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CITATION.cff

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- family-names: "Chen"
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given-names: "Jun"
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title: "mLLMCelltype: Multi-LLM consensus framework for cell type annotation"
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version: 2.0.3
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date-released: 2025-04-10
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version: 2.0.5
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date-released: 2026-05-11
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url: "https://github.com/cafferychen777/mLLMCelltype"
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repository-code: "https://github.com/cafferychen777/mLLMCelltype"
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license: MIT
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title: "Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data"
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journal: "Communications Biology"
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year: 2026
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volume: 9
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start: 779
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date-released: 2026-06-08
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doi: "10.1038/s42003-026-10420-8"
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url: "https://doi.org/10.1038/s42003-026-10420-8"
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publisher: "Nature Publishing Group"
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publisher: "Springer Nature"

R/NEWS.md

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# mLLMCelltype Changelog
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## Unreleased
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### Documentation
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* Updated paper citation metadata to the Communications Biology publication DOI.
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## 2.0.5 (2026-05-11)
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### Bug Fixes

R/_pkgdown.yml

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<p>Yang, C., Zhang, X., & Chen, J. (2026).
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<em>Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data</em>.
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Communications Biology, 9, 779. <a href="https://doi.org/10.1038/s42003-026-10420-8">doi:10.1038/s42003-026-10420-8</a>.</p>
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Communications Biology. <a href="https://doi.org/10.1038/s42003-026-10420-8">doi:10.1038/s42003-026-10420-8</a>.</p>
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```bibtex
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@article{yang2026llmconsensus,
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author = {Yang, Chen and Zhang, Xianyang and Chen, Jun},
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title = {Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data},
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journal = {Communications Biology},
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year = {2026},
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volume = {9},
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pages = {779},
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doi = {10.1038/s42003-026-10420-8},
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publisher = {Nature Publishing Group}
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url = {https://doi.org/10.1038/s42003-026-10420-8},
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publisher = {Springer Nature}
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}
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```
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title: "mLLMCelltype: Cell Type Annotation Using Multi-LLM Consensus"

R/index.md

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mLLMCelltype is an R package that leverages various large language models (LLMs) for automated cell type annotation in single-cell RNA sequencing data. The package implements a **multi-LLM consensus architecture** where multiple LLMs collaborate through structured deliberation that aims to improve annotation reliability by combining multiple model predictions.
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The mLLMCelltype paper was published online in *Communications Biology* on June 8, 2026.
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### Key Features
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* **Multi-LLM Consensus Mechanism**: Combines predictions from multiple LLMs to reduce individual model biases
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title = {Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data},
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journal = {Communications Biology},
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year = {2026},
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volume = {9},
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pages = {779},
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doi = {10.1038/s42003-026-10420-8},
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publisher = {Nature Publishing Group}
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url = {https://doi.org/10.1038/s42003-026-10420-8},
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publisher = {Springer Nature}
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}
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```
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You can also cite this in plain text format:
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*, 9, 779. https://doi.org/10.1038/s42003-026-10420-8
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*. https://doi.org/10.1038/s42003-026-10420-8
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### Learn More
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R/inst/CITATION

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bibentry(
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bibtype = "Article",
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title = "Large Language Model Consensus Substantially Improves the Cell Type Annotation Accuracy for scRNA-seq Data",
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title = "Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data",
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author = c(person("Chen", "Yang"),
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person("Xianyang", "Zhang"),
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person("Jun", "Chen")),
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journal = "bioRxiv",
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year = "2025",
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doi = "10.1101/2025.04.10.647852",
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publisher = "Cold Spring Harbor Laboratory",
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journal = "Communications Biology",
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year = "2026",
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doi = "10.1038/s42003-026-10420-8",
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url = "https://doi.org/10.1038/s42003-026-10420-8",
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publisher = "Springer Nature",
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textVersion = paste(
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"Yang, C., Zhang, X., & Chen, J. (2025).",
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"Large Language Model Consensus Substantially Improves the Cell Type Annotation Accuracy for scRNA-seq Data.",
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"bioRxiv.",
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"doi:10.1101/2025.04.10.647852"
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"Yang, C., Zhang, X., & Chen, J. (2026).",
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"Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data.",
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"Communications Biology.",
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"https://doi.org/10.1038/s42003-026-10420-8"
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)
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)

R/man/mLLMCelltype-package.Rd

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R/vignettes/introduction.Rmd

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```
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially
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improves the cell type annotation accuracy for scRNA-seq data. Communications Biology, 9, 779.
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improves the cell type annotation accuracy for scRNA-seq data. Communications Biology.
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https://doi.org/10.1038/s42003-026-10420-8
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```
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R/vignettes/version-history.Rmd

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```
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially
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improves the cell type annotation accuracy for scRNA-seq data. Communications Biology, 9, 779.
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improves the cell type annotation accuracy for scRNA-seq data. Communications Biology.
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https://doi.org/10.1038/s42003-026-10420-8
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```
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R/vignettes/vs-single-agent.Rmd

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For benchmark results comparing the two approaches, see Yang et al. (2026):
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*, 9, 779. https://doi.org/10.1038/s42003-026-10420-8
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*. https://doi.org/10.1038/s42003-026-10420-8
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## Cost and Resource Trade-offs
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R/vignettes/why-consensus.Rmd

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# Why Choose Consensus? The Scientific Foundation of Multi-LLM Annotation
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Multi-LLM consensus can improve annotation accuracy by combining the strengths of diverse AI models while reducing the impact of individual model limitations (see Yang et al., 2025).
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Multi-LLM consensus can improve annotation accuracy by combining the strengths of diverse AI models while reducing the impact of individual model limitations (see Yang et al., 2026).
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## The Challenge with Single-Model Approaches
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For benchmark results, see Yang et al. (2026):
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*, 9, 779. https://doi.org/10.1038/s42003-026-10420-8
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Yang, C., Zhang, X., & Chen, J. (2026). Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data. *Communications Biology*. https://doi.org/10.1038/s42003-026-10420-8
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## Cost Considerations
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