***Multi-LLM Consensus Mechanism**: Combines predictions from multiple LLMs to reduce individual model biases
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title = {Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data},
Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*, 9, 779. https://doi.org/10.1038/s42003-026-10420-8
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*. https://doi.org/10.1038/s42003-026-10420-8
For benchmark results comparing the two approaches, see Yang et al. (2026):
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*, 9, 779. https://doi.org/10.1038/s42003-026-10420-8
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*. https://doi.org/10.1038/s42003-026-10420-8
Copy file name to clipboardExpand all lines: R/vignettes/why-consensus.Rmd
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# Why Choose Consensus? The Scientific Foundation of Multi-LLM Annotation
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Multi-LLM consensus can improve annotation accuracy by combining the strengths of diverse AI models while reducing the impact of individual model limitations (see Yang et al., 2025).
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Multi-LLM consensus can improve annotation accuracy by combining the strengths of diverse AI models while reducing the impact of individual model limitations (see Yang et al., 2026).
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## The Challenge with Single-Model Approaches
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For benchmark results, see Yang et al. (2026):
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*, 9, 779. https://doi.org/10.1038/s42003-026-10420-8
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*. https://doi.org/10.1038/s42003-026-10420-8
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