diff --git a/src/functionalTest/groovy/com/autonomousapps/android/AbiExclusionsSpec.groovy b/src/functionalTest/groovy/com/autonomousapps/android/AbiExclusionsSpec.groovy
new file mode 100644
index 000000000..6a1962e8e
--- /dev/null
+++ b/src/functionalTest/groovy/com/autonomousapps/android/AbiExclusionsSpec.groovy
@@ -0,0 +1,26 @@
+// Copyright (c) 2025. Tony Robalik.
+// SPDX-License-Identifier: Apache-2.0
+package com.autonomousapps.android
+
+import com.autonomousapps.android.projects.AbiExcludedVariantProject
+
+import static com.autonomousapps.utils.Runner.build
+import static com.google.common.truth.Truth.assertThat
+
+final class AbiExclusionsSpec extends AbstractAndroidSpec {
+
+  def "can exclude variant from ABI analysis (#gradleVersion AGP #agpVersion)"() {
+    given:
+    def project = new AbiExcludedVariantProject(agpVersion)
+    gradleProject = project.gradleProject
+
+    when:
+    build(gradleVersion, gradleProject.rootDir, 'buildHealth')
+
+    then:
+    assertThat(project.actualBuildHealth()).containsExactlyElementsIn(project.expectedBuildHealth)
+
+    where:
+    [gradleVersion, agpVersion] << gradleAgpMatrix()
+  }
+}
diff --git a/src/functionalTest/groovy/com/autonomousapps/android/projects/AbiExcludedVariantProject.groovy b/src/functionalTest/groovy/com/autonomousapps/android/projects/AbiExcludedVariantProject.groovy
new file mode 100644
index 000000000..c1c45dd3f
--- /dev/null
+++ b/src/functionalTest/groovy/com/autonomousapps/android/projects/AbiExcludedVariantProject.groovy
@@ -0,0 +1,93 @@
+// Copyright (c) 2025. Tony Robalik.
+// SPDX-License-Identifier: Apache-2.0
+package com.autonomousapps.android.projects
+
+import com.autonomousapps.kit.GradleProject
+import com.autonomousapps.kit.Source
+import com.autonomousapps.kit.SourceType
+import com.autonomousapps.model.Advice
+import com.autonomousapps.model.AndroidScore
+import com.autonomousapps.model.ModuleAdvice
+import com.autonomousapps.model.PluginAdvice
+import com.autonomousapps.model.ProjectAdvice
+
+import static com.autonomousapps.AdviceHelper.*
+import static com.autonomousapps.kit.gradle.dependencies.Dependencies.commonsCollections
+
+final class AbiExcludedVariantProject extends AbstractAndroidProject {
+
+  final GradleProject gradleProject
+
+  AbiExcludedVariantProject(String agpVersion) {
+    super(agpVersion)
+    this.gradleProject = build()
+  }
+
+  private GradleProject build() {
+    return newAndroidGradleProjectBuilder(agpVersion)
+      .withRootProject { root ->
+        root.withBuildScript { bs ->
+          bs.withGroovy("""\
+            dependencyAnalysis {
+              abi {
+                exclusions {
+                  excludeVariants('release')
+                }
+              }
+            }"""
+          )
+        }
+      }
+      .withAndroidSubproject('lib') { l ->
+        l.sources = libSources
+        l.manifest = libraryManifest()
+        l.withBuildScript { bs ->
+          bs.plugins = androidLibWithKotlin
+          bs.android = defaultAndroidLibBlock()
+          bs.dependencies = [
+            // This dependency would normally cause an unused dependency warning
+            // but we're excluding the release variant from analysis
+            commonsCollections("releaseImplementation")
+          ]
+        }
+      }
+      .write()
+  }
+
+  private List<Source> libSources = [
+    // Only has code in debug source set - no code in main source set
+    new Source(
+      SourceType.KOTLIN, "DebugLibrary", "com/example/lib",
+      """\
+        package com.example.lib
+        
+        class DebugLibrary
+      """.stripIndent(),
+      "debug"
+    )
+  ]
+
+  Set<ProjectAdvice> actualBuildHealth() {
+    return actualProjectAdvice(gradleProject)
+  }
+
+  private final AndroidScore androidScore = androidScoreBuilder().with {
+    hasAndroidAssets = false
+    hasAndroidRes = false
+    usesAndroidClasses = false
+    hasBuildConfig = false
+    hasAndroidDependencies = false
+    hasBuildTypeSourceSplits = true
+    build()
+  }
+
+  final Set<ProjectAdvice> expectedBuildHealth = [
+    projectAdvice(
+      ':lib',
+      [] as Set<Advice>,
+      [] as Set<PluginAdvice>,
+      [androidScore] as Set<ModuleAdvice>,
+      false
+    ),
+  ]
+}
diff --git a/src/main/kotlin/com/autonomousapps/extension/AbiHandler.kt b/src/main/kotlin/com/autonomousapps/extension/AbiHandler.kt
index 9ac10e9b6..24be3be06 100644
--- a/src/main/kotlin/com/autonomousapps/extension/AbiHandler.kt
+++ b/src/main/kotlin/com/autonomousapps/extension/AbiHandler.kt
@@ -19,6 +19,7 @@ import javax.inject.Inject
  *   abi {
  *     exclusions {
  *       excludeSourceSets(/* source sets to exclude from ABI analysis */)
+ *       excludeVariants(/* variants to exclude from ABI analysis */)
  *
  *       ignoreSubPackage("internal")
  *       ignoreInternalPackages()
@@ -46,6 +47,7 @@ abstract class ExclusionsHandler @Inject constructor(objects: ObjectFactory) {
   internal val annotationExclusions = objects.setProperty<String>().convention(emptySet())
   internal val pathExclusions = objects.setProperty<String>().convention(emptySet())
   internal val excludedSourceSets = objects.setProperty<String>().convention(emptySet())
+  internal val excludedVariants = objects.setProperty<String>().convention(emptySet())
 
   /**
    * Exclude the given [sourceSets] from ABI analysis, which means that regardless of the level of exposure of any given
@@ -55,6 +57,14 @@ abstract class ExclusionsHandler @Inject constructor(objects: ObjectFactory) {
     excludedSourceSets.addAll(*sourceSets)
   }
 
+  /**
+   * Exclude the given [variants] from ABI analysis. This is useful for Android projects that have only debug sources
+   * and analyzing the release configuration is not useful.
+   */
+  fun excludeVariants(vararg variants: String) {
+    excludedVariants.addAll(*variants)
+  }
+
   /**
    * Exclude "internal" packages from ABI analysis, which means that any class in a package that contains ".internal."
    * will not be considered as part of the module's ABI.
diff --git a/src/main/kotlin/com/autonomousapps/subplugin/ProjectPlugin.kt b/src/main/kotlin/com/autonomousapps/subplugin/ProjectPlugin.kt
index 304bf80f3..b4d7995a8 100644
--- a/src/main/kotlin/com/autonomousapps/subplugin/ProjectPlugin.kt
+++ b/src/main/kotlin/com/autonomousapps/subplugin/ProjectPlugin.kt
@@ -236,7 +236,8 @@ internal class ProjectPlugin(private val project: Project) {
   /** Has the `com.android.application` plugin applied. */
   private fun Project.configureAndroidAppProject() {
     val project = this
-    val ignoredVariantNames = androidIgnoredVariants()
+    val ignoredVariantNames = androidIgnoredVariants() +
+      dagpExtension.abiHandler.exclusionsHandler.excludedVariants.get()
 
     val androidComponents = project.extensions.getByType(AndroidComponentsExtension::class.java)
     // val newAgpVersion = androidComponents.pluginVersion.toString().removePrefix("Android Gradle Plugin version ")
@@ -312,7 +313,8 @@ internal class ProjectPlugin(private val project: Project) {
   /** Has the `com.android.library` plugin applied. */
   private fun Project.configureAndroidLibProject() {
     val project = this
-    val ignoredVariantNames = androidIgnoredVariants()
+    val ignoredVariantNames = androidIgnoredVariants() +
+      dagpExtension.abiHandler.exclusionsHandler.excludedVariants.get()
 
     val androidComponents = project.extensions.getByType(AndroidComponentsExtension::class.java)
     // val newAgpVersion = androidComponents.pluginVersion.toString().removePrefix("Android Gradle Plugin version ")
@@ -391,7 +393,8 @@ internal class ProjectPlugin(private val project: Project) {
   /** Has the `com.android.test` plugin applied. */
   private fun Project.configureAndroidTestProject() {
     val project = this
-    val ignoredVariantNames = androidIgnoredVariants()
+    val ignoredVariantNames = androidIgnoredVariants() +
+      dagpExtension.abiHandler.exclusionsHandler.excludedVariants.get()
 
     val androidComponents = project.extensions.getByType(AndroidComponentsExtension::class.java)
     // val newAgpVersion = androidComponents.pluginVersion.toString().removePrefix("Android Gradle Plugin version ")